BR112014011064A8 - derivados de antibióticos 2-oxo-oxazolidin-3,5-diila - Google Patents

derivados de antibióticos 2-oxo-oxazolidin-3,5-diila

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Publication number
BR112014011064A8
BR112014011064A8 BR112014011064A BR112014011064A BR112014011064A8 BR 112014011064 A8 BR112014011064 A8 BR 112014011064A8 BR 112014011064 A BR112014011064 A BR 112014011064A BR 112014011064 A BR112014011064 A BR 112014011064A BR 112014011064 A8 BR112014011064 A8 BR 112014011064A8
Authority
BR
Brazil
Prior art keywords
oxazolidin
oxo
diyl
antibiotic derivatives
alkyl
Prior art date
Application number
BR112014011064A
Other languages
English (en)
Other versions
BR112014011064A2 (pt
Inventor
Hubschwerlen Christian
Rueedi Georg
Surivet Jean-Philippe
Zumbrunn Acklin Cornelia
Original Assignee
Actelion Pharmaceuticals Ltd
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd, Idorsia Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of BR112014011064A2 publication Critical patent/BR112014011064A2/pt
Publication of BR112014011064A8 publication Critical patent/BR112014011064A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)

Abstract

DERIVADOS DE ANTIBIÓTICOS 2-OXO-OXAZOLIDIN-3,5-DIILA. A invenção refere-se aos compostos anti-bacterianos da fórmula I em que R1a representa H ou carboxi e R1b representa H, ou R1a e R1b representam em conjunto seja o grupo *-C (O) -NH-S-# ou o grupo *-C (OH) =N-S-# em que "*" representa o ponto de ligação de R1a e "#" representa o ponto de ligação de R1b; R2 representa H, alquila(C1-C3), hidroxi-alquila(C1-C3), benzila ou cicloalquila(C3-C5); R3 representa H ou halogênio; U representa N ou CR4; em que R4 é H ou alcoxi(C1-C3); A representa CH, B representa NH e m representa 1 ou 2 e n representa 1 ou 2; ou A representa N, B está ausente, m representa 2 e n representa 2; Y representa CH ou N; e Q representa O ou S; e os sais de tais compostos.
BR112014011064A 2011-11-08 2012-11-07 derivados de antibióticos 2-oxo-oxazolidin-3,5-diila BR112014011064A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2011054968 2011-11-08
PCT/IB2012/056236 WO2013068948A1 (en) 2011-11-08 2012-11-07 2-oxo-oxazolidin-3,5-diyl antibiotic derivatives

Publications (2)

Publication Number Publication Date
BR112014011064A2 BR112014011064A2 (pt) 2017-06-13
BR112014011064A8 true BR112014011064A8 (pt) 2017-12-26

Family

ID=47258051

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014011064A BR112014011064A8 (pt) 2011-11-08 2012-11-07 derivados de antibióticos 2-oxo-oxazolidin-3,5-diila

Country Status (20)

Country Link
US (1) US9079922B2 (pt)
EP (1) EP2776431B1 (pt)
JP (1) JP6030146B2 (pt)
KR (1) KR20140096337A (pt)
AR (1) AR088691A1 (pt)
AU (1) AU2012335207B2 (pt)
BR (1) BR112014011064A8 (pt)
CA (1) CA2854264A1 (pt)
CL (1) CL2014001154A1 (pt)
ES (1) ES2581056T3 (pt)
HK (1) HK1202288A1 (pt)
IL (1) IL232463A0 (pt)
IN (1) IN2014CN04126A (pt)
MX (1) MX344529B (pt)
PL (1) PL2776431T3 (pt)
RU (1) RU2616609C2 (pt)
SG (1) SG11201401710PA (pt)
TW (1) TWI594996B (pt)
WO (1) WO2013068948A1 (pt)
ZA (1) ZA201404176B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
BR112015026261A8 (pt) 2013-04-16 2017-12-26 Actelion Pharmaceuticals Ltd Derivados biaromáticos antibacterianos
AR096135A1 (es) 2013-05-02 2015-12-09 Actelion Pharmaceuticals Ltd Derivados de la quinolona
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
MA41168A (fr) 2014-12-17 2017-10-24 Acraf Nouveaux composés antibactériens
MA41169A (fr) 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
CA3012569A1 (en) * 2016-02-08 2017-08-17 Redx Pharma Plc Antibacterial compounds
GB201602235D0 (en) * 2016-02-08 2016-03-23 Redx Pharma Plc Antibacterial compounds
EA201891654A1 (ru) * 2016-02-08 2019-01-31 РЭДКС ФАРМА ПиЭлСи Антибактериальные соединения
BR112018075297A2 (pt) 2016-06-08 2019-03-19 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A composto, composição farmacêutica, e, método para tratar uma infecção bacteriana
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
FI3634968T3 (fi) * 2017-06-08 2023-04-26 Bugworks Res Inc Bakteerilääkkeinä käyttökelpoisia heterosyklisiä yhdisteitä ja menetelmä niiden valmistamiseksi
ES2952989T3 (es) 2017-11-29 2023-11-07 Bugworks Res Inc Compuestos heterocíclicos antibacterianos y su síntesis

