PL1937650T3 - Związki heterocykliczne - Google Patents

Związki heterocykliczne

Info

Publication number
PL1937650T3
PL1937650T3 PL06769700T PL06769700T PL1937650T3 PL 1937650 T3 PL1937650 T3 PL 1937650T3 PL 06769700 T PL06769700 T PL 06769700T PL 06769700 T PL06769700 T PL 06769700T PL 1937650 T3 PL1937650 T3 PL 1937650T3
Authority
PL
Poland
Prior art keywords
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
PL06769700T
Other languages
English (en)
Inventor
Dizhong Chen
Weiping Deng
Ken Chi Lik Lee
Pek Ling Lye
Eric T Sun
Haishan Wang
Niefang Yu
Original Assignee
Mei Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mei Pharma Inc filed Critical Mei Pharma Inc
Publication of PL1937650T3 publication Critical patent/PL1937650T3/pl

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • C—CHEMISTRY; METALLURGY
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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    • C07D235/10—Radicals substituted by halogen atoms or nitro radicals
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    • C07D235/12—Radicals substituted by oxygen atoms
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    • C07D235/14—Radicals substituted by nitrogen atoms
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PL06769700T 2005-09-08 2006-08-01 Związki heterocykliczne PL1937650T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71482705P 2005-09-08 2005-09-08
US78381906P 2006-03-21 2006-03-21
PCT/SG2006/000217 WO2007030080A1 (en) 2005-09-08 2006-08-01 Heterocyclic compounds
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Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101127201B1 (ko) 2003-09-22 2012-04-12 에스*바이오 피티이 리미티드 벤즈이미다졸 유도체와 그의 제조방법 및 약학적 적용
DE102007037579B4 (de) 2007-08-09 2012-05-16 Emc Microcollections Gmbh Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe
WO2009084544A1 (ja) * 2007-12-27 2009-07-09 Idemitsu Kosan Co., Ltd. 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子
WO2010043953A2 (en) * 2008-10-15 2010-04-22 Orchid Research Laboratories Ltd. Novel bridged cyclic compounds as histone deacetylase inhibitors
KR101168801B1 (ko) * 2009-03-27 2012-07-25 주식회사종근당 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물
US20110245154A1 (en) 2010-03-11 2011-10-06 Hemaquest Pharmaceuticals, Inc. Methods and Compositions for Treating Viral or Virally-Induced Conditions
ES2616238T3 (es) 2010-10-06 2017-06-12 Glaxosmithkline Llc, Corporation Service Company Derivados de bencimidazol como inhibidores de PI3 quinasa
ES2842970T3 (es) * 2011-03-09 2021-07-15 Cereno Scient Ab Compuestos y métodos para mejorar la fibrinólisis endógena alterada usando inhibidores de la histona desacetilasa
US9018257B2 (en) * 2011-03-24 2015-04-28 Bar Ilan University 5-aminolevulinic acid derivatives, methods for their preparation and uses thereof
SMT202000168T1 (it) * 2012-10-30 2020-05-08 Mei Pharma Inc Terapie di combinazione per il trattamento dei tumori chemioresistenti
GB201417828D0 (en) 2014-10-08 2014-11-19 Cereno Scient Ab New methods and compositions
WO2017030938A1 (en) * 2015-08-14 2017-02-23 Incyte Corporation Heterocyclic compounds and uses thereof
RU2760304C2 (ru) 2016-04-08 2021-11-23 Серено Сайентифик Аб Фармацевтические составы с отсроченным высвобождением, содержащие вальпроевую кислоту, и их применение
AR108257A1 (es) * 2016-05-02 2018-08-01 Mei Pharma Inc Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas
WO2019126282A1 (en) 2017-12-19 2019-06-27 Assia Chemical Industries Ltd. Crystalline polymorphs of pracinostat and pracinostat salts
KR102106032B1 (ko) * 2018-08-24 2020-04-29 인제대학교산학협력단 프라시노스타트를 포함하는 다발성 경화증 치료용 약학 조성물
KR102162744B1 (ko) * 2018-09-18 2020-10-07 인제대학교산학협력단 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물
CN110950848B (zh) * 2018-09-27 2024-03-26 徐诺药业 新型氨基吡唑类衍生物的合成与应用
MX2021014639A (es) 2019-05-31 2022-04-06 Viracta Subsidiary Inc Metodos para tratar canceres asociados con virus con inhibidores de la histona deacetilasa.
WO2021217180A1 (en) * 2020-04-22 2021-10-28 Johnson Matthey Public Limited Company Novel forms of pracinostat dihydrochloride

Family Cites Families (4)

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KR20050122210A (ko) * 2003-03-17 2005-12-28 다케다 샌디에고, 인코포레이티드 히스톤 탈아세틸화 효소 억제제
AR043850A1 (es) * 2003-04-17 2005-08-17 Bayer Pharmaceuticals Corp Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos
KR101127201B1 (ko) * 2003-09-22 2012-04-12 에스*바이오 피티이 리미티드 벤즈이미다졸 유도체와 그의 제조방법 및 약학적 적용
WO2005066151A2 (en) * 2003-12-19 2005-07-21 Takeda San Diego, Inc. Histone deacetylase inhibitors

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KR20080046219A (ko) 2008-05-26
BRPI0615690B8 (pt) 2021-05-25
BRPI0615690B1 (pt) 2020-12-08
EP1937650B1 (en) 2011-06-15
EP1937650A1 (en) 2008-07-02
TW200745047A (en) 2007-12-16
NZ594108A (en) 2012-12-21
WO2007030080A1 (en) 2007-03-15
ATE512953T1 (de) 2011-07-15
MY144970A (en) 2011-11-30
TWI393708B (zh) 2013-04-21
US8143282B2 (en) 2012-03-27
US20090048300A1 (en) 2009-02-19
HK1123038A1 (en) 2009-06-05
AR055364A1 (es) 2007-08-22
BRPI0615690A2 (pt) 2011-05-24
EP1937650A4 (en) 2010-02-24
JP2009507829A (ja) 2009-02-26
PT1937650E (pt) 2011-09-21
DK1937650T3 (da) 2011-10-03
CY1111789T1 (el) 2015-10-07
KR101346823B1 (ko) 2014-02-14

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