AR073774A1 - Compuestos antibioticos oxazolidinona triciclicos - Google Patents
Compuestos antibioticos oxazolidinona triciclicosInfo
- Publication number
- AR073774A1 AR073774A1 ARP090103838A ARP090103838A AR073774A1 AR 073774 A1 AR073774 A1 AR 073774A1 AR P090103838 A ARP090103838 A AR P090103838A AR P090103838 A ARP090103838 A AR P090103838A AR 073774 A1 AR073774 A1 AR 073774A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- hydroxyalkyl
- alkoxy
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de formula (1) en la cual ô-------ô, es un enlace o está ausente; R0 representa H o, en el caso en que ô------ô es un enlace, también puede representar alcoxilo C1-3; R1 representa H, halogeno, ciano, alquilo C1-3 o etinilo; U representa CH o N cuando ô-------ô es un enlace, o, en caso en que ô------ô esté ausente, U representa CH2, NH o NR9; V representa CH, CR6 o N; R2 representa H, alquilcarbonilo C1-3, o un grupo de formula -CH2-R3; R3 representa H, alquilo C1-3, o hidroxialquilo C1-3; R4 representa H o, en los casos en que n no es 0 y R5 es H, también puede representar OH; R5 representa H, alquilo C1-3, hidroxialquilo C1-3, aminoalquilo C1-3, alcoxi C1-3-alquilo C1-3, carboxilo o alcoxicarbonilo C1-3; R6 representa hidroxialquilo C1-3, carboxilo, alcoxicarbonilo C1-3 o un grupo -(CH2)q-NR7R8 en donde q es 1, 2 o 3 y cada uno de R78 y R8 representa de manera independiente H o alquilo C1-3 o R7 y R8 forman en conjunto con el átomo de N que los porta un anillo pirrolidinilo, piperidinilo, morfolinilo o tiomorfolinilo; R9 representa alquilo C1-3, 2-hidroxi-etilo, -hidroxi-propilo o 3-hidroxi-propilo; A representa -(CH2)p-, -CH2CH2CH(OH)- o -COCH2CH(OH)-; G representa un grupo fenilo que está substituido una o dos veces en la o las posiciones meta y/o para con sustituyentes seleccionados de manera independiente de entre alquilo C1-4, alcoxi C1-3 y un halogeno, o G es un grupo que tiene una de las formulas G1 y G2 en las cuales Q es O o S y X es CH o N; e Y1, Y2 e Y3 cada uno representa CH, o Y1 e Y3 cada uno representa CH e Y2 representa N, o Y1 representa N, Y2 representa CH o N e Y3 representa CH, o Y1 e Y2 cada uno representa CH e Y3 representa N; y n es 0 cuando A representa -CH2CH2CH(OH)- o -COCH2CH(OH)-, y n es 0, 1 o 2 cuando A representa (CH2)p, p siendo 1, 2, 3 o 4, siempre que la soma de n y p sea entonces 2, 3 o 4; o una sal de un tal compuesto.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2008054109 | 2008-10-07 | ||
| IB2009051059 | 2009-03-13 | ||
| IB2009052843 | 2009-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR073774A1 true AR073774A1 (es) | 2010-12-01 |
Family
ID=41402623
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090103838A AR073774A1 (es) | 2008-10-07 | 2009-10-06 | Compuestos antibioticos oxazolidinona triciclicos |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8618092B2 (es) |
| EP (1) | EP2344495B1 (es) |
| JP (1) | JP4833385B1 (es) |
| KR (1) | KR101294962B1 (es) |
| CN (3) | CN104151315B (es) |
| AR (1) | AR073774A1 (es) |
| AU (1) | AU2009302075B2 (es) |
| BR (1) | BRPI0920895A8 (es) |
| CA (1) | CA2739373C (es) |
| CY (1) | CY1116155T1 (es) |
| DK (1) | DK2344495T3 (es) |
| ES (1) | ES2533217T3 (es) |
| HK (1) | HK1159611A1 (es) |
| HR (1) | HRP20150370T1 (es) |
| IL (1) | IL212139A (es) |
| MA (1) | MA32768B1 (es) |
| MX (1) | MX2011003370A (es) |
| MY (1) | MY158520A (es) |
| NZ (1) | NZ592642A (es) |
| PL (1) | PL2344495T3 (es) |
| PT (1) | PT2344495E (es) |
| RU (1) | RU2530884C2 (es) |
| SI (1) | SI2344495T1 (es) |
| TW (1) | TWI415853B (es) |
| WO (1) | WO2010041194A1 (es) |
| ZA (1) | ZA201103332B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2674430A4 (en) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | AMINO-GROUP-PYRROLIDINONE DERIVATIVES |
| KR20130002712A (ko) | 2011-06-29 | 2013-01-08 | 현대자동차주식회사 | 하이브리드 자동차의 파워트레인 제어방법 |
