GT200300218A - Agonistas ppar quirales - Google Patents

Agonistas ppar quirales

Info

Publication number
GT200300218A
GT200300218A GT200300218A GT200300218A GT200300218A GT 200300218 A GT200300218 A GT 200300218A GT 200300218 A GT200300218 A GT 200300218A GT 200300218 A GT200300218 A GT 200300218A GT 200300218 A GT200300218 A GT 200300218A
Authority
GT
Guatemala
Prior art keywords
ppar
quiral
agonists
compounds
peroxisoma
Prior art date
Application number
GT200300218A
Other languages
English (en)
Inventor
Alfred Binggeli
Markus Boehringer
Uwe Grether
Hans Hilpert
Georges Hirth
Hans-Peter Maerki
Markus Meyer
Peter Mohr
Fabienne Ricklin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200300218A publication Critical patent/GT200300218A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL I EN LA QUE R1,R2,R3,R4,R5,R6,N, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS SE UNEN Y ACTIVAN A LOS RECEPTORES PROLIFERATIVOS DE PEROXISOMA (PPAR) POR LO QUE SON DE UTILIDAD EN CUADROS DE DIABETES, PRINCIPALMENTE.
GT200300218A 2002-10-07 2003-10-06 Agonistas ppar quirales GT200300218A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02022286 2002-10-07

Publications (1)

Publication Number Publication Date
GT200300218A true GT200300218A (es) 2004-05-24

Family

ID=32049977

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200300218A GT200300218A (es) 2002-10-07 2003-10-06 Agonistas ppar quirales

Country Status (32)

Country Link
US (2) US6969725B2 (es)
EP (1) EP1551814B1 (es)
JP (1) JP4414886B2 (es)
KR (1) KR100623819B1 (es)
CN (1) CN100415727C (es)
AR (1) AR041481A1 (es)
AT (1) ATE402153T1 (es)
AU (1) AU2003273949B2 (es)
BR (1) BR0315114A (es)
CA (1) CA2499721C (es)
CO (1) CO5540385A2 (es)
DE (1) DE60322408D1 (es)
DK (1) DK1551814T3 (es)
ES (1) ES2311110T3 (es)
GT (1) GT200300218A (es)
HK (1) HK1083339A1 (es)
HR (1) HRP20050308A2 (es)
IL (1) IL167250A (es)
MX (1) MXPA05003392A (es)
MY (1) MY143576A (es)
NO (1) NO330171B1 (es)
NZ (1) NZ538465A (es)
PA (1) PA8584501A1 (es)
PE (1) PE20040591A1 (es)
PL (1) PL208743B1 (es)
PT (1) PT1551814E (es)
RU (1) RU2303593C2 (es)
SI (1) SI1551814T1 (es)
TW (1) TWI343915B (es)
UY (1) UY28006A1 (es)
WO (1) WO2004031162A1 (es)
ZA (1) ZA200502664B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7105551B2 (en) * 2000-12-20 2006-09-12 Smithkline Beecham Corporation Thiazole derivatives for treating PPAR related disorders
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar
DK1569916T3 (da) * 2002-11-15 2009-04-06 Cadila Healthcare Ltd Substituerede aralkylderivater
US7262303B2 (en) * 2003-09-29 2007-08-28 Hoffman-La Roche Inc. Process for the production of chiral propionic acid derivatives
GB2460784A (en) * 2007-03-07 2009-12-16 Dong A Pharmtech Co Ltd Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators,method of the same,and pharmaceutical composition
RU2361581C2 (ru) 2007-09-14 2009-07-20 Закрытое Акционерное Общество "Мастерклон" Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний
US20100216827A1 (en) * 2008-10-21 2010-08-26 Metabolex, Inc. Aryl gpr120 receptor agonists and uses thereof
AR074760A1 (es) 2008-12-18 2011-02-09 Metabolex Inc Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.
CN101805337B (zh) * 2009-02-13 2012-05-23 天津药物研究院 一类含脯氨酸和异恶唑骨架的化合物、其制备方法和用途
US8637096B2 (en) 2009-12-04 2014-01-28 Curtis C. Stojan Compositions and method for enhancing insulin activity
US8299117B2 (en) 2010-06-16 2012-10-30 Metabolex Inc. GPR120 receptor agonists and uses thereof
CN102285933B (zh) 2010-06-18 2016-03-09 浙江海正药业股份有限公司 一种对亚型过氧化物酶增殖物激活受体具有激动作用的化合物、其制备方法和应用
ES2861268T3 (es) 2011-09-20 2021-10-06 Basf Se Moduladores de bajo peso molecular del receptor de mentol frío TRPM8 y su uso

