CY1116155T1 - Αντιβιοτικες ενωσεις τρικυκλικης οξαζολιδινονης - Google Patents
Αντιβιοτικες ενωσεις τρικυκλικης οξαζολιδινονηςInfo
- Publication number
- CY1116155T1 CY1116155T1 CY20151100303T CY151100303T CY1116155T1 CY 1116155 T1 CY1116155 T1 CY 1116155T1 CY 20151100303 T CY20151100303 T CY 20151100303T CY 151100303 T CY151100303 T CY 151100303T CY 1116155 T1 CY1116155 T1 CY 1116155T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- tricylic
- antibiotic
- hydroxyalkyl
- bond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με αντιβακτηριακές ενώσεις του χημικού τύπου (I) όπου το "-----" είναι ένας δεσμός ή είναι απόν ˙ το V είναι CH, CR6 ή Ν ˙ το R0 είναι Η ή, στην περίπτωση που το "....." είναι ένας δεσμός, μπορεί επίσης να είναι αλκοξυ ˙ το R1 είναι κυρίως Η ή αλογόνο ˙ το U είναι CH ή Ν όταν το "-----" είναι ένας δεσμός, ή, στην περίπτωση που το "-----" είναι απόν, το U είναι CH2, ΝΗ ή NR9 · το R2 είναι Η, αλκυλκαρβονυλ ή CH2-R3 · το R3 είναι Η, αλκυλ ή υδροξυαλκυλ · το R4 είναι Η ή, στην περίπτωση που το n δεν είναι 0 και το R5 είναι Η, μπορεί επίσης να είναι ΟΗ · το R5 είναι Η, αλκυλ, υδροξυαλκυλ, αμινοαλκυλ, αλκοξυαλκυλ, καρβοξυ ή αλκοξυκαρβονυλ ˙ το R6 είναι υδροξυαλκυλ, καρβοξυ, αλκοξυκαρβονυλ ή -(CH2)q-NR7R8 όπου το q είναι 1, 2 ή 3 και καθένα από τα R7 και R8 ανεξάρτητα είναι Η ή αλκυλ ή το R7 και το R8 σχηματίζουν μαζί με το άτομο Ν το οποίο τα φέρει έναν δακτύλιο ˙ το R9 είναι αλκυλ ή υδροξυαλκυλ ˙ το Α είναι -(CH2)P-, -CH2CH2CH(OH)- ή -COCH2CH(OH)- ˙ το G είναι υποκατεστημένο φαινυλ ή G1 ή G2 όπου το Q είναι Ο ή S και το Χ είναι CH ή Ν ˙ και το Υ1, το Υ2 και το Υ3 μπορεί το καθένα να είναι CH ή Ν ˙ και το n είναι 0 όταν το Α είναι -CH2CH2CH(OH)- ή -COCH2CH(OH)-, και το n είναι 0, 1 ή 2 όταν το Α είναι (CH2)P, το p είναι 1, 2, 3 ή 4, με την προϋπόθεση πως το σύνολο των n και p είναι 2, 3 ή 4 ' και με άλατα τέτοιου είδους ενώσεων.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2008054109 | 2008-10-07 | ||
IB2009051059 | 2009-03-13 | ||
IB2009052843 | 2009-06-30 | ||
EP09740759.7A EP2344495B1 (en) | 2008-10-07 | 2009-10-06 | Tricyclic oxazolidinone antibiotic compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1116155T1 true CY1116155T1 (el) | 2017-02-08 |
Family
ID=41402623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100303T CY1116155T1 (el) | 2008-10-07 | 2015-03-26 | Αντιβιοτικες ενωσεις τρικυκλικης οξαζολιδινονης |
Country Status (26)
Country | Link |
---|---|
US (3) | US8618092B2 (el) |
EP (1) | EP2344495B1 (el) |
JP (1) | JP4833385B1 (el) |
KR (1) | KR101294962B1 (el) |
CN (3) | CN104151316B (el) |
AR (1) | AR073774A1 (el) |
AU (1) | AU2009302075B2 (el) |
BR (1) | BRPI0920895A8 (el) |
CA (1) | CA2739373C (el) |
CY (1) | CY1116155T1 (el) |
DK (1) | DK2344495T3 (el) |
ES (1) | ES2533217T3 (el) |
HK (1) | HK1159611A1 (el) |
HR (1) | HRP20150370T1 (el) |
IL (1) | IL212139A (el) |
MA (1) | MA32768B1 (el) |
MX (1) | MX2011003370A (el) |
MY (1) | MY158520A (el) |
NZ (1) | NZ592642A (el) |
PL (1) | PL2344495T3 (el) |
PT (1) | PT2344495E (el) |
RU (1) | RU2530884C2 (el) |
SI (1) | SI2344495T1 (el) |
TW (1) | TWI415853B (el) |
WO (1) | WO2010041194A1 (el) |
ZA (1) | ZA201103332B (el) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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JPWO2012108376A1 (ja) | 2011-02-07 | 2014-07-03 | 第一三共株式会社 | アミノ基含有ピロリジノン誘導体 |
KR20130002712A (ko) | 2011-06-29 | 2013-01-08 | 현대자동차주식회사 | 하이브리드 자동차의 파워트레인 제어방법 |
CA2840611A1 (en) * | 2011-06-30 | 2013-01-03 | Dsm Ip Assets B.V. | Silicone-containing monomer |
KR20140054057A (ko) | 2011-08-11 | 2014-05-08 | 액테리온 파마슈티칼 리미티드 | 퀴나졸린-2,4-디온 유도체 |
CA2854264A1 (en) | 2011-11-08 | 2013-05-16 | Actelion Pharmaceuticals Ltd | 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives |
