AR088691A1 - Derivados antibioticos de 2-oxo-oxazolidin-3,5-diilo - Google Patents
Derivados antibioticos de 2-oxo-oxazolidin-3,5-diiloInfo
- Publication number
- AR088691A1 AR088691A1 ARP120104192A ARP120104192A AR088691A1 AR 088691 A1 AR088691 A1 AR 088691A1 AR P120104192 A ARP120104192 A AR P120104192A AR P120104192 A ARP120104192 A AR P120104192A AR 088691 A1 AR088691 A1 AR 088691A1
- Authority
- AR
- Argentina
- Prior art keywords
- diilo
- oxazolidin
- oxo
- antibiotic derivatives
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1) en donde R¹ᵃ representa H o carboxi y R¹ᵇ representa H, o R¹ y R¹ᵇ representan en conjunto el grupo *-C(O)-NH-S-# o el grupo *-C(OH)=N-S-# en donde * representa el punto de unión de R¹ᵃ y # representa el punto de unión de R¹ᵇ; R² representa H, alquilo C₁₋₃, hidroxi-alquilo C₁₋₃, bencilo o cicloalquilo C₃₋₅; R³ representa H o halógeno; U representa N o CR⁴; en donde R⁴ es H o alcoxi C₁₋₃; A representa CH, B representa NH, m representa 1 ó 2 y n representa 1 ó 2; o A representa N, B está ausente, m representa 2 y n representa 2; Y representa CH o N; y Q representa O ó S; o una sal de dicho compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011054968 | 2011-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088691A1 true AR088691A1 (es) | 2014-06-25 |
Family
ID=47258051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120104192A AR088691A1 (es) | 2011-11-08 | 2012-11-07 | Derivados antibioticos de 2-oxo-oxazolidin-3,5-diilo |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9079922B2 (es) |
| EP (1) | EP2776431B1 (es) |
| JP (1) | JP6030146B2 (es) |
| KR (1) | KR20140096337A (es) |
| AR (1) | AR088691A1 (es) |
| AU (1) | AU2012335207B2 (es) |
| BR (1) | BR112014011064A8 (es) |
| CA (1) | CA2854264A1 (es) |
| CL (1) | CL2014001154A1 (es) |
| ES (1) | ES2581056T3 (es) |
| HK (1) | HK1202288A1 (es) |
| IL (1) | IL232463A0 (es) |
| IN (1) | IN2014CN04126A (es) |
| MX (1) | MX344529B (es) |
| PL (1) | PL2776431T3 (es) |
| RU (1) | RU2616609C2 (es) |
| SG (1) | SG11201401710PA (es) |
| TW (1) | TWI594996B (es) |
| WO (1) | WO2013068948A1 (es) |
| ZA (1) | ZA201404176B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2533217T3 (es) | 2008-10-07 | 2015-04-08 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos de oxazolidinona tricíclicos |
| BR112015026261A8 (pt) | 2013-04-16 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos |
| AR096135A1 (es) | 2013-05-02 | 2015-12-09 | Actelion Pharmaceuticals Ltd | Derivados de la quinolona |
| AR102256A1 (es) | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| MA41169A (fr) * | 2014-12-17 | 2017-10-24 | Acraf | Composés antibactériens à large spectre d'activité |
| MA41168A (fr) | 2014-12-17 | 2017-10-24 | Acraf | Nouveaux composés antibactériens |
| GB201602235D0 (en) * | 2016-02-08 | 2016-03-23 | Redx Pharma Plc | Antibacterial compounds |
| EP3413976A1 (en) * | 2016-02-08 | 2018-12-19 | Redx Pharma PLC | Heterocyclic compounds, in particular 2-oxo-4,4,5,5,6,6,7,7-octahydrobenzoxazole derivatives, and their use as antibacterial compounds |
| WO2017137743A1 (en) * | 2016-02-08 | 2017-08-17 | Redx Pharma Plc | Antibacterial compounds |
