EA201591632A1 - Цитотоксические и антимитотические соединения и способы их применения - Google Patents

Цитотоксические и антимитотические соединения и способы их применения

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Publication number
EA201591632A1
EA201591632A1 EA201591632A EA201591632A EA201591632A1 EA 201591632 A1 EA201591632 A1 EA 201591632A1 EA 201591632 A EA201591632 A EA 201591632A EA 201591632 A EA201591632 A EA 201591632A EA 201591632 A1 EA201591632 A1 EA 201591632A1
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EA
Eurasian Patent Office
Prior art keywords
cytotoxic
methods
compounds
application
antimitotic compounds
Prior art date
Application number
EA201591632A
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English (en)
Other versions
EA029818B8 (ru
EA029818B1 (ru
Inventor
Джофри С. Уинтерс
Александер Лоренс Мандел
Джеймс Р. Рич
Бредли Джон Хедберг
Том Хан Хсяо Хсих
Элис Мари Хосе Бурк
Джон Бабкук
Original Assignee
Зе Сентр Фор Драг Рисеч Энд Дивелопмент
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Application filed by Зе Сентр Фор Драг Рисеч Энд Дивелопмент filed Critical Зе Сентр Фор Драг Рисеч Энд Дивелопмент
Publication of EA201591632A1 publication Critical patent/EA201591632A1/ru
Publication of EA029818B1 publication Critical patent/EA029818B1/ru
Publication of EA029818B8 publication Critical patent/EA029818B8/ru

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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

Описываются соединения, имеющие цитотоксическую и/или антимитотическую активность. Описываются способы, связанные с получением и применением таких соединений, так же как и фармацевтические композиции, содержащие такие соединения. Также описываются композиции, имеющие структуру: (T)-(L)-(D), где (Т) представляет собой нацеливающий фрагмент, (L) представляет собой необязательный линкер и (D) представляет собой соединение, имеющее цитотоксическую и/или антимитотическую активность.
EA201591632A 2013-03-15 2014-03-14 Цитотоксические и антимитотические соединения и способы их применения EA029818B8 (ru)

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