TW200745047A - Heterocyclic compounds - Google Patents

Heterocyclic compounds

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Publication number
TW200745047A
TW200745047A TW095128137A TW95128137A TW200745047A TW 200745047 A TW200745047 A TW 200745047A TW 095128137 A TW095128137 A TW 095128137A TW 95128137 A TW95128137 A TW 95128137A TW 200745047 A TW200745047 A TW 200745047A
Authority
TW
Taiwan
Prior art keywords
heterocyclic compounds
compounds
relates
present
histone deacetylase
Prior art date
Application number
TW095128137A
Other languages
Chinese (zh)
Other versions
TWI393708B (en
Inventor
Di-Zhong Chen
wei-ping Deng
Ken Chi-Lik Lee
Pek-Ling Lye
Eric T Sun
Haishan Wang
Niefang Yu
Original Assignee
S Bio Pte Ltd
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Filing date
Publication date
Application filed by S Bio Pte Ltd filed Critical S Bio Pte Ltd
Publication of TW200745047A publication Critical patent/TW200745047A/en
Application granted granted Critical
Publication of TWI393708B publication Critical patent/TWI393708B/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

The present invention relates to compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
TW095128137A 2005-09-08 2006-08-01 Hydroxamate compounds, use thereof and synthesizing method for the same TWI393708B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71482705P 2005-09-08 2005-09-08
US78381906P 2006-03-21 2006-03-21

Publications (2)

Publication Number Publication Date
TW200745047A true TW200745047A (en) 2007-12-16
TWI393708B TWI393708B (en) 2013-04-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW095128137A TWI393708B (en) 2005-09-08 2006-08-01 Hydroxamate compounds, use thereof and synthesizing method for the same

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Country Link
US (1) US8143282B2 (en)
EP (1) EP1937650B1 (en)
JP (1) JP5207064B2 (en)
KR (1) KR101346823B1 (en)
AR (1) AR055364A1 (en)
AT (1) ATE512953T1 (en)
BR (1) BRPI0615690B8 (en)
CY (1) CY1111789T1 (en)
DK (1) DK1937650T3 (en)
HK (1) HK1123038A1 (en)
MY (1) MY144970A (en)
NZ (1) NZ594108A (en)
PL (1) PL1937650T3 (en)
PT (1) PT1937650E (en)
TW (1) TWI393708B (en)
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