EA201490518A1 - Пирролбензодиазепины - Google Patents

Пирролбензодиазепины

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Publication number
EA201490518A1
EA201490518A1 EA201490518A EA201490518A EA201490518A1 EA 201490518 A1 EA201490518 A1 EA 201490518A1 EA 201490518 A EA201490518 A EA 201490518A EA 201490518 A EA201490518 A EA 201490518A EA 201490518 A1 EA201490518 A1 EA 201490518A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolbenzodiazepine
compound
formula
drug
ethyl
Prior art date
Application number
EA201490518A
Other languages
English (en)
Other versions
EA027971B1 (ru
Inventor
Филип Уилсон Ховард
Original Assignee
Спироген Сарл
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Спироген Сарл filed Critical Спироген Сарл
Publication of EA201490518A1 publication Critical patent/EA201490518A1/ru
Publication of EA027971B1 publication Critical patent/EA027971B1/ru

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
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Abstract

Соединение, имеющее формулу Iгде Rимеет формулу IIгде Q выбран из ОН, SH и NRи Rвыбран из Н, метила и этила, а также линкеры лекарственного соединения и конъюгаты лекарственного соединения, полученные из указанного соединения.
EA201490518A 2011-09-20 2012-09-20 Пирролбензодиазепины EA027971B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161536669P 2011-09-20 2011-09-20
PCT/EP2012/068506 WO2013041606A1 (en) 2011-09-20 2012-09-20 Pyrrolobenzodiazepines as unsymmetrical dimeric pbd compounds for inclusion in targeted conjugates

Publications (2)

Publication Number Publication Date
EA201490518A1 true EA201490518A1 (ru) 2014-08-29
EA027971B1 EA027971B1 (ru) 2017-09-29

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EA201490518A EA027971B1 (ru) 2011-09-20 2012-09-20 Пирролбензодиазепины

Country Status (12)

Country Link
US (1) US9399641B2 (ru)
EP (1) EP2751120B1 (ru)
JP (1) JP6170494B2 (ru)
KR (1) KR101860174B1 (ru)
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US20150158869A1 (en) 2015-06-11
US9399641B2 (en) 2016-07-26
EP2751120A1 (en) 2014-07-09
AU2012311505B2 (en) 2016-09-29
BR112014006703A2 (pt) 2017-04-11
EP2751120B1 (en) 2018-08-22
WO2013041606A1 (en) 2013-03-28
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JP2014527974A (ja) 2014-10-23
EA027971B1 (ru) 2017-09-29
CN103987718A (zh) 2014-08-13
SG11201400770SA (en) 2014-04-28
BR112014006703A8 (pt) 2018-01-09
KR101860174B1 (ko) 2018-05-21
CA2849039C (en) 2018-09-18
MX2014003349A (es) 2015-04-10
AU2012311505A1 (en) 2014-05-01
MX341524B (es) 2016-08-24
CA2849039A1 (en) 2013-03-28

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