MX362338B - Derivados biaromaticos antibacterianos. - Google Patents
Derivados biaromaticos antibacterianos.Info
- Publication number
- MX362338B MX362338B MX2015014576A MX2015014576A MX362338B MX 362338 B MX362338 B MX 362338B MX 2015014576 A MX2015014576 A MX 2015014576A MX 2015014576 A MX2015014576 A MX 2015014576A MX 362338 B MX362338 B MX 362338B
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxy
- alkoxy
- cyano
- dotted line
- oxoethoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
La invención se refiere a compuestos antibacterianos de la fórmula I (I), en donde R es H, ciano, alcoxi, cianometoxi, cicloalquilmetoxi, hidroxialcoxi, alcoxialcoxi, alcoxicarbonilo, 2-etoxi- 2-oxoetoxi, 2-(metilam ino)-2-oxoetoxi, (1 -cianociclobutil)metoxi, 3-hidroxi-pirrolidin-1-ilo o 3,4-dihidroxiciclopentil)metoxi; U1 es N o CR1, U2 es N o CR2, U3 es N o CR3 y U4 es N o CR4, y se entiende que como máximo tres de U1, U2, U3 y U4 pueden ser N al mismo tiempo; V1 es N o CR5, V2 es N o CR6, V3 es N o CR7 y V4 es N o CH, y se entiende que como máximo dos de V1, V2, V3 y V4 pueden ser N al mismo tiempo; R1 es H, ciano, hidroxi o alcoxi; R2 es H, hidroxi o alcoxi; R3 es H, ciano, hidroxi, alcoxi o carboxamido; R4 es H o alcoxi; R5 es H, hidroxi o halógeno; R6 es H, hidroxi o halógeno; R7 es H; la línea de puntos "-----" representa un enlace o se encuentra ausente; W representa CH o N cuando la línea de puntos "-----" es un enlace, o W representa CH2 cuando la línea de puntos "-----" se encuentra ausente; X representa CH o N; y Q representa O u S; y sus sales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013053021 | 2013-04-16 | ||
| PCT/IB2014/060724 WO2014170821A1 (en) | 2013-04-16 | 2014-04-15 | Antibacterial biaromatic derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015014576A MX2015014576A (es) | 2016-03-04 |
| MX362338B true MX362338B (es) | 2019-01-11 |
Family
ID=50639826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015014576A MX362338B (es) | 2013-04-16 | 2014-04-15 | Derivados biaromaticos antibacterianos. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9527867B2 (es) |
| EP (1) | EP2986607B1 (es) |
| JP (1) | JP6375365B2 (es) |
| KR (1) | KR20150143720A (es) |
| CN (1) | CN105143216B (es) |
| AR (1) | AR095884A1 (es) |
| AU (1) | AU2014255326B2 (es) |
| BR (1) | BR112015026261A8 (es) |
| CA (1) | CA2907832A1 (es) |
| CL (1) | CL2015003019A1 (es) |
| EA (1) | EA029361B1 (es) |
| ES (1) | ES2640482T3 (es) |
| HK (1) | HK1221459A1 (es) |
| MA (1) | MA38588B1 (es) |
| MX (1) | MX362338B (es) |
| PH (1) | PH12015502411A1 (es) |
| PL (1) | PL2986607T3 (es) |
| SA (1) | SA515361261B1 (es) |
| SG (1) | SG11201508479RA (es) |
| TW (1) | TWI631119B (es) |
| WO (1) | WO2014170821A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0920895A8 (pt) | 2008-10-07 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Compostos antibióticos de oxazolidinona tricíclica |
| AR102256A1 (es) * | 2014-10-15 | 2017-02-15 | Actelion Pharmaceuticals Ltd | Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi |
| UY36851A (es) | 2015-08-16 | 2017-03-31 | Glaxosmithkline Ip Dev Ltd | Compuestos para uso en aplicaciones antibacterianas |
| WO2017157885A1 (de) | 2016-03-16 | 2017-09-21 | Bayer Cropscience Aktiengesellschaft | N-(cyanbenzyl)-6-(cyclopropylcarbonylamino)-4-(phenyl)-pyridin-2-carboxamid-derivate und verwandte verbindungen als pestizide pflanzenschutzmittel |
| AR108108A1 (es) | 2016-04-14 | 2018-07-18 | Idorsia Pharmaceuticals Ltd | Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| TW201833120A (zh) | 2017-02-17 | 2018-09-16 | 瑞士商愛杜西亞製藥有限公司 | 芳基噁唑啶酮抗生素化合物 |