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
DE2362553A1 (de) 1972-12-18 1974-06-20 Dainippon Pharmaceutical Co Neue piperazinderivate
SE444566B (sv) 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
GB1598915A (en) 1977-09-20 1981-09-23 Bellon Labor Sa Roger 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them
CS274601B2 (en) 1983-07-27 1991-09-15 Dainippon Pharmaceutical Co Method of 1,8-naphthyridine derivative production
JPS62205060A (ja) 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
NO871333L (no) 1986-03-31 1987-10-01 Sankyo Co Kinolin-3-karboksylsyrederivater, fremgangsmaate til fremstilling og anvendelse derav.
JP2631854B2 (ja) 1987-12-23 1997-07-16 藤本製薬株式会社 新規な１，８−ナフチリジン誘導体
DE4301246A1 (de) 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
US20050215801A1 (en) 2002-06-28 2005-09-29 Kumi Kitajima Process for preparation of optically active 1-substituted amino-2,3-epoxypropanes, intermediates for synthesis thereof and process for preparation of the intermediates
ES2308171T3 (es) * 2003-04-30 2008-12-01 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones.
RU2371443C2 (ru) * 2003-12-18 2009-10-27 Морфохем Акциенгезельшафт Фюр Комбинаторише Хеми Оксазолидинон-хинолонгибридные антибиотики
EP1771456A2 (fr) 2004-07-30 2007-04-11 Palumed SA Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
CA2578081A1 (en) 2004-09-01 2006-03-09 Ubitrak Inc. System for gaming chip identification and counting
US20090156577A1 (en) 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
WO2007118130A2 (en) 2006-04-06 2007-10-18 Glaxo Group Limited Antibacterial agents
BRPI0718862B8 (pt) * 2006-11-10 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica que o contém e uso do composto
CL2008001003A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001002A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
MX2010006111A (es) * 2007-12-18 2010-06-25 Actelion Pharmaceuticals Ltd Derivados de 5-aminociclilmetil-oxazolidin-2-ona y su uso como antibacteriales.
WO2009104159A1 (en) * 2008-02-22 2009-08-27 Actelion Pharmaceuticals Ltd Oxazolidinone derivatives
DK2344495T3 (en) 2008-10-07 2015-02-02 Actelion Pharmaceuticals Ltd TRICYCLIC OXAZOLIDINON ANTIBIOTIC COMPOUNDS
CA2738775A1 (en) * 2008-10-10 2010-04-15 Actelion Pharmaceuticals Ltd 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents
WO2010041218A2 (en) * 2008-10-10 2010-04-15 Actelion Pharmaceuticals Ltd Oxazolidinyl antibiotics
TW201121965A (en) 2009-09-28 2011-07-01 Lg Life Sciences Ltd Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis
CN101792443A (zh) 2010-03-09 2010-08-04 北京欧凯纳斯科技有限公司 氟代喹诺酮衍生物及其制备方法和用途

Also Published As

Publication number Publication date
BR112014011064A2 (pt) 2017-06-13
AR088691A1 (es) 2014-06-25
HK1202288A1 (en) 2015-09-25
MX344529B (es) 2016-12-19
SG11201401710PA (en) 2014-09-26
AU2012335207A1 (en) 2014-07-03
IL232463A0 (en) 2014-06-30
US20150051188A1 (en) 2015-02-19
KR20140096337A (ko) 2014-08-05
JP6030146B2 (ja) 2016-11-24
MX2014005637A (es) 2014-06-23
US9079922B2 (en) 2015-07-14
ZA201404176B (en) 2016-05-25
RU2616609C2 (ru) 2017-04-18
ES2581056T3 (es) 2016-08-31
EP2776431A1 (en) 2014-09-17
TWI594996B (zh) 2017-08-11
IN2014CN04126A (pt) 2015-07-10
CL2014001154A1 (es) 2014-09-12
AU2012335207B2 (en) 2017-05-25
WO2013068948A1 (en) 2013-05-16
CA2854264A1 (en) 2013-05-16
PL2776431T3 (pl) 2016-11-30
JP2014532754A (ja) 2014-12-08
RU2014123109A (ru) 2015-12-20
CN103917539A (zh) 2014-07-09
EP2776431B1 (en) 2016-05-04
TW201326166A (zh) 2013-07-01

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B25A Requested transfer of rights approved

Owner name: IDORSIA PHARMACEUTICALS LTD (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B25L Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled

Owner name: ACTELION PHARMACEUTICALS LTD (CH)

B25C Requirement related to requested transfer of rights

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11T Dismissal of application maintained [chapter 11.20 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]