ATE66477T1 - 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren. - Google Patents
2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren.Info
- Publication number
- ATE66477T1 ATE66477T1 AT87307495T AT87307495T ATE66477T1 AT E66477 T1 ATE66477 T1 AT E66477T1 AT 87307495 T AT87307495 T AT 87307495T AT 87307495 T AT87307495 T AT 87307495T AT E66477 T1 ATE66477 T1 AT E66477T1
- Authority
- AT
- Austria
- Prior art keywords
- guanidino
- treatment
- optionally substituted
- thiazole
- aryl
- Prior art date
Links
- 208000008469 Peptic Ulcer Diseases 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 108091006112 ATPases Proteins 0.000 abstract 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000001711 oxyntic cell Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 abstract 1
- 229960002702 piroxicam Drugs 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8601795 | 1986-08-29 | ||
| EP87307495A EP0259085B1 (de) | 1986-08-29 | 1987-08-25 | 2-Guanidino-4-aryl-thiazole für die Behandlung von peptischen Geschwüren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE66477T1 true ATE66477T1 (de) | 1991-09-15 |
Family
ID=22195621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87307495T ATE66477T1 (de) | 1986-08-29 | 1987-08-25 | 2-guanidino-4-aryl-thiazole fuer die behandlung von peptischen geschwueren. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5026715A (de) |
| EP (1) | EP0259085B1 (de) |
| JP (1) | JPH0633258B2 (de) |
| AT (1) | ATE66477T1 (de) |
| DE (1) | DE3772301D1 (de) |
| DK (1) | DK451687A (de) |
| ES (1) | ES2031514T3 (de) |
| GR (1) | GR3002596T3 (de) |
| IE (1) | IE60039B1 (de) |
| PT (1) | PT85604B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6313156B1 (en) * | 1999-12-23 | 2001-11-06 | Icos Corporation | Thiazole compounds as cyclic-AMP-specific phosphodiesterase inhibitors |
| DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
| JP5173192B2 (ja) * | 2004-09-30 | 2013-03-27 | 武田薬品工業株式会社 | プロトンポンプ阻害薬 |
| BRPI0615111B8 (pt) * | 2005-08-30 | 2021-05-25 | Takeda Pharmaceuticals Co | composto, composição farmacêutica, e, uso do composto |
| EP2005957B1 (de) | 2006-03-31 | 2012-05-30 | Takeda Pharmaceutical Company Limited | Säuresekretionshemmer |
| US8933105B2 (en) * | 2007-02-28 | 2015-01-13 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| WO2010021149A1 (ja) * | 2008-08-21 | 2010-02-25 | 武田薬品工業株式会社 | 酸分泌抑制スピロ化合物 |
| WO2010024451A1 (en) | 2008-08-27 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Pyrrole compounds |
| PL2718290T3 (pl) * | 2011-06-07 | 2016-11-30 | Kompozycje i sposoby modulowania kinazy |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| CA963908A (en) * | 1971-01-29 | 1975-03-04 | David B. Capps | Thiazolium salts |
| US3758491A (en) * | 1972-01-07 | 1973-09-11 | Parke Davis & Co | Novel anti infective agents and means of producing the same |
| IE47458B1 (en) * | 1977-11-07 | 1984-03-21 | Leo Pharm Prod Ltd | Quinolylguanidine derivatives |
| US4374843A (en) * | 1980-10-14 | 1983-02-22 | Pfizer Inc. | 2-Guanidino-4-heteroarylthiazoles |
| US4435396A (en) * | 1982-05-10 | 1984-03-06 | Pfizer Inc. | Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor |
| JPS59225186A (ja) * | 1983-05-18 | 1984-12-18 | Yamanouchi Pharmaceut Co Ltd | 新規なグアニジノチアゾ−ル誘導体及びその製造方法 |
| JPS59225172A (ja) * | 1983-06-03 | 1984-12-18 | Yamanouchi Pharmaceut Co Ltd | 新規グアニジノチアゾ−ル誘導体及びその製法 |
| US4560690A (en) * | 1984-04-30 | 1985-12-24 | Pfizer Inc. | 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents |
| US4791200A (en) * | 1987-06-22 | 1988-12-13 | Ortho Pharmaceutical Corporation | 2-substituted-4-aryl-substituted thiazoles |
-
1987
- 1987-08-25 EP EP87307495A patent/EP0259085B1/de not_active Expired - Lifetime
- 1987-08-25 AT AT87307495T patent/ATE66477T1/de not_active IP Right Cessation
- 1987-08-25 ES ES198787307495T patent/ES2031514T3/es not_active Expired - Lifetime
- 1987-08-25 DE DE8787307495T patent/DE3772301D1/de not_active Expired - Lifetime
- 1987-08-26 IE IE227787A patent/IE60039B1/en not_active IP Right Cessation
- 1987-08-27 PT PT85604A patent/PT85604B/pt not_active IP Right Cessation
- 1987-08-28 DK DK451687A patent/DK451687A/da not_active Application Discontinuation
- 1987-08-28 JP JP62214960A patent/JPH0633258B2/ja not_active Expired - Lifetime
-
1989
- 1989-10-20 US US07/426,455 patent/US5026715A/en not_active Expired - Fee Related
-
1991
- 1991-08-22 GR GR91401225T patent/GR3002596T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0259085B1 (de) | 1991-08-21 |
| EP0259085A1 (de) | 1988-03-09 |
| GR3002596T3 (en) | 1993-01-25 |
| DK451687A (da) | 1988-05-13 |
| JPS6363678A (ja) | 1988-03-22 |
| DE3772301D1 (de) | 1991-09-26 |
| ES2031514T3 (es) | 1992-12-16 |
| US5026715A (en) | 1991-06-25 |
| JPH0633258B2 (ja) | 1994-05-02 |
| DK451687D0 (da) | 1987-08-28 |
| PT85604A (en) | 1987-09-01 |
| IE60039B1 (en) | 1994-05-18 |
| PT85604B (pt) | 1990-05-31 |
| IE872277L (en) | 1988-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |