ES8504461A1 - Un procedimiento para obtener un polidoma. - Google Patents

Un procedimiento para obtener un polidoma.

Info

Publication number
ES8504461A1
ES8504461A1 ES521370A ES521370A ES8504461A1 ES 8504461 A1 ES8504461 A1 ES 8504461A1 ES 521370 A ES521370 A ES 521370A ES 521370 A ES521370 A ES 521370A ES 8504461 A1 ES8504461 A1 ES 8504461A1
Authority
ES
Spain
Prior art keywords
antibodies
preparation
uses therefor
polydomas
target antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES521370A
Other languages
English (en)
Other versions
ES521370A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of ES8504461A1 publication Critical patent/ES8504461A1/es
Publication of ES521370A0 publication Critical patent/ES521370A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

PROCEDIMIENTO PARA OBTENER UN POLIDOMA.CONSISTE EN FUSIONAR UN HIBRIDOMA QUE PRODUCE UN ANTICUERPO MONOCLONAL CONTRA UN PRIMER DETERMINANTE ANTIGENICO CON UN LINFOCITO B QUE SEGREGA UN ANTICUERPO MONOCLONAL CONTRA UN SEGUNDO DETERMINANTE ANTIGENICO EN PRESENCIA DE UN AGENTE PROMOTOR DE LA FUSION. EL HIBRIDOMA ES SOMETIDO A RETRO-SELECCION QUE SE REALIZA POR CULTIVO DE CELULAS DE HIBRIDOMA EN UN MEDIO QUE COMPRENDE UN MIEMBRO DEL GRUPO CONSTITUIDO POR 8-AZAGUANINA, 6-TIOGUANINA, 5-BROMOURACIL-DESOXIRRIBOSA O 2-AMINOPURINA, CON LO QUE SE OBTIENEN CELULAS DE HIBRIDOMA SENSIBLES A UN MEDIO QUE CONTIENE HIPOXANTINA-AMINOPTERINA-TIMIDINA.TIENE APLICACION COMO ANTICUERPOS CON ESPECIFICACIONES DUALES.
ES521370A 1982-04-12 1983-04-11 Un procedimiento para obtener un polidoma. Granted ES521370A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36778482A 1982-04-12 1982-04-12

Publications (2)

Publication Number Publication Date
ES8504461A1 true ES8504461A1 (es) 1985-04-16
ES521370A0 ES521370A0 (es) 1985-04-16

Family

ID=23448582

Family Applications (7)

Application Number Title Priority Date Filing Date
ES521370A Granted ES521370A0 (es) 1982-04-12 1983-04-11 Un procedimiento para obtener un polidoma.
ES527963A Granted ES527963A0 (es) 1982-04-12 1983-12-12 Un procedimiento de inmunoensayo
ES533931A Expired ES8506091A1 (es) 1982-04-12 1984-07-02 Un procedimiento para obtener un polidoma
ES533930A Granted ES533930A0 (es) 1982-04-12 1984-07-02 Un procedimiento para obtener un polidoma
ES537257A Expired ES8606655A1 (es) 1982-04-12 1984-10-31 Un procedimiento de inmunoensayo
ES538727A Expired ES8604424A1 (es) 1982-04-12 1984-12-18 Un procedimiento para obtener un hibridoma selectivamente destructible (como divisional de la solicitud de patente de invencion num 521370 presentada el 11 de abril de 1983
ES545247A Expired ES8607386A1 (es) 1982-04-12 1985-07-16 Un procedimiento para obtener un polidoma

Family Applications After (6)

Application Number Title Priority Date Filing Date
ES527963A Granted ES527963A0 (es) 1982-04-12 1983-12-12 Un procedimiento de inmunoensayo
ES533931A Expired ES8506091A1 (es) 1982-04-12 1984-07-02 Un procedimiento para obtener un polidoma
ES533930A Granted ES533930A0 (es) 1982-04-12 1984-07-02 Un procedimiento para obtener un polidoma
ES537257A Expired ES8606655A1 (es) 1982-04-12 1984-10-31 Un procedimiento de inmunoensayo
ES538727A Expired ES8604424A1 (es) 1982-04-12 1984-12-18 Un procedimiento para obtener un hibridoma selectivamente destructible (como divisional de la solicitud de patente de invencion num 521370 presentada el 11 de abril de 1983
ES545247A Expired ES8607386A1 (es) 1982-04-12 1985-07-16 Un procedimiento para obtener un polidoma