| JP5944987B2 (ja) * | 2011-06-30 | 2016-07-05 | ディーエスエム アイピー アセッツ ビー．ブイ． | シリコーン含有モノマー |
| US8916573B2 (en) | 2011-08-11 | 2014-12-23 | Actelion Pharmaceuticals Ltd. | Quinazoline-2,4-dione derivatives |
| BR112014011064A8 (pt) | 2011-11-08 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados de antibióticos 2-oxo-oxazolidin-3,5-diila |
| JP2014533747A (ja) * | 2011-11-30 | 2014-12-15 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ３，７−二置換オクタヒドロ−２Ｈ−ピリド［４，３−ｅ］［１，３］オキサジン−２−オン抗生物質 |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
| TW201429973A (zh) * | 2013-01-09 | 2014-08-01 | Actelion Pharmaceuticals Ltd | 抗菌噁二唑酮衍生物 |
| WO2014108832A1 (en) | 2013-01-09 | 2014-07-17 | Actelion Pharmaceuticals Ltd | Antibacterial oxazolone derivatives |
| KR20150143720A (ko) | 2013-04-16 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 항균성 이방향족 유도체 |
| US20160090383A1 (en) * | 2013-05-08 | 2016-03-31 | Actelion Pharmaceuticals Ltd. | Antibacterial phthalide derivatives |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| TW201722965A (zh) * | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| RU2602503C1 (ru) * | 2015-09-23 | 2016-11-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА) | Трициклические соединения, обладающие противобактериальной активностью, способ их получения и содержащее их фармацевтическое средство |
| WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| JP7148991B2 (ja) * | 2017-06-08 | 2022-10-06 | バグワークス・リサーチ・インコーポレイテッド | 抗菌剤として有用な複素環式化合物及びその生成方法 |
| EP3717490B1 (en) * | 2017-11-29 | 2023-05-24 | Bugworks Research, Inc. | Anti-bacterial heterocyclic compounds and their synthesis |
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| WO2007115947A1 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
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| BR112014011064A8 (pt) | 2011-11-08 | 2017-12-26 | Actelion Pharmaceuticals Ltd | derivados de antibióticos 2-oxo-oxazolidin-3,5-diila |
| TW201429973A (zh) | 2013-01-09 | 2014-08-01 | Actelion Pharmaceuticals Ltd | 抗菌噁二唑酮衍生物 |
| KR20150143720A (ko) | 2013-04-16 | 2015-12-23 | 액테리온 파마슈티칼 리미티드 | 항균성 이방향족 유도체 |
| US20160090383A1 (en) | 2013-05-08 | 2016-03-31 | Actelion Pharmaceuticals Ltd. | Antibacterial phthalide derivatives |
-
2009
- 2009-10-06 CA CA2739373A patent/CA2739373C/en not_active Expired - Fee Related
- 2009-10-06 CN CN201410353631.1A patent/CN104151315B/zh not_active Expired - Fee Related
- 2009-10-06 DK DK09740759.7T patent/DK2344495T3/en active
- 2009-10-06 PT PT97407597T patent/PT2344495E/pt unknown
- 2009-10-06 CN CN200980137273.8A patent/CN102164925B/zh not_active Expired - Fee Related
- 2009-10-06 PL PL09740759T patent/PL2344495T3/pl unknown
- 2009-10-06 KR KR1020117008964A patent/KR101294962B1/ko active IP Right Grant
- 2009-10-06 TW TW098133867A patent/TWI415853B/zh not_active IP Right Cessation
- 2009-10-06 BR BRPI0920895A patent/BRPI0920895A8/pt not_active Application Discontinuation
- 2009-10-06 AR ARP090103838A patent/AR073774A1/es not_active Application Discontinuation
- 2009-10-06 MX MX2011003370A patent/MX2011003370A/es active IP Right Grant
- 2009-10-06 NZ NZ592642A patent/NZ592642A/xx not_active IP Right Cessation
- 2009-10-06 CN CN201410352890.2A patent/CN104151316B/zh not_active Expired - Fee Related
- 2009-10-06 MY MYPI2011001523A patent/MY158520A/en unknown
- 2009-10-06 ES ES09740759.7T patent/ES2533217T3/es active Active
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- 2009-10-06 WO PCT/IB2009/054357 patent/WO2010041194A1/en active Application Filing
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2011
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2013
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2015
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2016
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