MX2015006930A - Compuestos de isoxazol amina sustituidos como inhibidores de scd1. - Google Patents

Compuestos de isoxazol amina sustituidos como inhibidores de scd1.

Info

Publication number
MX2015006930A
MX2015006930A MX2015006930A MX2015006930A MX2015006930A MX 2015006930 A MX2015006930 A MX 2015006930A MX 2015006930 A MX2015006930 A MX 2015006930A MX 2015006930 A MX2015006930 A MX 2015006930A MX 2015006930 A MX2015006930 A MX 2015006930A
Authority
MX
Mexico
Prior art keywords
scd1
inhibitors
amine compounds
substituted isoxazole
isoxazole amine
Prior art date
Application number
MX2015006930A
Other languages
English (en)
Inventor
Paul Gillespie
Eric Mertz
Shawn David Erickson
Johnmark Derryberry
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015006930A publication Critical patent/MX2015006930A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)

Abstract

La invención se refiere a un compuesto de la Fórmula (ver fórmula) en donde R1 a R3 se definen como en la descripción y en las reivindicaciones. El compuesto de la Fórmula (I) puede utilizarse como un medicamento.
MX2015006930A 2012-12-03 2013-11-29 Compuestos de isoxazol amina sustituidos como inhibidores de scd1. MX2015006930A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261732463P 2012-12-03 2012-12-03
PCT/EP2013/075035 WO2014086667A1 (en) 2012-12-03 2013-11-29 Substituted isoxazole amine compounds as inhibitors of scd1

Publications (1)

Publication Number Publication Date
MX2015006930A true MX2015006930A (es) 2015-09-08

Family

ID=49709654

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015006930A MX2015006930A (es) 2012-12-03 2013-11-29 Compuestos de isoxazol amina sustituidos como inhibidores de scd1.

Country Status (11)

Country Link
US (1) US9290465B2 (es)
EP (1) EP2925408A1 (es)
JP (1) JP2016501210A (es)
KR (1) KR20150091071A (es)
CN (1) CN104822420A (es)
BR (1) BR112015012877A2 (es)
CA (1) CA2890300A1 (es)
HK (1) HK1211863A1 (es)
MX (1) MX2015006930A (es)
RU (1) RU2015123276A (es)
WO (1) WO2014086667A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA46589A (fr) 2016-10-24 2019-08-28 Yumanity Therapeutics Inc Composés et utilisations de ces derniers
CN110392833A (zh) 2017-01-06 2019-10-29 优曼尼蒂治疗公司 治疗神经病症的方法
US11873298B2 (en) 2017-10-24 2024-01-16 Janssen Pharmaceutica Nv Compounds and uses thereof
EP3914593A4 (en) 2019-01-24 2022-11-02 Yumanity Therapeutics, Inc. COMPOUNDS AND THEIR USES
CN112724157B (zh) * 2021-01-23 2022-04-19 中国科学院新疆理化技术研究所 二氢噁唑并[5,4-d]吡咯并[1,2-a]嘧啶-9(5H)-酮类衍生物及用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0515483A (pt) * 2004-09-20 2008-07-22 Xenon Pharmaceuticals Inc derivados heterocìclicos para o tratamento de doenças mediadas por enzimas estearoil-coa desaturase
AU2008241313A1 (en) * 2007-04-20 2008-10-30 Merck Frosst Canada Ltd. Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
US20100249192A1 (en) * 2007-12-11 2010-09-30 Merck Frosst Canada Ltd. Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase

Also Published As

Publication number Publication date
US9290465B2 (en) 2016-03-22
CN104822420A (zh) 2015-08-05
WO2014086667A1 (en) 2014-06-12
HK1211863A1 (en) 2016-06-03
RU2015123276A (ru) 2017-01-13
CA2890300A1 (en) 2014-06-12
BR112015012877A2 (pt) 2018-04-24
JP2016501210A (ja) 2016-01-18
KR20150091071A (ko) 2015-08-07
EP2925408A1 (en) 2015-10-07
US20150315160A1 (en) 2015-11-05

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