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089514A (en) 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
CA2291620C (en) 1998-03-30 2003-10-07 Japan Tobacco Inc. Production method of isoxazolidinedione compound
AR029876A1 (es) * 1998-05-11 2003-07-23 Takeda Pharmaceutical Compuesto de acido oxiiminoalcanoilo, composicion farmaceutica y agente para controlar receptores relacionados con retinoide que lo comprenden y su uso
GB9817118D0 (en) 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
CZ20013593A3 (cs) * 1999-04-06 2002-03-13 Sankyo Company, Limited Alfa-Substituované deriváty karboxylových kyselin
TW200528436A (en) 1999-09-22 2005-09-01 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
DE10031657A1 (de) 2000-06-29 2002-01-24 Siemens Ag Hochfrequenz-Bauelement
PL360744A1 (en) * 2000-08-23 2004-09-20 Eli Lilly And Company Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists
CN100356917C (zh) 2001-05-15 2007-12-26 霍夫曼-拉罗奇有限公司 用作糖尿病治疗中的PPAR－α和PPAR－γ激活剂的羧酸取代的噁唑衍生物
AR041481A1 (es) * 2002-10-07 2005-05-18 Hoffmann La Roche Derivados de acido arilpropionico-oxazol y su uso como agonistas de ppar

Also Published As

Publication number Publication date
KR20050055750A (ko) 2005-06-13
NO330171B1 (no) 2011-02-28
CA2499721C (en) 2011-03-15
KR100623819B1 (ko) 2006-09-13
CA2499721A1 (en) 2004-04-15
CO5540385A2 (es) 2005-07-29
CN1703406A (zh) 2005-11-30
SI1551814T1 (sl) 2008-10-31
MY143576A (en) 2011-05-31
US6969725B2 (en) 2005-11-29
TWI343915B (en) 2011-06-21
JP4414886B2 (ja) 2010-02-10
CN100415727C (zh) 2008-09-03
PL376363A1 (en) 2005-12-27
TW200409761A (en) 2004-06-16
AU2003273949A1 (en) 2004-04-23
UY28006A1 (es) 2004-04-30
PE20040591A1 (es) 2004-08-30
ZA200502664B (en) 2006-02-22
ES2311110T3 (es) 2009-02-01
ATE402153T1 (de) 2008-08-15
RU2005114373A (ru) 2006-05-10
US7348349B2 (en) 2008-03-25
US20050267180A1 (en) 2005-12-01
US20040116487A1 (en) 2004-06-17
PT1551814E (pt) 2008-09-22
WO2004031162A1 (en) 2004-04-15
HRP20050308A2 (en) 2006-07-31
NO20051011L (no) 2005-05-02
RU2303593C2 (ru) 2007-07-27
DE60322408D1 (de) 2008-09-04
PA8584501A1 (es) 2004-05-21
EP1551814B1 (en) 2008-07-23
EP1551814A1 (en) 2005-07-13
AU2003273949B2 (en) 2007-04-05
AR041481A1 (es) 2005-05-18
MXPA05003392A (es) 2005-06-22
IL167250A (en) 2010-12-30
HK1083339A1 (en) 2006-06-30
BR0315114A (pt) 2005-08-16
PL208743B1 (pl) 2011-06-30
DK1551814T3 (da) 2008-10-27
NZ538465A (en) 2007-08-31
JP2006504709A (ja) 2006-02-09

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