| SI3468975T1 (sl) | 2016-06-08 | 2020-08-31 | Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. | Nove antibakterijske spojine |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| EP3634968B1 (en) * | 2017-06-08 | 2023-01-25 | Bugworks Research, Inc. | Heterocyclic compounds useful as anti-bacterial agents and method for production thereof |
| WO2019106693A1 (en) * | 2017-11-29 | 2019-06-06 | Bugworks Research India Pvt Ltd | Anti-bacterial heterocyclic compounds and their synthesis |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3149104A (en) | 1961-01-03 | 1964-09-15 | Sterling Drug Inc | 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters |
| CA1006521A (en) | 1972-12-18 | 1977-03-08 | Minoru Sugita | Piperazine derivatives and process for preparing them |
| SE444566B (sv) | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav |
| GB1598915A (en) | 1977-09-20 | 1981-09-23 | Bellon Labor Sa Roger | 1,4-dihydro-quinoline-3-carboxylic acid derivatives process for their preparation and composition containing them |
| CS274601B2 (en) | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| JPS62205060A (ja) | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | ８位置換キノロンカルボン酸誘導体 |
| EP0241206A3 (en) | 1986-03-31 | 1989-05-10 | Sankyo Company Limited | Quinoline-3-carboxylic acid derivatives, their preparation and use |
| JP2631854B2 (ja) | 1987-12-23 | 1997-07-16 | 藤本製薬株式会社 | 新規な１，８−ナフチリジン誘導体 |
| DE4301246A1 (de) | 1993-01-19 | 1994-07-21 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäurederivate |
| WO2004002973A1 (ja) | 2002-06-28 | 2004-01-08 | Kaneka Corporation | 光学活性１−置換アミノー２，３−エポキシプロパンの製造方法並びにその合成中間体およびそれらの製造方法 |
| ES2308171T3 (es) * | 2003-04-30 | 2008-12-01 | Morphochem Aktiengesellschaft Fur Kombinatorische Chemie | Uso de antibioticos hibridos de oxazolidinona-quinolina para el tratamiento del antrax y de otras infecciones. |
| PL1709044T5 (pl) * | 2003-12-18 | 2014-03-31 | Morphochem Aktiengesellschaft Fuer Komb Chemie | Antybiotyki hybrydowe oksazolidynon-chinolon |
| BRPI0514381A (pt) | 2004-07-30 | 2008-06-10 | Palumed Sa | compostos hìbridos de aminoquinolina-antibiótico, composições farmacêuticas, método de preparação e uso destes |
| CA2578081A1 (en) | 2004-09-01 | 2006-03-09 | Ubitrak Inc. | System for gaming chip identification and counting |
| US20090156577A1 (en) | 2004-09-09 | 2009-06-18 | Benjamin Davis | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| EP2007377A4 (en) | 2006-04-06 | 2011-08-17 | Glaxo Group Ltd | ANTIBACTERIAL ACTIVE SUBSTANCES |
| TWI374138B (en) * | 2006-11-10 | 2012-10-11 | Actelion Pharmaceuticals Ltd | 5-hydroxymethyl-oxazolidin-2-one derivatives |
| CL2008001003A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| CL2008001002A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| EP2245028B1 (en) * | 2007-12-18 | 2012-02-22 | Actelion Pharmaceuticals Ltd. | 5-aminocyclylmethyl-oxazolidin-2-one derivatives |
| TWI429643B (zh) * | 2008-02-22 | 2014-03-11 | Actelion Pharmaceuticals Ltd | 唑啶酮衍生物 |
| ES2533217T3 (es) | 2008-10-07 | 2015-04-08 | Actelion Pharmaceuticals Ltd. | Compuestos antibióticos de oxazolidinona tricíclicos |
