BR9810456A - Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico - Google Patents
Composto de sulfonamida, método para sua obtenção e seu uso farmacêuticoInfo
- Publication number
- BR9810456A BR9810456A BR9810456-0A BR9810456A BR9810456A BR 9810456 A BR9810456 A BR 9810456A BR 9810456 A BR9810456 A BR 9810456A BR 9810456 A BR9810456 A BR 9810456A
- Authority
- BR
- Brazil
- Prior art keywords
- activity
- sulfonamide compound
- obtaining
- pharmaceutical use
- oxa
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/50—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to ring nitrogen atoms
- C07D241/52—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C07D249/18—Benzotriazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"COMPOSTO DE SULFONAMIDA, MéTODO PARA SUA OBTENçãO E SEU USO FARMACêUTICO", a presente invenção compreende um composto de sulfonamida da fórmula (I): R^ 1^-SO~ 2~NHCO-A-X - R^ 2^ ) onde R^ 1^ é alquila, alquenila, alquinila e similares; A é um grupo heteropolicíclico opcionalmente substituído, exceto benzimidazolila, indolila, 4,7-dihidrobenzimidazolila e 2,3-dihidrobenzoxazinila; X é alquileno, oxa, oxa alquileno (inferior e similares; e R^ 2^ é arila opcionalmente substituída, bifenilila substituída e similares, um sal dos mesmos e uma composição farmacêutica compreendendo os mesmos. O composto de sulfonamida é eficaz para as doenças tratáveis, com base em sua atividade depressora de nível de açúcar sanguíneo, atividade inibidora de cGMP-PDE (especialmente PDE-V), atividade relaxadora de músculo liso, atividade bronquiodilatadora, atividade vasodilatadora, atividade supressora de célula de músculo liso, e atividade antialérgica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20829597 | 1997-06-27 | ||
JP11471898 | 1998-04-24 | ||
PCT/JP1998/002877 WO1999000372A1 (en) | 1997-06-27 | 1998-06-24 | Sulfonamide compounds and medicinal use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9810456A true BR9810456A (pt) | 2001-09-25 |
Family
ID=26453401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9810456-0A BR9810456A (pt) | 1997-06-27 | 1998-06-24 | Composto de sulfonamida, método para sua obtenção e seu uso farmacêutico |
Country Status (12)
Country | Link |
---|---|
US (3) | US6348474B1 (pt) |
EP (1) | EP0995742A4 (pt) |
KR (1) | KR20010014183A (pt) |
CN (1) | CN1268942A (pt) |
AU (1) | AU745081B2 (pt) |
BR (1) | BR9810456A (pt) |
CA (1) | CA2295239A1 (pt) |
IL (1) | IL133575A0 (pt) |
RU (1) | RU2199532C2 (pt) |
TW (1) | TW426666B (pt) |
WO (1) | WO1999000372A1 (pt) |
ZA (1) | ZA985618B (pt) |
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IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
DE69410093T2 (de) | 1993-06-22 | 1998-10-01 | Knoll Ag | Isochinolin-derivate mit therapeutischer wirkung |
US5599811A (en) | 1995-02-21 | 1997-02-04 | Warner-Lambert Company | Benzothiazine dioxides as endothelin antagonists |
FR2733233B1 (fr) | 1995-04-20 | 1997-05-30 | Roussel Uclaf | Nouveaux derives de quinoleine, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
US6166219A (en) * | 1995-12-28 | 2000-12-26 | Fujisawa Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
WO1997044321A1 (en) * | 1996-05-20 | 1997-11-27 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
WO1998008818A1 (en) * | 1996-08-26 | 1998-03-05 | Genetics Institute, Inc. | Inhibitors of phospholipase enzymes |
FR2756284B1 (fr) * | 1996-11-26 | 2000-04-28 | Adir | Nouveaux derives du benzopyrane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE69826286T2 (de) * | 1997-06-27 | 2005-11-24 | Fujisawa Pharmaceutical Co., Ltd. | Derivate mit einem aromatischen ring |
CN1268942A (zh) * | 1997-06-27 | 2000-10-04 | 藤泽药品工业株式会社 | 磺酰胺化合物及其药物用途 |
TW453999B (en) * | 1997-06-27 | 2001-09-11 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
EP1136492A4 (en) * | 1998-12-04 | 2002-03-27 | Fujisawa Pharmaceutical Co | SULFAMIDE COMPOUNDS AND USES THEREOF AS MEDICAMENTS |
-
1998
- 1998-06-24 CN CN98808571A patent/CN1268942A/zh active Pending
- 1998-06-24 EP EP98929715A patent/EP0995742A4/en not_active Withdrawn
- 1998-06-24 AU AU79345/98A patent/AU745081B2/en not_active Ceased
- 1998-06-24 KR KR19997012258A patent/KR20010014183A/ko not_active Application Discontinuation
- 1998-06-24 CA CA002295239A patent/CA2295239A1/en not_active Abandoned
- 1998-06-24 BR BR9810456-0A patent/BR9810456A/pt not_active IP Right Cessation
- 1998-06-24 US US09/446,110 patent/US6348474B1/en not_active Expired - Fee Related
- 1998-06-24 IL IL13357598A patent/IL133575A0/xx unknown
- 1998-06-24 RU RU2000101813/04A patent/RU2199532C2/ru not_active IP Right Cessation
- 1998-06-24 WO PCT/JP1998/002877 patent/WO1999000372A1/ja not_active Application Discontinuation
- 1998-06-25 TW TW087110245A patent/TW426666B/zh not_active IP Right Cessation
- 1998-06-26 ZA ZA985618A patent/ZA985618B/xx unknown
-
2002
- 2002-01-17 US US10/047,093 patent/US6911469B2/en not_active Expired - Fee Related
-
2004
- 2004-03-30 US US10/811,989 patent/US20040180947A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1268942A (zh) | 2000-10-04 |
US20020099212A1 (en) | 2002-07-25 |
AU7934598A (en) | 1999-01-19 |
AU745081B2 (en) | 2002-03-14 |
US6911469B2 (en) | 2005-06-28 |
US6348474B1 (en) | 2002-02-19 |
CA2295239A1 (en) | 1999-01-07 |
TW426666B (en) | 2001-03-21 |
EP0995742A4 (en) | 2004-08-25 |
US20040180947A1 (en) | 2004-09-16 |
KR20010014183A (ko) | 2001-02-26 |
ZA985618B (en) | 1999-01-19 |
IL133575A0 (en) | 2001-04-30 |
WO1999000372A1 (en) | 1999-01-07 |
EP0995742A1 (en) | 2000-04-26 |
RU2199532C2 (ru) | 2003-02-27 |
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