NO20051011L - Kirale oksazol-arylpropionsyrederivater og anvendelse derav som PPAR agonister - Google Patents

Kirale oksazol-arylpropionsyrederivater og anvendelse derav som PPAR agonister

Info

Publication number
NO20051011L
NO20051011L NO20051011A NO20051011A NO20051011L NO 20051011 L NO20051011 L NO 20051011L NO 20051011 A NO20051011 A NO 20051011A NO 20051011 A NO20051011 A NO 20051011A NO 20051011 L NO20051011 L NO 20051011L
Authority
NO
Norway
Prior art keywords
acid derivatives
ppar agonists
arylpropionic acid
chiral oxazole
oxazole
Prior art date
Application number
NO20051011A
Other languages
English (en)
Other versions
NO330171B1 (no
Inventor
Georges Hirth
Alfred Binggeli
Markus Boehringer
Uwe Grether
Hans Hilpert
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO20051011L publication Critical patent/NO20051011L/no
Publication of NO330171B1 publication Critical patent/NO330171B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Legemiddel. Foreliggende oppfinnelse angår forbindelser med formel (I) hvor Rtil Rog n er som definert i beskrivelsen og kravene og farmasøytisk akseptable salter og estere derav. Forbindelsene er anvendelige for behandling og/eller forhindring av sykdommer som blir modulert av PPARo- og/eller PPARy-agonister som f.eks. type II diabetes.
NO20051011A 2002-10-07 2005-02-24 Kirale oksazol-arylpropionsyrederivater, fremgangsmate for fremstilling av slike, farmasoytisk preparat inneholdende slike, slike forbindelser for anvendelse som terapeutisk aktive substanser samt slike forbindelser for behandling og/eller forbygging av sykdom NO330171B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02022286 2002-10-07
PCT/EP2003/011030 WO2004031162A1 (en) 2002-10-07 2003-10-06 Chirale oxazole-arylpropionic acid derivatives and their use as ppar agonists

Publications (2)

Publication Number Publication Date
NO20051011L true NO20051011L (no) 2005-05-02
NO330171B1 NO330171B1 (no) 2011-02-28

Family

ID=32049977

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20051011A NO330171B1 (no) 2002-10-07 2005-02-24 Kirale oksazol-arylpropionsyrederivater, fremgangsmate for fremstilling av slike, farmasoytisk preparat inneholdende slike, slike forbindelser for anvendelse som terapeutisk aktive substanser samt slike forbindelser for behandling og/eller forbygging av sykdom

Country Status (32)

Country Link
US (2) US6969725B2 (no)
EP (1) EP1551814B1 (no)
JP (1) JP4414886B2 (no)
KR (1) KR100623819B1 (no)
CN (1) CN100415727C (no)
AR (1) AR041481A1 (no)
AT (1) ATE402153T1 (no)
AU (1) AU2003273949B2 (no)
BR (1) BR0315114A (no)
CA (1) CA2499721C (no)
CO (1) CO5540385A2 (no)
DE (1) DE60322408D1 (no)
DK (1) DK1551814T3 (no)
ES (1) ES2311110T3 (no)
GT (1) GT200300218A (no)
HK (1) HK1083339A1 (no)
HR (1) HRP20050308A2 (no)
IL (1) IL167250A (no)
MX (1) MXPA05003392A (no)
MY (1) MY143576A (no)
NO (1) NO330171B1 (no)
NZ (1) NZ538465A (no)
PA (1) PA8584501A1 (no)
PE (1) PE20040591A1 (no)
PL (1) PL208743B1 (no)
PT (1) PT1551814E (no)
RU (1) RU2303593C2 (no)
SI (1) SI1551814T1 (no)
TW (1) TWI343915B (no)
UY (1) UY28006A1 (no)
WO (1) WO2004031162A1 (no)
ZA (1) ZA200502664B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105551B2 (en) * 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
JP2006514976A (ja) * 2002-11-15 2006-05-18 カディラ ヘルスケア リミティド 置換されているアラルキル誘導体
US7262303B2 (en) * 2003-09-29 2007-08-28 Hoffman-La Roche Inc. Process for the production of chiral propionic acid derivatives
US20100063041A1 (en) * 2007-03-07 2010-03-11 Ho-Sang Moon Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
RU2361581C2 (ru) 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
MX2011004125A (es) * 2008-10-21 2011-05-19 Metabolex Inc Agonistas del receptor gpr120 de arilo y usos de los mismos.
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
CN101805337B (zh) * 2009-02-13 2012-05-23 天津药物研究院 一类含脯氨酸和异恶唑骨架的化合物、其制备方法和用途
US8637096B2 (en) 2009-12-04 2014-01-28 Curtis C. Stojan Compositions and method for enhancing insulin activity
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
CN102285933B (zh) 2010-06-18 2016-03-09 浙江海正药业股份有限公司 一种对亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用
WO2013041621A1 (de) 2011-09-20 2013-03-28 Basf Se Niedermolekulare modulatoren des kälte-menthol-rezeptors trpm8 und deren verwendung

