EA200800700A1 - Новые сульфонилпирролы как ингибиторы гдац (гистондезацетилазы) - Google Patents

Новые сульфонилпирролы как ингибиторы гдац (гистондезацетилазы)

Info

Publication number
EA200800700A1
EA200800700A1 EA200800700A EA200800700A EA200800700A1 EA 200800700 A1 EA200800700 A1 EA 200800700A1 EA 200800700 A EA200800700 A EA 200800700A EA 200800700 A EA200800700 A EA 200800700A EA 200800700 A1 EA200800700 A1 EA 200800700A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrol
inhibitors
new
sulphonilpyrroles
gdaz
Prior art date
Application number
EA200800700A
Other languages
English (en)
Other versions
EA016345B1 (ru
Inventor
Томас Майер
Томас Беккерс
Рольф-Петер Хуммель
Мартин Фет
Маттиас МЮЛЛЕР
Томас Бэр
Юрген Фольц
Original Assignee
4Сц Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 4Сц Аг filed Critical 4Сц Аг
Publication of EA200800700A1 publication Critical patent/EA200800700A1/ru
Publication of EA016345B1 publication Critical patent/EA016345B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к солям (Е)-3-[1-(бифенил-4-сульфонил)-1Н-пиррол-3-ил]-N-гидроксиакриламида, (Е)-N-гидрокси-3-(1-[4-(([2-(1Н-индол-2-ил)этил]метиламино)метил)бензолсульфонил]-1Н-пиррол-3-ил)акриламида, (Е)-3-[1-(4-диметиламинометилбензолсульфонил)-1Н-пиррол-3-ил]-N-гидроксиакриламида и (Е)-N-гидрокси-3-[1-(5-пиридин-2-илтиофен-2-сульфонил)-1Н-пиррол-3-ил]акриламида с кислотой или основанием, которые являются новыми эффективными ингибиторами гистондезацетилазы (ГДАЦ).
EA200800700A 2005-09-21 2006-09-08 Новые сульфонилпирролы в качестве ингибиторов гдац (гистондезацетилазы) EA016345B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05108728 2005-09-21
PCT/EP2006/066197 WO2007039404A1 (en) 2005-09-21 2006-09-08 Novel sulphonylpyrroles as inhibitors of hdac s novel sulphonylpyrroles

Publications (2)

Publication Number Publication Date
EA200800700A1 true EA200800700A1 (ru) 2009-04-28
EA016345B1 EA016345B1 (ru) 2012-04-30

Family

ID=37035343

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200800700A EA016345B1 (ru) 2005-09-21 2006-09-08 Новые сульфонилпирролы в качестве ингибиторов гдац (гистондезацетилазы)

Country Status (26)

Country Link
US (1) US8232297B2 (ru)
EP (1) EP1928872B1 (ru)
JP (1) JP5305910B2 (ru)
KR (1) KR101256846B1 (ru)
CN (1) CN101268070B (ru)
AR (1) AR057824A1 (ru)
AT (1) ATE549333T1 (ru)
AU (1) AU2006298882B2 (ru)
BR (1) BRPI0617167B8 (ru)
CA (1) CA2622673C (ru)
CY (1) CY1112780T1 (ru)
DK (1) DK1928872T3 (ru)
EA (1) EA016345B1 (ru)
ES (1) ES2381962T3 (ru)
HK (1) HK1124320A1 (ru)
HR (1) HRP20120399T1 (ru)
IL (1) IL189782A (ru)
NO (1) NO341744B1 (ru)
NZ (1) NZ566074A (ru)
PL (1) PL1928872T3 (ru)
PT (1) PT1928872E (ru)
RS (1) RS52383B (ru)
SI (1) SI1928872T1 (ru)
TW (1) TWI406846B (ru)
WO (1) WO2007039404A1 (ru)
ZA (1) ZA200801394B (ru)

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BRPI0616040A2 (pt) 2005-09-21 2011-06-07 Nycomed Gmbh cloridrato de sulfonilpirról como inibidor de histona desacetilases
EP2100878A1 (en) 2008-03-12 2009-09-16 4Sc Ag Novel method for the production of sulphonylpyrroles as HDAC inhibitors
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KR102173433B1 (ko) 2013-07-11 2020-11-04 에이시아 바이오사이언시스 인코포레이티드. 키나아제 억제제로써의 피리미딘 유도체
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Also Published As

Publication number Publication date
US20090263353A1 (en) 2009-10-22
CA2622673C (en) 2017-06-27
RS52383B (en) 2012-12-31
SI1928872T1 (sl) 2012-06-29
DK1928872T3 (da) 2012-05-07
NO341744B1 (no) 2018-01-15
NO20081797L (no) 2008-04-17
PT1928872E (pt) 2012-05-25
IL189782A (en) 2013-06-27
BRPI0617167B8 (pt) 2021-05-25
PL1928872T3 (pl) 2012-08-31
IL189782A0 (en) 2008-08-07
US8232297B2 (en) 2012-07-31
ES2381962T3 (es) 2012-06-04
EP1928872B1 (en) 2012-03-14
CA2622673A1 (en) 2007-04-12
BRPI0617167B1 (pt) 2021-02-09
KR20080047607A (ko) 2008-05-29
CN101268070A (zh) 2008-09-17
BRPI0617167A2 (pt) 2011-07-12
AR057824A1 (es) 2007-12-19
KR101256846B1 (ko) 2013-04-24
ZA200801394B (en) 2009-12-30
HK1124320A1 (en) 2009-07-10
WO2007039404A1 (en) 2007-04-12
TW200745028A (en) 2007-12-16
CY1112780T1 (el) 2016-02-10
NZ566074A (en) 2011-08-26
ATE549333T1 (de) 2012-03-15
TWI406846B (zh) 2013-09-01
EA016345B1 (ru) 2012-04-30
JP5305910B2 (ja) 2013-10-02
AU2006298882B2 (en) 2011-10-27
HRP20120399T1 (hr) 2012-06-30
EP1928872A1 (en) 2008-06-11
CN101268070B (zh) 2012-09-05
JP2009508826A (ja) 2009-03-05
AU2006298882A1 (en) 2007-04-12

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