EA201591486A1 - Соединения имидазопиридина - Google Patents

Соединения имидазопиридина

Info

Publication number
EA201591486A1
EA201591486A1 EA201591486A EA201591486A EA201591486A1 EA 201591486 A1 EA201591486 A1 EA 201591486A1 EA 201591486 A EA201591486 A EA 201591486A EA 201591486 A EA201591486 A EA 201591486A EA 201591486 A1 EA201591486 A1 EA 201591486A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
iomidazopyridine
och
cho
bond
Prior art date
Application number
EA201591486A
Other languages
English (en)
Inventor
Спенсер Брайан Джонс
Брайан Херст Норман
Лэнс Аллен Пфейфер
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201591486A1 publication Critical patent/EA201591486A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings

Abstract

Согласно изобретению предложены соединения формулы Iгде X представляет собой связь или СН; Q представляет собой СНили О; L выбран из группы, состоящей из -ОСН- и -СНО-; или их фармацевтически приемлемые соли. Соединения согласно изобретению представляют собой ингибиторы аутотаксина.
EA201591486A 2013-03-12 2014-03-04 Соединения имидазопиридина EA201591486A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777216P 2013-03-12 2013-03-12
PCT/US2014/020297 WO2014143583A1 (en) 2013-03-12 2014-03-04 Imidazo pyridine compounds

Publications (1)

Publication Number Publication Date
EA201591486A1 true EA201591486A1 (ru) 2016-01-29

Family

ID=50382634

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201591486A EA201591486A1 (ru) 2013-03-12 2014-03-04 Соединения имидазопиридина

Country Status (15)

Country Link
US (1) US9394317B2 (ru)
EP (1) EP2970254B1 (ru)
JP (1) JP6163248B2 (ru)
KR (1) KR20150119081A (ru)
CN (1) CN105143218B (ru)
AR (1) AR094959A1 (ru)
AU (1) AU2014228355B2 (ru)
BR (1) BR112015018509A2 (ru)
CA (1) CA2900956C (ru)
EA (1) EA201591486A1 (ru)
ES (1) ES2639125T3 (ru)
MX (1) MX2015012629A (ru)
TW (1) TW201520219A (ru)
WO (1) WO2014143583A1 (ru)
ZA (1) ZA201506747B (ru)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI499591B (zh) * 2013-01-11 2015-09-11 Lilly Co Eli 雙環嘧啶化合物
TW201500356A (zh) * 2013-04-12 2015-01-01 Lilly Co Eli 二氫吡啶并嘧啶化合物
GB201501870D0 (en) 2015-02-04 2015-03-18 Cancer Rec Tech Ltd Autotaxin inhibitors
GB201502020D0 (en) 2015-02-06 2015-03-25 Cancer Rec Tech Ltd Autotaxin inhibitory compounds
US10118904B2 (en) 2015-06-05 2018-11-06 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of Demyelinating Diseases
WO2018106643A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Heterocyclic azoles for the treatment of demyelinating diseases
WO2018106641A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Pyrazoles for the treatment of demyelinating diseases
WO2018106646A1 (en) 2016-12-06 2018-06-14 Vertex Pharmaceuticals Incorporated Aminotriazoles for the treatment of demyelinating diseases
US10961242B2 (en) 2017-05-17 2021-03-30 Legochem Biosciences, Inc. Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
KR101798840B1 (ko) * 2017-05-17 2017-11-17 주식회사 레고켐 바이오사이언스 신규 오토탁신 저해 화합물 및 이를 함유하는 약제학적 조성물
AU2019272377B2 (en) * 2018-05-24 2022-03-10 Guangzhou Henovcom Bioscience Co., Ltd. Heteroaromatic compounds, pharmaceutical compositions and uses thereof
WO2020156459A1 (zh) * 2019-02-01 2020-08-06 湖北生物医药产业技术研究院有限公司 吡咯并嘧啶衍生物及其用途
CN112778334B (zh) * 2019-11-07 2022-04-15 广州市恒诺康医药科技有限公司 芳杂环化合物、其药物组合物及其应用
AU2020402940A1 (en) * 2019-12-11 2022-06-02 Sichuan Haisco Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic autotaxin inhibitor, and composition containing same and use thereof
TW202214644A (zh) * 2020-07-28 2022-04-16 大陸商武漢人福創新藥物研發中心有限公司 含氮雜環化合物的固體形式及其藥物組合物和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1230225A2 (en) * 1999-11-01 2002-08-14 Eli Lilly And Company Pharmaceutically active 4-substituted pyrimidine derivatives
JPWO2003104230A1 (ja) 2002-06-07 2005-10-06 協和醗酵工業株式会社 二環性ピリミジン誘導体
US7465739B2 (en) * 2003-06-10 2008-12-16 Solvay Pharmaceuticals B.V. Compounds and their use in therapy
DE102004020908A1 (de) * 2004-04-28 2005-11-17 Grünenthal GmbH Substituierte 5,6,7,8,-Tetrahydro-pyrido[4,3-d]pyrimidin-2-yl- und 5,6,7,8,-Tetrahydro-chinazolin-2-yl-Verbindungen
BRPI0419229A (pt) * 2004-12-13 2007-12-18 Solvay Pharm Gmbh derivados de tiofenopirimidinona substituìdos como inibidores de 17beta-hidroxiesteróide-desidrogenase, uso e composição farmacêutica
EA201100879A1 (ru) * 2008-12-01 2012-01-30 Мерк Патент Гмбх Производные пиридопиримидина в качестве ингибиторов аутотаксина
ITRE20090102A1 (it) 2009-10-22 2011-04-23 Cgm Spa Stampo, attrezzatura e metodo per la formatura dietro compressione di oggetti di materiale termoplastico
CN103201262B (zh) * 2010-08-20 2016-06-01 艾米拉医药股份有限公司 自分泌运动因子抑制剂及其用途
US9260416B2 (en) * 2011-05-27 2016-02-16 Amira Pharmaceuticals, Inc. Heterocyclic autotaxin inhibitors and uses thereof

Also Published As

Publication number Publication date
MX2015012629A (es) 2016-07-07
EP2970254A1 (en) 2016-01-20
AR094959A1 (es) 2015-09-09
TW201520219A (zh) 2015-06-01
AU2014228355A1 (en) 2015-10-01
ZA201506747B (en) 2017-09-27
JP2016512254A (ja) 2016-04-25
EP2970254B1 (en) 2017-06-21
US9394317B2 (en) 2016-07-19
CN105143218B (zh) 2016-12-14
WO2014143583A1 (en) 2014-09-18
CA2900956C (en) 2017-11-28
CA2900956A1 (en) 2014-09-18
JP6163248B2 (ja) 2017-07-12
CN105143218A (zh) 2015-12-09
US20150368273A1 (en) 2015-12-24
KR20150119081A (ko) 2015-10-23
BR112015018509A2 (pt) 2017-07-18
AU2014228355B2 (en) 2016-02-25
ES2639125T3 (es) 2017-10-25

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