GB2128631A - Antibodies having dual specificities their preparation and uses therefor - Google Patents

Antibodies having dual specificities their preparation and uses therefor

Info

Publication number
GB2128631A
GB2128631A GB08332646A GB8332646A GB2128631A GB 2128631 A GB2128631 A GB 2128631A GB 08332646 A GB08332646 A GB 08332646A GB 8332646 A GB8332646 A GB 8332646A GB 2128631 A GB2128631 A GB 2128631A
Authority
GB
United Kingdom
Prior art keywords
antibodies
preparation
uses therefor
polydomas
target antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB08332646A
Other versions
GB2128631B (en
GB8332646D0 (en
Inventor
Joanne Martinis
Richard M Bartholomew
Gary S David
Thomas H Adams
James M Frincke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of GB8332646D0 publication Critical patent/GB8332646D0/en
Publication of GB2128631A publication Critical patent/GB2128631A/en
Application granted granted Critical
Publication of GB2128631B publication Critical patent/GB2128631B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Described herein are "polydomas", the product of the fusion of a hybridoma with a B-lymphocyte or another hybridoma. The polydomas produce a hybrid monoclonal antibody having a dual specificity against two different antigenic determinants. Also described are immunodiagnostic and immunotherapeutic processes which utilize the hybrid monoclonal antibodies or other antibodies having a dual specificity. In those processes, one specificity of the antibody is directed against a target antigen and the other against a moiety which permits a diagnosis to be made or which delivers an agent lethal to the target antigen or associated tissue.
GB08332646A 1982-04-12 1983-04-12 Antibodies having dual specificities their preparation and uses therefor Expired GB2128631B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36778482A 1982-04-12 1982-04-12
PCT/US1983/000525 WO1983003679A1 (en) 1982-04-12 1983-04-12 Antibodies having dual specificities, their preparation and uses therefor

Publications (3)

Publication Number Publication Date
GB8332646D0 GB8332646D0 (en) 1984-01-11
GB2128631A true GB2128631A (en) 1984-05-02
GB2128631B GB2128631B (en) 1987-02-25

Family

ID=23448582

Family Applications (4)

Application Number Title Priority Date Filing Date
GB08332646A Expired GB2128631B (en) 1982-04-12 1983-04-12 Antibodies having dual specificities their preparation and uses therefor
GB08530310A Expired GB2167086B (en) 1982-04-12 1985-12-09 Antibodies having dual specificities, their preparation and uses therefor
GB08530309A Expired GB2169921B (en) 1982-04-12 1985-12-09 Antibodies having dual specificities, their preparation and uses therefor
GB08530308A Expired GB2168998B (en) 1982-04-12 1985-12-09 Antibodies having dual specificities, their preparation and uses therefor

Family Applications After (3)

Application Number Title Priority Date Filing Date
GB08530310A Expired GB2167086B (en) 1982-04-12 1985-12-09 Antibodies having dual specificities, their preparation and uses therefor
GB08530309A Expired GB2169921B (en) 1982-04-12 1985-12-09 Antibodies having dual specificities, their preparation and uses therefor
GB08530308A Expired GB2168998B (en) 1982-04-12 1985-12-09 Antibodies having dual specificities, their preparation and uses therefor

Country Status (11)

Country Link
EP (1) EP0105360A4 (en)
JP (2) JPH0753119B2 (en)
AT (1) AT394577B (en)
AU (1) AU550486B2 (en)
CA (1) CA1213229A (en)
CH (1) CH672796A5 (en)
ES (7) ES8504461A1 (en)
FI (1) FI834529A0 (en)
GB (4) GB2128631B (en)
IT (1) IT1219778B (en)
WO (1) WO1983003679A1 (en)

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JP3177776B2 (en) * 1988-09-27 2001-06-18 武田薬品工業株式会社 Hybrid monoclonal antibodies, antibody-producing polydomas and antibody-containing drugs
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
EP0467416A1 (en) * 1983-09-01 1992-01-22 Hybritech Incorporated Antibody compositions of therapeutic agents having an extended serum half-life
ATE64622T1 (en) * 1984-04-23 1991-07-15 Boston Biomed Res Inst DOUBLE SPECIFIC ANTIBODY DETERMINANTS.
NL8501219A (en) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic IMMUNOLOGICAL COMPLEX, ITS PREPARATION AND APPLICATION.
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
JP2635343B2 (en) 1986-04-14 1997-07-30 ザ・ジェネラル・ホスピタル・コーポレーション Heterobifunctional antibodies and methods of use
FR2604092B1 (en) * 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies
GB8626413D0 (en) * 1986-11-05 1986-12-03 Gilliland L K Antibodies
US5053226A (en) * 1987-07-15 1991-10-01 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
JP2755395B2 (en) * 1987-09-23 1998-05-20 ブリストル―マイアーズ スクイブ コムパニー Antibody heteroconjugate that kills HIV-infected cells
GB2218100A (en) * 1988-03-02 1989-11-08 Erling Sundrehagen Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
JPH02196799A (en) * 1988-04-08 1990-08-03 Agency Of Ind Science & Technol Complex of anti-human cancer protein
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
IT1235349B (en) * 1988-12-23 1992-06-30 Biodata Spa IMMUNOLOGICAL TEST FOR HOMOGENEOUS DETERMINATIONS
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) * 1989-03-30 1990-10-18 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
FR2652004B1 (en) * 1989-09-21 1994-10-28 Immunotech Partners NOVEL HYDROPHILIC DERIVATIVES, APPLICATION TO DIAGNOSIS AND THERAPEUTICS, DIAGNOSTIC OR THERAPEUTIC KITS AND IMMUNOLOGICAL REAGENTS.
DE69130561T2 (en) * 1990-02-16 1999-06-24 Boston Biomed Res Inst Hybrid reagents with the ability to selectively release molecules into cells
TW212184B (en) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
AP257A (en) * 1991-04-26 1993-06-03 Surface Active Ltd A method of releasing an antigen from an antibody and methods for their use in diagnosis and therapy.
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) * 1994-10-18 1994-12-07 Surface Active Ltd Biosensor
JP2001502895A (en) * 1996-09-20 2001-03-06 ザ・ジェネラル・ホスピタル・コーポレイション Chimeric, humanized and single chain antibodies to alpha-2-antiplasmin
US20020132274A1 (en) 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
WO2004010957A2 (en) 2002-07-31 2004-02-05 Seattle Genetics, Inc. Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
BR122018071808B8 (en) 2003-11-06 2020-06-30 Seattle Genetics Inc conjugate
EA012980B1 (en) 2004-03-16 2010-02-26 Темпл Юниверсити Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн Substituted phenoxy- and phenylthio-derivatives for treating proliferative disorders
ES2715776T3 (en) 2004-11-12 2019-06-06 Seattle Genetics Inc Auristatins that have an aminobenzoic acid unit at the N-terminus
AU2006236225C1 (en) 2005-04-19 2013-05-02 Seagen Inc. Humanized anti-CD70 binding agents and uses thereof
HUE057936T2 (en) 2005-07-18 2022-06-28 Seagen Inc Beta-glucuronide drug linker conjugates
ES2523915T5 (en) 2006-12-01 2022-05-26 Seagen Inc Variant Target Binding Agents and Uses Thereof
AU2008209404B2 (en) 2007-01-22 2012-08-16 Genentech, Inc. Polyelectrolyte precipitation and purification of antibodies
CA2723197C (en) 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
JP6431038B2 (en) 2013-03-15 2018-11-28 ザイムワークス インコーポレイティド Cytotoxic and antimitotic compounds and methods of use
JP6473418B2 (en) * 2013-10-10 2019-02-20 幸成 加藤 Anti-podopranin antibody
KR102384740B1 (en) 2013-12-27 2022-04-07 자임워크스 인코포레이티드 Sulfonamide-containing linkage systems for drug conjugates
HUE057768T2 (en) 2014-09-17 2022-06-28 Zymeworks Inc Cytotoxic and anti-mitotic compounds, and methods of using the same
EP3165532B1 (en) 2015-11-03 2018-12-19 Industrial Technology Research Institute Auristatin derivatives, linker-drugs and ligand-drug conjugates
SG11201807827VA (en) 2016-03-25 2018-10-30 Seattle Genetics Inc Process for the preparation of pegylated drug-linkers and intermediates thereof
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
IL269398B2 (en) 2017-03-24 2024-05-01 Seagen Inc Process for the preparation of glucuronide drug-linkers and intermediates thereof
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
EP3847195A4 (en) * 2018-08-30 2022-09-07 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
TW202108177A (en) 2019-05-10 2021-03-01 日商武田藥品工業股份有限公司 Antibody drug conjugates
TW202138388A (en) 2019-12-30 2021-10-16 美商西根公司 Methods of treating cancer with nonfucosylated anti-cd70 antibodies
US20220168330A1 (en) 2020-11-09 2022-06-02 Takeda Pharmaceutical Company Limited Antibody drug conjugates
KR20240025597A (en) 2021-06-29 2024-02-27 씨젠 인크. Methods of treating cancer with a combination of afucosylated anti-CD70 antibody and CD47 antagonist

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US4130634A (en) * 1974-03-15 1978-12-19 University Of Illinois Foundation Method for detecting and quantifying antigens
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies

Also Published As

Publication number Publication date
GB2169921B (en) 1987-03-04
GB8530309D0 (en) 1986-01-22
ES521370A0 (en) 1985-04-16
ES537257A0 (en) 1986-04-01
ES8604424A1 (en) 1986-02-01
JPH0753600A (en) 1995-02-28
ES533930A0 (en) 1985-12-01
ES8504461A1 (en) 1985-04-16
GB2128631B (en) 1987-02-25
JPH0753119B2 (en) 1995-06-07
FI834529A (en) 1983-12-09
ES8603080A1 (en) 1985-12-01
GB8530310D0 (en) 1986-01-22
ATA901883A (en) 1991-10-15
GB2167086B (en) 1987-03-04
GB2168998A (en) 1986-07-02
ES8606655A1 (en) 1986-04-01
CA1213229A (en) 1986-10-28
ES8506091A1 (en) 1985-06-16
IT1219778B (en) 1990-05-24
GB8332646D0 (en) 1984-01-11
GB2168998B (en) 1987-03-04
IT8320548A0 (en) 1983-04-12
ES538727A0 (en) 1986-02-01
ES545247A0 (en) 1986-05-16
FI834529A0 (en) 1983-12-09
EP0105360A1 (en) 1984-04-18
AU550486B2 (en) 1986-03-20
ES8503441A1 (en) 1985-02-16
EP0105360A4 (en) 1986-07-08
AU1555983A (en) 1983-11-04
ES533931A0 (en) 1985-06-16
AT394577B (en) 1992-05-11
CH672796A5 (en) 1989-12-29
ES8607386A1 (en) 1986-05-16
GB2167086A (en) 1986-05-21
JP2562002B2 (en) 1996-12-11
GB2169921A (en) 1986-07-23
WO1983003679A1 (en) 1983-10-27
ES527963A0 (en) 1985-02-16
JPS6312276A (en) 1988-01-19
GB8530308D0 (en) 1986-01-22

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930412