ATE355269T1 - Phenylalaninderivate - Google Patents
PhenylalaninderivateInfo
- Publication number
- ATE355269T1 ATE355269T1 AT00976347T AT00976347T ATE355269T1 AT E355269 T1 ATE355269 T1 AT E355269T1 AT 00976347 T AT00976347 T AT 00976347T AT 00976347 T AT00976347 T AT 00976347T AT E355269 T1 ATE355269 T1 AT E355269T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylalanine derivatives
- integrin
- alpha
- analogues
- specified
- Prior art date
Links
- 150000002993 phenylalanine derivatives Chemical class 0.000 title abstract 2
- 108010041012 Integrin alpha4 Proteins 0.000 abstract 2
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
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- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
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- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP32846899 | 1999-11-18 | ||
| JP2000197139 | 2000-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE355269T1 true ATE355269T1 (de) | 2006-03-15 |
Family
ID=26572884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00976347T ATE355269T1 (de) | 1999-11-18 | 2000-11-20 | Phenylalaninderivate |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6855706B2 (de) |
| EP (1) | EP1233013B1 (de) |
| JP (1) | JP4788939B2 (de) |
| AT (1) | ATE355269T1 (de) |
| AU (1) | AU1416501A (de) |
| DE (1) | DE60033684T2 (de) |
| WO (1) | WO2001036376A1 (de) |
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| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| AU7874001A (en) | 2000-08-18 | 2002-03-04 | Ajinomoto Kk | Novel phenylalanine derivatives |
| AU2001290303A1 (en) * | 2000-09-29 | 2002-04-15 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
| JP4164871B2 (ja) * | 2001-07-26 | 2008-10-15 | 味の素株式会社 | 新規フェニルプロピオン酸誘導体 |
| EP1454898A4 (de) | 2001-12-13 | 2006-12-13 | Ajinomoto Kk | Neue phenylalaninderivate |
| EP1481965B1 (de) * | 2002-02-07 | 2015-07-29 | Hitoshi Endo | Aromatische aminosäurederivate und medizinische zusammensetzungen |
| EP1477482B1 (de) * | 2002-02-20 | 2010-04-14 | Ajinomoto Co., Inc. | Neues phenylalaninderivat |
| WO2003074478A1 (en) | 2002-03-05 | 2003-09-12 | Sumitomo Chemical Company, Limited | Process for the preparation of biaryl compounds |
| EP1346971B1 (de) | 2002-03-18 | 2010-01-20 | Sumitomo Chemical Company, Limited | Verfahren zur Herstellung von Biarylalanin |
| JPWO2003089410A1 (ja) * | 2002-04-19 | 2005-08-25 | 協和醗酵工業株式会社 | フェニルアラニン誘導体 |
| EP1546089A2 (de) * | 2002-08-09 | 2005-06-29 | TransTech Pharma Inc. | Aryl- und heteroarylverbindungen und verfahren zur modulierung der koagulation |
| WO2004074264A1 (ja) * | 2003-02-20 | 2004-09-02 | Ajinomoto Co., Inc. | キナゾリンジオン骨格を有するフェニルアラニン誘導体の製造方法及び製造中間体 |
| WO2004098518A2 (en) | 2003-05-01 | 2004-11-18 | Bristol-Myers Squibb Company | Pyrazole-amide compounds useful as kinase inhibitors |
| US7208601B2 (en) * | 2003-08-08 | 2007-04-24 | Mjalli Adnan M M | Aryl and heteroaryl compounds, compositions, and methods of use |
| JP2007501844A (ja) * | 2003-08-08 | 2007-02-01 | トランス テック ファーマ,インコーポレイテッド | アリール及びヘテロアリール化合物、組成物並びに使用方法 |
| US7459472B2 (en) * | 2003-08-08 | 2008-12-02 | Transtech Pharma, Inc. | Aryl and heteroaryl compounds, compositions, and methods of use |
| GB0324269D0 (en) * | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
| US7160902B2 (en) * | 2003-11-14 | 2007-01-09 | Adolor Corporation | Amide derivatives and methods of their use |
| EP1700850B1 (de) | 2003-12-22 | 2015-07-15 | Ajinomoto Co., Inc. | Phenylalaninderivat |
| EP1725542A1 (de) * | 2004-03-10 | 2006-11-29 | Merck & Co., Inc. | Vla-4-antagonisten |
| CA2576647C (en) * | 2004-08-16 | 2011-12-13 | Merck & Co., Inc. | Vla-4 antagonists |
| WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| WO2006039356A2 (en) * | 2004-09-29 | 2006-04-13 | Cytovia, Inc. | Substituted n-aryl-9-oxo-9h-fluorene-1-carboxamides and analogs as activators of caspases and inducers of apoptosis |
| US20090111828A1 (en) * | 2005-11-23 | 2009-04-30 | Astrazeneca Ab | L-alanine derivatives |
| US7671221B2 (en) * | 2005-12-28 | 2010-03-02 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| CA2856037C (en) * | 2005-12-28 | 2017-03-07 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| WO2007089335A2 (en) * | 2005-12-29 | 2007-08-09 | Lexicon Pharmaceutical Inc. | Multicyclic amino acid derivatives and methods of their use |