| EP3284739A1 (de) | 2017-07-19 | 2018-02-21 | Bayer CropScience Aktiengesellschaft | Substituierte (het)arylverbindungen als schädlingsbekämpfungsmittel |
| WO2019106693A1 (en) | 2017-11-29 | 2019-06-06 | Bugworks Research India Pvt Ltd | Anti-bacterial heterocyclic compounds and their synthesis |
| EP3837263A1 (en) | 2018-08-13 | 2021-06-23 | F. Hoffmann-La Roche AG | New heterocyclic compounds as monoacylglycerol lipase inhibitors |
| EP4028403B1 (en) | 2019-09-12 | 2023-11-22 | F. Hoffmann-La Roche AG | 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors |
| CN115298176A (zh) * | 2020-03-24 | 2022-11-04 | 豪夫迈·罗氏有限公司 | 化合物以及它们在治疗细菌感染中的用途 |
| CN115785718B (zh) * | 2022-11-25 | 2023-08-22 | 四川大学 | 一种多基底表面的金属配位抗菌涂层及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0297042A1 (de) | 1987-06-23 | 1988-12-28 | Ciba-Geigy Ag | Substituierte Penem-Verbindungen |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| AU1026901A (en) | 1999-10-29 | 2001-05-08 | Syngenta Participations Ag | Novel herbicides |
| WO2003043997A1 (en) | 2001-11-15 | 2003-05-30 | Eli Lilly And Company | Peroxisome proliferator activated receptor alpha agonists |
| AR040335A1 (es) | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de ciclohexano o ciclohexeno, uso del mismo para preparar un medicamento, composicion farmaceutica que lo comprende, procedimiento y compuestos intermediarios de utilidad para preparar dicho compuesto |
| US20090186834A1 (en) | 2005-03-24 | 2009-07-23 | Microbia, Inc. | Diphenylheterocycle cholesterol absorption inhibitors |
| TW200734311A (en) | 2005-11-21 | 2007-09-16 | Astrazeneca Ab | New compounds |
| US7998992B2 (en) | 2007-03-30 | 2011-08-16 | Institute Of Medicinal Molecular Design, Inc. | Oxazolidinone derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
| CL2008001003A1 (es) * | 2007-04-11 | 2008-10-17 | Actelion Pharmaceuticals Ltd | Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana. |
| DK2231590T3 (da) | 2007-12-20 | 2012-07-09 | Pharma Mar Sa | Antitumorforbindelser |
| MX2010008922A (es) | 2008-02-20 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos azatriciclicos. |
| ES2398939T3 (es) | 2008-02-22 | 2013-03-22 | Actelion Pharmaceuticals Ltd. | Derivados de oxazolidinona |
| MX2011000968A (es) * | 2008-08-04 | 2011-03-02 | Actelion Pharmaceuticals Ltd | Derivados de alquilaminometiloxazolidinona triciclicos. |
| BRPI0920895A8 (pt) | 2008-10-07 | 2017-12-26 | Actelion Pharmaceuticals Ltd | Compostos antibióticos de oxazolidinona tricíclica |
| CN102164915A (zh) * | 2008-10-10 | 2011-08-24 | 埃科特莱茵药品有限公司 | 作为抗菌剂的2-苯并噻吩基-和2-萘基-噁唑烷酮及其氮杂等排体类似物 |
| PL2776431T3 (pl) | 2011-11-08 | 2016-11-30 | Stanowiące antybiotyki pochodne 2-okso-oksazolidyno-3,5-diylu |
-
2014
- 2014-04-15 PL PL14721539T patent/PL2986607T3/pl unknown
- 2014-04-15 KR KR1020157032552A patent/KR20150143720A/ko active IP Right Grant
- 2014-04-15 WO PCT/IB2014/060724 patent/WO2014170821A1/en active Application Filing
- 2014-04-15 JP JP2016508263A patent/JP6375365B2/ja not_active Expired - Fee Related
- 2014-04-15 US US14/784,602 patent/US9527867B2/en active Active
- 2014-04-15 CN CN201480022059.9A patent/CN105143216B/zh not_active Expired - Fee Related
- 2014-04-15 AU AU2014255326A patent/AU2014255326B2/en not_active Ceased
- 2014-04-15 SG SG11201508479RA patent/SG11201508479RA/en unknown
- 2014-04-15 TW TW103113729A patent/TWI631119B/zh not_active IP Right Cessation
- 2014-04-15 MA MA38588A patent/MA38588B1/fr unknown
- 2014-04-15 EP EP14721539.6A patent/EP2986607B1/en not_active Not-in-force
- 2014-04-15 EA EA201501025A patent/EA029361B1/ru not_active IP Right Cessation
- 2014-04-15 CA CA2907832A patent/CA2907832A1/en not_active Abandoned
- 2014-04-15 ES ES14721539.6T patent/ES2640482T3/es active Active
- 2014-04-15 MX MX2015014576A patent/MX362338B/es active IP Right Grant
- 2014-04-15 BR BR112015026261A patent/BR112015026261A8/pt not_active Application Discontinuation
- 2014-04-16 AR ARP140101625A patent/AR095884A1/es unknown
-
2015
- 2015-10-04 SA SA515361261A patent/SA515361261B1/ar unknown
- 2015-10-09 CL CL2015003019A patent/CL2015003019A1/es unknown
- 2015-10-16 PH PH12015502411A patent/PH12015502411A1/en unknown
-
2016
- 2016-08-10 HK HK16109490.8A patent/HK1221459A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI631119B (zh) | 2018-08-01 |
| TW201516043A (zh) | 2015-05-01 |
| EP2986607B1 (en) | 2017-06-14 |
| WO2014170821A1 (en) | 2014-10-23 |
| CA2907832A1 (en) | 2014-10-23 |
| US20160075722A1 (en) | 2016-03-17 |
| KR20150143720A (ko) | 2015-12-23 |
| MA38588B1 (fr) | 2018-04-30 |
| PL2986607T3 (pl) | 2017-11-30 |
| CL2015003019A1 (es) | 2016-09-30 |
| CN105143216B (zh) | 2018-04-13 |
| BR112015026261A2 (pt) | 2017-07-25 |
| US9527867B2 (en) | 2016-12-27 |
| HK1221459A1 (zh) | 2017-06-02 |
| ES2640482T3 (es) | 2017-11-03 |
| JP6375365B2 (ja) | 2018-08-15 |
| CN105143216A (zh) | 2015-12-09 |
| AR095884A1 (es) | 2015-11-18 |
| SA515361261B1 (ar) | 2016-06-15 |
| SG11201508479RA (en) | 2015-11-27 |
| MX2015014576A (es) | 2016-03-04 |
| EP2986607A1 (en) | 2016-02-24 |
| EA029361B1 (ru) | 2018-03-30 |
| AU2014255326A1 (en) | 2015-11-26 |
| EA201501025A1 (ru) | 2016-08-31 |
| JP2016516805A (ja) | 2016-06-09 |
| AU2014255326B2 (en) | 2018-09-13 |
| MA38588A1 (fr) | 2017-05-31 |
| BR112015026261A8 (pt) | 2017-12-26 |
| PH12015502411A1 (en) | 2016-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015502411A1 (en) | Antibacterial biaromatic derivatives | |
| CY1120066T1 (el) | Ενωση κινολονης | |
| EA201591429A1 (ru) | 2,3-дизамещенные производные 1-ацил-4-амино-1,2,3,4-тетрагидрохинолинов и их применение в качестве ингибиторов бромодомена | |
| PH12015501929B1 (en) | Substituted 2-azabicycles and their use as orexin receptor modulators | |
| MX2016005853A (es) | Compuestos de piridilo sustituidos con alquilamida utiles como muduladores de respuestas de citocinas heterodimericas interleucina 12 y 23 (il-12 e il-23) y/o interferon alfa (ifnalfa). | |
| UA116794C2 (uk) | Моноциклічна піридинова похідна | |
| MA39189A1 (fr) | Dérivés de 1h-indazole et de 1h-indole antibactériens | |
| MX2016017405A (es) | Compuestos derivados de 2-(3-piridinil)-1h-benzimidazol y medicamentos que los contienen. | |
| PH12016500109B1 (en) | Substituted pyrazolylpyrazole derivative and use of same as herbicide | |
| CR20160082A (es) | Nuevo derivado de triazina | |
| MX2015015010A (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| MX366678B (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| ES2561674T3 (es) | Antagonistas de TRPV4 | |
| IN2014CN02036A (es) | ||
| RS53054B (en) | PROTEATING INHIBITORS | |
| MX2015006930A (es) | Compuestos de isoxazol amina sustituidos como inhibidores de scd1. | |
| MX368759B (es) | Nuevos compuestos de 3,4-dihidro-2h-isoquinolin-1-ona y 2,3-dihidro-isoindol-1-ona. | |
| MX2015002705A (es) | Compuestos de piridinona para usarse en terapia fotodinamica. | |
| TH164069B (th) | อนุพันธ์ไบอะโรมาติกต้านแบคทีเรีย | |
| AR094386A1 (es) | Derivados de oxazolona antibacterianos | |
| PL405775A1 (pl) | Nowy związek, zwłaszcza do stosowania jako pigment | |
| BR112015030591A2 (pt) | formas de polimorfos de maleato de icotinib e usos dos mesmos | |
| LV14984A (lv) | 2-Fenilamino-4-(piridīn-3-il)-6-perfluoralkilpirimidīni | |
| AR083279A1 (es) | Composicion de control de fitoenfermedades y su uso |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or rights |
Owner name: IDORSIA PHARMACEUTICALS LTD |
|
| FG | Grant or registration |