AR063788A1 - Derivados de 5-hidroximetil-oxazolidin -2-ona - Google Patents

Derivados de 5-hidroximetil-oxazolidin -2-ona

Info

Publication number
AR063788A1
AR063788A1 ARP070105031A ARP070105031A AR063788A1 AR 063788 A1 AR063788 A1 AR 063788A1 AR P070105031 A ARP070105031 A AR P070105031A AR P070105031 A ARP070105031 A AR P070105031A AR 063788 A1 AR063788 A1 AR 063788A1
Authority
AR
Argentina
Prior art keywords
hydroximethyl
oxazolidin
ona
derivatives
opo3h2
Prior art date
Application number
ARP070105031A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39170372&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR063788(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR063788A1 publication Critical patent/AR063788A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente se refiere a nuevos antibióticos quiméricos de fórmula (1) donde R1 representa OH, OPO3H2 o OCOR5; R2 representa H, OH o OPO3H2; A representa N o CR6; R3 representa H o flúor; R4 es H, alquil C1-3, o cicloalquil; R5 es el residuo de un aminoácido natural, del enantiómero de un aminoácido natural o de dimetilaminoglicina; R6 representa H, alcoxi o halógeno; y n es 0 o 1; y sales (en particular sales farmacéuticamente aceptables de compuestos de fórmula (1). Estos compuestos son útiles en el tratamiento y prevención de infecciones bacterianas.
ARP070105031A 2006-11-10 2007-11-12 Derivados de 5-hidroximetil-oxazolidin -2-ona AR063788A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2006054189 2006-11-10

Publications (1)

Publication Number Publication Date
AR063788A1 true AR063788A1 (es) 2009-02-18

Family

ID=39170372

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070105031A AR063788A1 (es) 2006-11-10 2007-11-12 Derivados de 5-hidroximetil-oxazolidin -2-ona

Country Status (28)

Country Link
EP (1) EP2086968B1 (es)
JP (2) JP4484965B2 (es)
KR (1) KR101118402B1 (es)
CN (1) CN101535305B (es)
AR (1) AR063788A1 (es)
AT (1) ATE544764T1 (es)
AU (1) AU2007318901B2 (es)
BR (1) BRPI0718862B8 (es)
CA (1) CA2668280C (es)
CL (1) CL2007003232A1 (es)
CY (1) CY1112696T1 (es)
DK (1) DK2086968T3 (es)
ES (1) ES2380388T3 (es)
HK (1) HK1136276A1 (es)
HR (1) HRP20120385T1 (es)
IL (1) IL198645A (es)
MA (1) MA30960B1 (es)
MX (1) MX2009004764A (es)
MY (1) MY148847A (es)
NO (1) NO344727B1 (es)
NZ (1) NZ577538A (es)
PL (1) PL2086968T3 (es)
PT (1) PT2086968E (es)
RU (1) RU2453546C2 (es)
SI (1) SI2086968T1 (es)
TW (1) TWI374138B (es)
WO (1) WO2008056335A1 (es)
ZA (1) ZA200904028B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003031443A1 (en) 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual actions antibiotics comprising a oxazoldinone and a quinolone or naphthyridinone moiety
RU2351335C2 (ru) 2003-04-30 2009-04-10 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Применение оксазолидинон-хинолиновых гибридных антибиотиков для лечения сибирской язвы и других инфекций
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
US8158797B2 (en) 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
SI1709044T2 (sl) 2003-12-18 2014-02-28 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Oksazolidinon-kinolonski hibridni antibiotiki
US8124623B2 (en) 2006-11-10 2012-02-28 Actelion Pharmaceuticals Ltd. 5-hydroxymethyl-oxazolidin-2-one-derivatives and their uses as antibacterials
MY156304A (en) * 2008-05-09 2016-01-29 Actelion Pharmaceuticals Ltd 5-hydroxymethyl-oxazolidin-2-one derivatives for treating bacterial intestinal diseases
RU2616609C2 (ru) * 2011-11-08 2017-04-18 Актелион Фармасьютиклз Лтд Антибиотические производные 2-оксо-оксазолидин-3, 5-диила
AU2014273471B2 (en) 2013-05-28 2019-10-03 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Combination therapy comprising oxazolidinone-quinolones for use in treating bacterial infections
DK3003289T3 (da) 2013-05-28 2019-05-20 Morphochem Aktiengesellschaft Fuer Komb Chemie Indgivelse af antibakteriele oxazolidinon-quinolon-hybrid-midler
WO2016079757A2 (en) * 2014-11-19 2016-05-26 Symed Labs Limited Novel processes for preparing 5-hydroxymethyl-oxazolidin-2-one derivatives
EP3421454B9 (en) * 2016-02-26 2023-08-09 Otsuka Pharmaceutical Co., Ltd. Piperidine derivative
US10087171B2 (en) 2016-12-19 2018-10-02 Actelion Pharmaceuticals Ltd Crystalline forms of cadazolid

