ES521370A0 - A PROCEDURE FOR OBTAINING A POLYDOMA. - Google Patents
A PROCEDURE FOR OBTAINING A POLYDOMA.Info
- Publication number
- ES521370A0 ES521370A0 ES521370A ES521370A ES521370A0 ES 521370 A0 ES521370 A0 ES 521370A0 ES 521370 A ES521370 A ES 521370A ES 521370 A ES521370 A ES 521370A ES 521370 A0 ES521370 A0 ES 521370A0
- Authority
- ES
- Spain
- Prior art keywords
- polydoma
- procedure
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1084—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin
- A61K51/109—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody the antibody being a hybrid immunoglobulin immunoglobulins having two or more different antigen-binding sites or multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36778482A | 1982-04-12 | 1982-04-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES521370A0 true ES521370A0 (en) | 1985-04-16 |
ES8504461A1 ES8504461A1 (en) | 1985-04-16 |
Family
ID=23448582
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521370A Expired ES8504461A1 (en) | 1982-04-12 | 1983-04-11 | Antibodies having dual specificities, their preparation and uses therefor. |
ES527963A Granted ES527963A0 (en) | 1982-04-12 | 1983-12-12 | AN IMMUNO ASSAY PROCEDURE |
ES533931A Expired ES8506091A1 (en) | 1982-04-12 | 1984-07-02 | Antibodies having dual specificities, their preparation and uses therefor. |
ES533930A Granted ES533930A0 (en) | 1982-04-12 | 1984-07-02 | A PROCEDURE FOR OBTAINING A POLYDOMA |
ES537257A Expired ES8606655A1 (en) | 1982-04-12 | 1984-10-31 | Antibodies having dual specificities, their preparation and uses therefor. |
ES538727A Expired ES8604424A1 (en) | 1982-04-12 | 1984-12-18 | Antibodies having dual specificities, their preparation and uses therefor. |
ES545247A Expired ES8607386A1 (en) | 1982-04-12 | 1985-07-16 | Antibodies having dual specificities, their preparation and uses therefor. |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES527963A Granted ES527963A0 (en) | 1982-04-12 | 1983-12-12 | AN IMMUNO ASSAY PROCEDURE |
ES533931A Expired ES8506091A1 (en) | 1982-04-12 | 1984-07-02 | Antibodies having dual specificities, their preparation and uses therefor. |
ES533930A Granted ES533930A0 (en) | 1982-04-12 | 1984-07-02 | A PROCEDURE FOR OBTAINING A POLYDOMA |
ES537257A Expired ES8606655A1 (en) | 1982-04-12 | 1984-10-31 | Antibodies having dual specificities, their preparation and uses therefor. |
ES538727A Expired ES8604424A1 (en) | 1982-04-12 | 1984-12-18 | Antibodies having dual specificities, their preparation and uses therefor. |
ES545247A Expired ES8607386A1 (en) | 1982-04-12 | 1985-07-16 | Antibodies having dual specificities, their preparation and uses therefor. |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP0105360A4 (en) |
JP (2) | JPH0753119B2 (en) |
AT (1) | AT394577B (en) |
AU (1) | AU550486B2 (en) |
CA (1) | CA1213229A (en) |
CH (1) | CH672796A5 (en) |
ES (7) | ES8504461A1 (en) |
FI (1) | FI834529A (en) |
GB (4) | GB2128631B (en) |
IT (1) | IT1219778B (en) |
WO (1) | WO1983003679A1 (en) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3177776B2 (en) * | 1988-09-27 | 2001-06-18 | 武田薬品工業株式会社 | Hybrid monoclonal antibodies, antibody-producing polydomas and antibody-containing drugs |
US5292668A (en) * | 1981-12-21 | 1994-03-08 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
IL70686A (en) * | 1983-01-20 | 1988-07-31 | Suntory Ltd | Mutant tumor cell lines for use in the preparation of hybridomas and the hybridomas obtained therefrom |
GB2148299B (en) * | 1983-09-01 | 1988-01-06 | Hybritech Inc | Antibody compositions of therapeutic agents having an extended serum half-life |
EP0467416A1 (en) * | 1983-09-01 | 1992-01-22 | Hybritech Incorporated | Antibody compositions of therapeutic agents having an extended serum half-life |
AU595159B2 (en) * | 1984-04-23 | 1990-03-29 | Boston Biomedical Research Institute Incorporated | Bispecific antibody determinants |
NL8501219A (en) * | 1985-04-29 | 1986-11-17 | Stichting Vrienden Van De Stic | IMMUNOLOGICAL COMPLEX, ITS PREPARATION AND APPLICATION. |
WO1987006240A1 (en) | 1986-04-14 | 1987-10-22 | The General Hospital Corporation | Heterobifunctional antibodies and method of use |
US5453269A (en) * | 1986-04-14 | 1995-09-26 | The General Hospital Corporation | Heterobifunctional antibodies having dual specificity for fibrin and thrombolylic agents and methods of use |
