AU1555983A - Antibodies having dual specificities, their preparation and uses therefor - Google Patents

Antibodies having dual specificities, their preparation and uses therefor

Info

Publication number
AU1555983A
AU1555983A AU15559/83A AU1555983A AU1555983A AU 1555983 A AU1555983 A AU 1555983A AU 15559/83 A AU15559/83 A AU 15559/83A AU 1555983 A AU1555983 A AU 1555983A AU 1555983 A AU1555983 A AU 1555983A
Authority
AU
Australia
Prior art keywords
antibodies
preparation
uses therefor
dual specificities
specificities
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU15559/83A
Other versions
AU550486B2 (en
Inventor
Thomas H. Adams
Richard M. Bartholomew
Gary S. David
James M. Frincke
Joanne Martinis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybritech Inc
Original Assignee
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybritech Inc filed Critical Hybritech Inc
Publication of AU1555983A publication Critical patent/AU1555983A/en
Application granted granted Critical
Publication of AU550486B2 publication Critical patent/AU550486B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
    • A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
AU15559/83A 1982-04-12 1983-04-12 Antibodies having dual specificities, their preparation and uses therefor Expired AU550486B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36778482A 1982-04-12 1982-04-12
US367784 1982-04-12

Publications (2)

Publication Number Publication Date
AU1555983A true AU1555983A (en) 1983-11-04
AU550486B2 AU550486B2 (en) 1986-03-20

Family

ID=23448582

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15559/83A Expired AU550486B2 (en) 1982-04-12 1983-04-12 Antibodies having dual specificities, their preparation and uses therefor

Country Status (11)

Country Link
EP (1) EP0105360A4 (en)
JP (2) JPH0753119B2 (en)
AT (1) AT394577B (en)
AU (1) AU550486B2 (en)
CA (1) CA1213229A (en)
CH (1) CH672796A5 (en)
ES (7) ES8504461A1 (en)
FI (1) FI834529A (en)
GB (4) GB2128631B (en)
IT (1) IT1219778B (en)
WO (1) WO1983003679A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU569002B2 (en) * 1983-01-20 1988-01-14 Suntory Limited Novel cell lines for use in preparation of hybridoma cells

