BRPI0615690B8 - compostos heterocíclicos de hidroxamato, seus usos e composição farmacêutica - Google Patents
compostos heterocíclicos de hidroxamato, seus usos e composição farmacêuticaInfo
- Publication number
- BRPI0615690B8 BRPI0615690B8 BRPI0615690A BRPI0615690A BRPI0615690B8 BR PI0615690 B8 BRPI0615690 B8 BR PI0615690B8 BR PI0615690 A BRPI0615690 A BR PI0615690A BR PI0615690 A BRPI0615690 A BR PI0615690A BR PI0615690 B8 BRPI0615690 B8 BR PI0615690B8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- compounds
- heterocyclic
- hydroxamate compounds
- heterocyclic hydroxamate
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D235/14—Radicals substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
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- C07D235/22—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms directly attached to ring nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71482705P | 2005-09-08 | 2005-09-08 | |
US60/714.827 | 2005-09-08 | ||
US78381906P | 2006-03-21 | 2006-03-21 | |
US60/783.819 | 2006-03-21 | ||
PCT/SG2006/000217 WO2007030080A1 (en) | 2005-09-08 | 2006-08-01 | Heterocyclic compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0615690A2 BRPI0615690A2 (pt) | 2011-05-24 |
BRPI0615690B1 BRPI0615690B1 (pt) | 2020-12-08 |
BRPI0615690B8 true BRPI0615690B8 (pt) | 2021-05-25 |
Family
ID=37836122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0615690A BRPI0615690B8 (pt) | 2005-09-08 | 2006-08-01 | compostos heterocíclicos de hidroxamato, seus usos e composição farmacêutica |
Country Status (16)
Country | Link |
---|---|
US (1) | US8143282B2 (pt) |
EP (1) | EP1937650B1 (pt) |
JP (1) | JP5207064B2 (pt) |
KR (1) | KR101346823B1 (pt) |
AR (1) | AR055364A1 (pt) |
AT (1) | ATE512953T1 (pt) |
BR (1) | BRPI0615690B8 (pt) |
CY (1) | CY1111789T1 (pt) |
DK (1) | DK1937650T3 (pt) |
HK (1) | HK1123038A1 (pt) |
MY (1) | MY144970A (pt) |
NZ (1) | NZ594108A (pt) |
PL (1) | PL1937650T3 (pt) |
PT (1) | PT1937650E (pt) |
TW (1) | TWI393708B (pt) |
WO (1) | WO2007030080A1 (pt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0414581C1 (pt) | 2003-09-22 | 2021-05-25 | Mei Pharma Inc | composto, composição farmacêutica compreendendo o referido composto e uso do referido composto |
DE102007037579B4 (de) | 2007-08-09 | 2012-05-16 | Emc Microcollections Gmbh | Neue Benzimidazol-2-yl-alkylamine und ihre Anwendung als mikrobizide Wirkstoffe |
WO2009084544A1 (ja) * | 2007-12-27 | 2009-07-09 | Idemitsu Kosan Co., Ltd. | 含窒素複素環誘導体及びそれを用いた有機エレクトロルミネッセンス素子 |
US20110212943A1 (en) * | 2008-10-15 | 2011-09-01 | Orchid Research Laboratories Limited | Novel bridged cyclic compounds as histone deacetylase inhibitors |
KR101168801B1 (ko) * | 2009-03-27 | 2012-07-25 | 주식회사종근당 | 신규한 하이드록사메이트 유도체, 이의 제조방법, 및 이를 함유하는 약제학적 조성물 |
WO2011113013A2 (en) | 2010-03-11 | 2011-09-15 | Hemaquest Pharmaceuticals, Inc. | Methods and compositions for treating viral or virally-induced conditions |
DK2624696T3 (en) | 2010-10-06 | 2017-03-13 | Glaxosmithkline Llc Corp Service Company | BENZIMIDAZOLD DERIVATIVES AS PI3-KINASE INHIBITORS |
ES2842970T3 (es) * | 2011-03-09 | 2021-07-15 | Cereno Scient Ab | Compuestos y métodos para mejorar la fibrinólisis endógena alterada usando inhibidores de la histona desacetilasa |
WO2012127466A1 (en) * | 2011-03-24 | 2012-09-27 | Bar Ilan University | 5-aminolevulinic acid derivatives, methods for their preparation and uses thereof |
SI2914254T1 (sl) * | 2012-10-30 | 2020-07-31 | Mei Pharma, Inc. | Kombinacija terapij za zdravljenje kemorezistentnih rakov |
GB201417828D0 (en) | 2014-10-08 | 2014-11-19 | Cereno Scient Ab | New methods and compositions |