| JP2012505201A (ja) * | 2008-10-10 | 2012-03-01 | アクテリオン ファーマシューティカルズ リミテッド | ２−ベンゾチオフェニル−及び２−ナフチル−オキサゾリジノン、並びにそれらのアザアイソスター（ａｚａｉｓｏｓｔｅｒｅ）類似体 |
| AU2009302007B2 (en) | 2008-10-10 | 2015-01-15 | Actelion Pharmaceuticals Ltd | Oxazolidinyl antibiotics |
| TW201121965A (en) | 2009-09-28 | 2011-07-01 | Lg Life Sciences Ltd | Use of a quinolone derivative containing 7-(4-aminomethyl-3-oxime)pyrrolidine group that is capable of inducing granulocyte colony stimulating factor for treatment of neutropenia and recovery of hematopoiesis |
| CN101792443A (zh) | 2010-03-09 | 2010-08-04 | 北京欧凯纳斯科技有限公司 | 氟代喹诺酮衍生物及其制备方法和用途 |
-
2012
- 2012-11-07 WO PCT/IB2012/056236 patent/WO2013068948A1/en active Application Filing
- 2012-11-07 EP EP12791863.9A patent/EP2776431B1/en not_active Not-in-force
- 2012-11-07 AR ARP120104192A patent/AR088691A1/es unknown
- 2012-11-07 AU AU2012335207A patent/AU2012335207B2/en not_active Ceased
- 2012-11-07 US US14/356,896 patent/US9079922B2/en not_active Expired - Fee Related
- 2012-11-07 PL PL12791863.9T patent/PL2776431T3/pl unknown
- 2012-11-07 TW TW101141423A patent/TWI594996B/zh not_active IP Right Cessation
- 2012-11-07 KR KR1020147014957A patent/KR20140096337A/ko active IP Right Grant
- 2012-11-07 IN IN4126CHN2014 patent/IN2014CN04126A/en unknown
- 2012-11-07 JP JP2014540612A patent/JP6030146B2/ja not_active Expired - Fee Related
- 2012-11-07 MX MX2014005637A patent/MX344529B/es active IP Right Grant
- 2012-11-07 BR BR112014011064A patent/BR112014011064A8/pt not_active Application Discontinuation
- 2012-11-07 ES ES12791863.9T patent/ES2581056T3/es active Active
- 2012-11-07 SG SG11201401710PA patent/SG11201401710PA/en unknown
- 2012-11-07 RU RU2014123109A patent/RU2616609C2/ru not_active IP Right Cessation
- 2012-11-07 CA CA2854264A patent/CA2854264A1/en not_active Abandoned
-
2014
- 2014-04-30 CL CL2014001154A patent/CL2014001154A1/es unknown
- 2014-05-05 IL IL232463A patent/IL232463A0/en unknown
- 2014-06-06 ZA ZA2014/04176A patent/ZA201404176B/en unknown
-
2015
- 2015-03-16 HK HK15102622.5A patent/HK1202288A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013068948A1 (en) | 2013-05-16 |
| EP2776431B1 (en) | 2016-05-04 |
| KR20140096337A (ko) | 2014-08-05 |
| MX2014005637A (es) | 2014-06-23 |
| TWI594996B (zh) | 2017-08-11 |
| RU2616609C2 (ru) | 2017-04-18 |
| CN103917539A (zh) | 2014-07-09 |
| BR112014011064A8 (pt) | 2017-12-26 |
| RU2014123109A (ru) | 2015-12-20 |
| HK1202288A1 (en) | 2015-09-25 |
| ES2581056T3 (es) | 2016-08-31 |
| IL232463A0 (en) | 2014-06-30 |
| SG11201401710PA (en) | 2014-09-26 |
| JP6030146B2 (ja) | 2016-11-24 |
| JP2014532754A (ja) | 2014-12-08 |
| AU2012335207B2 (en) | 2017-05-25 |
| PL2776431T3 (pl) | 2016-11-30 |
| CL2014001154A1 (es) | 2014-09-12 |
| MX344529B (es) | 2016-12-19 |
| IN2014CN04126A (es) | 2015-07-10 |
| TW201326166A (zh) | 2013-07-01 |
| US20150051188A1 (en) | 2015-02-19 |
| CA2854264A1 (en) | 2013-05-16 |
| ZA201404176B (en) | 2016-05-25 |
| US9079922B2 (en) | 2015-07-14 |
| AU2012335207A1 (en) | 2014-07-03 |
| EP2776431A1 (en) | 2014-09-17 |
| BR112014011064A2 (pt) | 2017-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |