BRPI0617167B8 - sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação - Google Patents
sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinaçãoInfo
- Publication number
- BRPI0617167B8 BRPI0617167B8 BRPI0617167A BRPI0617167A BRPI0617167B8 BR PI0617167 B8 BRPI0617167 B8 BR PI0617167B8 BR PI0617167 A BRPI0617167 A BR PI0617167A BR PI0617167 A BRPI0617167 A BR PI0617167A BR PI0617167 B8 BRPI0617167 B8 BR PI0617167B8
- Authority
- BR
- Brazil
- Prior art keywords
- sulfonylpyrroles
- combination
- pharmaceutical composition
- hdac inhibitors
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
Abstract
SULFONILPIRRÓIS COMO INIBIDORES DE HDAC'S. A presente invenção refere-se a compostos de uma certa fórmula I, em que R1, R2, R3, R4, R5, R6 e R7 têm os significados indicados na descrição, bem como os sais dos mesmos são novos inibidores de HDAC eficazes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05108728 | 2005-09-21 | ||
EP05108728.6 | 2005-09-21 | ||
PCT/EP2006/066197 WO2007039404A1 (en) | 2005-09-21 | 2006-09-08 | Novel sulphonylpyrroles as inhibitors of hdac s novel sulphonylpyrroles |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0617167A2 BRPI0617167A2 (pt) | 2011-07-12 |
BRPI0617167B1 BRPI0617167B1 (pt) | 2021-02-09 |
BRPI0617167B8 true BRPI0617167B8 (pt) | 2021-05-25 |
Family
ID=37035343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0617167A BRPI0617167B8 (pt) | 2005-09-21 | 2006-09-08 | sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação |
Country Status (26)
Country | Link |
---|---|
US (1) | US8232297B2 (pt) |
EP (1) | EP1928872B1 (pt) |
JP (1) | JP5305910B2 (pt) |
KR (1) | KR101256846B1 (pt) |
CN (1) | CN101268070B (pt) |
AR (1) | AR057824A1 (pt) |
AT (1) | ATE549333T1 (pt) |
AU (1) | AU2006298882B2 (pt) |
BR (1) | BRPI0617167B8 (pt) |
CA (1) | CA2622673C (pt) |
CY (1) | CY1112780T1 (pt) |
DK (1) | DK1928872T3 (pt) |
EA (1) | EA016345B1 (pt) |
ES (1) | ES2381962T3 (pt) |
HK (1) | HK1124320A1 (pt) |
HR (1) | HRP20120399T1 (pt) |
IL (1) | IL189782A (pt) |
NO (1) | NO341744B1 (pt) |
NZ (1) | NZ566074A (pt) |
PL (1) | PL1928872T3 (pt) |
PT (1) | PT1928872E (pt) |
RS (1) | RS52383B (pt) |
SI (1) | SI1928872T1 (pt) |
TW (1) | TWI406846B (pt) |
WO (1) | WO2007039404A1 (pt) |
ZA (1) | ZA200801394B (pt) |
Families Citing this family (29)
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US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Corporation | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
WO2003068228A1 (en) | 2002-02-11 | 2003-08-21 | Bayer Pharmaceuticals Corporation | Aryl ureas with angiogenesis inhibiting activity |
DK1626714T3 (da) | 2003-05-20 | 2007-10-15 | Bayer Pharmaceuticals Corp | Dirarylurinstoffer mod sygdomme medieret af PDGFR |
WO2005009961A2 (en) | 2003-07-23 | 2005-02-03 | Bayer Pharmaceuticals Corporation | Fluoro substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions |
US7842820B2 (en) | 2004-03-11 | 2010-11-30 | 4Sc Ag | Sulfonylpyrroles |
EA015533B1 (ru) | 2005-03-15 | 2011-08-30 | 4Сц Аг | N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы |
ES2381962T3 (es) | 2005-09-21 | 2012-06-04 | 4Sc Ag | Nuevos sulfonilpirroles como inhibidores de las HDAC |
CN101287706A (zh) | 2005-09-21 | 2008-10-15 | 尼科梅德有限责任公司 | 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐 |
EP2100878A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Novel method for the production of sulphonylpyrroles as HDAC inhibitors |
EP2100882A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts |
ES2620027T3 (es) | 2008-09-03 | 2017-06-27 | Biomarin Pharmaceutical Inc. | Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
CA2828524C (en) | 2011-02-28 | 2020-01-07 | Repligen Corporation | Histone deacetylase inhibitors |
EP3628329B1 (en) * | 2011-09-30 | 2022-08-10 | Dana-Farber Cancer Institute, Inc. | Therapeutic peptides comprising antibodies binding to mhc class 1 polypeptide related sequence a (mica) |
CN104136410A (zh) * | 2011-12-29 | 2014-11-05 | 药品循环公司 | 作为组蛋白脱乙酰酶8抑制剂的肉桂酸羟基酰胺 |
