EA201491854A1 - Асимметрический синтез соединений спирооксиндола, полезных в качестве терапевтических средств - Google Patents

Асимметрический синтез соединений спирооксиндола, полезных в качестве терапевтических средств

Info

Publication number
EA201491854A1
EA201491854A1 EA201491854A EA201491854A EA201491854A1 EA 201491854 A1 EA201491854 A1 EA 201491854A1 EA 201491854 A EA201491854 A EA 201491854A EA 201491854 A EA201491854 A EA 201491854A EA 201491854 A1 EA201491854 A1 EA 201491854A1
Authority
EA
Eurasian Patent Office
Prior art keywords
useful
spiroxindol
asymmetric synthesis
compounds
medical treatment
Prior art date
Application number
EA201491854A
Other languages
English (en)
Inventor
Шаои Сунь
Цзяньминь Фу
Султан Човдхури
Иван Уилльям Хемеон
Майкл Эдвард Гримвуд
Тарек Сухайл Мансур
Original Assignee
Ксенон Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ксенон Фармасьютикалз Инк. filed Critical Ксенон Фармасьютикалз Инк.
Publication of EA201491854A1 publication Critical patent/EA201491854A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Abstract

Изобретение направлено на асимметрический синтез некоторых производных спирооксиндола, которые являются полезными в лечении и/или предупреждении опосредованных функцией натриевых каналов заболеваний или состояний, таких как боль.
EA201491854A 2012-04-12 2013-03-11 Асимметрический синтез соединений спирооксиндола, полезных в качестве терапевтических средств EA201491854A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261623336P 2012-04-12 2012-04-12
PCT/US2013/030219 WO2013154712A1 (en) 2012-04-12 2013-03-11 Asymmetric syntheses for spiro-oxindole compounds useful as therapeutic agents

Publications (1)

Publication Number Publication Date
EA201491854A1 true EA201491854A1 (ru) 2015-03-31

Family

ID=47902379

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491854A EA201491854A1 (ru) 2012-04-12 2013-03-11 Асимметрический синтез соединений спирооксиндола, полезных в качестве терапевтических средств

Country Status (14)

Country Link
US (2) US9487535B2 (ru)
EP (1) EP2838902B1 (ru)
JP (1) JP6195609B2 (ru)
KR (1) KR20150002794A (ru)
CN (2) CN104350057A (ru)
AU (1) AU2013246485A1 (ru)
CA (1) CA2869547A1 (ru)
EA (1) EA201491854A1 (ru)
ES (1) ES2714314T3 (ru)
HK (3) HK1205113A1 (ru)
IL (1) IL235006A0 (ru)
MX (1) MX2014012266A (ru)
WO (1) WO2013154712A1 (ru)
ZA (1) ZA201407334B (ru)

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EP3266444A1 (en) 2010-02-26 2018-01-10 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
KR20150002794A (ko) 2012-04-12 2015-01-07 제논 파마슈티칼스 인크. 치료제로서 유용한 스파이로-옥시인돌 화합물을 위한 비대칭적 합성
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JP2019518058A (ja) * 2016-06-16 2019-06-27 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． スピロ−オキシインドール化合物の固体状態形
WO2017218920A1 (en) 2016-06-16 2017-12-21 Teva Pharmaceuticals International Gmbh Asymmetric synthesis of funapide
CN108395438A (zh) * 2018-04-03 2018-08-14 陕西科技大学 一类具有抗菌活性的靛红母核螺环化合物及其合成方法
EP3801512A4 (en) 2018-05-29 2022-01-19 President and Fellows of Harvard College COMPOSITIONS AND METHODS TO REDUCE TACTILE DYSFUNCTION, ANXIETY AND SOCIAL DISABILITIES
JP2023529867A (ja) 2020-06-05 2023-07-12 キネート バイオファーマ インク． 線維芽細胞増殖因子受容体キナーゼの阻害剤

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Also Published As

Publication number Publication date
MX2014012266A (es) 2014-12-05
US20130274483A1 (en) 2013-10-17
US20170066777A1 (en) 2017-03-09
HK1205113A1 (en) 2015-12-11
CA2869547A1 (en) 2013-10-17
ES2714314T3 (es) 2019-05-28
IL235006A0 (en) 2014-12-31
HK1226389A1 (zh) 2017-09-29
HK1205114A1 (en) 2015-12-11
ZA201407334B (en) 2017-05-31
JP6195609B2 (ja) 2017-09-13
KR20150002794A (ko) 2015-01-07
CN104350057A (zh) 2015-02-11
EP2838902A1 (en) 2015-02-25
CN105753877A (zh) 2016-07-13
US9487535B2 (en) 2016-11-08
EP2838902B1 (en) 2018-12-05
WO2013154712A1 (en) 2013-10-17
AU2013246485A1 (en) 2014-10-16
JP2015516389A (ja) 2015-06-11

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