AR057824A1 - Sulfonilpirroles; composicion farmaceutica y uso del compuesto para prepararlas - Google Patents
Sulfonilpirroles; composicion farmaceutica y uso del compuesto para prepararlasInfo
- Publication number
- AR057824A1 AR057824A1 ARP060104135A ARP060104135A AR057824A1 AR 057824 A1 AR057824 A1 AR 057824A1 AR P060104135 A ARP060104135 A AR P060104135A AR P060104135 A ARP060104135 A AR P060104135A AR 057824 A1 AR057824 A1 AR 057824A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- salt
- hydroxy
- acrylamide
- pyrrol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Estos compuestos resultan utiles en la terapia del cáncer. Reivindicacion 1: Una sal de un compuesto seleccionado de: (E)-3-[1-(bifenil-4-sulfonil)-1H-pirrol-3-il]-N-hidroxi-acrilamida; (E)-N- hidroxi-3-(1-[4-(([2-(1H-indol-2-il)-etil]-metil-amino)- metil)-bencensulfonil]-1H-pirrol-3-il)-acrilamida; (E)-3-[1-(4-dimetilaminometil- bencensulfonil)-1H-pirrol-3-il]-N-hidroxi-acrilamida; y (E)-N-hidroxi-3-[1-(5-piridin-2-il-tiofen-2-sulfonil)-1H-pirrol-3-il]-acrilamida, con un ácido seleccionado del grupo que comprende: ácido bromohídrico, ácido fosforico, ácido nítrico, ácido sulfurico, ácido acético, ácido cítrico, ácido D- gluconico, ácido benzoico, ácido 2-(4-hidroxibenzoil)benzoico, ácido butírico, ácido sulfosalicílico, ácido maleico, ácido láurico, ácido málico como por ejemplo ácido (-)-L-málico o ácido (+)-D-málico, ácido fumárico, ácido succínico, ácido oxálico, ácido tartático como por ejemplo ácido (+)-L-tartárico o ácido (-)-D-tartárico o ácido mesotartárico, ácido embonico, ácido esteárico, ácido toluensulfonico, ácido metansulfonico, ácido 3-hidroxi-2-naftolico, ácido adípico, ácido L-ascorbico, ácido L-aspártico, ácido bencensulfonico, ácido 4-acetamido-benzoico, ácido (+)- canforico, ácido (+)-canfor-10- sulfonico, ácido caprílico (ácido octanoico), ácido dodecilsulfonico, ácido etan-1,2-disulfonico, ácido etansulfonico, ácido 2-hidroxi-etansulfonico, ácido formico, ácido galactárico, ácido gentísico, ácido D-glucoheptonico, ácido D-glucuronico, ácido glutámico, ácido 2-oxo-glutárico, ácido hipurico, ácido láctico como por ejemplo ácido D-láctico o ácido L-láctico, ácido malonico, ácido mandélico como por ejemplo ácido (+)-mandélico o ácido (-)-mandélico, ácido naftalen-1,5-disulfonico, ácido naftalen-2-sulfonico, ácido nicotínico, ácido palmítico, ácido piroglutámico como por ejemplo ácido L-piroglutámico, ácido yohídrico, ácido ciclámico, ácido tiociánico, ácido 2,2-dicloroacético, ácido glicerofosforico, ácido 1-hidroxi-2- naftoico, ácido salicílico, ácido 4-aminosalicílico, ácido glicolico, ácido oleico, ácido glutárico, ácido cinámico, ácido capronico, ácido isobutírico, ácido propionico, ácido cáprico, ácido undecilénico y ácido orotico, con una base seleccionado del grupo que comprende: una sal sodio, una sal de guanidinio, una sal de litio, una sal de magnesio, una sal de calcio, una sal de potasio, una sal férrica, una sal de amonio y una sal de trietilamonio; o un hidrato de ellos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05108728 | 2005-09-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR057824A1 true AR057824A1 (es) | 2007-12-19 |
Family
ID=37035343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104135A AR057824A1 (es) | 2005-09-21 | 2006-09-21 | Sulfonilpirroles; composicion farmaceutica y uso del compuesto para prepararlas |
Country Status (26)
Country | Link |
---|---|
US (1) | US8232297B2 (es) |
EP (1) | EP1928872B1 (es) |
JP (1) | JP5305910B2 (es) |
KR (1) | KR101256846B1 (es) |
CN (1) | CN101268070B (es) |
AR (1) | AR057824A1 (es) |
AT (1) | ATE549333T1 (es) |
AU (1) | AU2006298882B2 (es) |
BR (1) | BRPI0617167B8 (es) |
CA (1) | CA2622673C (es) |
CY (1) | CY1112780T1 (es) |
DK (1) | DK1928872T3 (es) |
EA (1) | EA016345B1 (es) |
ES (1) | ES2381962T3 (es) |
HK (1) | HK1124320A1 (es) |
HR (1) | HRP20120399T1 (es) |
IL (1) | IL189782A (es) |
NO (1) | NO341744B1 (es) |
NZ (1) | NZ566074A (es) |
PL (1) | PL1928872T3 (es) |
PT (1) | PT1928872E (es) |
RS (1) | RS52383B (es) |
SI (1) | SI1928872T1 (es) |
TW (1) | TWI406846B (es) |
WO (1) | WO2007039404A1 (es) |
ZA (1) | ZA200801394B (es) |
Families Citing this family (29)
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AU2725000A (en) | 1999-01-13 | 2000-08-01 | Bayer Corporation | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
MXPA04007832A (es) | 2002-02-11 | 2005-09-08 | Bayer Pharmaceuticals Corp | Aril-ureas con actividad inhibitoria de angiogenesis. |
WO2004113274A2 (en) | 2003-05-20 | 2004-12-29 | Bayer Pharmaceuticals Corporation | Diaryl ureas with kinase inhibiting activity |
PL1663978T3 (pl) | 2003-07-23 | 2008-04-30 | Bayer Healthcare Llc | Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów |
ME02122B (me) | 2004-03-11 | 2014-02-28 | Altana Pharma Ag | Sulfonilpiroli kao inhibitori hdac |
JP5119143B2 (ja) | 2005-03-15 | 2013-01-16 | フォーエスシー アクチエンゲゼルシャフト | N−スルホニルピロール類及びヒストンデアセチラーゼインヒビターとしてのそれらの使用 |
CN101268070B (zh) | 2005-09-21 | 2012-09-05 | 奈科明有限责任公司 | 作为hdac抑制剂的磺酰基吡咯 |
EP1928826B1 (en) * | 2005-09-21 | 2013-04-24 | 4Sc Ag | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors |
EP2100878A1 (en) | 2008-03-12 | 2009-09-16 | 4Sc Ag | Novel method for the production of sulphonylpyrroles as HDAC inhibitors |
EP2100882A1 (en) * | 2008-03-12 | 2009-09-16 | 4Sc Ag | (E) -N -(2-Amino-phenyl) -3-{1-[4-(1-methyl-1H-pyrazol-4-yl)- benzenesulfonyl]-1H-pyrrol-3-yl} -acrylamide salts |
ES2620027T3 (es) | 2008-09-03 | 2017-06-27 | Biomarin Pharmaceutical Inc. | Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC |
CA3061239A1 (en) | 2011-02-28 | 2012-09-07 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
EA201490644A1 (ru) * | 2011-09-30 | 2014-09-30 | Дана-Фарбер Кэнсер Инститьют, Инк. | Терапевтические пептиды |
US20150045367A1 (en) * | 2011-12-29 | 2015-02-12 | Pharmacyclics, Inc. | Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8 |
CN110194748A (zh) | 2012-01-13 | 2019-09-03 | 艾森生物科学公司 | 杂环化合物及其作为抗癌药的用途 |
US9034885B2 (en) | 2012-01-13 | 2015-05-19 | Acea Biosciences Inc. | EGFR modulators and uses thereof |
US9464089B2 (en) | 2012-01-13 | 2016-10-11 | Acea Biosciences Inc. | Heterocyclic compounds and uses thereof |
CN107266453B (zh) * | 2012-08-06 | 2020-02-07 | 艾森医药公司 | 作为蛋白激酶抑制剂的吡咯并嘧啶化合物 |
CA2903490C (en) | 2013-03-15 | 2021-04-13 | Biomarin Pharmaceutical Inc. | Hdac inhibitors |
BR112016000195A8 (pt) | 2013-07-11 | 2019-12-31 | Acea Biosciences Inc | compostos heterocíclicos, composição farmacêutica, combinação, seu uso, e método para inibir uma atividade da tirosina quinase btk ou jak, egfr, alk, pdgfr, blk, bmx/etk, flt3(d835y), itk, tec, txk, e suas respectivas vias |
JP6889494B2 (ja) | 2015-10-09 | 2021-06-18 | エイシア セラピューティクス, インコーポレイテッド | ピロロピリミジンキナーゼ阻害剤の薬学的塩、物理的形態、および組成物、ならびにそれらを作製する方法 |
CN105622680B (zh) * | 2015-12-22 | 2018-01-19 | 杭州卢普生物科技有限公司 | 一种舒尼替尼衍生物及其制备方法和应用 |
KR20180130565A (ko) | 2016-04-14 | 2018-12-07 | 4에스체 악티엔게젤샤프트 | 아시아 환자에서의 레스미노스타트의 의학적 적용 |
BR112019020840A2 (pt) | 2017-04-07 | 2020-04-28 | Acea Therapeutics Inc | sais farmacêuticos, formas físicas e composições de inibidores da pirrolopirimidina quinase e métodos de produção dos mesmos |
TW201912183A (zh) | 2017-08-31 | 2019-04-01 | 德商4Sc製藥公司 | Hdac抑制劑與抗代謝藥劑組合用於癌症治療 |
CN110496136A (zh) * | 2018-05-17 | 2019-11-26 | 王孝恩 | 锂制剂在制备治疗或预防癌症药物中的应用 |
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US4960787A (en) | 1989-02-06 | 1990-10-02 | Ciba-Geigy Corporation | Certain pyrrolyl-substituted hydroxamic acid derivatives |
JP3342485B2 (ja) | 1991-12-10 | 2002-11-11 | 塩野義製薬株式会社 | 芳香族スルホンアミド系ヒドロキサム酸誘導体 |
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KR20020070285A (ko) | 1999-11-23 | 2002-09-05 | 메틸진, 인크. | 히스톤 디아세틸라제의 억제제 |
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EP1431267A4 (en) | 2001-08-09 | 2004-12-22 | Ono Pharmaceutical Co | COMPOUNDS DERIVED FROM CARBOXYLIC ACID AND MEDICAMENTS COMPRISING SUCH COMPOUNDS AS ACTIVE INGREDIENT |
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EP1429765A2 (en) | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US7482488B2 (en) | 2002-08-29 | 2009-01-27 | Temple University - Of The Commonwealth System Of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
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EP1709007A1 (en) | 2004-01-22 | 2006-10-11 | Altana Pharma AG | N-4-(6-(heteo)aryl-pyrimidin-4-ylaminophenyl)-benzenesulfonamides as kinase inhibitors |
US20050197336A1 (en) | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
ME02122B (me) | 2004-03-11 | 2014-02-28 | Altana Pharma Ag | Sulfonilpiroli kao inhibitori hdac |
US7345043B2 (en) | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
US7432808B2 (en) | 2004-12-15 | 2008-10-07 | Intel Corporation | Wireless module enabled component carrier for parts inventory and tracking |
JP5119143B2 (ja) | 2005-03-15 | 2013-01-16 | フォーエスシー アクチエンゲゼルシャフト | N−スルホニルピロール類及びヒストンデアセチラーゼインヒビターとしてのそれらの使用 |
JP5054671B2 (ja) * | 2005-04-07 | 2012-10-24 | フォーエスシー アクチエンゲゼルシャフト | ヒストンデアセチラーゼインヒビターとしてのスルホニルピロール |
CN101268070B (zh) | 2005-09-21 | 2012-09-05 | 奈科明有限责任公司 | 作为hdac抑制剂的磺酰基吡咯 |
EP1928826B1 (en) * | 2005-09-21 | 2013-04-24 | 4Sc Ag | Sulphonylpyrrole hydrochloride salts as histone deacetylases inhibitors |
-
2006
- 2006-09-08 CN CN2006800347491A patent/CN101268070B/zh active Active
- 2006-09-08 US US11/992,015 patent/US8232297B2/en active Active
- 2006-09-08 KR KR1020087008938A patent/KR101256846B1/ko active IP Right Grant
- 2006-09-08 RS RS20120248A patent/RS52383B/en unknown
- 2006-09-08 CA CA2622673A patent/CA2622673C/en active Active
- 2006-09-08 ES ES06793379T patent/ES2381962T3/es active Active
- 2006-09-08 PT PT06793379T patent/PT1928872E/pt unknown
- 2006-09-08 PL PL06793379T patent/PL1928872T3/pl unknown
- 2006-09-08 JP JP2008530492A patent/JP5305910B2/ja active Active
- 2006-09-08 AT AT06793379T patent/ATE549333T1/de active
- 2006-09-08 BR BRPI0617167A patent/BRPI0617167B8/pt active IP Right Grant
- 2006-09-08 SI SI200631335T patent/SI1928872T1/sl unknown
- 2006-09-08 DK DK06793379.6T patent/DK1928872T3/da active
- 2006-09-08 WO PCT/EP2006/066197 patent/WO2007039404A1/en active Application Filing
- 2006-09-08 AU AU2006298882A patent/AU2006298882B2/en active Active
- 2006-09-08 EA EA200800700A patent/EA016345B1/ru not_active IP Right Cessation
- 2006-09-08 NZ NZ566074A patent/NZ566074A/en unknown
- 2006-09-08 EP EP06793379A patent/EP1928872B1/en active Active
- 2006-09-21 AR ARP060104135A patent/AR057824A1/es active IP Right Grant
- 2006-09-21 TW TW095135005A patent/TWI406846B/zh active
-
2008
- 2008-02-11 ZA ZA2008/01394A patent/ZA200801394B/en unknown
- 2008-02-26 IL IL189782A patent/IL189782A/en active IP Right Grant
- 2008-04-14 NO NO20081797A patent/NO341744B1/no unknown
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2009
- 2009-02-19 HK HK09101602.9A patent/HK1124320A1/xx unknown
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2012
- 2012-05-11 HR HRP20120399TT patent/HRP20120399T1/hr unknown
- 2012-05-21 CY CY20121100465T patent/CY1112780T1/el unknown
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