AR052419A1 - Derivados de bencimidazolil n-sustituidos,inhibidores del protooncogen c-kit - Google Patents
Derivados de bencimidazolil n-sustituidos,inhibidores del protooncogen c-kitInfo
- Publication number
- AR052419A1 AR052419A1 ARP050105014A ARP050105014A AR052419A1 AR 052419 A1 AR052419 A1 AR 052419A1 AR P050105014 A ARP050105014 A AR P050105014A AR P050105014 A ARP050105014 A AR P050105014A AR 052419 A1 AR052419 A1 AR 052419A1
- Authority
- AR
- Argentina
- Prior art keywords
- 8alkyl
- optionally substituted
- independent
- cyclyl
- substituted
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Composiciones farmacéuticas que los contienen, usos como anticancerígenos y bancos combinatorios de benzimidazoles. Reivindicacion 1: Un compuesto represnetadop por la formula (1) o una sal o un N-oxido farmacéuticamente aceptable de la misma, en donde: R1 y R2 son independientemente C0-8 alquil sustituido opcionalmente con un sustituyente heterociclilo; C0-8 alquil sustituido opcionalmente con un halo independiente 1-6, -CONR11R12, -NR13CONR11R12, -NR13CO2R11, -S(O)0-2NR11R12, -NR11S(O)0- 2R12, CN, OH, o sustituyentes del arilo sustituido opcionalmente; -C0-8alquil-C3-8cicloalquil; -C0-8alquil-O-C0-8alquil-, -C0-8alquil- N(C0-8alquil)(C0-8alquil), -C0-8alquil-S(O)0-2-C0-8alquil-; o heterociclilo sustituido opcionalmente con ciclilo, C0-8alquil independiente 1-4, o sustituyentes del ciclilo sustituido; o R1 y R2, tomados juntos con el N al cual se encuentran unidos, forman un grupo heterocíclico, sustituido opcionalmente con grupos C0-8alquil, -C0-8alquil-O-C0-8alquil-, -C0- 8alquil-arilo independientes 1-4, o grupos -C0-8alquil-heteroarilo, siempre que el grupo heterocíclico que se forme no sea piperazina; R3 es un grupo arilo o hetarilo, sustituido opcionalmente con C0-8alquil, C0-8alquil-ciclil, halo, OH, -NR31S(O)0- 2R32, -(O)0-2NR31R32, -NR31COR32, -NR31CONR32R33, - CONR31R32, S(O)0-2R31, O-arilo, -O-hetarilo, NO2, CN, CF3, OCF3, OCHF2; independiente 1-4; R11, R12, R13, R31, R32, y R33 son cada uno independientemente C0-8alquil sustituido opcionalmente con un sustituyente heterociclilo, C0-8alquil sustituido opcionalmente con un sustituyente halo -CON(C0-8alquil)(C0-8alquil), -N(C0-8alquil)CON(C0-8alquil)(C0-8alquil), -N(C0-8alquil)CO2(C0-8alquil), S(O) 0-2N(C0-8alquil)(C0-8alquil), -NR11S(O)0-2(C0- 8alquil), CN, OH, independiente 1-6, o sustituyentes del arilo sustituido opcionalmente; -C0-8alquil-C3-8cicloalquil; -C0-8alquil-O-C0-8alquil-, -C0-8alquil-N(C0-8alquil)(C0-8alquil), -C0-8alquil-S(O)0-2-C0-8alquil-; o heterociclilo sustituido opcionalmente con ciclilo, C0-8alquil independiente 1-4, o sustituyentes del ciclilo sustituido; y siempre que R3 no sea un grupo tetrazolilo, 5-pirimidinilo, o 4-bifenilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63243204P | 2004-12-01 | 2004-12-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052419A1 true AR052419A1 (es) | 2007-03-21 |
Family
ID=36128376
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050105014A AR052419A1 (es) | 2004-12-01 | 2005-11-30 | Derivados de bencimidazolil n-sustituidos,inhibidores del protooncogen c-kit |
Country Status (12)
Country | Link |
---|---|
US (1) | US7419995B2 (es) |
EP (1) | EP1831206B1 (es) |
JP (1) | JP2008521903A (es) |
KR (1) | KR20070086865A (es) |
CN (1) | CN101193867A (es) |
AR (1) | AR052419A1 (es) |
AT (1) | ATE521604T1 (es) |
AU (1) | AU2005312028A1 (es) |
BR (1) | BRPI0518794A2 (es) |
CA (1) | CA2589770A1 (es) |
TW (1) | TW200633704A (es) |
WO (1) | WO2006060381A2 (es) |
Families Citing this family (26)