CN103958525A (zh) * | 2011-11-30 | 2014-07-30 | 埃科特莱茵药品有限公司 | 3,7-二取代八氢-2H-吡啶并[4,3-e][1,3]噁嗪-2-酮抗生素 |
WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
US9487516B2 (en) * | 2013-01-09 | 2016-11-08 | Actelion Pharmaceuticals, Ltd. | Antibacterial oxadiazolone derivatives |
TW201429972A (zh) | 2013-01-09 | 2014-08-01 | Actelion Pharmaceuticals Ltd | 抗菌噁唑酮衍生物 |
AU2014255326B2 (en) | 2013-04-16 | 2018-09-13 | Idorsia Pharmaceuticals Ltd | Antibacterial biaromatic derivatives |
CA2910177A1 (en) | 2013-05-08 | 2014-11-13 | Actelion Pharmaceuticals Ltd | Antibacterial phthalide derivatives |
AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
TW201722965A (zh) * | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
RU2602503C1 (ru) * | 2015-09-23 | 2016-11-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СПХФА) | Трициклические соединения, обладающие противобактериальной активностью, способ их получения и содержащее их фармацевтическое средство |
WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
WO2018225097A1 (en) * | 2017-06-08 | 2018-12-13 | Bugworks Research India Pvt Ltd | Heterocyclic compounds useful as anti-bacterial agents and method for production thereof |
EP3717490B1 (en) * | 2017-11-29 | 2023-05-24 | Bugworks Research, Inc. | Anti-bacterial heterocyclic compounds and their synthesis |
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-
2009
- 2009-10-06 AR ARP090103838A patent/AR073774A1/es not_active Application Discontinuation
- 2009-10-06 ES ES09740759.7T patent/ES2533217T3/es active Active
- 2009-10-06 BR BRPI0920895A patent/BRPI0920895A8/pt not_active Application Discontinuation
- 2009-10-06 AU AU2009302075A patent/AU2009302075B2/en not_active Ceased
- 2009-10-06 KR KR1020117008964A patent/KR101294962B1/ko active IP Right Grant
- 2009-10-06 PL PL09740759T patent/PL2344495T3/pl unknown
- 2009-10-06 DK DK09740759.7T patent/DK2344495T3/en active
- 2009-10-06 SI SI200931132T patent/SI2344495T1/sl unknown
- 2009-10-06 NZ NZ592642A patent/NZ592642A/xx not_active IP Right Cessation
- 2009-10-06 CN CN201410352890.2A patent/CN104151316B/zh not_active Expired - Fee Related
- 2009-10-06 RU RU2011117412/04A patent/RU2530884C2/ru not_active IP Right Cessation
- 2009-10-06 CN CN200980137273.8A patent/CN102164925B/zh not_active Expired - Fee Related
- 2009-10-06 TW TW098133867A patent/TWI415853B/zh not_active IP Right Cessation
- 2009-10-06 US US13/123,218 patent/US8618092B2/en not_active Expired - Fee Related
- 2009-10-06 CN CN201410353631.1A patent/CN104151315B/zh not_active Expired - Fee Related
- 2009-10-06 JP JP2011530605A patent/JP4833385B1/ja not_active Expired - Fee Related
- 2009-10-06 EP EP09740759.7A patent/EP2344495B1/en active Active
- 2009-10-06 WO PCT/IB2009/054357 patent/WO2010041194A1/en active Application Filing
- 2009-10-06 CA CA2739373A patent/CA2739373C/en not_active Expired - Fee Related
- 2009-10-06 MY MYPI2011001523A patent/MY158520A/en unknown
- 2009-10-06 PT PT97407597T patent/PT2344495E/pt unknown
- 2009-10-06 MX MX2011003370A patent/MX2011003370A/es active IP Right Grant
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2011
- 2011-04-05 IL IL212139A patent/IL212139A/en not_active IP Right Cessation
- 2011-05-05 MA MA33812A patent/MA32768B1/fr unknown
- 2011-05-06 ZA ZA2011/03332A patent/ZA201103332B/en unknown
- 2011-12-23 HK HK11113916.1A patent/HK1159611A1/xx not_active IP Right Cessation
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2013
- 2013-12-04 US US14/096,419 patent/US9346804B2/en not_active Expired - Fee Related
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2015
- 2015-03-26 CY CY20151100303T patent/CY1116155T1/el unknown
- 2015-03-30 HR HRP20150370TT patent/HRP20150370T1/hr unknown
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2016
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