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3177776B2 (en) * 1988-09-27 2001-06-18 武田薬品工業株式会社 Hybrid monoclonal antibodies, antibody-producing polydomas and antibody-containing drugs
US5292668A (en) * 1981-12-21 1994-03-08 Boston Biomedical Research Institute, Inc. Bispecific antibody determinants
GB2148299B (en) * 1983-09-01 1988-01-06 Hybritech Inc Antibody compositions of therapeutic agents having an extended serum half-life
EP0467416A1 (en) * 1983-09-01 1992-01-22 Hybritech Incorporated Antibody compositions of therapeutic agents having an extended serum half-life
ATE64622T1 (en) * 1984-04-23 1991-07-15 Boston Biomed Res Inst DOUBLE SPECIFIC ANTIBODY DETERMINANTS.
NL8501219A (en) * 1985-04-29 1986-11-17 Stichting Vrienden Van De Stic IMMUNOLOGICAL COMPLEX, ITS PREPARATION AND APPLICATION.
US5453269A (en) * 1986-04-14 1995-09-26 The General Hospital Corporation Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use
EP0241907A3 (en) 1986-04-14 1989-09-13 The General Hospital Corporation Heterobifunctional antibodies and method of use
FR2604092B1 (en) * 1986-09-19 1990-04-13 Immunotech Sa IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO
GB8626413D0 (en) * 1986-11-05 1986-12-03 Gilliland L K Antibodies
GB8626412D0 (en) * 1986-11-05 1986-12-03 Clark M R Antibodies
US5053226A (en) * 1987-07-15 1991-10-01 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
CA1338518C (en) * 1987-09-23 1996-08-13 Joyce M. Zarling Antibody heteroconjugates for the killing of hiv-infected cells
GB2218100A (en) * 1988-03-02 1989-11-08 Erling Sundrehagen Conjugates for the detection and/or quantification of antigenic substances in body fluids
US4892824A (en) * 1988-03-15 1990-01-09 Synbiotics Corporation Fast track method for producing monoclonal bi-specific immunoglobulins
US5582862A (en) 1988-04-04 1996-12-10 General Hospital Corporation Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin
US5372812A (en) * 1988-04-04 1994-12-13 The General Hospital Corporation Composition and method for acceleration of clot lysis
JPH02196799A (en) * 1988-04-08 1990-08-03 Agency Of Ind Science & Technol Complex of anti-human cancer protein
US5851527A (en) * 1988-04-18 1998-12-22 Immunomedics, Inc. Method for antibody targeting of therapeutic agents
IT1235349B (en) * 1988-12-23 1992-06-30 Biodata Spa IMMUNOLOGICAL TEST FOR HOMOGENEOUS DETERMINATIONS
CA2006408A1 (en) * 1988-12-27 1990-06-27 Susumu Iwasa Bispecific monoclonal antibody, its production and use
US5217713A (en) * 1988-12-27 1993-06-08 Takeda Chemical Industries, Ltd. Cytotoxic bispecific monoclonal antibody, its production and use
WO1990012109A1 (en) * 1989-03-30 1990-10-18 Board Of Regents, The University Of Texas System Monoclonal antibodies binding platinum complexes
FR2652004B1 (en) * 1989-09-21 1994-10-28 Immunotech Partners NOVEL HYDROPHILIC DERIVATIVES, APPLICATION TO DIAGNOSIS AND THERAPEUTICS, DIAGNOSTIC OR THERAPEUTIC KITS AND IMMUNOLOGICAL REAGENTS.
WO1991012023A2 (en) * 1990-02-16 1991-08-22 Boston Biomedical Research Institute Hybrid reagents capable of selectively releasing molecules into cells
TW212184B (en) * 1990-04-02 1993-09-01 Takeda Pharm Industry Co Ltd
DE69214709T2 (en) * 1991-04-26 1997-02-20 Surface Active Ltd New antibodies and methods of using them
GB9316369D0 (en) * 1993-08-06 1993-09-22 Surface Active Ltd Diagnostic method
US5541110A (en) 1994-05-17 1996-07-30 Bristol-Myers Squibb Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica
GB9421468D0 (en) * 1994-10-18 1994-12-07 Surface Active Ltd Biosensor
US6114506A (en) * 1996-09-20 2000-09-05 General Hospital Corporation Composition and method for enhancing fibrinolysis
US20020132274A1 (en) 2001-01-17 2002-09-19 Nevalainen Marja T. Diagnostic and monitorings methods for cancer
EP1545613B9 (en) 2002-07-31 2012-01-25 Seattle Genetics, Inc. Auristatin conjugates and their use for treating cancer, an autoimmune disease or an infectious disease
WO2006113909A2 (en) 2005-04-19 2006-10-26 Seattle Genetics, Inc. Humanized anti-cd70 binding agents and uses thereof
KR101520209B1 (en) 2003-11-06 2015-05-13 시애틀 지네틱스, 인크. Monomethylvaline compounds capable of conjugation to ligands
HUE030786T2 (en) 2004-03-16 2017-06-28 Temple Univ - Of The Commonwealth System Of Higher Education Substituted phenoxy- and phenylthio-derivatives for treating proliferative disorders
US8288352B2 (en) 2004-11-12 2012-10-16 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the N terminus
AU2006269940C1 (en) 2005-07-18 2013-11-07 Seagen Inc. Beta-glucuronide-linker drug conjugates
US8455622B2 (en) 2006-12-01 2013-06-04 Seattle Genetics, Inc. Variant target binding agents and uses thereof
ES2426158T3 (en) 2007-01-22 2013-10-21 Genentech, Inc. Precipitation with polyelectrolyte and antibody purification
ES2458541T3 (en) 2008-05-02 2014-05-06 Seattle Genetics, Inc. Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation
WO2011133658A1 (en) 2010-04-22 2011-10-27 Boston Medical Center Corporation Compositions and methods for targeting and delivering therapeutics into cells
US9353150B2 (en) 2012-12-04 2016-05-31 Massachusetts Institute Of Technology Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
MY174813A (en) 2013-03-15 2020-05-16 Zymeworks Inc Cytotoxic and anti-mitotic compounds, and methods of using the same
WO2015053381A1 (en) * 2013-10-10 2015-04-16 幸成 加藤 Anti-podoplanin antibody
CA2935077C (en) 2013-12-27 2022-03-15 Geoffrey C. Winters Sulfonamide-containing linkage systems for drug conjugates
DK3194421T3 (en) 2014-09-17 2022-02-14 Zymeworks Inc CYTOTOXIC AND ANTIMITOTIC COMPOUNDS AND PROCEDURES FOR USE
US10618935B2 (en) 2015-11-03 2020-04-14 Industrial Technology Research Institute Antibody-drug conjugate (ADC) and method for forming the same
AU2017237186A1 (en) 2016-03-25 2018-11-01 Seagen Inc. Process for the preparation of PEGylated drug-linkers and intermediates thereof
US10918627B2 (en) 2016-05-11 2021-02-16 Massachusetts Institute Of Technology Convergent and enantioselective total synthesis of Communesin analogs
US11730822B2 (en) 2017-03-24 2023-08-22 Seagen Inc. Process for the preparation of glucuronide drug-linkers and intermediates thereof
US11932650B2 (en) 2017-05-11 2024-03-19 Massachusetts Institute Of Technology Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en) 2017-10-13 2020-05-05 Massachusetts Institute Of Technology Diazene directed modular synthesis of compounds with quaternary carbon centers
CA3110096A1 (en) * 2018-08-30 2020-03-05 Innovative Cellular Therapeutics CO., LTD. Chimeric antigen receptor cells for treating solid tumor
JP2022532192A (en) 2019-05-10 2022-07-13 武田薬品工業株式会社 Antibody drug conjugate
TW202138388A (en) 2019-12-30 2021-10-16 美商西根公司 Methods of treating cancer with nonfucosylated anti-cd70 antibodies
WO2022097117A1 (en) 2020-11-09 2022-05-12 Takeda Pharmaceutical Company Ltd. Antibody drug conjugates
IL309405A (en) 2021-06-29 2024-02-01 Seagen Inc Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4130634A (en) * 1974-03-15 1978-12-19 University Of Illinois Foundation Method for detecting and quantifying antigens
US4331647A (en) * 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4474893A (en) * 1981-07-01 1984-10-02 The University of Texas System Cancer Center Recombinant monoclonal antibodies