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1156597A3 (ru) * 1982-04-28 1985-05-15 Е.И.Дюпон Де Немур Энд Компани (Фирма) Способ получени производных 3-( @ -алкилсульфонилфенил)оксазолидинона или их фармацевтически приемлемых кислотно-аддитивных солей
US4461773A (en) * 1982-09-15 1984-07-24 E. I. Dupont De Nemours And Company P-Oxooxazolidinylbenzene compounds as antibacterial agents
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6413981B1 (en) * 1999-08-12 2002-07-02 Ortho-Mcneil Pharamceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
EP1349853B1 (en) * 2000-12-21 2006-03-08 Pharmacia & Upjohn Company LLC Antimicrobial quinolone derivatives and use of the same to treat bacterial infections
EP1358185A2 (en) * 2001-02-07 2003-11-05 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
RU2351335C2 (ru) * 2003-04-30 2009-04-10 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Применение оксазолидинон-хинолиновых гибридных антибиотиков для лечения сибирской язвы и других инфекций
ZA200509147B (en) * 2003-04-30 2007-03-28 Morphochem Ag Use of oxazolidinone-quinoline hybrid antibiotics for the treatment of anthrax and other infections
SI1709044T2 (sl) * 2003-12-18 2014-02-28 Morphochem Aktiengesellschaft Fuer Kombinatorische Chemie Oksazolidinon-kinolonski hibridni antibiotiki
KR100854211B1 (ko) * 2003-12-18 2008-08-26 동아제약주식회사 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물

Also Published As

Publication number Publication date
KR20090075875A (ko) 2009-07-09
CA2668280A1 (en) 2008-05-15
RU2453546C2 (ru) 2012-06-20
MX2009004764A (es) 2009-05-21
PT2086968E (pt) 2012-04-13
CY1112696T1 (el) 2016-02-10
HRP20120385T1 (hr) 2012-06-30
DK2086968T3 (da) 2012-03-19
CA2668280C (en) 2015-02-10
ZA200904028B (en) 2010-08-25
BRPI0718862B8 (pt) 2021-05-25
TW200829580A (en) 2008-07-16
MY148847A (en) 2013-06-14
JP2010509314A (ja) 2010-03-25
ES2380388T3 (es) 2012-05-11
IL198645A0 (en) 2010-02-17
CN101535305A (zh) 2009-09-16
MA30960B1 (fr) 2009-12-01
CL2007003232A1 (es) 2008-06-27
BRPI0718862B1 (pt) 2020-10-13
PL2086968T3 (pl) 2012-07-31
EP2086968A1 (en) 2009-08-12
NZ577538A (en) 2011-11-25
AU2007318901B2 (en) 2013-03-14
NO344727B1 (no) 2020-03-23
JP4484965B2 (ja) 2010-06-16
BRPI0718862A2 (pt) 2013-12-17
NO20092209L (no) 2009-06-09
HK1136276A1 (en) 2010-06-25
RU2009121812A (ru) 2010-12-20
WO2008056335A1 (en) 2008-05-15
CN101535305B (zh) 2013-09-18
IL198645A (en) 2014-05-28
EP2086968B1 (en) 2012-02-08
JP5490553B2 (ja) 2014-05-14
ATE544764T1 (de) 2012-02-15
KR101118402B1 (ko) 2012-03-07
AU2007318901A1 (en) 2008-05-15
TWI374138B (en) 2012-10-11
JP2010132677A (ja) 2010-06-17
SI2086968T1 (sl) 2012-06-29

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