PE20140397A1 - Derivados de fluoro-piridinona utiles como agentes antibacterianos - Google Patents
Derivados de fluoro-piridinona utiles como agentes antibacterianosInfo
- Publication number
- PE20140397A1 PE20140397A1 PE2013002016A PE2013002016A PE20140397A1 PE 20140397 A1 PE20140397 A1 PE 20140397A1 PE 2013002016 A PE2013002016 A PE 2013002016A PE 2013002016 A PE2013002016 A PE 2013002016A PE 20140397 A1 PE20140397 A1 PE 20140397A1
- Authority
- PE
- Peru
- Prior art keywords
- fluoro
- hydroxy
- antibacterial agents
- derivatives useful
- pyridinone derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE FLUORO-PIRIDINONA DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C3); R2 ES H O ALQUILO(C1-C3); R3 ES H, HALOGENO, HIDROXI, CN, ENTRE OTROS; T ES ETINILO, ARILO(C6-C10) O HETEROARILO; D ESTA AUSENTE O ES UN ENLACE, (CH2)r O (CH2)n-O-(CH2)p, EN DONDE r ES DE 1 A 3; n Y p SON CADA UNO DE 0 A 2; E ESTA AUSENTE O ES CICLOALQUILO(C3-C10), ARILO(C6-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2R)-4-{5-FLUORO-2-OXO-4-[4-(2H-1,2,3-TRIAZOL-2-IL)FENIL]PIRIDIN-1(2H)-IL}-N-HIDROXI-2-METIL-2-(METILSULFONIL)BUTANAMIDA; (2R)-4-[5-FLUORO-4-(2-FLUORO-4-METOXIFENIL)-2-OXOPIRIDIN-1(2H)-IL]-N-HIDROXI-2-METIL-2-(METILSULFONIL)BUTANAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTIBACTERIANOS EN ESPECIAL CONTRA GRAM-NEGATIVOS SIENDO UTILES EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161449825P | 2011-03-07 | 2011-03-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20140397A1 true PE20140397A1 (es) | 2014-03-28 |
Family
ID=45841548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002016A PE20140397A1 (es) | 2011-03-07 | 2012-02-22 | Derivados de fluoro-piridinona utiles como agentes antibacterianos |
Country Status (33)
Country | Link |
---|---|
US (2) | US8624034B2 (es) |
EP (1) | EP2683689B1 (es) |
JP (1) | JP5620020B2 (es) |
KR (1) | KR101593288B1 (es) |
CN (2) | CN103443079B (es) |
AP (1) | AP3336A (es) |
AR (1) | AR085615A1 (es) |
AU (1) | AU2012226473B8 (es) |
BR (1) | BR112013022536B1 (es) |
CA (1) | CA2828337C (es) |
CL (1) | CL2013002417A1 (es) |
CO (1) | CO6761338A2 (es) |
CR (1) | CR20130403A (es) |
CU (1) | CU20130117A7 (es) |
DO (1) | DOP2013000200A (es) |
EA (1) | EA024782B1 (es) |
EC (1) | ECSP13012928A (es) |
ES (1) | ES2626457T3 (es) |
GE (1) | GEP20156370B (es) |
GT (1) | GT201300213A (es) |
HK (2) | HK1191951A1 (es) |
IL (1) | IL228100A0 (es) |
MA (1) | MA34963B1 (es) |
MX (1) | MX341977B (es) |
NI (1) | NI201300077A (es) |
PE (1) | PE20140397A1 (es) |
SG (1) | SG192766A1 (es) |
TN (1) | TN2013000353A1 (es) |
TW (1) | TWI453197B (es) |
UA (1) | UA107423C2 (es) |
UY (1) | UY33936A (es) |
WO (1) | WO2012120397A1 (es) |
ZA (1) | ZA201306515B (es) |
Families Citing this family (23)
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JP5524215B2 (ja) | 2008-09-19 | 2014-06-18 | ファイザー・インク | 抗菌剤として有用なヒドロキサム酸誘導体 |
PT2512474E (pt) | 2009-12-16 | 2014-12-23 | Pfizer | Derivados de ácido hidroxâmico n-ligado úteis como agentes antibacterianos |
MA34963B1 (fr) | 2011-03-07 | 2014-03-01 | Pfizer | Derives de fluoro-pyridinone utiles en tant qu'agents antibacteriens |
CN103717582B (zh) | 2011-04-08 | 2015-09-30 | 辉瑞大药厂 | 用作抗菌剂的异*唑衍生物 |
US8809333B2 (en) | 2011-04-08 | 2014-08-19 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
WO2015085238A1 (en) * | 2013-12-05 | 2015-06-11 | The Regents Of The University Of California, A California Corporation | Inhibitors of lpxc |
JP6407288B2 (ja) * | 2013-12-19 | 2018-10-17 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | 抗菌性1h−インダゾール及び1h−インドール誘導体 |
AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
JP6514716B2 (ja) | 2014-04-22 | 2019-05-15 | ノバルティス アーゲー | LpxC阻害剤としてのイソオキサゾリンヒドロキサム酸誘導体 |
EP3143007B1 (en) * | 2014-05-16 | 2018-07-11 | Idorsia Pharmaceuticals Ltd | Antibacterial quinazoline-4(3h)-one derivatives |
PT3152199T (pt) | 2014-06-03 | 2018-11-26 | Idorsia Pharmaceuticals Ltd | Compostos de pirazol e a sua utilização como bloqueadores de canais de cálcio do tipo t |
CA2963875A1 (en) | 2014-11-19 | 2016-05-26 | Actelion Pharmaceuticals Ltd | Antibacterial benzothiazole derivatives |
MX2017007980A (es) | 2014-12-16 | 2017-09-29 | Novartis Ag | Compuestos de isoxazol de acido hidroxamico como inhibidores de lpxc. |
CN104876883B (zh) * | 2015-06-05 | 2017-11-28 | 安徽联创生物医药股份有限公司 | 抗失眠药物苏沃雷生中间体的合成方法 |
AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
AR105889A1 (es) * | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
EP3468957B1 (en) | 2016-06-14 | 2020-08-26 | Novartis Ag | Crystalline form of (r)-4-(5-(cyclopropylethynyl)isoxazol-3-yl)-n-hydroxy-2-methyl-2-(methylsulfonyl)butanamide as an antibacterial agent |
EP3554490B1 (en) | 2016-12-16 | 2022-02-16 | Idorsia Pharmaceuticals Ltd | Pharmaceutical combination comprising a t-type calcium channel blocker |
JP6972144B2 (ja) | 2017-02-06 | 2021-11-24 | イドーシア ファーマシューティカルズ リミテッドIdorsia Pharmaceuticals Ltd | 1−アリール−1−トリフルオロメチルシクロプロパンを合成するための新規な方法 |
CN111867600A (zh) * | 2018-03-15 | 2020-10-30 | 辉瑞大药厂 | 用作抗菌剂的吡啶酮和嘧啶酮磷酸盐和硼酸盐 |
US11981696B2 (en) | 2018-03-15 | 2024-05-14 | Pfizer Inc. | Fluoro-pyridinone phosphates and boronates useful as antibacterial agents |
CN110699312B (zh) * | 2019-11-28 | 2022-08-12 | 西北农林科技大学 | 一种猪种布鲁氏菌bi-1基因缺失菌株及其构建方法和应用 |
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US5110831A (en) | 1990-11-30 | 1992-05-05 | Du Pont Merck Pharmaceutical Company | Vinylogous hydroxamic acids and derivatives thereof as 5-lipoxygenase inhibitors |
CA2320476A1 (en) | 1998-02-07 | 1999-08-12 | British Biotech Pharmaceuticals Limited | Antibacterial agents |
GB9925470D0 (en) | 1999-10-27 | 1999-12-29 | Smithkline Beecham Plc | Novel compounds |
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JP5227304B2 (ja) | 2007-02-28 | 2013-07-03 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体 |
US20080234297A1 (en) | 2007-03-20 | 2008-09-25 | Changgeng Qian | HSP90 Inhibitors Containing a Zinc Binding Moiety |
CN101239978A (zh) * | 2008-03-05 | 2008-08-13 | 南方医科大学 | 一种咪唑并吡啶类化合物 |
WO2010017060A1 (en) * | 2008-08-04 | 2010-02-11 | Schering Corporation | Urea derivatives as antibacterial agents |
JP5455913B2 (ja) | 2008-08-27 | 2014-03-26 | 大正製薬株式会社 | ナフチリジン−n−オキシドを有する新規ヒドロキサム酸誘導体 |
US8372885B2 (en) | 2008-09-17 | 2013-02-12 | Novartis Ag | Organic compounds and their uses |
