RU2012148909A - Новый синтез соединений тиазолидиндиона - Google Patents
Новый синтез соединений тиазолидиндиона Download PDFInfo
- Publication number
- RU2012148909A RU2012148909A RU2012148909/04A RU2012148909A RU2012148909A RU 2012148909 A RU2012148909 A RU 2012148909A RU 2012148909/04 A RU2012148909/04 A RU 2012148909/04A RU 2012148909 A RU2012148909 A RU 2012148909A RU 2012148909 A RU2012148909 A RU 2012148909A
- Authority
- RU
- Russia
- Prior art keywords
- thiazolidindione
- compounds
- new synthesis
- compound
- formula
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
1. Соединение, имеющее формулу:или его соль.2. Гидробромидная соль соединения, имеющего формулу:
Claims (2)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32552810P | 2010-04-19 | 2010-04-19 | |
US61/325,528 | 2010-04-19 | ||
PCT/US2011/032816 WO2011133441A2 (en) | 2010-04-19 | 2011-04-18 | Novel synthesis for thiazolidinedione compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2012148909A true RU2012148909A (ru) | 2014-05-27 |
Family
ID=44041528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2012148909/04A RU2012148909A (ru) | 2010-04-19 | 2011-04-18 | Новый синтез соединений тиазолидиндиона |
Country Status (10)
Country | Link |
---|---|
US (2) | US20130211095A1 (ru) |
EP (1) | EP2563767A2 (ru) |
JP (1) | JP2013532121A (ru) |
KR (1) | KR20130051944A (ru) |
CN (1) | CN103153972A (ru) |
AU (1) | AU2011242955A1 (ru) |
CA (1) | CA2796872A1 (ru) |
MX (1) | MX2012012094A (ru) |
RU (1) | RU2012148909A (ru) |
WO (1) | WO2011133441A2 (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8722710B2 (en) | 2007-09-26 | 2014-05-13 | Deuterx, Llc | Deuterium-enriched pioglitazone |
CN102947269B (zh) | 2010-04-19 | 2015-11-25 | 新陈代谢解决方案开发公司 | 噻唑烷二酮化合物的新的合成方法 |
JP5851506B2 (ja) | 2010-08-10 | 2016-02-03 | メタボリック ソリューションズ ディベロップメント カンパニー, エルエルシー | チアゾリジンジオン化合物のための合成 |
JP5927190B2 (ja) * | 2010-08-10 | 2016-06-01 | メタボリック ソリューションズ ディベロップメント カンパニー, エルエルシー | チアゾリジンジオン化合物のための新規合成 |
JP6800013B2 (ja) | 2013-03-14 | 2020-12-16 | ポクセル・ソシエテ・アノニムPoxel SA | 重水素化2,4−チアゾリジンジオン及び治療方法 |
US10188639B2 (en) | 2014-01-15 | 2019-01-29 | Deuterx, Llc | Methods of treating neurological, metabolic, and other disorders using enantiopure deuterium-enriched pioglitazone |
US10326748B1 (en) | 2015-02-25 | 2019-06-18 | Quest Software Inc. | Systems and methods for event-based authentication |
US10417613B1 (en) | 2015-03-17 | 2019-09-17 | Quest Software Inc. | Systems and methods of patternizing logged user-initiated events for scheduling functions |
US10536352B1 (en) | 2015-08-05 | 2020-01-14 | Quest Software Inc. | Systems and methods for tuning cross-platform data collection |
TW202246215A (zh) | 2015-12-18 | 2022-12-01 | 美商亞德利克斯公司 | 作為非全身tgr5促效劑之經取代之4-苯基吡啶化合物 |
US11767317B1 (en) | 2020-06-30 | 2023-09-26 | Poxel Sa | Methods of synthesizing enantiopure deuterium-enriched pioglitazone |
US11319313B2 (en) | 2020-06-30 | 2022-05-03 | Poxel Sa | Crystalline forms of deuterium-enriched pioglitazone |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK109993A3 (en) * | 1991-04-11 | 1994-12-07 | Upjohn Co | Thiazolidinedione derivatives producing and use thereof |
SE9702305D0 (sv) * | 1997-06-17 | 1997-06-17 | Astra Ab | New thiazolidinedione, oxazolidinedione and oxadiazolidinedione derivatives |
AU2007227581B2 (en) * | 2006-03-16 | 2012-11-08 | Metabolic Solutions Development Company, Llc | Thiazolidinedione analogues for the treatment of metabolic inflammation mediated disease |
NZ571870A (en) * | 2006-03-16 | 2011-07-29 | Metabolic Solutions Dev Co | Thiazolidinedione analogues for the treatment of hypertension and for lowering lipids |
JP2009013091A (ja) * | 2007-07-03 | 2009-01-22 | Tokuyama Corp | ピオグリタゾン塩酸塩の製造方法 |
-
2011
- 2011-04-18 US US13/641,898 patent/US20130211095A1/en not_active Abandoned
- 2011-04-18 CN CN2011800302449A patent/CN103153972A/zh active Pending
- 2011-04-18 EP EP11716760A patent/EP2563767A2/en not_active Withdrawn
- 2011-04-18 JP JP2013506201A patent/JP2013532121A/ja not_active Withdrawn
- 2011-04-18 WO PCT/US2011/032816 patent/WO2011133441A2/en active Application Filing
- 2011-04-18 MX MX2012012094A patent/MX2012012094A/es not_active Application Discontinuation
- 2011-04-18 CA CA2796872A patent/CA2796872A1/en not_active Abandoned
- 2011-04-18 AU AU2011242955A patent/AU2011242955A1/en not_active Abandoned
- 2011-04-18 RU RU2012148909/04A patent/RU2012148909A/ru not_active Application Discontinuation
- 2011-04-18 KR KR1020127030055A patent/KR20130051944A/ko not_active Application Discontinuation
-
2013
- 2013-09-20 US US14/032,284 patent/US20140018542A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2011242955A1 (en) | 2012-11-01 |
CA2796872A1 (en) | 2011-10-27 |
MX2012012094A (es) | 2012-12-17 |
US20130211095A1 (en) | 2013-08-15 |
WO2011133441A3 (en) | 2015-09-17 |
JP2013532121A (ja) | 2013-08-15 |
WO2011133441A2 (en) | 2011-10-27 |
EP2563767A2 (en) | 2013-03-06 |
KR20130051944A (ko) | 2013-05-21 |
CN103153972A (zh) | 2013-06-12 |
US20140018542A1 (en) | 2014-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20140421 |