AR084173A1 - Derivados oxazolil-metileter como agonistas del receptor alx - Google Patents

Derivados oxazolil-metileter como agonistas del receptor alx

Info

Publication number
AR084173A1
AR084173A1 ARP110104559A ARP110104559A AR084173A1 AR 084173 A1 AR084173 A1 AR 084173A1 AR P110104559 A ARP110104559 A AR P110104559A AR P110104559 A ARP110104559 A AR P110104559A AR 084173 A1 AR084173 A1 AR 084173A1
Authority
AR
Argentina
Prior art keywords
metileter
oxazolil
alx
derivatives
receiver agonists
Prior art date
Application number
ARP110104559A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR084173A1 publication Critical patent/AR084173A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas y sus usos.Reivindicación 1: Un compuesto de fórmula (1), donde R1 representa fenilo que está no sustituido o está mono-sustituido con halógeno, alquilo C1-4, alcoxi C1-4, fluoroalquilo C1-2 o fluoroalcoxi C1-2; R2 representa hidrógeno, metilo o ciclopropilo; R3 y R4 son idénticos y representan hidrógeno o metilo; y R5 representa alquilo C1-2; o una sal de dicho compuesto.
ARP110104559A 2010-12-07 2011-12-06 Derivados oxazolil-metileter como agonistas del receptor alx AR084173A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2010055616 2010-12-07

Publications (1)

Publication Number Publication Date
AR084173A1 true AR084173A1 (es) 2013-04-24

Family

ID=45444667

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104559A AR084173A1 (es) 2010-12-07 2011-12-06 Derivados oxazolil-metileter como agonistas del receptor alx

Country Status (19)

Country Link
US (1) US8846733B2 (es)
EP (1) EP2649068B1 (es)
JP (1) JP5923107B2 (es)
KR (1) KR101864463B1 (es)
CN (1) CN103261194B (es)
AR (1) AR084173A1 (es)
AU (1) AU2011340146B2 (es)
CA (1) CA2816376C (es)
CY (1) CY1116004T1 (es)
DK (1) DK2649068T3 (es)
ES (1) ES2526132T3 (es)
HR (1) HRP20150049T1 (es)
MX (1) MX2013006418A (es)
PL (1) PL2649068T3 (es)
PT (1) PT2649068E (es)
RU (1) RU2588567C2 (es)
SI (1) SI2649068T1 (es)
TW (1) TWI523853B (es)
WO (1) WO2012077049A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2553635T3 (es) 2010-11-17 2015-12-10 Actelion Pharmaceuticals Ltd. Derivados de éster spiro[2.4]heptano puenteados
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
US9284288B2 (en) 2012-05-16 2016-03-15 Actelion Pharmaceuticals Ltd. 1-(p-tolyl) cyclopropyl substituted bridged spiro[2.4]heptane derivatives as ALX receptor agonists
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
KR20160033747A (ko) 2013-07-18 2016-03-28 액테리온 파마슈티칼 리미티드 Ａｌｘ 수용체 아고니스트로서의 피페라진 치환된 브릿지연결 스피로［２．４］헵탄 유도체
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
NZ720508A (en) 2013-11-28 2019-03-29 Kyorin Seiyaku Kk Urea derivative or pharmacologically acceptable salt thereof
US10858314B2 (en) 2015-05-27 2020-12-08 Kyorin Pharmaceutical Co., Ltd. Urea derivative or pharmacologically acceptable salt thereof
CN107849049B (zh) 2015-05-27 2021-03-16 杏林制药株式会社 脲衍生物或其药用盐
US11439615B2 (en) 2017-03-09 2022-09-13 University Health Network Lipoxin and lipoxin analogue mediated neuroprotection and treatments
EA202092094A1 (ru) 2018-03-05 2020-12-10 Бристол-Маерс Сквибб Компани Фенилпирролидиноновые агонисты формилпептидного рецептора 2

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62234018A (ja) 1986-04-02 1987-10-14 Rooto Seiyaku Kk 糖尿病併発症治療剤
WO2002024656A1 (fr) 2000-09-22 2002-03-28 Nihon Nohyaku Co., Ltd. Derives de n-(4-pyrazolyl amide, produits chimiques pour utilisation agricole et horticole et applications desdits derives
JP2005536187A (ja) 2002-04-03 2005-12-02 バイエル・ヘルスケア・アクチェンゲゼルシャフト Ｎ−ホルミルペプチド受容体様１（ｆｐｒｌ１）に関連する疾患の診断および治療
KR20060130064A (ko) 2003-11-07 2006-12-18 아카디아 파마슈티칼스 인코포레이티드 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, ｆｐｒｌ1의 용도
KR20070036076A (ko) * 2004-05-25 2007-04-02 메타볼렉스, 인코포레이티드 Ｐｐａｒ의 조절제로서의 치환된 트리아졸 및 이의제조방법
WO2007055941A2 (en) 2005-11-03 2007-05-18 Merck & Co., Inc. Histone deacetylase inhibitors with aryl-pyrazolyl motifs
EP2487169B1 (en) 2007-08-21 2015-05-20 Senomyx, Inc. Compounds that inhibit (block) bitter taste in compositions and use thereof
AR069650A1 (es) 2007-12-14 2010-02-10 Actelion Pharmaceuticals Ltd Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano
TWI434685B (zh) * 2007-12-18 2014-04-21 Actelion Pharmaceuticals Ltd 胺基三唑衍生物
PT2432760E (pt) 2009-05-18 2013-10-21 Actelion Pharmaceuticals Ltd Derivados de espiro [2,4] heptano ligados em ponte como agonistas do receptor fprl2 e/ou receptor alx
CN101909306A (zh) * 2009-06-08 2010-12-08 中兴通讯股份有限公司 中继站管理方法及基站
EP2440555B1 (en) 2009-06-09 2016-05-18 Actelion Pharmaceuticals Ltd Fluorinated aminotriazole derivatives
KR20120046159A (ko) 2009-06-12 2012-05-09 액테리온 파마슈티칼 리미티드 Ａｌｘ 수용체 아고니스트로서의 옥사졸 및 티아졸 유도체
JP2012254939A (ja) * 2009-10-07 2012-12-27 Astellas Pharma Inc オキサゾール化合物

Also Published As

Publication number Publication date
PL2649068T3 (pl) 2015-03-31
SI2649068T1 (sl) 2015-01-30
AU2011340146B2 (en) 2016-05-19
US8846733B2 (en) 2014-09-30
HRP20150049T1 (hr) 2015-02-27
DK2649068T3 (en) 2014-12-08
MX2013006418A (es) 2013-07-15
ES2526132T3 (es) 2015-01-07
CN103261194B (zh) 2016-02-24
KR20130133240A (ko) 2013-12-06
CA2816376A1 (en) 2012-06-14
CN103261194A (zh) 2013-08-21
CA2816376C (en) 2018-11-20
RU2013130879A (ru) 2015-01-20
PT2649068E (pt) 2014-12-23
CY1116004T1 (el) 2017-01-25
TW201305151A (zh) 2013-02-01
RU2588567C2 (ru) 2016-07-10
JP5923107B2 (ja) 2016-05-24
JP2013544878A (ja) 2013-12-19
TWI523853B (zh) 2016-03-01
EP2649068A1 (en) 2013-10-16
AU2011340146A1 (en) 2013-07-25
US20130261159A1 (en) 2013-10-03
WO2012077049A1 (en) 2012-06-14
KR101864463B1 (ko) 2018-06-04
EP2649068B1 (en) 2014-10-29

Similar Documents

Publication Publication Date Title
AR084173A1 (es) Derivados oxazolil-metileter como agonistas del receptor alx
CY1120188T1 (el) ΠΑΡΑΓΩΓΑ ΝΑΦΘΥΡΙΔΙΝΗΣ ΧΡΗΣΙΜΑ ΩΣ ΑΝΤΑΓΩΝΙΣΤΕΣ ΙΝΤΕΓΚΡΙΝΗΣ αvβ6
CO2018004124A2 (es) Compuestos heterocíclicos
MA34389B1 (fr) Nouvelles aminopyrazoloquinazolines
AR101815A1 (es) Compuestos y composiciones como inhibidores de quinasa
PE20142461A1 (es) Moduladores del receptor de estrogeno y sus usos
AR089143A1 (es) Triazolopiridinas sustituidas con actividad inhibidora de ttk
MA38390A1 (fr) Composés tétrahydropyrrolothiazines
CR20140045A (es) Compuestos de n-tio-antranilamida y sus usos como plaguicidas
CU20180144A7 (es) Derivados de carbonucleósidos sustituidos útiles como agentes antineoplásicos
BR112017006251A2 (pt) novos compostos
EA201690019A1 (ru) Производное аминотриазина и содержащая его фармацевтическая композиция
CO6390057A2 (es) Indazoles oxazol sustituidos como inhibidores de pi3-quinasa
MA38472B1 (fr) Composé peptidique
EA201591632A1 (ru) Цитотоксические и антимитотические соединения и способы их применения
AR084172A1 (es) Derivados aminotriazol hidroxilados como agonistas del receptor alx
AR100312A1 (es) Compuestos de diaminotriazina
PE20130155A1 (es) Derivados de ariletinilo
CR20150661A (es) Compuestos de n-(tetrazol-5-il)- y n-(triazol-5-il)arilcarboxamida sustituidos y su uso como herbicidas
AR091519A1 (es) Inhibidores pirrolopirazona de tanquirasa
RS54526B1 (en) USE OF PIRAZOLOSPIROKETONE DERIVATIVES AS ACETYL-COA CARBOXYLASE INHIBITORS
AR093937A1 (es) Compuestos quimicos
AR080703A1 (es) Derivados de 3-(heteroaril-amino)-1,2,3,4-tetrahidro-9h-carbazol, moduladores de receptores de prostaglandina d2, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de trastornos alergicos o inmunitarios tales como asma.
AR095523A1 (es) Derivados piridin-4-ilo
AR094053A1 (es) Derivados de indol carboxamida como antagonistas del receptor p2x₇

Legal Events

Date Code Title Description
FB Suspension of granting procedure