JP5524215B2 (ja) | 2008-09-19 | 2014-06-18 | ファイザー・インク | 抗菌剤として有用なヒドロキサム酸誘導体 |
WO2010100475A1 (en) | 2009-03-02 | 2010-09-10 | Astrazeneca Ab | Hydroxamic acid derivatives as gram-negative antibacterial agents |
EP2443119A1 (en) * | 2009-06-16 | 2012-04-25 | Schering Corporation | Gamma secretase modulators |
EP2443121A2 (en) * | 2009-06-16 | 2012-04-25 | Schering Corporation | Gamma secretase modulators |
PT2512474E (pt) * | 2009-12-16 | 2014-12-23 | Pfizer | Derivados de ácido hidroxâmico n-ligado úteis como agentes antibacterianos |
MA34963B1 (fr) | 2011-03-07 | 2014-03-01 | Pfizer | Derives de fluoro-pyridinone utiles en tant qu'agents antibacteriens |
US8809333B2 (en) | 2011-04-08 | 2014-08-19 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
CN103717582B (zh) | 2011-04-08 | 2015-09-30 | 辉瑞大药厂 | 用作抗菌剂的异*唑衍生物 |
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2012
- 2012-02-22 MA MA36233A patent/MA34963B1/fr unknown
- 2012-02-22 EA EA201391072A patent/EA024782B1/ru not_active IP Right Cessation
- 2012-02-22 AP AP2013007074A patent/AP3336A/xx active
- 2012-02-22 JP JP2013557190A patent/JP5620020B2/ja not_active Expired - Fee Related
- 2012-02-22 MX MX2013010276A patent/MX341977B/es active IP Right Grant
- 2012-02-22 AU AU2012226473A patent/AU2012226473B8/en active Active
- 2012-02-22 BR BR112013022536-0A patent/BR112013022536B1/pt active IP Right Grant
- 2012-02-22 WO PCT/IB2012/050812 patent/WO2012120397A1/en active Application Filing
- 2012-02-22 KR KR1020137026034A patent/KR101593288B1/ko not_active IP Right Cessation
- 2012-02-22 ES ES12709179.1T patent/ES2626457T3/es active Active
- 2012-02-22 CA CA2828337A patent/CA2828337C/en active Active
- 2012-02-22 PE PE2013002016A patent/PE20140397A1/es not_active Application Discontinuation
- 2012-02-22 UA UAA201310358A patent/UA107423C2/ru unknown
- 2012-02-22 EP EP12709179.1A patent/EP2683689B1/en active Active
- 2012-02-22 SG SG2013061643A patent/SG192766A1/en unknown
- 2012-02-22 CN CN201280012230.9A patent/CN103443079B/zh active Active
- 2012-02-22 CN CN201410611970.5A patent/CN104529883A/zh active Pending
- 2012-02-22 GE GEAP201213215A patent/GEP20156370B/en unknown
- 2012-03-05 TW TW101107363A patent/TWI453197B/zh not_active IP Right Cessation
- 2012-03-05 AR ARP120100708A patent/AR085615A1/es unknown
- 2012-03-06 UY UY0001033936A patent/UY33936A/es not_active Application Discontinuation
- 2012-03-07 US US13/414,057 patent/US8624034B2/en active Active
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2013
- 2013-08-20 CR CR20130403A patent/CR20130403A/es unknown
- 2013-08-21 CL CL2013002417A patent/CL2013002417A1/es unknown
- 2013-08-22 IL IL228100A patent/IL228100A0/en unknown
- 2013-08-26 CU CU2013000117A patent/CU20130117A7/es unknown
- 2013-08-27 TN TNP2013000353A patent/TN2013000353A1/fr unknown
- 2013-08-29 ZA ZA2013/06515A patent/ZA201306515B/en unknown
- 2013-09-06 GT GT201300213A patent/GT201300213A/es unknown
- 2013-09-06 NI NI201300077A patent/NI201300077A/es unknown
- 2013-09-06 DO DO2013000200A patent/DOP2013000200A/es unknown
- 2013-09-06 CO CO13211884A patent/CO6761338A2/es active IP Right Grant
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