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
CN1232511C (zh) 1998-03-30 2005-12-21 日本烟草产业株式会社 噁唑基乙酸酯衍生物及其盐的制备方法
EP1428531A1 (en) * 1998-05-11 2004-06-16 Takeda Chemical Industries, Ltd. Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
WO2000059889A1 (en) * 1999-04-06 2000-10-12 Sankyo Company, Limited α-SUBSTITUTED CARBOXYLIC ACID DERIVATIVES
TWI302149B (en) 1999-09-22 2008-10-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
DE10031657A1 (de) 2000-06-29 2002-01-24 Siemens Ag Hochfrequenz-Bauelement
SK1872003A3 (en) * 2000-08-23 2003-07-01 Lilly Co Eli Oxazolyl-arylpropionic acid derivatives and their use as PPAR agonists
PL208074B1 (pl) * 2001-05-15 2011-03-31 Hoffmann La Roche Pochodne oksazolu, sposób ich wytwarzania, środek farmaceutyczny i zastosowanie pochodnych oksazolu
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar

Also Published As

Publication number Publication date
CA2499721C (en) 2011-03-15
ATE402153T1 (de) 2008-08-15
US20050267180A1 (en) 2005-12-01
CN100415727C (zh) 2008-09-03
ZA200502664B (en) 2006-02-22
IL167250A (en) 2010-12-30
MY143576A (en) 2011-05-31
UY28006A1 (es) 2004-04-30
ES2311110T3 (es) 2009-02-01
BR0315114A (pt) 2005-08-16
AU2003273949A1 (en) 2004-04-23
CO5540385A2 (es) 2005-07-29
TW200409761A (en) 2004-06-16
PL376363A1 (en) 2005-12-27
PT1551814E (pt) 2008-09-22
RU2303593C2 (ru) 2007-07-27
US7348349B2 (en) 2008-03-25
US20040116487A1 (en) 2004-06-17
HK1083339A1 (en) 2006-06-30
SI1551814T1 (sl) 2008-10-31
PA8584501A1 (es) 2004-05-21
AU2003273949B2 (en) 2007-04-05
CA2499721A1 (en) 2004-04-15
NO330171B1 (no) 2011-02-28
AR041481A1 (es) 2005-05-18
MXPA05003392A (es) 2005-06-22
HRP20050308A2 (en) 2006-07-31
PL208743B1 (pl) 2011-06-30
EP1551814B1 (en) 2008-07-23
WO2004031162A1 (en) 2004-04-15
EP1551814A1 (en) 2005-07-13
PE20040591A1 (es) 2004-08-30
DE60322408D1 (de) 2008-09-04
NZ538465A (en) 2007-08-31
KR100623819B1 (ko) 2006-09-13
TWI343915B (en) 2011-06-21
CN1703406A (zh) 2005-11-30
US6969725B2 (en) 2005-11-29
DK1551814T3 (da) 2008-10-27
RU2005114373A (ru) 2006-05-10
GT200300218A (es) 2004-05-24
KR20050055750A (ko) 2005-06-13
JP4414886B2 (ja) 2010-02-10
JP2006504709A (ja) 2006-02-09

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