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU569002B2 (en) * 1983-01-20 1988-01-14 Suntory Limited Novel cell lines for use in preparation of hybridoma cells

Also Published As

Publication number Publication date
ATA901883A (en) 1991-10-15
GB2167086B (en) 1987-03-04
ES537257A0 (en) 1986-04-01
GB2169921B (en) 1987-03-04
ES521370A0 (en) 1985-04-16
ES527963A0 (en) 1985-02-16
GB2167086A (en) 1986-05-21
ES8606655A1 (en) 1986-04-01
JP2562002B2 (en) 1996-12-11
AU550486B2 (en) 1986-03-20
IT1219778B (en) 1990-05-24
ES8604424A1 (en) 1986-02-01
IT8320548A0 (en) 1983-04-12
ES8603080A1 (en) 1985-12-01
ES538727A0 (en) 1986-02-01
GB8332646D0 (en) 1984-01-11
GB2168998A (en) 1986-07-02
ES8504461A1 (en) 1985-04-16
ES8503441A1 (en) 1985-02-16
WO1983003679A1 (en) 1983-10-27
JPH0753600A (en) 1995-02-28
CH672796A5 (en) 1989-12-29
EP0105360A4 (en) 1986-07-08
FI834529A0 (en) 1983-12-09
ES8506091A1 (en) 1985-06-16
GB8530309D0 (en) 1986-01-22
GB2128631A (en) 1984-05-02
FI834529A (en) 1983-12-09
GB2128631B (en) 1987-02-25
ES533931A0 (en) 1985-06-16
CA1213229A (en) 1986-10-28
EP0105360A1 (en) 1984-04-18
ES8607386A1 (en) 1986-05-16
ES545247A0 (en) 1986-05-16
GB8530310D0 (en) 1986-01-22
GB8530308D0 (en) 1986-01-22
JPS6312276A (en) 1988-01-19
ES533930A0 (en) 1985-12-01
GB2168998B (en) 1987-03-04
AT394577B (en) 1992-05-11
GB2169921A (en) 1986-07-23
JPH0753119B2 (en) 1995-06-07

Similar Documents

Publication Publication Date Title
AU550486B2 (en) Antibodies having dual specificities, their preparation and uses therefor
AU558258B2 (en) Immunogenic protein complex
AU4154385A (en) Antibodies, manufacture and use
AU4493685A (en) Polyclonal antibodies, preparation and use
AU537806B2 (en) Monoclonal antibody
AU560305B2 (en) Plant-promoting preparations
AU2144083A (en) Boomerang
AU3330689A (en) Monoclonal antibodies
AU554817B2 (en) Human immunoglobulin
GB8416902D0 (en) Antibody preparations
AU1467483A (en) Improved mycostatic whey and its manufacture
AU569816B2 (en) Monoclonal anti-alpha-amylase antibody
AU553154B2 (en) Iron-selenium preparation
AU563881B2 (en) Carbacycline, preparation and utilization thereof
AU7165891A (en) Tumor-specific, cell surface-binding monoclonal antibodies
AU4174789A (en) Hybrid monoclonal antibodies, their production and use
IL69531A (en) Antibodies against bacterial peptidoglycans,their preparation and determination
AU6071780A (en) Antibody serum
AU618720B2 (en) Monoclonal antibodies
AU565485B2 (en) Supported viral antigen
AU555029B2 (en) Combined shampoo-conditioner
AU6639186A (en) Monoclonal antibodies to p. aeruginosa
AU556941B2 (en) Glycosidic linkage related antigen
AU612122C (en) Monoclonal antibodies
AU8003187A (en) Monoclonal antibodies

Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired