TR201807881T4 - Antibakteriyel 1h-ındazol ve 1h-ındol türevleri. - Google Patents
Antibakteriyel 1h-ındazol ve 1h-ındol türevleri. Download PDFInfo
- Publication number
- TR201807881T4 TR201807881T4 TR2018/07881T TR201807881T TR201807881T4 TR 201807881 T4 TR201807881 T4 TR 201807881T4 TR 2018/07881 T TR2018/07881 T TR 2018/07881T TR 201807881 T TR201807881 T TR 201807881T TR 201807881 T4 TR201807881 T4 TR 201807881T4
- Authority
- TR
- Turkey
- Prior art keywords
- cycloprop
- hydroxymethyl
- halogen
- azetidin
- hydroxyalkyl
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- BNIFVTPIXGUZCU-UHFFFAOYSA-N 1h-indazole Chemical compound C1=CC=C2C=NNC2=C1.C1=CC=C2C=NNC2=C1 BNIFVTPIXGUZCU-UHFFFAOYSA-N 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- -1 trifluoromethoxy, amino Chemical group 0.000 abstract 17
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000004567 azetidin-3-yl group Chemical group N1CC(C1)* 0.000 abstract 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 2
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000005133 alkynyloxy group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 abstract 1
- 125000006299 oxetan-3-yl group Chemical group [H]C1([H])OC([H])([H])C1([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005309 thioalkoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Abstract
Bu buluş; X?in N veya CH olduğu; R1?in, H veya halojen olduğu; R2?nin alkiniloksi veya M grubu olduğu; R3?ün, H veya halojen olduğu; M?nin, A?nın bir bağ, CH2CH2, CH=CH veya C?C olduğu; R1A?nın, H veya halojen olduğu; R2A?nın, H, alkoksi veya halojen olduğu; R3A?nın H, alkoksi, hidroksialkoksi, alkoksialkoksi, tiyoalkoksi, triflorometoksi, amino, hidroksialkil, 2 hidroksiasetamido, 1 aminosiklopropil, 1 hidroksimetil-sikloprop-1 il, 1 ((fosfonooksi)metil)siklopropil, 1 (((dimetilglisil)oksi)metil)siklopropil, trans 2 hidroksimetil-sikloprop-1 il, 1,2 dihidroksietil, 3 hidroksioksetan-3 il, 3 (hidroksialkil)oksetan-3 il, 3 aminooksetan-3 il, 3 hidroksithietan-3 il, morfolin-4 ilalkoksi, morfolin-4 il-alkil, oksazol-2 il veya [1,2,3]triazol-2 il; ve R1B'nin hidroksialkil, dihidroksialkil, aminoalkil, 1 hidroksimetil-sikloprop-1 il, 1 aminometil-sikloprop-1 il, trans 2 hidroksimetil-sikloprop-1 il, 3 hidroksioksetan-3 il, 3 hidroksithietan-3 il, 1 (2 hidroksiaetil)azetidin-3 il, 1 (2 aminoaetil)azetidin-3 il, 1 glisilazetidin-3 il, 1 (2 amino-2 metilpropanoil)azetidin-3 il, 3 (2 aminoasetamido)siklopentil, trans (cis 3,4 dihidroksi)-siklopent-1 il veya 3 hidroksimetilbisiklo[1,1,1]pentan-1 il olduğu aşağıda gösterilen MA ve MB gruplarından biri olduğu; MAMB formül I'e ait antibakteriyel bileşikler ve bunların tuzları.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13198338 | 2013-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201807881T4 true TR201807881T4 (tr) | 2018-06-21 |
Family
ID=49880464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2018/07881T TR201807881T4 (tr) | 2013-12-19 | 2014-12-18 | Antibakteriyel 1h-ındazol ve 1h-ındol türevleri. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9624206B2 (tr) |
| EP (1) | EP3083567B1 (tr) |
