SI2649068T1 - Derivati oksazolil-metiletra kot agonisti alx-receptorja - Google Patents
Derivati oksazolil-metiletra kot agonisti alx-receptorjaInfo
- Publication number
- SI2649068T1 SI2649068T1 SI201130348T SI201130348T SI2649068T1 SI 2649068 T1 SI2649068 T1 SI 2649068T1 SI 201130348 T SI201130348 T SI 201130348T SI 201130348 T SI201130348 T SI 201130348T SI 2649068 T1 SI2649068 T1 SI 2649068T1
- Authority
- SI
- Slovenia
- Prior art keywords
- oxazolyl
- receptor agonists
- alx receptor
- methylether derivatives
- methylether
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2010055616 | 2010-12-07 | ||
| PCT/IB2011/055487 WO2012077049A1 (en) | 2010-12-07 | 2011-12-06 | Oxazolyl-methylether derivatives as alx receptor agonists |
| EP11804810.7A EP2649068B1 (en) | 2010-12-07 | 2011-12-06 | Oxazolyl-methylether derivatives as alx receptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2649068T1 true SI2649068T1 (sl) | 2015-01-30 |
Family
ID=45444667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201130348T SI2649068T1 (sl) | 2010-12-07 | 2011-12-06 | Derivati oksazolil-metiletra kot agonisti alx-receptorja |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8846733B2 (sl) |
| EP (1) | EP2649068B1 (sl) |
| JP (1) | JP5923107B2 (sl) |
| KR (1) | KR101864463B1 (sl) |
| CN (1) | CN103261194B (sl) |
| AR (1) | AR084173A1 (sl) |
| AU (1) | AU2011340146B2 (sl) |
| CA (1) | CA2816376C (sl) |
| CY (1) | CY1116004T1 (sl) |
| DK (1) | DK2649068T3 (sl) |
| ES (1) | ES2526132T3 (sl) |
| HR (1) | HRP20150049T1 (sl) |
| MX (1) | MX2013006418A (sl) |
| PL (1) | PL2649068T3 (sl) |
| PT (1) | PT2649068E (sl) |
| RU (1) | RU2588567C2 (sl) |
| SI (1) | SI2649068T1 (sl) |
| TW (1) | TWI523853B (sl) |
| WO (1) | WO2012077049A1 (sl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2640699B1 (en) | 2010-11-17 | 2015-10-07 | Actelion Pharmaceuticals Ltd. | Bridged spiro[2,4]heptane ester derivatives |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| US9284288B2 (en) | 2012-05-16 | 2016-03-15 | Actelion Pharmaceuticals Ltd. | 1-(p-tolyl) cyclopropyl substituted bridged spiro[2.4]heptane derivatives as ALX receptor agonists |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| RU2016105310A (ru) | 2013-07-18 | 2017-08-23 | Актелион Фармасьютиклз Лтд | Пиперазин-замещенные мостиковые производные спиро[2.4]гептана в качестве агонистов alx рецептора |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| MA39069B1 (fr) | 2013-11-28 | 2018-11-30 | Kyorin Pharmaceutical Co Ltd | Dérivé d'urée ou sel pharmacologiquement acceptable de celui-ci |
| EP3331884B1 (en) | 2015-05-27 | 2020-06-17 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| ES2791340T3 (es) | 2015-05-27 | 2020-11-03 | Kyorin Seiyaku Kk | Derivado de urea o sal farmacológicamente aceptable del mismo |
| WO2018161175A1 (en) * | 2017-03-09 | 2018-09-13 | University Health Network | Lipoxin and lipoxin analogue mediated neuroprotection and treatments |
| PE20210046A1 (es) | 2018-03-05 | 2021-01-08 | Bristol Myers Squibb Co | Agonistas de fenilpirrolidinona del receptor 2 de formil peptido |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234018A (ja) | 1986-04-02 | 1987-10-14 | Rooto Seiyaku Kk | 糖尿病併発症治療剤 |
| KR20030030029A (ko) | 2000-09-22 | 2003-04-16 | 니혼노야쿠가부시키가이샤 | Ｎ-(4-피라졸릴)아미드 유도체 및 농원예용 약제 그리고그 사용방법 |
| WO2003082314A2 (en) | 2002-04-03 | 2003-10-09 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| CA2544983A1 (en) | 2003-11-07 | 2005-05-26 | Acadia Pharmaceuticals Inc. | Use of the lipoxin receptor, fprl1, as a tool for identifying compounds effective in the treatment of pain and inflammation |