WO2017030938A1 (en) * | 2015-08-14 | 2017-02-23 | Incyte Corporation | Heterocyclic compounds and uses thereof |
ES2969021T3 (es) | 2016-04-08 | 2024-05-16 | Cereno Scient Ab | Formulaciones farmacéuticas de liberación retardada que comprenden ácido valproico y usos de las mismas |
AR108257A1 (es) * | 2016-05-02 | 2018-08-01 | Mei Pharma Inc | Formas polimórficas de 3-[2-butil-1-(2-dietilamino-etil)-1h-bencimidazol-5-il]-n-hidroxi-acrilamida y usos de las mismas |
US11465974B2 (en) | 2017-12-19 | 2022-10-11 | Assia Chemical Industries Ltd. | Crystalline polymorphs of Pracinostat and Pracinostat salts |
KR102106032B1 (ko) * | 2018-08-24 | 2020-04-29 | 인제대학교산학협력단 | 프라시노스타트를 포함하는 다발성 경화증 치료용 약학 조성물 |
KR102162744B1 (ko) * | 2018-09-18 | 2020-10-07 | 인제대학교산학협력단 | 프라시노스타트를 포함하는 염증성 장질환 치료용 약학 조성물 |
CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
KR20220034736A (ko) | 2019-05-31 | 2022-03-18 | 비락타 서브시디어리 인크. | 히스톤 데아세틸라제 억제제를 사용하여 바이러스 관련 암을 치료하는 방법 |
WO2021217180A1 (en) * | 2020-04-22 | 2021-10-28 | Johnson Matthey Public Limited Company | Novel forms of pracinostat dihydrochloride |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1608628A2 (en) * | 2003-03-17 | 2005-12-28 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
AR043850A1 (es) * | 2003-04-17 | 2005-08-17 | Bayer Pharmaceuticals Corp | Acidos hidroxamicos utiles en el tratamiento de trastornos hiperproliferativos |
BRPI0414581C1 (pt) * | 2003-09-22 | 2021-05-25 | Mei Pharma Inc | composto, composição farmacêutica compreendendo o referido composto e uso do referido composto |
WO2005066151A2 (en) | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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2006
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- 2006-08-01 EP EP06769700A patent/EP1937650B1/en active Active
- 2006-08-01 PL PL06769700T patent/PL1937650T3/pl unknown
- 2006-08-01 WO PCT/SG2006/000217 patent/WO2007030080A1/en active Application Filing
- 2006-08-01 MY MYPI20063724A patent/MY144970A/en unknown
- 2006-08-01 BR BRPI0615690A patent/BRPI0615690B8/pt not_active IP Right Cessation
- 2006-08-01 TW TW095128137A patent/TWI393708B/zh not_active IP Right Cessation
- 2006-08-01 DK DK06769700.3T patent/DK1937650T3/da active
- 2006-08-01 US US12/065,989 patent/US8143282B2/en not_active Expired - Fee Related
- 2006-08-01 PT PT06769700T patent/PT1937650E/pt unknown
- 2006-08-01 JP JP2008529964A patent/JP5207064B2/ja not_active Expired - Fee Related
- 2006-08-01 KR KR1020087007856A patent/KR101346823B1/ko active IP Right Grant
- 2006-08-01 AR ARP060103353A patent/AR055364A1/es not_active Application Discontinuation
- 2006-08-01 AT AT06769700T patent/ATE512953T1/de active
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2008
- 2008-12-31 HK HK08114137.7A patent/HK1123038A1/xx not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
HK1123038A1 (en) | 2009-06-05 |
KR101346823B1 (ko) | 2014-02-14 |
ATE512953T1 (de) | 2011-07-15 |
WO2007030080A1 (en) | 2007-03-15 |
JP5207064B2 (ja) | 2013-06-12 |
BRPI0615690A2 (pt) | 2011-05-24 |
TWI393708B (zh) | 2013-04-21 |
US8143282B2 (en) | 2012-03-27 |
AR055364A1 (es) | 2007-08-22 |
DK1937650T3 (da) | 2011-10-03 |
JP2009507829A (ja) | 2009-02-26 |
CY1111789T1 (el) | 2015-10-07 |
PT1937650E (pt) | 2011-09-21 |
TW200745047A (en) | 2007-12-16 |
KR20080046219A (ko) | 2008-05-26 |
EP1937650B1 (en) | 2011-06-15 |
BRPI0615690B1 (pt) | 2020-12-08 |
US20090048300A1 (en) | 2009-02-19 |
EP1937650A4 (en) | 2010-02-24 |
PL1937650T3 (pl) | 2011-11-30 |
EP1937650A1 (en) | 2008-07-02 |
NZ594108A (en) | 2012-12-21 |
MY144970A (en) | 2011-11-30 |
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