BR112015026261A8 - Derivados biaromáticos antibacterianos - Google Patents
Derivados biaromáticos antibacterianosInfo
- Publication number
- BR112015026261A8 BR112015026261A8 BR112015026261A BR112015026261A BR112015026261A8 BR 112015026261 A8 BR112015026261 A8 BR 112015026261A8 BR 112015026261 A BR112015026261 A BR 112015026261A BR 112015026261 A BR112015026261 A BR 112015026261A BR 112015026261 A8 BR112015026261 A8 BR 112015026261A8
- Authority
- BR
- Brazil
- Prior art keywords
- understood
- comprised
- hydroxyl
- alkoxide
- cyano
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS BIAROMÁTICOS ANTIBACTERIANOS. A invenção refere-se a compostos antibacterianos da fórmula I em que R é compreendido por H, ciano, alcóxido, cianometóxi, cicloalquil-metóxi, hidroxi-alcóxido, alcóxido-alcóxido, alcóxido-carbonil, 2-etóxi-2-oxoetóxi, 2-(metilamino)-2-oxoetóxi, (1-cianociclobutil)-metóxi, 3-hidroxi-pirrolidin-1-il ou 3,4-diidroxil-ciclopentil)metóxi; U1 é compreendido por N ou CR1, U2 é compreendido por N ou CR2, U3 é compreendido por N ou CR3 e U4 é compreendido por N ou CR4, ficando subtendido que na maior parte das vezes três dos U1, U2, U3 e U4 podem ser N ao mesmo tempo; V1 é compreendido por N ou CR5, V2 é compreendido por N ou CR6, V3 é compreendido por N ou CR7 e V4 é compreendido por N ou CH, ficando subtendido que na maioria dois dos V1, V2, V3 e V4 podem ser N ao mesmo tempo; R1 é compreendido por H, ciano, hidroxila ou alcóxido; R2 é compreendido por H, hidroxila ou alcóxido; R3 é compreendido por H, ciano, hidroxila, alcóxido ou carboxamida; R4 é compreendido por H ou alcóxido; R5 é compreendido por H, hidroxila ou halogênio; R6 é compreendido por H, hidroxila ou halogênio; R7 é compreendido por H; a linha pontilhada ----- é compreendido por uma ligação ou está ausente; W é compreendido por CH ou N quando a linha pontilhada ----- é uma ligação, ou W é compreendido por CH2 quando a linha pontilhada ----- estáausente; X é compreendido por CH ou N; e Q é compreendido por O ou S; e seus respectivos sais.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013053021 | 2013-04-16 | ||
| PCT/IB2014/060724 WO2014170821A1 (en) | 2013-04-16 | 2014-04-15 | Antibacterial biaromatic derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015026261A2 BR112015026261A2 (pt) | 2017-07-25 |
| BR112015026261A8 true BR112015026261A8 (pt) | 2017-12-26 |
Family
ID=50639826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015026261A BR112015026261A8 (pt) | 2013-04-16 | 2014-04-15 | Derivados biaromáticos antibacterianos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9527867B2 (pt) |
| EP (1) | EP2986607B1 (pt) |
| JP (1) | JP6375365B2 (pt) |
| KR (1) | KR20150143720A (pt) |
| CN (1) | CN105143216B (pt) |
| AR (1) | AR095884A1 (pt) |
| AU (1) | AU2014255326B2 (pt) |
| BR (1) | BR112015026261A8 (pt) |
| CA (1) | CA2907832A1 (pt) |
| CL (1) | CL2015003019A1 (pt) |
| EA (1) | EA029361B1 (pt) |
| ES (1) | ES2640482T3 (pt) |
| HK (1) | HK1221459A1 (pt) |
| MA (1) | MA38588B1 (pt) |