US9034885B2 (en) | 2012-01-13 | 2015-05-19 | Acea Biosciences Inc. | EGFR modulators and uses thereof |
CA2861010A1 (en) | 2012-01-13 | 2013-07-18 | Xiao Xu | Heterocyclic compounds and uses as anticancer agents |
US9464089B2 (en) | 2012-01-13 | 2016-10-11 | Acea Biosciences Inc. | Heterocyclic compounds and uses thereof |
ES2618007T3 (es) * | 2012-08-06 | 2017-06-20 | Acea Biosciences, Inc. | Nuevos compuestos de pirrolopirimidina como inhibidores de proteína cinasas |
CA2903490C (en) | 2013-03-15 | 2021-04-13 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
CA2917364C (en) | 2013-07-11 | 2020-09-29 | Acea Biosciences Inc. | Heterocyclic compounds and uses thereof |
US10533011B2 (en) | 2015-10-09 | 2020-01-14 | ACEA Therapeutics, Inc. | Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same |
CN105622680B (zh) * | 2015-12-22 | 2018-01-19 | 杭州卢普生物科技有限公司 | 一种舒尼替尼衍生物及其制备方法和应用 |
CN109069647A (zh) | 2016-04-14 | 2018-12-21 | 4Sc股份公司 | 瑞米司他(Resminostat)在亚洲患者中的医疗应用 |
EP3606925A1 (en) | 2017-04-07 | 2020-02-12 | ACEA Therapeutics, Inc. | Pharmaceutical salts, physical forms, and compositions of pyrrolopyrimidine kinase inhibitors, and methods of making same |
TW201912183A (zh) | 2017-08-31 | 2019-04-01 | 德商4Sc製藥公司 | Hdac抑制劑與抗代謝藥劑組合用於癌症治療 |
CN110496136A (zh) * | 2018-05-17 | 2019-11-26 | 王孝恩 | 锂制剂在制备治疗或预防癌症药物中的应用 |
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US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
US7842820B2 (en) | 2004-03-11 | 2010-11-30 | 4Sc Ag | Sulfonylpyrroles |
US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
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EA015533B1 (ru) | 2005-03-15 | 2011-08-30 | 4Сц Аг | N-сульфонилпирролы и их применение в качестве ингибиторов гистондезацетилазы |
WO2006105979A1 (en) | 2005-04-07 | 2006-10-12 | Nycomed Gmbh | Sulfonylpyrroles as histone deacetylase inhibitors |
ES2381962T3 (es) | 2005-09-21 | 2012-06-04 | 4Sc Ag | Nuevos sulfonilpirroles como inhibidores de las HDAC |
CN101287706A (zh) * | 2005-09-21 | 2008-10-15 | 尼科梅德有限责任公司 | 作为组蛋白脱乙酰基酶抑制剂的磺酰基吡咯盐酸盐 |
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2006
- 2006-09-08 ES ES06793379T patent/ES2381962T3/es active Active
- 2006-09-08 CA CA2622673A patent/CA2622673C/en active Active
- 2006-09-08 SI SI200631335T patent/SI1928872T1/sl unknown
- 2006-09-08 WO PCT/EP2006/066197 patent/WO2007039404A1/en active Application Filing
- 2006-09-08 JP JP2008530492A patent/JP5305910B2/ja active Active
- 2006-09-08 AU AU2006298882A patent/AU2006298882B2/en active Active
- 2006-09-08 KR KR1020087008938A patent/KR101256846B1/ko active IP Right Grant
- 2006-09-08 US US11/992,015 patent/US8232297B2/en active Active
- 2006-09-08 EP EP06793379A patent/EP1928872B1/en active Active
- 2006-09-08 RS RS20120248A patent/RS52383B/en unknown
- 2006-09-08 AT AT06793379T patent/ATE549333T1/de active
- 2006-09-08 NZ NZ566074A patent/NZ566074A/en unknown
- 2006-09-08 DK DK06793379.6T patent/DK1928872T3/da active
- 2006-09-08 PL PL06793379T patent/PL1928872T3/pl unknown
- 2006-09-08 PT PT06793379T patent/PT1928872E/pt unknown
- 2006-09-08 BR BRPI0617167A patent/BRPI0617167B8/pt active IP Right Grant
- 2006-09-08 EA EA200800700A patent/EA016345B1/ru not_active IP Right Cessation
- 2006-09-08 CN CN2006800347491A patent/CN101268070B/zh active Active
- 2006-09-21 TW TW095135005A patent/TWI406846B/zh active
- 2006-09-21 AR ARP060104135A patent/AR057824A1/es active IP Right Grant
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2008
- 2008-02-11 ZA ZA2008/01394A patent/ZA200801394B/en unknown
- 2008-02-26 IL IL189782A patent/IL189782A/en active IP Right Grant
- 2008-04-14 NO NO20081797A patent/NO341744B1/no unknown
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2009
- 2009-02-19 HK HK09101602.9A patent/HK1124320A1/xx unknown
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2012
- 2012-05-11 HR HRP20120399TT patent/HRP20120399T1/hr unknown
- 2012-05-21 CY CY20121100465T patent/CY1112780T1/el unknown
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Owner name: TAKEDA GMBH (DE) |
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