Country Status (11)

Country Link
EP (1) EP0105360A4 (es)
JP (2) JPH0753119B2 (es)
AT (1) AT394577B (es)
AU (1) AU550486B2 (es)
CA (1) CA1213229A (es)
CH (1) CH672796A5 (es)
ES (7) ES521370A0 (es)
FI (1) FI834529A (es)
GB (4) GB2128631B (es)
IT (1) IT1219778B (es)
WO (1) WO1983003679A1 (es)

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JP3177776B2 (ja) * 1988-09-27 2001-06-18 武田薬品工業株式会社 ハイブリッドモノクローナル抗体，抗体産生ポリドーマおよび抗体含有薬剤
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
EP0467416A1 (en) * 1983-09-01 1992-01-22 Hybritech Incorporated Antibody compositions of therapeutic agents having an extended serum half-life
ATE64622T1 (de) * 1984-04-23 1991-07-15 Boston Biomed Res Inst Doppelspezifische antikoerper-determinanten.
NL8501219A (nl) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic Immunologisch complex, de bereiding en toepassing daarvan.
WO1987006240A1 (en) 1986-04-14 1987-10-22 The General Hospital Corporation Heterobifunctional antibodies and method of use
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
FR2604092B1 (fr) * 1986-09-19 1990-04-13 Immunotech Sa Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies
GB8626413D0 (en) * 1986-11-05 1986-12-03 Gilliland L K Antibodies
US5053226A (en) * 1987-07-15 1991-10-01 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
EP0308936B1 (en) * 1987-09-23 1994-07-06 Bristol-Myers Squibb Company Antibody heteroconjugates for the killing of HIV-infected cells
GB2218100A (en) * 1988-03-02 1989-11-08 Erling Sundrehagen Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
JPH02196799A (ja) * 1988-04-08 1990-08-03 Agency Of Ind Science & Technol 抗ヒト癌蛋白複合体
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
IT1235349B (it) * 1988-12-23 1992-06-30 Biodata Spa Saggio immunologico per determinazioni in fase omogenea
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) * 1989-03-30 1990-10-18 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
FR2652004B1 (fr) * 1989-09-21 1994-10-28 Immunotech Partners Nouveaux derives hydrophiles, application au diagnostic et a la therapeutique, kits diagnostiques ou therapeutiques et reactifs immunologiques.
DE69130561T2 (de) * 1990-02-16 1999-06-24 Boston Biomed Res Inst Hybride Reagenzien mit der Fähigkeit, Moleküle selektiv in Zellen freizusetzen
TW212184B (es) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
WO1992019973A1 (en) * 1991-04-26 1992-11-12 Surface Active Limited Novel antibodies, and methods for their use
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) * 1994-10-18 1994-12-07 Surface Active Ltd Biosensor
EP0937146A2 (en) * 1996-09-20 1999-08-25 The General Hospital Corporation Composition and method for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin
US20020132274A1 (en) 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
ES2556641T3 (es) 2002-07-31 2016-01-19 Seattle Genetics, Inc. Conjugados de fármacos y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa
BR122018071808B8 (pt) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugado
JP4918476B2 (ja) 2004-03-16 2012-04-18 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 増殖性疾患を治療するための置換フェノキシ−及びフェニルチオ−誘導体
JP2008519863A (ja) 2004-11-12 2008-06-12 シアトル ジェネティクス インコーポレイティッド Ｎ末端にアミノ安息香酸単位を有するオーリスタチン
ES2477765T3 (es) 2005-04-19 2014-07-17 Seattle Genetics, Inc. Agentes de unión al anti-cd70 humanizado y usos de los mismos
SI3248613T1 (sl) 2005-07-18 2022-04-29 Seagen Inc. Konjugati beta-glukuronidni linker-zdravilo
US8455622B2 (en) 2006-12-01 2013-06-04 Seattle Genetics, Inc. Variant target binding agents and uses thereof
NZ577933A (en) 2007-01-22 2011-12-22 Genentech Inc Polyelectrolyte precipitation and purification of antibodies
CN102076865B (zh) 2008-05-02 2016-03-16 西雅图基因公司 用于制造核心岩藻糖基化降低的抗体和抗体衍生物的方法和组合物
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CA2906784C (en) 2013-03-15 2023-02-28 The Centre For Drug Research And Development Cytotoxic and anti-mitotic compounds, and methods of using the same
WO2015053381A1 (ja) * 2013-10-10 2015-04-16 幸成 加藤 抗ポドプラニン抗体
CN106255513B (zh) 2013-12-27 2022-01-14 酵活有限公司 用于药物偶联物的含磺酰胺连接系统
RU2723651C2 (ru) 2014-09-17 2020-06-17 Займворкс Инк. Цитотоксические и антимитотические соединения и способы их применения
JP6412906B2 (ja) 2015-11-03 2018-10-24 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 化合物、リンカー−薬物およびリガンド−薬物複合体
UA125510C2 (uk) 2016-03-25 2022-04-13 Сіджен Інк. Спосіб отримання пегильованої сполуки лікарський препарат-лінкер, де лікарським препаратом є ауристатин, та її проміжних сполук
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
EP3600443A1 (en) 2017-03-24 2020-02-05 Seattle Genetics, Inc. Process for the preparation of glucuronide drug-linkers and intermediates thereof
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
EP3847195A4 (en) * 2018-08-30 2022-09-07 Innovative Cellular Therapeutics Holdings, Ltd. CHEMERA ANTIGEN RECEPTOR CELLS FOR SOLID TUMOR TREATMENT
SG11202112223XA (en) 2019-05-10 2021-12-30 Takeda Pharmaceuticals Co Antibody drug conjugates
TW202138388A (zh) 2019-12-30 2021-10-16 美商西根公司 以非海藻糖苷化抗－ｃｄ７０抗體治療癌症之方法
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US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies

Also Published As

Publication number Publication date
ES8607386A1 (es) 1986-05-16
IT8320548A0 (it) 1983-04-12
ATA901883A (de) 1991-10-15
ES8604424A1 (es) 1986-02-01
ES533931A0 (es) 1985-06-16
JPS6312276A (ja) 1988-01-19
CA1213229A (en) 1986-10-28
CH672796A5 (es) 1989-12-29
JPH0753600A (ja) 1995-02-28
WO1983003679A1 (en) 1983-10-27
JP2562002B2 (ja) 1996-12-11
IT1219778B (it) 1990-05-24
FI834529A0 (fi) 1983-12-09
AU1555983A (en) 1983-11-04
FI834529A (fi) 1983-12-09
ES8603080A1 (es) 1985-12-01
GB2169921A (en) 1986-07-23
ES538727A0 (es) 1986-02-01
GB8530310D0 (en) 1986-01-22
GB2168998B (en) 1987-03-04
GB8530308D0 (en) 1986-01-22
ES8606655A1 (es) 1986-04-01
GB8530309D0 (en) 1986-01-22
GB2167086A (en) 1986-05-21
ES545247A0 (es) 1986-05-16
GB8332646D0 (en) 1984-01-11
JPH0753119B2 (ja) 1995-06-07
AU550486B2 (en) 1986-03-20
EP0105360A1 (en) 1984-04-18
ES533930A0 (es) 1985-12-01
EP0105360A4 (en) 1986-07-08
ES537257A0 (es) 1986-04-01
ES521370A0 (es) 1985-04-16
GB2128631B (en) 1987-02-25
GB2128631A (en) 1984-05-02
GB2167086B (en) 1987-03-04
ES8503441A1 (es) 1985-02-16
AT394577B (de) 1992-05-11
ES8506091A1 (es) 1985-06-16
GB2168998A (en) 1986-07-02
GB2169921B (en) 1987-03-04
ES527963A0 (es) 1985-02-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401