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US7442709B2 (en) * | 2003-08-21 | 2008-10-28 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine c-Kit inhibitors |
ES2330468T3 (es) * | 2005-04-13 | 2009-12-10 | Neurosearch A/S | Derivados de benzimidazol y su uso para modular el complejo del receptor gabaa. |
US7776900B2 (en) * | 2005-04-19 | 2010-08-17 | Neurosearch A/S | Benzimidazole derivatives and their use for modulating the GABAAreceptor complex |
KR20080077620A (ko) * | 2005-12-05 | 2008-08-25 | 뉴로서치 에이/에스 | 벤즈이미다졸 및 gabaa 수용체 복합체를 조절하기위한 이의 용도 |
TWI391381B (zh) * | 2006-03-24 | 2013-04-01 | Neurosearch As | 新穎的苯并咪唑衍生物、含有其之醫藥組成物、及其於製造藥物之用途 |
AU2007337895C1 (en) * | 2006-12-22 | 2014-07-31 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
JP5442448B2 (ja) * | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | Fgfrインヒビターとしての二環式ヘテロ環式化合物 |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
GB0720038D0 (en) * | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
US20110030037A1 (en) * | 2009-07-07 | 2011-02-03 | Vadim Olshansky | Zone migration in network access |
WO2012131501A1 (en) * | 2011-03-28 | 2012-10-04 | Glenmark Pharmaceuticals S.A. | Substituted benzimidazole compounds as cot kinase inhibitors |
UA111382C2 (uk) * | 2011-10-10 | 2016-04-25 | Оріон Корпорейшн | Інгібітори протеїнкінази |
CN103254134B (zh) * | 2012-06-29 | 2015-09-02 | 苏州大学 | 一种多取代咪唑的合成方法 |
US9790188B2 (en) | 2013-03-15 | 2017-10-17 | Whitehead Institute For Biomedical Research | Benzimidazole derivatives and uses thereof |
CN103254136B (zh) * | 2013-05-30 | 2015-03-25 | 苏州大学 | 一种制备四[4-(1-咪唑基)苯基]甲烷的方法 |
CN103497179B (zh) * | 2013-09-26 | 2015-03-25 | 郑州大学 | 含苯并咪唑结构单元的嘧啶衍生物及其制备方法和用途 |
MX2018000880A (es) * | 2015-07-20 | 2018-08-24 | Genzyme Corp | Inhibidores del receptor del factor estimulante de colonias 1 (csf-1r). |
WO2018112140A1 (en) * | 2016-12-15 | 2018-06-21 | Ariad Pharmaceuticals, Inc. | Benzimidazole compounds as c-kit inhibitors |
CN108754141B (zh) * | 2018-08-22 | 2020-12-08 | 中国科学院上海有机化学研究所 | 一种萃取有机相及其应用 |
CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
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-
2005
- 2005-11-30 CN CNA2005800476125A patent/CN101193867A/zh active Pending
- 2005-11-30 BR BRPI0518794-0A patent/BRPI0518794A2/pt not_active IP Right Cessation
- 2005-11-30 CA CA002589770A patent/CA2589770A1/en not_active Abandoned
- 2005-11-30 EP EP05852400A patent/EP1831206B1/en active Active
- 2005-11-30 JP JP2007544433A patent/JP2008521903A/ja active Pending
- 2005-11-30 AR ARP050105014A patent/AR052419A1/es not_active Application Discontinuation
- 2005-11-30 WO PCT/US2005/043114 patent/WO2006060381A2/en active Application Filing
- 2005-11-30 AT AT05852400T patent/ATE521604T1/de not_active IP Right Cessation
- 2005-11-30 US US11/290,028 patent/US7419995B2/en not_active Expired - Fee Related
- 2005-11-30 AU AU2005312028A patent/AU2005312028A1/en not_active Abandoned
- 2005-11-30 KR KR1020077015090A patent/KR20070086865A/ko not_active Application Discontinuation
- 2005-12-01 TW TW094142316A patent/TW200633704A/zh unknown
Also Published As
Publication number | Publication date |
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CN101193867A (zh) | 2008-06-04 |
KR20070086865A (ko) | 2007-08-27 |
US20060116402A1 (en) | 2006-06-01 |
WO2006060381A2 (en) | 2006-06-08 |
EP1831206A2 (en) | 2007-09-12 |
WO2006060381A3 (en) | 2006-12-28 |
TW200633704A (en) | 2006-10-01 |
EP1831206B1 (en) | 2011-08-24 |
CA2589770A1 (en) | 2006-06-08 |
ATE521604T1 (de) | 2011-09-15 |
US7419995B2 (en) | 2008-09-02 |
JP2008521903A (ja) | 2008-06-26 |
BRPI0518794A2 (pt) | 2008-12-09 |
AU2005312028A1 (en) | 2006-06-08 |
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