CY1111789T1 - Ετεροκυκλικες ενωσεις - Google Patents

Ετεροκυκλικες ενωσεις

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Publication number
CY1111789T1
CY1111789T1 CY20111100829T CY111100829T CY1111789T1 CY 1111789 T1 CY1111789 T1 CY 1111789T1 CY 20111100829 T CY20111100829 T CY 20111100829T CY 111100829 T CY111100829 T CY 111100829T CY 1111789 T1 CY1111789 T1 CY 1111789T1
Authority
CY
Cyprus
Prior art keywords
heterocyclic compounds
compounds
relates
present
histone deacetylase
Prior art date
Application number
CY20111100829T
Other languages
English (en)
Inventor
Dizhong Chen
Weiping Deng
Ken Chi Lik Lee
Pek Ling Lye
Eric T Sun
Haishan Wang
Niefang Yu
Original Assignee
S*Bio Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S*Bio Pte Ltd filed Critical S*Bio Pte Ltd
Publication of CY1111789T1 publication Critical patent/CY1111789T1/el

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Abstract

Η παρούσα εφεύρεση σχετίζεται με ενώσεις οι οποίες είναι αναστολείς της απακετυλάσης της ιστόνης. Περισσότερο δε ειδικότερα, η παρούσα εφεύρεση σχετίζεται με ετεροκυκλικές ενώσεις και μεθόδους για την παρασκευή αυτών. Αυτές οι ενώσεις μπορεί να είναι χρήσιμες ως φάρμακα για την αγωγή των υπερπλαστικών διαταραχών ως επίσης και άλλων παθήσεων ενέχοντας, σχετιζόμενες σε ή που συσχετίζονται με ένζυμα έχοντα δραστηριότητες της απακετυλάσης της ιστόνης (HDAC).
CY20111100829T 2005-09-08 2011-08-30 Ετεροκυκλικες ενωσεις CY1111789T1 (el)

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US71482705P 2005-09-08 2005-09-08
US78381906P 2006-03-21 2006-03-21
EP06769700A EP1937650B1 (en) 2005-09-08 2006-08-01 Heterocyclic compounds

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JP (1) JP5207064B2 (el)
KR (1) KR101346823B1 (el)
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0414581C1 (pt) 2003-09-22 2021-05-25 Mei Pharma Inc composto, composição farmacêutica compreendendo o referido composto e uso do referido composto
DE102007037579B4 (de) 2007-08-09 2012-05-16 Emc Microcollections Gmbh Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
US20110212943A1 (en) * 2008-10-15 2011-09-01 Orchid Research Laboratories Limited Novel bridged cyclic compounds as histone deacetylase inhibitors
KR101168801B1 (ko) * 2009-03-27 2012-07-25 주식회사종근당 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물
WO2011113013A2 (en) 2010-03-11 2011-09-15 Hemaquest Pharmaceuticals, Inc. Methods and compositions for treating viral or virally-induced conditions
DK2624696T3 (en) 2010-10-06 2017-03-13 Glaxosmithkline Llc Corp Service Company BENZIMIDAZOLD DERIVATIVES AS PI3-KINASE INHIBITORS
ES2842970T3 (es) * 2011-03-09 2021-07-15 Cereno Scient Ab Compuestos y métodos para mejorar la fibrinólisis endógena alterada usando inhibidores de la histona desacetilasa
WO2012127466A1 (en) * 2011-03-24 2012-09-27 Bar Ilan University 5-aminolevulinic acid derivatives, methods for their preparation and uses thereof
SI2914254T1 (sl) * 2012-10-30 2020-07-31 Mei Pharma, Inc. Kombinacija terapij za zdravljenje kemorezistentnih rakov
GB201417828D0 (en) 2014-10-08 2014-11-19 Cereno Scient Ab New methods and compositions
WO2017030938A1 (en) * 2015-08-14 2017-02-23 Incyte Corporation Heterocyclic compounds and uses thereof
ES2969021T3 (es) 2016-04-08 2024-05-16 Cereno Scient Ab Formulaciones farmacéuticas de liberación retardada que comprenden ácido valproico y usos de las mismas
AR108257A1 (es) * 2016-05-02 2018-08-01 Mei Pharma Inc Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
US11465974B2 (en) 2017-12-19 2022-10-11 Assia Chemical Industries Ltd. Crystalline polymorphs of Pracinostat and Pracinostat salts
KR102106032B1 (ko) * 2018-08-24 2020-04-29 인제대학교산학협력단 프라시노스타트를 포함하는 다발성 경화증 치료용 약학 조성물
KR102162744B1 (ko) * 2018-09-18 2020-10-07 인제대학교산학협력단 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
KR20220034736A (ko) 2019-05-31 2022-03-18 비락타 서브시디어리 인크. 히스톤 데아세틸라제 억제제를 사용하여 바이러스 관련 암을 치료하는 방법
WO2021217180A1 (en) * 2020-04-22 2021-10-28 Johnson Matthey Public Limited Company Novel forms of pracinostat dihydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1608628A2 (en) * 2003-03-17 2005-12-28 Takeda San Diego, Inc. Histone deacetylase inhibitors
AR043850A1 (es) * 2003-04-17 2005-08-17 Bayer Pharmaceuticals Corp Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos
BRPI0414581C1 (pt) * 2003-09-22 2021-05-25 Mei Pharma Inc composto, composição farmacêutica compreendendo o referido composto e uso do referido composto
WO2005066151A2 (en) 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors

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HK1123038A1 (en) 2009-06-05
KR101346823B1 (ko) 2014-02-14
ATE512953T1 (de) 2011-07-15
WO2007030080A1 (en) 2007-03-15
JP5207064B2 (ja) 2013-06-12
BRPI0615690A2 (pt) 2011-05-24
TWI393708B (zh) 2013-04-21
US8143282B2 (en) 2012-03-27
AR055364A1 (es) 2007-08-22
DK1937650T3 (da) 2011-10-03
JP2009507829A (ja) 2009-02-26
BRPI0615690B8 (pt) 2021-05-25
PT1937650E (pt) 2011-09-21
TW200745047A (en) 2007-12-16
KR20080046219A (ko) 2008-05-26
EP1937650B1 (en) 2011-06-15
BRPI0615690B1 (pt) 2020-12-08
US20090048300A1 (en) 2009-02-19
EP1937650A4 (en) 2010-02-24
PL1937650T3 (pl) 2011-11-30
EP1937650A1 (en) 2008-07-02
NZ594108A (en) 2012-12-21
MY144970A (en) 2011-11-30

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