AR055364A1 - Derivados de benzimidazol - Google Patents

Derivados de benzimidazol

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Publication number
AR055364A1
AR055364A1 ARP060103353A ARP060103353A AR055364A1 AR 055364 A1 AR055364 A1 AR 055364A1 AR P060103353 A ARP060103353 A AR P060103353A AR P060103353 A ARP060103353 A AR P060103353A AR 055364 A1 AR055364 A1 AR 055364A1
Authority
AR
Argentina
Prior art keywords
group
optionally substituted
alkyl
alkynyl
alkenyl
Prior art date
Application number
ARP060103353A
Other languages
English (en)
Original Assignee
S Bio Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by S Bio Pte Ltd filed Critical S Bio Pte Ltd
Publication of AR055364A1 publication Critical patent/AR055364A1/es

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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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Abstract

Reivindicacion 1: Un compuesto de la formula (1) caracterizado porque R1 es un grupo heteroarilo opcionalmente sustituido, es un grupo heterocicloalquilo opcionalmente sustituido o un grupo de la formula -(CR20R21)m-(CR22R23)n-(CR24R25)o-NR26R27; R2 está seleccionado del grupo que consiste en: H, alquilo, alquenilo, alquinilo, heteroalquilo, cicloalquilo, cicloalquenilo, cicloalquilalquilo, alcoxialquilo, R11S(O)R13-, R11S(O)2R13-, R11C(O)N(R12)R13-, R11SO2N(R12)R13-, R11N(R12)C(O)R13-, R11N(R12)SO2R13-, R11N(R12)C(O)N(R12)R13- y acilo, cada uno de los cuales puede estar opcionalmente sustituido; R3 está seleccionado del grupo que consiste en H, alquilo C1-6 y acilo, cada uno de los cuales puede estar opcionalmente sustituido; X e Y son iguales o diferentes y están seleccionados, de modo independiente, del grupo que consiste en: H, halogeno, -CN, -NO2, -CF3, -OCF3, alquilo, alquenilo, alquinilo, haloalquilo, haloalquenilo, haloalquinilo, heteroalquilo, cicloalquilo, cicloalquenilo, heterocicloalquilo, heterocicloalquenilo, arilo, heteroarilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, alcoxiarilo, alcoxiheteroarilo, alqueniloxi, alquiniloxi, cicloalquiloxi, cicloalqueniloxi, heterocicloalquiloxi, heterocicloalqueniloxi, ariloxi, heteroariloxi, arilalquilo, heteroarilalquilo, arilalquiloxi, -amino, alquilamino, acilamino, aminoalquilo, arilamino, sulfonilo, alquilsulfonilo, arilsulfonilo, aminosulfonilo, aminoalquilo, alcoxialquilo, -COOH, - C(O)OR5, -COR5, -SH, -SR6, -OR6 acilo y -NR7R8, cada uno de los cuales puede estar opcionalmente sustituido; cada R4 está seleccionado del grupo que consiste en H, alquilo, alquenilo, alquinilo, haloalquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, cicloalquilalquilo, heterocicloalquilalquilo, arilalquilo, heteroarilalquilo y acilo, cada uno de los cuales puede estar opcionalmente sustituido; cada R5 está seleccionado, de modo independiente, del grupo que consiste en: H, alquilo, alquenilo, alquinilo, haloalquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, cicloalquilalquilo, heterocicloalquilalquilo, arilalquilo, heteroarilalquilo y acilo, cada uno de los cuales puede estar opcionalmente sustituido; cada R6 está seleccionado, de modo independiente, del grupo que consiste en: H, alquilo, alquenilo, alquinilo, haloalquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, cicloalquilalquilo, heterocicloalquilalquilo, arilalquilo, heteroarilalquilo y acilo, cada uno de los cuales puede estar opcionalmente sustituido; cada R7 y R8 está seleccionado, de modo independiente, del grupo que consiste en: H, alquilo, alquenilo, alquinilo, haloalquilo, heteroalquilo, cicloalquilo, heterocicloalquilo, arilo, heteroarilo, cicloalquilalquilo, heterocicloalquilalquilo, arilalquilo, heteroarilalquilo y acilo, cada uno de los cuales puede estar opcionalmente sustituido; cada R11 y R12 está seleccionado, de modo independiente, del grupo que consiste en: H, alquilo, alquenilo, y alquinilo, cada uno de los cuales puede estar opcionalmente sustituido; cada R13 es un enlace o está seleccionado, de modo independiente, del grupo que consiste en: alquilo, alquenilo, y alquinilo, cada uno de los cuales puede estar opcionalmente sustituido; cada R20, R21, R22, R23, R24 y R25 está seleccionado, de modo independiente, del grupo que consiste en : H, halogeno, -CN, -NO2, -CF3, -OCF3, alquilo, alquenilo, alquinilo, haloalquilo, haloalquenilo, haloalquinilo, heteroalquilo, cicloalquilo, cicloalquenilo, heterocicloalquilo, heterocicloalquenilo, arilo, heteroarilo, cicloalquilalquilo, heterocicloalquilalquilo, arilalquilo, heteroarilalquilo, arilalquenilo, cicloalquilheteroalquilo, heterocicloalquilheteroalquilo, heteroarilheteroalquilo, arilheteroalquilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, alcoxiarilo, alcoxiheteroarilo, alqueniloxi, alquiniloxi, cicloalquiloxi, heterocicloalquiloxi, ariloxi, arilalquiloxi, fenoxi, benciloxi, heteroariloxi, amino, alquilamino, acilamino, aminoalquilo, arilamino, alcoxicarbonilo, alquilaminocarbonilo, sulfonilo, alquilsulfonilo, aminosulfonilo, arilsulfonilo, arilsulfinilo, - COOH, -C(O)OR5, -COR5, -SH, -SR6, -OR6 y acilo, cada uno de los cuales puede estar opcionalmente sustituido; o R20 y R21 pueden formar, cuando se toman juntos, un grupo de la formula =O o =S, y/o R22 y R23 pueden formar, cuando se toman juntos, un grupo de la formula =O o =S, y/o R24 y R25 pueden formar, cuando se toman juntos, un grupo de la formula =O o =S; cada R26 y R27 está seleccionado, de modo independiente, del grupo que consiste en H, halogeno, alquilo, alquenilo, alquinilo, haloalquilo, haloalquenilo, heteroalquilo, cicloalquilo, cicloalquenilo, heterocicloalquilo, heterocicloalquenilo, arilo, heteroarilo, cicloalquilalquilo, heterocicloalquilalquilo, arilalquilo, heteroarilalquilo, arilalquenilo, cicloalquilheteroalquilo, heterocicloalquilheteroalquilo, heteroarilheteroalquilo, arilheteroalquilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, alcoxiarilo, alqueniloxi, alquiniloxi, cicloalquiloxi, heterocicloalquiloxi, ariloxi, arilalquiloxi, heteroariloxi, amino, alquilamino, aminoalquilo, acilamino, arilamino, fenoxi, COOH, alcoxicarbonilo, alquilaminocarbonilo, sulfonilo, alquilsulfonilo, alquilsulfinilo, arilsulfonilo, arilsulfinilo, aminosulfonilo, SR5, y acilo, cada uno de los cuales puede estar opcionalmente sustituido, o R26 y R27 son, cuando se toman juntos con el átomo de N al que están unidos, un grupo heterocicloalquilo opcionalmente sustituido; Z está seleccionado el grupo que consiste en: -CH2-, -CH2CH2- , -CH=CH-, alquileno C3-6, alquenileno C3-6, alquinileno C3-6, cicloalquilo C3-6, no sustituido o sustituido con uno o varios sustituyentes seleccionados, de modo independiente, del grupo que consiste en alquilo C1-4; m, n y o son numeros enteros seleccionados, de modo independiente, del grupo que consiste en 0, 1, 2, 3 y 4; o una de sus sales o profármacos farmacéuticamente aceptables.
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