| MX (1) | MX362338B (pt) |
| PH (1) | PH12015502411A1 (pt) |
| PL (1) | PL2986607T3 (pt) |
| SA (1) | SA515361261B1 (pt) |
| SG (1) | SG11201508479RA (pt) |
| TW (1) | TWI631119B (pt) |
| WO (1) | WO2014170821A1 (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104151316B (zh) | 2008-10-07 | 2016-06-15 | 埃科特莱茵药品有限公司 | 三环噁唑烷酮抗生素化合物 |
| AR102256A1 (es) * | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| WO2017157885A1 (de) | 2016-03-16 | 2017-09-21 | Bayer Cropscience Aktiengesellschaft | N-(cyanbenzyl)-6-(cyclopropylcarbonylamino)-4-(phenyl)-pyridin-2-carboxamid-derivate und verwandte verbindungen als pestizide pflanzenschutzmittel |
| AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| EP3284739A1 (de) | 2017-07-19 | 2018-02-21 | Bayer CropScience Aktiengesellschaft | Substituierte (het)arylverbindungen als schädlingsbekämpfungsmittel |
| US11401277B2 (en) | 2017-11-29 | 2022-08-02 | Bugworks Research, Inc. | Anti-bacterial heterocyclic compounds and their synthesis |
| BR112021002298A2 (pt) | 2018-08-13 | 2021-05-04 | F. Hoffmann-La Roche Ag | compostos heterocíclicos como inibidores da monoacilglicerol lipase |
| JP2022548028A (ja) | 2019-09-12 | 2022-11-16 | エフ．ホフマン－ラ ロシュ アーゲー | Ｍａｇｌ阻害剤としての４，４ａ，５，７，８，８ａ－ヘキサピリド［４，３－ｂ］［１，４］オキサジン－３－オン化合物 |
| WO2021190727A1 (en) * | 2020-03-24 | 2021-09-30 | F. Hoffmann-La Roche Ag | Compounds and their use in the treatment of bacterial infection |
| CN115785718B (zh) * | 2022-11-25 | 2023-08-22 | 四川大学 | 一种多基底表面的金属配位抗菌涂层及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0297042A1 (de) | 1987-06-23 | 1988-12-28 | Ciba-Geigy Ag | Substituierte Penem-Verbindungen |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| AU1026901A (en) | 1999-10-29 | 2001-05-08 | Syngenta Participations Ag | Novel herbicides |
| US7205321B2 (en) | 2001-11-15 | 2007-04-17 | Eli Lilly And Company | Peroxisome proliferator activated receptor alpha agonists |
| AR040335A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
| WO2006102674A2 (en) | 2005-03-24 | 2006-09-28 | Microbia, Inc. | Diphenylheterocycle cholesterol absorption inhibitors |
| TW200734311A (en) | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
| US7998992B2 (en) | 2007-03-30 | 2011-08-16 | Institute Of Medicinal Molecular Design, Inc. | Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
| CL2008001003A1 (es) | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| KR101541436B1 (ko) | 2007-12-20 | 2015-08-03 | 파르마 마르 에스.에이. | 항암 화합물 |
| JP5349500B2 (ja) | 2008-02-20 | 2013-11-20 | アクテリオン ファーマシューティカルズ リミテッド | アザトリシクリック抗菌性化合物 |
| AR070458A1 (es) | 2008-02-22 | 2010-04-07 | Actelion Pharmaceuticals Ltd | Derivados de oxazolidina, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento de una infeccion bacteriana. |
| WO2010015985A1 (en) * | 2008-08-04 | 2010-02-11 | Actelion Pharmaceuticals Ltd | Tricyclic alkylaminomethyloxazolidinone derivatives |
| CN104151316B (zh) | 2008-10-07 | 2016-06-15 | 埃科特莱茵药品有限公司 | 三环噁唑烷酮抗生素化合物 |
