MA39189A1 - Dérivés de 1h-indazole et de 1h-indole antibactériens - Google Patents

Dérivés de 1h-indazole et de 1h-indole antibactériens

Info

Publication number
MA39189A1
MA39189A1 MA39189A MA39189A MA39189A1 MA 39189 A1 MA39189 A1 MA 39189A1 MA 39189 A MA39189 A MA 39189A MA 39189 A MA39189 A MA 39189A MA 39189 A1 MA39189 A1 MA 39189A1
Authority
MA
Morocco
Prior art keywords
antibacterials
indazole
indole
derivatives
formula
Prior art date
Application number
MA39189A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Philippe Surivet
Jean-Christophe Gauvin
Azely Mirre
Etienne Ochala
Jean-Luc Specklin
Gaëlle Chapoux
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MA39189A1 publication Critical patent/MA39189A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention porte sur des composés antibactériens de formule (i) dans laquelle x représente n ou ch; r
MA39189A 2013-12-19 2014-12-18 Dérivés de 1h-indazole et de 1h-indole antibactériens MA39189A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13198338 2013-12-19
PCT/EP2014/078384 WO2015091741A1 (fr) 2013-12-19 2014-12-18 Dérivés de 1h-indazole et de 1h-indole antibactériens

Publications (1)

Publication Number Publication Date
MA39189A1 true MA39189A1 (fr) 2017-06-30

Family

ID=49880464

Family Applications (1)

Application Number Title Priority Date Filing Date
MA39189A MA39189A1 (fr) 2013-12-19 2014-12-18 Dérivés de 1h-indazole et de 1h-indole antibactériens

Country Status (22)

Country Link
US (1) US9624206B2 (fr)
EP (1) EP3083567B1 (fr)
JP (1) JP6407288B2 (fr)
KR (1) KR20160098503A (fr)
CN (1) CN105829288B (fr)
AR (1) AR100032A1 (fr)
AU (1) AU2014368619B2 (fr)
BR (1) BR112016014115A8 (fr)
CA (1) CA2933604A1 (fr)
CL (1) CL2016001524A1 (fr)
EA (1) EA030730B1 (fr)
ES (1) ES2666130T3 (fr)
IL (1) IL246201A0 (fr)
MA (1) MA39189A1 (fr)
MX (1) MX360983B (fr)
PH (1) PH12016501102A1 (fr)
PL (1) PL3083567T3 (fr)
SG (1) SG11201605014YA (fr)
TR (1) TR201807881T4 (fr)
TW (1) TW201609641A (fr)
WO (1) WO2015091741A1 (fr)
ZA (1) ZA201604968B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
MX2016014989A (es) 2014-05-16 2017-03-31 Actelion Pharmaceuticals Ltd Derivados antibacterianos de quinazolina-4 (3h)-ona.
CA2963875A1 (fr) 2014-11-19 2016-05-26 Actelion Pharmaceuticals Ltd Derives de benzothiazole antibacteriens
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
CN107922433A (zh) * 2015-08-28 2018-04-17 爱杜西亚药品有限公司 抗菌环化吡咯烷‑2‑酮衍生物
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
CA3024756A1 (fr) * 2016-05-17 2017-11-23 Idorsia Pharmaceuticals Ltd Derives de 6-(buta-1,3-diyn-1-yl)benzo [d] thiazole
TW201906819A (zh) 2017-05-25 2019-02-16 日商大正製藥股份有限公司 新穎之咪唑衍生物
WO2019086452A1 (fr) * 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Composés hétéroaromatiques antibactériens
CN113666860B (zh) * 2020-05-14 2024-03-15 鲁南制药集团股份有限公司 一种7-乙基色醇的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2549159T3 (es) 2002-03-13 2015-10-23 Array Biopharma, Inc. Derivados de bencimidazol N3-alquilados como inhibidores de MEK
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
ES2400689T3 (es) 2004-10-18 2013-04-11 Amgen, Inc Compuestos de tiadiazol y métodos de uso
BRPI0609719B8 (pt) 2005-03-23 2021-05-25 Hoffmann La Roche derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
EP2432468A2 (fr) 2009-05-20 2012-03-28 Ardea Biosciences, Inc. Procédés pour moduler des taux d'acide urique
JP5671545B2 (ja) 2009-10-13 2015-02-18 ファイザー・インク 抗菌薬として有用なｃ結合ヒドロキサム酸誘導体
PL2512474T3 (pl) 2009-12-16 2015-03-31 Pfizer N-przyłączone pochodne kwasu hydroksamowego użyteczne jako środki przeciwbakteryjne
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
EP2638006A1 (fr) 2010-11-10 2013-09-18 Achaogen, Inc. Dérivés d'acide hydroxamique et leur utilisation dans le traitement d'infections bactériennes
JP2014501274A (ja) 2011-01-03 2014-01-20 ハンミ ファーム． シーオー．， エルティーディー． Ｇタンパク質共役受容体調節のための新規な二環式化合物
UA107423C2 (en) * 2011-03-07 2014-12-25 Pfizer Fluoro-pyridinone derivatives useful as antibacterial agents
DK2694488T3 (en) 2011-04-08 2014-12-15 Pfizer Isoxazole derivatives useful as antibacterial SUBSTANCES
JP2014514299A (ja) 2011-04-08 2014-06-19 ファイザー・インク 抗菌剤として有用なイミダゾール、ピラゾールおよびトリアゾール誘導体
EP2847162A1 (fr) 2012-05-09 2015-03-18 Achaogen, Inc. Agents antibactériens
EP2847168A1 (fr) 2012-05-10 2015-03-18 Achaogen, Inc. Agents antibactériens
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
MX2016014989A (es) 2014-05-16 2017-03-31 Actelion Pharmaceuticals Ltd Derivados antibacterianos de quinazolina-4 (3h)-ona.

Also Published As

Publication number Publication date
US9624206B2 (en) 2017-04-18
US20170029411A1 (en) 2017-02-02
MX2016007991A (es) 2016-10-07
EA030730B1 (ru) 2018-09-28
EP3083567A1 (fr) 2016-10-26
JP2017500336A (ja) 2017-01-05
PH12016501102A1 (en) 2016-07-11
AU2014368619B2 (en) 2018-11-22
ES2666130T3 (es) 2018-05-03
TW201609641A (zh) 2016-03-16
SG11201605014YA (en) 2016-07-28
BR112016014115A8 (pt) 2017-12-26
CA2933604A1 (fr) 2015-06-25
CN105829288B (zh) 2019-01-15
BR112016014115A2 (fr) 2017-08-08
MX360983B (es) 2018-11-22
EA201600475A1 (ru) 2016-11-30
KR20160098503A (ko) 2016-08-18
CN105829288A (zh) 2016-08-03
ZA201604968B (en) 2018-11-28
AU2014368619A1 (en) 2016-07-28
IL246201A0 (en) 2016-08-02
WO2015091741A1 (fr) 2015-06-25
EP3083567B1 (fr) 2018-03-07
JP6407288B2 (ja) 2018-10-17
CL2016001524A1 (es) 2017-01-27
TR201807881T4 (tr) 2018-06-21
AR100032A1 (es) 2016-09-07
PL3083567T3 (pl) 2018-08-31

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