BRPI0617167B8 - sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação - Google Patents

sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação

Info

Publication number
BRPI0617167B8
BRPI0617167B8 BRPI0617167A BRPI0617167A BRPI0617167B8 BR PI0617167 B8 BRPI0617167 B8 BR PI0617167B8 BR PI0617167 A BRPI0617167 A BR PI0617167A BR PI0617167 A BRPI0617167 A BR PI0617167A BR PI0617167 B8 BRPI0617167 B8 BR PI0617167B8
Authority
BR
Brazil
Prior art keywords
sulfonylpyrroles
combination
pharmaceutical composition
hdac inhibitors
inhibitors
Prior art date
Application number
BRPI0617167A
Other languages
English (en)
Inventor
Volz Jurgen
Feth Martin
Muller Matthias
Hummel Rolf-Peter
Beckers Thomas
Bär Thomas
Maier Thomas
Original Assignee
Nycomed Gmbh
Takeda Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh, Takeda Gmbh filed Critical Nycomed Gmbh
Publication of BRPI0617167A2 publication Critical patent/BRPI0617167A2/pt
Publication of BRPI0617167B1 publication Critical patent/BRPI0617167B1/pt
Publication of BRPI0617167B8 publication Critical patent/BRPI0617167B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

SULFONILPIRRÓIS COMO INIBIDORES DE HDAC'S. A presente invenção refere-se a compostos de uma certa fórmula I, em que R1, R2, R3, R4, R5, R6 e R7 têm os significados indicados na descrição, bem como os sais dos mesmos são novos inibidores de HDAC eficazes.
BRPI0617167A 2005-09-21 2006-09-08 sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação BRPI0617167B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05108728 2005-09-21
EP05108728.6 2005-09-21
PCT/EP2006/066197 WO2007039404A1 (en) 2005-09-21 2006-09-08 Novel sulphonylpyrroles as inhibitors of hdac s novel sulphonylpyrroles

Publications (3)

Publication Number Publication Date
BRPI0617167A2 BRPI0617167A2 (pt) 2011-07-12
BRPI0617167B1 BRPI0617167B1 (pt) 2021-02-09
BRPI0617167B8 true BRPI0617167B8 (pt) 2021-05-25

Family

ID=37035343

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0617167A BRPI0617167B8 (pt) 2005-09-21 2006-09-08 sulfonilpirróis como inibidores de hdac's, seu uso, composição farmacêutica e combinação

Country Status (26)

Country Link
US (1) US8232297B2 (pt)
EP (1) EP1928872B1 (pt)
JP (1) JP5305910B2 (pt)
KR (1) KR101256846B1 (pt)
CN (1) CN101268070B (pt)
AR (1) AR057824A1 (pt)
AT (1) ATE549333T1 (pt)
AU (1) AU2006298882B2 (pt)
BR (1) BRPI0617167B8 (pt)
CA (1) CA2622673C (pt)
CY (1) CY1112780T1 (pt)
DK (1) DK1928872T3 (pt)
EA (1) EA016345B1 (pt)
ES (1) ES2381962T3 (pt)
HK (1) HK1124320A1 (pt)
HR (1) HRP20120399T1 (pt)
IL (1) IL189782A (pt)
NO (1) NO341744B1 (pt)
NZ (1) NZ566074A (pt)
PL (1) PL1928872T3 (pt)
PT (1) PT1928872E (pt)
RS (1) RS52383B (pt)
SI (1) SI1928872T1 (pt)
TW (1) TWI406846B (pt)
WO (1) WO2007039404A1 (pt)
ZA (1) ZA200801394B (pt)

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Also Published As

Publication number Publication date
IL189782A (en) 2013-06-27
JP5305910B2 (ja) 2013-10-02
US20090263353A1 (en) 2009-10-22
TWI406846B (zh) 2013-09-01
CN101268070B (zh) 2012-09-05
PT1928872E (pt) 2012-05-25
BRPI0617167B1 (pt) 2021-02-09
JP2009508826A (ja) 2009-03-05
NO20081797L (no) 2008-04-17
AR057824A1 (es) 2007-12-19
PL1928872T3 (pl) 2012-08-31
WO2007039404A1 (en) 2007-04-12
NO341744B1 (no) 2018-01-15
ES2381962T3 (es) 2012-06-04
RS52383B (en) 2012-12-31
HK1124320A1 (en) 2009-07-10
DK1928872T3 (da) 2012-05-07
ZA200801394B (en) 2009-12-30
ATE549333T1 (de) 2012-03-15
EP1928872B1 (en) 2012-03-14
BRPI0617167A2 (pt) 2011-07-12
HRP20120399T1 (hr) 2012-06-30
NZ566074A (en) 2011-08-26
EA200800700A1 (ru) 2009-04-28
CY1112780T1 (el) 2016-02-10
AU2006298882A1 (en) 2007-04-12
AU2006298882B2 (en) 2011-10-27
EP1928872A1 (en) 2008-06-11
US8232297B2 (en) 2012-07-31
CN101268070A (zh) 2008-09-17
SI1928872T1 (sl) 2012-06-29
CA2622673A1 (en) 2007-04-12
CA2622673C (en) 2017-06-27
KR20080047607A (ko) 2008-05-29
IL189782A0 (en) 2008-08-07
TW200745028A (en) 2007-12-16
KR101256846B1 (ko) 2013-04-24
EA016345B1 (ru) 2012-04-30

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