| JP5430943B2 (ja) * | 2006-01-25 | 2014-03-05 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫関連用途のための置換芳香族化合物 |
| AR059224A1 (es) * | 2006-01-31 | 2008-03-19 | Jerini Ag | Compuestos para la inhibicion de integrinas y uso de estas |
| US20080045521A1 (en) * | 2006-06-09 | 2008-02-21 | Astrazeneca Ab | Phenylalanine derivatives |
| US20080182842A1 (en) * | 2007-01-29 | 2008-07-31 | Astrazeneca Ab | L-alanine derivatives as a5beta1 antagonists |
| US20090062267A1 (en) * | 2007-01-29 | 2009-03-05 | Astrazeneca Ab | L-ALANINE DERIVATIVES AS a5beta1 ANTAGONISTS |
| WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| WO2008125811A1 (en) * | 2007-04-11 | 2008-10-23 | Astrazeneca Ab | N-[HETEROARYLCARBONYL]-S-THIENYL-L-ALANINE DERIVATIVES AS α5β1 ANTAGONISTS |
| CN102057054B (zh) | 2008-04-11 | 2015-06-10 | 梅里麦克制药股份有限公司 | 人血清白蛋白接头以及其结合物 |
| US8927694B2 (en) * | 2008-11-18 | 2015-01-06 | Merrimack Pharmaceuticals, Inc. | Human serum albumin linkers and conjugates thereof |
| WO2011094890A1 (en) * | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| EP2769223A1 (de) | 2011-10-17 | 2014-08-27 | Westfälische Wilhelms-Universität Münster | Beurteilung eines pml-risikos und darauf basierende verfahren |
| US20150202287A1 (en) | 2012-08-30 | 2015-07-23 | Merrimack Pharmaceuticals, Inc. | Combination therapies comprising anti-erbb3 agents |
| CN105593225B (zh) * | 2013-06-11 | 2019-04-16 | 赛尔基因第二国际有限公司 | 新型glp-1受体调节剂 |
| JP6447557B2 (ja) * | 2016-03-24 | 2019-01-09 | 日亜化学工業株式会社 | 発光装置の製造方法 |
| TW201900638A (zh) * | 2017-04-20 | 2019-01-01 | 加州大學董事會 | K-ras調節劑 |
| ES3013256T3 (en) | 2018-10-30 | 2025-04-11 | Gilead Sciences Inc | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| CN112996786B (zh) | 2018-10-30 | 2024-08-20 | 吉利德科学公司 | 用于抑制α4β7整合素的化合物 |
| US11179383B2 (en) | 2018-10-30 | 2021-11-23 | Gilead Sciences, Inc. | Compounds for inhibition of α4β7 integrin |
| WO2020092375A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Quinoline derivatives as alpha4beta7 integrin inhibitors |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US130320A (en) * | 1872-08-06 | Improvement in copying-press beds | ||
| GB8820844D0 (en) * | 1988-09-05 | 1988-10-05 | Pfizer Ltd | Therapeutic agents |
| GB9004260D0 (en) * | 1990-02-26 | 1990-04-18 | Pfizer Ltd | Therapeutic agents |
| JP3727536B2 (ja) * | 1997-08-22 | 2005-12-14 | エフ.ホフマン−ラ ロシュ アーゲー | N−アルカノイルフェニルアラニン誘導体 |
| DK1005445T3 (da) | 1997-08-22 | 2004-10-04 | Hoffmann La Roche | N-alkanoylphenylaninderivater |
| MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
| US6420418B1 (en) * | 1999-08-16 | 2002-07-16 | Merck & Co., Inc. | Heterocycle amides as cell adhesion inhibitors |
| WO2001047868A1 (en) * | 1999-12-28 | 2001-07-05 | Ajinomoto Co., Inc. | Novel phenylalanine derivatives |
| AU2001242743A1 (en) * | 2000-03-23 | 2001-10-03 | Ajinomoto Co. Inc. | Novel phenylalanine derivative |
| US6403584B1 (en) * | 2000-06-22 | 2002-06-11 | Merck & Co., Inc. | Substituted nipecotyl derivatives as inhibitors of cell adhesion |
| US6579889B2 (en) * | 2000-06-22 | 2003-06-17 | Merck & Co., Inc. | Substituted isonipecotyl derivatives as inhibitors of cell adhesion |
-
2000
- 2000-11-20 DE DE60033684T patent/DE60033684T2/de not_active Expired - Lifetime
- 2000-11-20 EP EP00976347A patent/EP1233013B1/de not_active Expired - Lifetime
- 2000-11-20 AT AT00976347T patent/ATE355269T1/de not_active IP Right Cessation
- 2000-11-20 JP JP2001538868A patent/JP4788939B2/ja not_active Expired - Fee Related
- 2000-11-20 AU AU14165/01A patent/AU1416501A/en not_active Abandoned
- 2000-11-20 WO PCT/JP2000/008152 patent/WO2001036376A1/ja not_active Ceased
-
2002
- 2002-05-20 US US10/150,067 patent/US6855706B2/en not_active Expired - Fee Related
-
2004
- 2004-11-15 US US10/986,829 patent/US7160874B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU1416501A (en) | 2001-05-30 |
| US7160874B2 (en) | 2007-01-09 |
| US20030149083A1 (en) | 2003-08-07 |
| EP1233013A4 (de) | 2004-05-12 |
| US6855706B2 (en) | 2005-02-15 |
| US20050070485A1 (en) | 2005-03-31 |
| DE60033684D1 (de) | 2007-04-12 |
| EP1233013B1 (de) | 2007-02-28 |
| WO2001036376A1 (en) | 2001-05-25 |
| EP1233013A1 (de) | 2002-08-21 |
| JP4788939B2 (ja) | 2011-10-05 |
| DE60033684T2 (de) | 2007-12-06 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |