FI834529A - ANTIKROPPAR MED DUBBEL SPECIFICITET. - Google Patents

ANTIKROPPAR MED DUBBEL SPECIFICITET. Download PDF

Info

Publication number
FI834529A
FI834529A FI834529A FI834529A FI834529A FI 834529 A FI834529 A FI 834529A FI 834529 A FI834529 A FI 834529A FI 834529 A FI834529 A FI 834529A FI 834529 A FI834529 A FI 834529A
Authority
FI
Finland
Prior art keywords
specificitet
antikroppar
dubbel
med
med dubbel
Prior art date
Application number
FI834529A
Other languages
Finnish (fi)
Other versions
FI834529A0 (en
Inventor
Joanne Martinis
Richard M Bartholomew
Gary S David
Thomas H Adams
James M Frincke
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of FI834529A0 publication Critical patent/FI834529A0/en
Publication of FI834529A publication Critical patent/FI834529A/en
Priority to FI900212A priority Critical patent/FI900212A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
FI834529A 1982-04-12 1983-12-09 ANTIKROPPAR MED DUBBEL SPECIFICITET. FI834529A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI900212A FI900212A0 (en) 1982-04-12 1990-01-15 POLYDOM SOM PRODUCER MONOCLONAL HYBRIDANTIKROPPAR MED DUBBEL SPECIFITET.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36778482A 1982-04-12 1982-04-12
PCT/US1983/000525 WO1983003679A1 (en) 1982-04-12 1983-04-12 Antibodies having dual specificities, their preparation and uses therefor

Publications (2)

Publication Number Publication Date
FI834529A0 FI834529A0 (en) 1983-12-09
FI834529A true FI834529A (en) 1983-12-09

Family

ID=23448582

Family Applications (1)

Application Number Title Priority Date Filing Date
FI834529A FI834529A (en) 1982-04-12 1983-12-09 ANTIKROPPAR MED DUBBEL SPECIFICITET.

Country Status (11)

Country Link
EP (1) EP0105360A4 (en)
JP (2) JPH0753119B2 (en)
AT (1) AT394577B (en)
AU (1) AU550486B2 (en)
CA (1) CA1213229A (en)
CH (1) CH672796A5 (en)
ES (7) ES521370A0 (en)
FI (1) FI834529A (en)
GB (4) GB2128631B (en)
IT (1) IT1219778B (en)
WO (1) WO1983003679A1 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3177776B2 (en) * 1988-09-27 2001-06-18 武田薬品工業株式会社 Hybrid monoclonal antibodies, antibody-producing polydomas and antibody-containing drugs
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
CA1214123A (en) * 1983-01-20 1986-11-18 Masashi Matsui Cell lines for use in the preparation of hybridoma cells
EP0467416A1 (en) * 1983-09-01 1992-01-22 Hybritech Incorporated Antibody compositions of therapeutic agents having an extended serum half-life
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
JPH0617909B2 (en) * 1984-04-23 1994-03-09 ボストン バイオメディカル リサーチ インスティテュート，インコーポレイテッド Bispecific antibody determinant
NL8501219A (en) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic IMMUNOLOGICAL COMPLEX, ITS PREPARATION AND APPLICATION.
WO1987006240A1 (en) 1986-04-14 1987-10-22 The General Hospital Corporation Heterobifunctional antibodies and method of use
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
FR2604092B1 (en) * 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
GB8626413D0 (en) * 1986-11-05 1986-12-03 Gilliland L K Antibodies
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies
US5053226A (en) * 1987-07-15 1991-10-01 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
JP2755395B2 (en) * 1987-09-23 1998-05-20 ブリストル―マイアーズ スクイブ コムパニー Antibody heteroconjugate that kills HIV-infected cells
GB2218100A (en) * 1988-03-02 1989-11-08 Erling Sundrehagen Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
US5582862A (en) * 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
JPH02196799A (en) * 1988-04-08 1990-08-03 Agency Of Ind Science & Technol Complex of anti-human cancer protein
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
IT1235349B (en) * 1988-12-23 1992-06-30 Biodata Spa IMMUNOLOGICAL TEST FOR HOMOGENEOUS DETERMINATIONS
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) * 1989-03-30 1990-10-18 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
FR2652004B1 (en) * 1989-09-21 1994-10-28 Immunotech Partners NOVEL HYDROPHILIC DERIVATIVES, APPLICATION TO DIAGNOSIS AND THERAPEUTICS, DIAGNOSTIC OR THERAPEUTIC KITS AND IMMUNOLOGICAL REAGENTS.
DE69130561T2 (en) * 1990-02-16 1999-06-24 Boston Biomed Res Inst Hybrid reagents with the ability to selectively release molecules into cells
TW212184B (en) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
ES2093778T3 (en) * 1991-04-26 1997-01-01 Surface Active Ltd NEW ANTIBODIES AND METHODS FOR USE.
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) * 1994-10-18 1994-12-07 Surface Active Ltd Biosensor
US20030017147A1 (en) * 1996-09-20 2003-01-23 Guy L Reed Composition and method for enhancing fibrinolysis
US20020132274A1 (en) 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
ES2544527T3 (en) 2002-07-31 2015-09-01 Seattle Genetics, Inc. Drug conjugates and their use to treat cancer, an autoimmune disease or an infectious disease
SG149815A1 (en) 2003-11-06 2009-02-27 Seattle Genetics Inc Monomethylvaline compounds capable of conjugation to ligands
NZ549962A (en) 2004-03-16 2010-04-30 Univ Temple Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders
WO2006132670A2 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the n terminus
DK1871418T3 (en) 2005-04-19 2014-06-10 Seattle Genetics Inc Humanized anti-CD70 binding agents and uses thereof
PL3248613T3 (en) 2005-07-18 2022-04-19 Seagen Inc. Beta-glucuronide drug linker conjugates
PT2099823E (en) 2006-12-01 2014-12-22 Seattle Genetics Inc Variant target binding agents and uses thereof
WO2008091740A2 (en) 2007-01-22 2008-07-31 Genentech, Inc. Polyelectrolyte precipitation and purification of antibodies
CA2723197C (en) 2008-05-02 2017-09-19 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
CA2906784C (en) 2013-03-15 2023-02-28 The Centre For Drug Research And Development Cytotoxic and anti-mitotic compounds, and methods of using the same
JP6473418B2 (en) * 2013-10-10 2019-02-20 幸成 加藤 Anti-podopranin antibody
KR102384740B1 (en) 2013-12-27 2022-04-07 자임워크스 인코포레이티드 Sulfonamide-containing linkage systems for drug conjugates
US9879086B2 (en) 2014-09-17 2018-01-30 Zymeworks Inc. Cytotoxic and anti-mitotic compounds, and methods of using the same
JP6412906B2 (en) 2015-11-03 2018-10-24 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ Compound, linker-drug and ligand-drug complex
KR20180134351A (en) 2016-03-25 2018-12-18 시애틀 지네틱스, 인크. Process for the preparation of pegylated drug-linkers and intermediates thereof
WO2017197045A1 (en) 2016-05-11 2017-11-16 Movassaghi Mohammad Convergent and enantioselective total synthesis of communesin analogs
JP2020512312A (en) 2017-03-24 2020-04-23 シアトル ジェネティックス， インコーポレイテッド Process for the preparation of glucuronide drug-linker and its intermediates
WO2018209239A1 (en) 2017-05-11 2018-11-15 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
CA3110096A1 (en) * 2018-08-30 2020-03-05 Innovative Cellular Therapeutics CO., LTD. Chimeric antigen receptor cells for treating solid tumor
SG11202112223XA (en) 2019-05-10 2021-12-30 Takeda Pharmaceuticals Co Antibody drug conjugates
TW202138388A (en) 2019-12-30 2021-10-16 美商西根公司 Methods of treating cancer with nonfucosylated anti-cd70 antibodies
PE20231947A1 (en) 2020-11-09 2023-12-05 Takeda Pharmaceuticals Co ANTIBODY AND DRUG CONJUGATES
KR20240025597A (en) 2021-06-29 2024-02-27 씨젠 인크. Methods of treating cancer with a combination of afucosylated anti-CD70 antibody and CD47 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130634A (en) * 1974-03-15 1978-12-19 University Of Illinois Foundation Method for detecting and quantifying antigens
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies

Also Published As

Publication number Publication date
GB2169921A (en) 1986-07-23
GB2167086A (en) 1986-05-21
IT1219778B (en) 1990-05-24
EP0105360A1 (en) 1984-04-18
AU1555983A (en) 1983-11-04
IT8320548A0 (en) 1983-04-12
JPH0753600A (en) 1995-02-28
ES537257A0 (en) 1986-04-01
GB8530309D0 (en) 1986-01-22
GB8332646D0 (en) 1984-01-11
CA1213229A (en) 1986-10-28
ES527963A0 (en) 1985-02-16
ES8606655A1 (en) 1986-04-01
JPS6312276A (en) 1988-01-19
AT394577B (en) 1992-05-11
ES533931A0 (en) 1985-06-16
ES8504461A1 (en) 1985-04-16
JP2562002B2 (en) 1996-12-11
ES8503441A1 (en) 1985-02-16
FI834529A0 (en) 1983-12-09
ES8603080A1 (en) 1985-12-01
WO1983003679A1 (en) 1983-10-27
ES8604424A1 (en) 1986-02-01
JPH0753119B2 (en) 1995-06-07
ES538727A0 (en) 1986-02-01
GB2128631A (en) 1984-05-02
GB8530310D0 (en) 1986-01-22
ES545247A0 (en) 1986-05-16
GB2167086B (en) 1987-03-04
GB2168998A (en) 1986-07-02
GB2169921B (en) 1987-03-04
ATA901883A (en) 1991-10-15
GB2168998B (en) 1987-03-04
ES8506091A1 (en) 1985-06-16
CH672796A5 (en) 1989-12-29
GB8530308D0 (en) 1986-01-22
ES521370A0 (en) 1985-04-16
EP0105360A4 (en) 1986-07-08
AU550486B2 (en) 1986-03-20
ES533930A0 (en) 1985-12-01
ES8607386A1 (en) 1986-05-16
GB2128631B (en) 1987-02-25

Similar Documents

Publication Publication Date Title
FI834529A (en) ANTIKROPPAR MED DUBBEL SPECIFICITET.
FI851075L (en) KOMPINERAD ENKEL / DUBBEL ORTODONTISK KANTSTAELLNING.
FI834747A (en) KATIONFOERENINGAR INNEHAOLLANDE TVAETTMEDELSKOMPOSITIONER MED LERSMUTS AVLAEGSNINGS- / AOTERUTFAELLNING FOERHINDRANDE EGENSKAPER.
FI73523B (en) TRYCK- ELLER TRYCKDIFFERENSMAETARE MED EN MOT OEVERBELASTNING SKYDDAD TRYCKAVKAENNINGSANORDNING.
FI78601B (en) ENGAONGSBLOEJA.
FI78611B (en) UPPBEVARINGSPAOSE.
FI73534B (en) BANDKASSETT.
FI73505B (en) FAESTELEMENT.
FI77050B (en) GELATINKOMPOSITION FOER SPRUTGJUTNING.
FI823990L (en) FAESTNINGSKLAEMMARE.
FI834240A0 (en) FAIRGTELEVISIONSMOTTAGARE MED DIGITALT BEHANDLINGSSYSTEM, VILKET BILDAR DIGITALA INFORMATIONSSIGNALER FOER BILDROERET
FI834311A (en) MED SAMLINGSROER FOERSEDD SZ- TVINNMASKIN.
FI841976A0 (en) PLASMIDER MED VILLKORLIGT OKONTROLLERAT REPLIKERINGSUPPFOERANDE.
FI78606B (en) SAEKERHETSSAETE.
DE3381054D1 (en) IMMUNOESSAY.
FI833831A (en) SPRIDARANORDNING I LAGERBEHAOLLARE FOER JAEMN FYLLNING AV BEHAOLLAREN MED KORNFORMIG LAGERVARA.
FI823573A0 (en) SPRITSROER MED DYSOR, SAERSKILT FLATSTRAOLDYSOR
FI73520B (en) MAOLANORDNING.
FI834886A (en) HYDROCYKLON MED VATTENTROESKEL I OEVERSTROEMNINGSKANALEN.
ES272075Y (en) CORRETILLA.
FI821663L (en) ACKUMULATOR MED DUBBEL STROEMKRETS
FI840309A (en) OLJEUPPSAMLINGSFARTYG MED TVAO FARTYGKROPPSHALVOR.
FI834266A (en) ASPARTAMEFOERENINGAR MED FOERBAETTRAD LOESLIGHET.
FI73929B (en) FOERFLYTTBAR LASTTRANSPORTOER.
FI870277A0 (en) GAONGJAERN MED SLUTNINGSMEKANISM FOER MOEBELDOERRAR.

Legal Events

Date Code Title Description
FD Application lapsed

Owner name: HYBRITECH INCORPORATED