| JP (1) | JP6407288B2 (tr) |
| KR (1) | KR20160098503A (tr) |
| CN (1) | CN105829288B (tr) |
| AR (1) | AR100032A1 (tr) |
| AU (1) | AU2014368619B2 (tr) |
| BR (1) | BR112016014115A8 (tr) |
| CA (1) | CA2933604A1 (tr) |
| CL (1) | CL2016001524A1 (tr) |
| EA (1) | EA030730B1 (tr) |
| ES (1) | ES2666130T3 (tr) |
| IL (1) | IL246201A0 (tr) |
| MA (1) | MA39189A1 (tr) |
| MX (1) | MX360983B (tr) |
| PH (1) | PH12016501102A1 (tr) |
| PL (1) | PL3083567T3 (tr) |
| SG (1) | SG11201605014YA (tr) |
| TR (1) | TR201807881T4 (tr) |
| TW (1) | TW201609641A (tr) |
| WO (1) | WO2015091741A1 (tr) |
| ZA (1) | ZA201604968B (tr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| AR100428A1 (es) | 2014-05-16 | 2016-10-05 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos quinazolina-4(3h)-ona |
| UA118722C2 (uk) | 2014-11-19 | 2019-02-25 | Ідорсія Фармасьютікалз Лтд | Антибактеріальні бензотіазольні похідні |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| KR20180041231A (ko) * | 2015-08-28 | 2018-04-23 | 이도르시아 파마슈티컬스 리미티드 | 항균성 애눌레이트화 피롤리딘-2-온 유도체 |
| AR105848A1 (es) * | 2015-08-31 | 2017-11-15 | Actelion Pharmaceuticals Ltd | Derivados heterocíclicos antibacterianos |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| EA201892585A1 (ru) * | 2016-05-17 | 2019-05-31 | Идорсия Фармасьютиклз Лтд | 6-(БУТА-1,3-ДИИН-1-ИЛ)БЕНЗО[d]ТИАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ |
| WO2018216822A1 (en) | 2017-05-25 | 2018-11-29 | Taisho Pharmaceutical Co., Ltd. | Novel imidazole derivatives |
| WO2019086452A1 (en) * | 2017-10-31 | 2019-05-09 | Idorsia Pharmaceuticals Ltd | Antibacterial heteroaromatic compounds |
| CN113666860B (zh) * | 2020-05-14 | 2024-03-15 | 鲁南制药集团股份有限公司 | 一种7-乙基色醇的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI343377B (en) | 2002-03-13 | 2011-06-11 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| DE102004017930A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| MX2007004551A (es) | 2004-10-18 | 2007-05-23 | Amgen Inc | Compuestos tiadiazol y metodos de uso. |
| WO2006099972A1 (en) | 2005-03-23 | 2006-09-28 | F. Hoffmann-La Roche Ag | Acetylenyl-pyrazolo-pvrimidine derivatives as mglur2 antagonists |
| EP2170814B1 (en) | 2007-06-12 | 2016-08-17 | Achaogen, Inc. | Antibacterial agents |
| WO2010135536A2 (en) | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| EP2488489A2 (en) | 2009-10-13 | 2012-08-22 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| CA2899583A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| GB2483736B (en) | 2010-09-16 | 2012-08-29 | Aragon Pharmaceuticals Inc | Estrogen receptor modulators and uses thereof |
| WO2012154204A1 (en) | 2010-11-10 | 2012-11-15 | Achaogen, Inc. | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
| US8853213B2 (en) | 2011-01-03 | 2014-10-07 | Hanmi Pharm. Co., Ltd | Bicyclic compound for modulating G protein-coupled receptors |
| PE20140397A1 (es) * | 2011-03-07 | 2014-03-28 | Pfizer | Derivados de fluoro-piridinona utiles como agentes antibacterianos |
| SG193367A1 (en) | 2011-04-08 | 2013-10-30 | Pfizer | Isoxazole derivatives useful as antibacterial agents |
| SG193458A1 (en) * | 2011-04-08 | 2013-10-30 | Pfizer | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| WO2013170030A1 (en) | 2012-05-09 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| WO2013170165A1 (en) | 2012-05-10 | 2013-11-14 | Achaogen, Inc. | Antibacterial agents |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| AR100428A1 (es) | 2014-05-16 | 2016-10-05 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos quinazolina-4(3h)-ona |
-
2014
- 2014-12-18 EP EP14812752.5A patent/EP3083567B1/en not_active Not-in-force
- 2014-12-18 CN CN201480067976.9A patent/CN105829288B/zh not_active Expired - Fee Related
- 2014-12-18 AR ARP140104742A patent/AR100032A1/es unknown
- 2014-12-18 US US15/106,790 patent/US9624206B2/en active Active
- 2014-12-18 MA MA39189A patent/MA39189A1/fr unknown
- 2014-12-18 TR TR2018/07881T patent/TR201807881T4/tr unknown
- 2014-12-18 JP JP2016541300A patent/JP6407288B2/ja not_active Expired - Fee Related
- 2014-12-18 BR BR112016014115A patent/BR112016014115A8/pt not_active Application Discontinuation
- 2014-12-18 PL PL14812752T patent/PL3083567T3/pl unknown
- 2014-12-18 TW TW103144395A patent/TW201609641A/zh unknown
- 2014-12-18 MX MX2016007991A patent/MX360983B/es active IP Right Grant
- 2014-12-18 KR KR1020167019669A patent/KR20160098503A/ko not_active Application Discontinuation
- 2014-12-18 WO PCT/EP2014/078384 patent/WO2015091741A1/en active Application Filing
- 2014-12-18 CA CA2933604A patent/CA2933604A1/en not_active Abandoned
- 2014-12-18 ES ES14812752.5T patent/ES2666130T3/es active Active
- 2014-12-18 AU AU2014368619A patent/AU2014368619B2/en not_active Ceased
- 2014-12-18 SG SG11201605014YA patent/SG11201605014YA/en unknown
- 2014-12-18 EA EA201600475A patent/EA030730B1/ru not_active IP Right Cessation
-
2016
- 2016-06-09 PH PH12016501102A patent/PH12016501102A1/en unknown
- 2016-06-14 IL IL246201A patent/IL246201A0/en unknown
- 2016-06-16 CL CL2016001524A patent/CL2016001524A1/es unknown
- 2016-07-18 ZA ZA2016/04968A patent/ZA201604968B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112016014115A2 (tr) | 2017-08-08 |
| EA030730B1 (ru) | 2018-09-28 |
| WO2015091741A1 (en) | 2015-06-25 |
| CA2933604A1 (en) | 2015-06-25 |
| CN105829288A (zh) | 2016-08-03 |
| TW201609641A (zh) | 2016-03-16 |
| EP3083567B1 (en) | 2018-03-07 |
| PH12016501102A1 (en) | 2016-07-11 |
| US9624206B2 (en) | 2017-04-18 |
| BR112016014115A8 (pt) | 2017-12-26 |
| MA39189A1 (fr) | 2017-06-30 |
| AR100032A1 (es) | 2016-09-07 |
| CN105829288B (zh) | 2019-01-15 |
| EP3083567A1 (en) | 2016-10-26 |
| JP2017500336A (ja) | 2017-01-05 |
| KR20160098503A (ko) | 2016-08-18 |
| ES2666130T3 (es) | 2018-05-03 |
| JP6407288B2 (ja) | 2018-10-17 |
| AU2014368619A1 (en) | 2016-07-28 |
| MX2016007991A (es) | 2016-10-07 |
| PL3083567T3 (pl) | 2018-08-31 |
| MX360983B (es) | 2018-11-22 |
| EA201600475A1 (ru) | 2016-11-30 |
| IL246201A0 (en) | 2016-08-02 |
| US20170029411A1 (en) | 2017-02-02 |
| SG11201605014YA (en) | 2016-07-28 |
| ZA201604968B (en) | 2018-11-28 |
| AU2014368619B2 (en) | 2018-11-22 |
| CL2016001524A1 (es) | 2017-01-27 |
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