| CA2567437A1 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Substituted triazoles as modulators of ppar and methods of their preparation |
| AU2006312083A1 (en) | 2005-11-03 | 2007-05-18 | Merck Sharp & Dohme Corp. | Histone deacetylase inhibitors with aryl-pyrazolyl motifs |
| CA2982520A1 (en) | 2007-08-21 | 2009-02-26 | Senomyx, Inc. | Identification of human t2r receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof |
| AR069650A1 (es) * | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| RU2492167C2 (ru) | 2007-12-18 | 2013-09-10 | Актелион Фармасьютиклз Лтд | Производные аминотриазола в качестве агонистов alх |
| JP5510945B2 (ja) | 2009-05-18 | 2014-06-04 | アクテリオン ファーマシューティカルズ リミテッド | Ａｌｘ受容体及び／又はｆｐｒｌ２アゴニストとしての架橋スピロ［２．４］ヘプタン誘導体 |
| CN101909306A (zh) * | 2009-06-08 | 2010-12-08 | 中兴通讯股份有限公司 | 中继站管理方法及基站 |
| EP2440555B1 (en) | 2009-06-09 | 2016-05-18 | Actelion Pharmaceuticals Ltd | Fluorinated aminotriazole derivatives |
| CN102803237B (zh) * | 2009-06-12 | 2014-09-24 | 埃科特莱茵药品有限公司 | 作为alx受体激动剂的噁唑和噻唑衍生物 |
| JP2012254939A (ja) * | 2009-10-07 | 2012-12-27 | Astellas Pharma Inc | オキサゾール化合物 |
-
2011
- 2011-12-06 US US13/992,143 patent/US8846733B2/en not_active Expired - Fee Related
- 2011-12-06 WO PCT/IB2011/055487 patent/WO2012077049A1/en active Application Filing
- 2011-12-06 JP JP2013542652A patent/JP5923107B2/ja not_active Expired - Fee Related
- 2011-12-06 PL PL11804810T patent/PL2649068T3/pl unknown
- 2011-12-06 AU AU2011340146A patent/AU2011340146B2/en not_active Ceased
- 2011-12-06 EP EP11804810.7A patent/EP2649068B1/en not_active Not-in-force
- 2011-12-06 ES ES11804810.7T patent/ES2526132T3/es active Active
- 2011-12-06 AR ARP110104559A patent/AR084173A1/es unknown
- 2011-12-06 CA CA2816376A patent/CA2816376C/en not_active Expired - Fee Related
- 2011-12-06 TW TW100144916A patent/TWI523853B/zh not_active IP Right Cessation
- 2011-12-06 CN CN201180058458.7A patent/CN103261194B/zh not_active Expired - Fee Related
- 2011-12-06 MX MX2013006418A patent/MX2013006418A/es active IP Right Grant
- 2011-12-06 DK DK11804810.7T patent/DK2649068T3/en active
- 2011-12-06 PT PT118048107T patent/PT2649068E/pt unknown
- 2011-12-06 KR KR1020137017686A patent/KR101864463B1/ko active IP Right Grant
- 2011-12-06 RU RU2013130879/04A patent/RU2588567C2/ru not_active IP Right Cessation
- 2011-12-06 SI SI201130348T patent/SI2649068T1/sl unknown
-
2015
- 2015-01-13 HR HRP20150049AT patent/HRP20150049T1/hr unknown
- 2015-01-23 CY CY20151100075T patent/CY1116004T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20150049T1 (hr) | 2015-02-27 |
| EP2649068A1 (en) | 2013-10-16 |
| WO2012077049A1 (en) | 2012-06-14 |
| PT2649068E (pt) | 2014-12-23 |
| JP5923107B2 (ja) | 2016-05-24 |
| JP2013544878A (ja) | 2013-12-19 |
| AU2011340146A1 (en) | 2013-07-25 |
| CN103261194A (zh) | 2013-08-21 |
| KR20130133240A (ko) | 2013-12-06 |
| US8846733B2 (en) | 2014-09-30 |
| MX2013006418A (es) | 2013-07-15 |
| TWI523853B (zh) | 2016-03-01 |
| AU2011340146B2 (en) | 2016-05-19 |
| CY1116004T1 (el) | 2017-01-25 |
| TW201305151A (zh) | 2013-02-01 |
| CA2816376C (en) | 2018-11-20 |
| ES2526132T3 (es) | 2015-01-07 |
| CN103261194B (zh) | 2016-02-24 |
| KR101864463B1 (ko) | 2018-06-04 |
| CA2816376A1 (en) | 2012-06-14 |
| AR084173A1 (es) | 2013-04-24 |
| US20130261159A1 (en) | 2013-10-03 |
| PL2649068T3 (pl) | 2015-03-31 |
| EP2649068B1 (en) | 2014-10-29 |
| RU2013130879A (ru) | 2015-01-20 |
| DK2649068T3 (en) | 2014-12-08 |
| RU2588567C2 (ru) | 2016-07-10 |
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