ES8503441A1 - Antibodies having dual specificities, their preparation and uses therefor. - Google Patents

Antibodies having dual specificities, their preparation and uses therefor.

Info

Publication number
ES8503441A1
ES8503441A1 ES527963A ES527963A ES8503441A1 ES 8503441 A1 ES8503441 A1 ES 8503441A1 ES 527963 A ES527963 A ES 527963A ES 527963 A ES527963 A ES 527963A ES 8503441 A1 ES8503441 A1 ES 8503441A1
Authority
ES
Spain
Prior art keywords
antibodies
preparation
uses therefor
polydomas
target antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527963A
Other languages
Spanish (es)
Other versions
ES527963A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of ES527963A0 publication Critical patent/ES527963A0/en
Publication of ES8503441A1 publication Critical patent/ES8503441A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • C07K16/468Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Abstract

Described herein are "polydomas", the product of the fusion of a hybridoma with a B-lymphocyte or another hybridoma. The polydomas produce a hybrid monoclonal antibody having a dual specificity against two different antigenic determinants. Also described are immunodiagnostic and immunotherapeutic processes which utilize the hybrid monoclonal antibodies or other antibodies having a dual specificity. In those processes, one specificity of the antibody is directed against a target antigen and the other against a moiety which permits a diagnosis to be made or which delivers an agent lethal to the target antigen or associated tissue.
ES527963A 1982-04-12 1983-12-12 Antibodies having dual specificities, their preparation and uses therefor. Expired ES8503441A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36778482A 1982-04-12 1982-04-12

Publications (2)

Publication Number Publication Date
ES527963A0 ES527963A0 (en) 1985-02-16
ES8503441A1 true ES8503441A1 (en) 1985-02-16

Family

ID=23448582

Family Applications (7)

Application Number Title Priority Date Filing Date
ES521370A Granted ES521370A0 (en) 1982-04-12 1983-04-11 A PROCEDURE FOR OBTAINING A POLYDOMA.
ES527963A Expired ES8503441A1 (en) 1982-04-12 1983-12-12 Antibodies having dual specificities, their preparation and uses therefor.
ES533931A Granted ES533931A0 (en) 1982-04-12 1984-07-02 A PROCEDURE FOR OBTAINING A POLYDOMA
ES533930A Expired ES8603080A1 (en) 1982-04-12 1984-07-02 Antibodies having dual specificities, their preparation and uses therefor.
ES537257A Expired ES8606655A1 (en) 1982-04-12 1984-10-31 Antibodies having dual specificities, their preparation and uses therefor.
ES538727A Expired ES8604424A1 (en) 1982-04-12 1984-12-18 Antibodies having dual specificities, their preparation and uses therefor.
ES545247A Expired ES8607386A1 (en) 1982-04-12 1985-07-16 Antibodies having dual specificities, their preparation and uses therefor.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES521370A Granted ES521370A0 (en) 1982-04-12 1983-04-11 A PROCEDURE FOR OBTAINING A POLYDOMA.

Family Applications After (5)

Application Number Title Priority Date Filing Date
ES533931A Granted ES533931A0 (en) 1982-04-12 1984-07-02 A PROCEDURE FOR OBTAINING A POLYDOMA
ES533930A Expired ES8603080A1 (en) 1982-04-12 1984-07-02 Antibodies having dual specificities, their preparation and uses therefor.
ES537257A Expired ES8606655A1 (en) 1982-04-12 1984-10-31 Antibodies having dual specificities, their preparation and uses therefor.
ES538727A Expired ES8604424A1 (en) 1982-04-12 1984-12-18 Antibodies having dual specificities, their preparation and uses therefor.
ES545247A Expired ES8607386A1 (en) 1982-04-12 1985-07-16 Antibodies having dual specificities, their preparation and uses therefor.

Country Status (11)

Country Link
EP (1) EP0105360A4 (en)
JP (2) JPH0753119B2 (en)
AT (1) AT394577B (en)
AU (1) AU550486B2 (en)
CA (1) CA1213229A (en)
CH (1) CH672796A5 (en)
ES (7) ES521370A0 (en)
FI (1) FI834529A (en)
GB (4) GB2128631B (en)
IT (1) IT1219778B (en)
WO (1) WO1983003679A1 (en)

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JP3177776B2 (en) * 1988-09-27 2001-06-18 武田薬品工業株式会社 Hybrid monoclonal antibodies, antibody-producing polydomas and antibody-containing drugs
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
IL70686A (en) * 1983-01-20 1988-07-31 Suntory Ltd Mutant tumor cell lines for use in the preparation of hybridomas and the hybridomas obtained therefrom
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
EP0467416A1 (en) * 1983-09-01 1992-01-22 Hybritech Incorporated Antibody compositions of therapeutic agents having an extended serum half-life
EP0179872B1 (en) * 1984-04-23 1991-06-19 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
NL8501219A (en) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic IMMUNOLOGICAL COMPLEX, ITS PREPARATION AND APPLICATION.
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
EP0241907A3 (en) 1986-04-14 1989-09-13 The General Hospital Corporation Heterobifunctional antibodies and method of use
FR2604092B1 (en) * 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
GB8626413D0 (en) * 1986-11-05 1986-12-03 Gilliland L K Antibodies
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies
US5053226A (en) * 1987-07-15 1991-10-01 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
EP0308936B1 (en) * 1987-09-23 1994-07-06 Bristol-Myers Squibb Company Antibody heteroconjugates for the killing of HIV-infected cells
GB2218100A (en) * 1988-03-02 1989-11-08 Erling Sundrehagen Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
JPH02196799A (en) * 1988-04-08 1990-08-03 Agency Of Ind Science & Technol Complex of anti-human cancer protein
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
IT1235349B (en) * 1988-12-23 1992-06-30 Biodata Spa IMMUNOLOGICAL TEST FOR HOMOGENEOUS DETERMINATIONS
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) * 1989-03-30 1990-10-18 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
FR2652004B1 (en) * 1989-09-21 1994-10-28 Immunotech Partners NOVEL HYDROPHILIC DERIVATIVES, APPLICATION TO DIAGNOSIS AND THERAPEUTICS, DIAGNOSTIC OR THERAPEUTIC KITS AND IMMUNOLOGICAL REAGENTS.
CA2075927A1 (en) * 1990-02-16 1991-08-17 Victor A. Raso Hybrid reagents capable of selectively releasing molecules into cells
TW212184B (en) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
ES2093778T3 (en) * 1991-04-26 1997-01-01 Surface Active Ltd NEW ANTIBODIES AND METHODS FOR USE.
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) * 1994-10-18 1994-12-07 Surface Active Ltd Biosensor
JP2001515345A (en) * 1996-09-20 2001-09-18 ザ・ジェネラル・ホスピタル・コーポレイション Compositions and methods for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin
US20020132274A1 (en) 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
ATE516818T1 (en) 2002-07-31 2011-08-15 Seattle Genetics Inc AURISTATIN CONJUGATES AND THEIR USE IN THE TREATMENT OF CANCER, AN AUTOIMMUNE DISEASE OR AN INFECTIOUS DISEASE
EP2486933B1 (en) 2003-11-06 2015-10-28 Seattle Genetics, Inc. Monomethylvaline compounds conjugated with antibodies
EA200901236A1 (en) 2004-03-16 2009-12-30 Темпл Юниверсити - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн SUBSTITUTED PHENOXY AND PHENYL DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISTURBANCES
AU2005332660A1 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the N terminus
AU2006236225C1 (en) 2005-04-19 2013-05-02 Seagen Inc. Humanized anti-CD70 binding agents and uses thereof
LT1912671T (en) 2005-07-18 2017-12-11 Seattle Genetics, Inc. Beta-glucuronide-linker drug conjugates
ES2523915T5 (en) 2006-12-01 2022-05-26 Seagen Inc Variant Target Binding Agents and Uses Thereof
ZA200904482B (en) 2007-01-22 2010-09-29 Genentech Inc Polyelectrolyte precipitation and purification of antibodies
PL2282773T3 (en) 2008-05-02 2014-08-29 Seattle Genetics Inc Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
WO2014089177A2 (en) 2012-12-04 2014-06-12 Massachusetts Institute Of Technology Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines
EA029818B8 (en) 2013-03-15 2018-09-28 Займворкс Инк. Cytotoxic and anti-mitotic compounds and methods of using the same
WO2015053381A1 (en) * 2013-10-10 2015-04-16 幸成 加藤 Anti-podoplanin antibody
US11560422B2 (en) 2013-12-27 2023-01-24 Zymeworks Inc. Sulfonamide-containing linkage systems for drug conjugates
SG11201702143PA (en) 2014-09-17 2017-04-27 Zymeworks Inc Cytotoxic and anti-mitotic compounds, and methods of using the same
US10618935B2 (en) 2015-11-03 2020-04-14 Industrial Technology Research Institute Antibody-drug conjugate (ADC) and method for forming the same
WO2017165851A1 (en) 2016-03-25 2017-09-28 Seattle Genetics, Inc. Process for the preparation of pegylated drug-linkers and intermediates thereof
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
EP3600443A1 (en) 2017-03-24 2020-02-05 Seattle Genetics, Inc. Process for the preparation of glucuronide drug-linkers and intermediates thereof
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
AU2019327490A1 (en) * 2018-08-30 2021-03-25 Innovative Cellular Therapeutics Holdings, Ltd. Chimeric antigen receptor cells for treating solid tumor
KR20220006519A (en) 2019-05-10 2022-01-17 다케다 야쿠힌 고교 가부시키가이샤 antibody drug conjugate
TW202138388A (en) 2019-12-30 2021-10-16 美商西根公司 Methods of treating cancer with nonfucosylated anti-cd70 antibodies
JP7397996B2 (en) 2020-11-09 2023-12-13 武田薬品工業株式会社 antibody drug conjugate
TW202317190A (en) 2021-06-29 2023-05-01 美商思進公司 Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
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US4130634A (en) * 1974-03-15 1978-12-19 University Of Illinois Foundation Method for detecting and quantifying antigens
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies

Also Published As

Publication number Publication date
GB2169921A (en) 1986-07-23
GB8530309D0 (en) 1986-01-22
CH672796A5 (en) 1989-12-29
ES8607386A1 (en) 1986-05-16
JP2562002B2 (en) 1996-12-11
ES538727A0 (en) 1986-02-01
FI834529A0 (en) 1983-12-09
AU550486B2 (en) 1986-03-20
GB2168998B (en) 1987-03-04
GB8332646D0 (en) 1984-01-11
ES8504461A1 (en) 1985-04-16
WO1983003679A1 (en) 1983-10-27
ES533930A0 (en) 1985-12-01
ES545247A0 (en) 1986-05-16
EP0105360A1 (en) 1984-04-18
EP0105360A4 (en) 1986-07-08
ES8506091A1 (en) 1985-06-16
GB2128631A (en) 1984-05-02
ES527963A0 (en) 1985-02-16
ES8604424A1 (en) 1986-02-01
ES521370A0 (en) 1985-04-16
GB2169921B (en) 1987-03-04
GB2128631B (en) 1987-02-25
ES533931A0 (en) 1985-06-16
JPH0753119B2 (en) 1995-06-07
AU1555983A (en) 1983-11-04
JPH0753600A (en) 1995-02-28
FI834529A (en) 1983-12-09
GB8530310D0 (en) 1986-01-22
AT394577B (en) 1992-05-11
GB2167086B (en) 1987-03-04
GB2168998A (en) 1986-07-02
CA1213229A (en) 1986-10-28
ES8603080A1 (en) 1985-12-01
GB8530308D0 (en) 1986-01-22
JPS6312276A (en) 1988-01-19
ATA901883A (en) 1991-10-15
ES8606655A1 (en) 1986-04-01
IT8320548A0 (en) 1983-04-12
GB2167086A (en) 1986-05-21
IT1219778B (en) 1990-05-24
ES537257A0 (en) 1986-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303