| US20110195949A1 (en) * | 2008-10-10 | 2011-08-11 | Actelion Pharmaceuticals Ltd. | 2-benzothiophenyl- and 2-naphthyl-oxazolidinones and their azaisostere analogues as antibacterial agents |
| RU2616609C2 (ru) | 2011-11-08 | 2017-04-18 | Актелион Фармасьютиклз Лтд | Антибиотические производные 2-оксо-оксазолидин-3, 5-диила |
-
2014
- 2014-04-15 ES ES14721539.6T patent/ES2640482T3/es active Active
- 2014-04-15 KR KR1020157032552A patent/KR20150143720A/ko active IP Right Grant
- 2014-04-15 WO PCT/IB2014/060724 patent/WO2014170821A1/en active Application Filing
- 2014-04-15 PL PL14721539T patent/PL2986607T3/pl unknown
- 2014-04-15 US US14/784,602 patent/US9527867B2/en active Active
- 2014-04-15 CA CA2907832A patent/CA2907832A1/en not_active Abandoned
- 2014-04-15 MX MX2015014576A patent/MX362338B/es active IP Right Grant
- 2014-04-15 CN CN201480022059.9A patent/CN105143216B/zh not_active Expired - Fee Related
- 2014-04-15 AU AU2014255326A patent/AU2014255326B2/en not_active Ceased
- 2014-04-15 BR BR112015026261A patent/BR112015026261A8/pt not_active Application Discontinuation
- 2014-04-15 EA EA201501025A patent/EA029361B1/ru not_active IP Right Cessation
- 2014-04-15 MA MA38588A patent/MA38588B1/fr unknown
- 2014-04-15 EP EP14721539.6A patent/EP2986607B1/en not_active Not-in-force
- 2014-04-15 SG SG11201508479RA patent/SG11201508479RA/en unknown
- 2014-04-15 TW TW103113729A patent/TWI631119B/zh not_active IP Right Cessation
- 2014-04-15 JP JP2016508263A patent/JP6375365B2/ja not_active Expired - Fee Related
- 2014-04-16 AR ARP140101625A patent/AR095884A1/es unknown
-
2015
- 2015-10-04 SA SA515361261A patent/SA515361261B1/ar unknown
- 2015-10-09 CL CL2015003019A patent/CL2015003019A1/es unknown
- 2015-10-16 PH PH12015502411A patent/PH12015502411A1/en unknown
-
2016
- 2016-08-10 HK HK16109490.8A patent/HK1221459A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL2986607T3 (pl) | 2017-11-30 |
| KR20150143720A (ko) | 2015-12-23 |
| MA38588A1 (fr) | 2017-05-31 |
| TW201516043A (zh) | 2015-05-01 |
| CN105143216A (zh) | 2015-12-09 |
| JP2016516805A (ja) | 2016-06-09 |
| CA2907832A1 (en) | 2014-10-23 |
| BR112015026261A2 (pt) | 2017-07-25 |
| EP2986607A1 (en) | 2016-02-24 |
| HK1221459A1 (zh) | 2017-06-02 |
| ES2640482T3 (es) | 2017-11-03 |
| MA38588B1 (fr) | 2018-04-30 |
| WO2014170821A1 (en) | 2014-10-23 |
| TWI631119B (zh) | 2018-08-01 |
| AU2014255326A1 (en) | 2015-11-26 |
| US9527867B2 (en) | 2016-12-27 |
| MX362338B (es) | 2019-01-11 |
| JP6375365B2 (ja) | 2018-08-15 |
| US20160075722A1 (en) | 2016-03-17 |
| EA201501025A1 (ru) | 2016-08-31 |
| AU2014255326B2 (en) | 2018-09-13 |
| CN105143216B (zh) | 2018-04-13 |
| CL2015003019A1 (es) | 2016-09-30 |
| SA515361261B1 (ar) | 2016-06-15 |
| SG11201508479RA (en) | 2015-11-27 |
| EA029361B1 (ru) | 2018-03-30 |
| AR095884A1 (es) | 2015-11-18 |
| PH12015502411A1 (en) | 2016-02-22 |
| MX2015014576A (es) | 2016-03-04 |
| EP2986607B1 (en) | 2017-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
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