FR2604092B1 (en) * | 1986-09-19 | 1990-04-13 | Immunotech Sa | IMMUNOREACTIVES FOR TARGETING ANIMAL CELLS FOR VISUALIZATION OR DESTRUCTION IN VIVO |
GB8626413D0 (en) * | 1986-11-05 | 1986-12-03 | Gilliland L K | Antibodies |
GB8626412D0 (en) * | 1986-11-05 | 1986-12-03 | Clark M R | Antibodies |
US5053226A (en) * | 1987-07-15 | 1991-10-01 | Board Of Regents, The University Of Texas System | Monoclonal antibodies binding platinum complexes |
DE3850542T2 (en) * | 1987-09-23 | 1994-11-24 | Bristol Myers Squibb Co | Antibody heteroconjugates for killing HIV-infected cells. |
GB2218100A (en) * | 1988-03-02 | 1989-11-08 | Erling Sundrehagen | Conjugates for the detection and/or quantification of antigenic substances in body fluids |
US4892824A (en) * | 1988-03-15 | 1990-01-09 | Synbiotics Corporation | Fast track method for producing monoclonal bi-specific immunoglobulins |
US5582862A (en) * | 1988-04-04 | 1996-12-10 | General Hospital Corporation | Antibodies that bind to α2-antiplasmin crosslinked to fibrin which do not inhibit plasma α2-antiplasmin |
US5372812A (en) * | 1988-04-04 | 1994-12-13 | The General Hospital Corporation | Composition and method for acceleration of clot lysis |
JPH02196799A (en) * | 1988-04-08 | 1990-08-03 | Agency Of Ind Science & Technol | Complex of anti-human cancer protein |
US5851527A (en) * | 1988-04-18 | 1998-12-22 | Immunomedics, Inc. | Method for antibody targeting of therapeutic agents |
IT1235349B (en) * | 1988-12-23 | 1992-06-30 | Biodata Spa | IMMUNOLOGICAL TEST FOR HOMOGENEOUS DETERMINATIONS |
CA2006408A1 (en) * | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
US5217713A (en) * | 1988-12-27 | 1993-06-08 | Takeda Chemical Industries, Ltd. | Cytotoxic bispecific monoclonal antibody, its production and use |
WO1990012109A1 (en) * | 1989-03-30 | 1990-10-18 | Board Of Regents, The University Of Texas System | Monoclonal antibodies binding platinum complexes |
FR2652004B1 (en) * | 1989-09-21 | 1994-10-28 | Immunotech Partners | NOVEL HYDROPHILIC DERIVATIVES, APPLICATION TO DIAGNOSIS AND THERAPEUTICS, DIAGNOSTIC OR THERAPEUTIC KITS AND IMMUNOLOGICAL REAGENTS. |
WO1991012023A2 (en) * | 1990-02-16 | 1991-08-22 | Boston Biomedical Research Institute | Hybrid reagents capable of selectively releasing molecules into cells |
TW212184B (en) * | 1990-04-02 | 1993-09-01 | Takeda Pharm Industry Co Ltd | |
CA2108451A1 (en) * | 1991-04-26 | 1992-10-27 | Beverley J. Randle | Novel antibodies, and methods for their use |
GB9316369D0 (en) * | 1993-08-06 | 1993-09-22 | Surface Active Ltd | Diagnostic method |
US5541110A (en) | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
GB9421468D0 (en) * | 1994-10-18 | 1994-12-07 | Surface Active Ltd | Biosensor |
JP2001515345A (en) * | 1996-09-20 | 2001-09-18 | ザ・ジェネラル・ホスピタル・コーポレイション | Compositions and methods for enhancing fibrinolysis using antibodies to alpha-2-antiplasmin |
US20020132274A1 (en) | 2001-01-17 | 2002-09-19 | Nevalainen Marja T. | Diagnostic and monitorings methods for cancer |
DK1545613T3 (en) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatin conjugates and their use in the treatment of cancer, an autoimmune disease or an infectious disease |
NZ583292A (en) | 2003-11-06 | 2012-03-30 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
CA2559187C (en) | 2004-03-16 | 2014-02-11 | Temple University - Of The Commonwealth System Of Higher Education | Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders |
ES2715776T3 (en) | 2004-11-12 | 2019-06-06 | Seattle Genetics Inc | Auristatins that have an aminobenzoic acid unit at the N-terminus |
ES2477765T3 (en) | 2005-04-19 | 2014-07-17 | Seattle Genetics, Inc. | Binding agents to humanized anti-cd70 and their uses |
PL1912671T3 (en) | 2005-07-18 | 2018-02-28 | Seattle Genetics, Inc. | Beta-glucuronide-linker drug conjugates |
PL2099823T5 (en) | 2006-12-01 | 2023-02-20 | Seagen Inc. | Variant target binding agents and uses thereof |
ZA200904482B (en) | 2007-01-22 | 2010-09-29 | Genentech Inc | Polyelectrolyte precipitation and purification of antibodies |
AU2009242453B2 (en) | 2008-05-02 | 2014-12-04 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
WO2011133658A1 (en) | 2010-04-22 | 2011-10-27 | Boston Medical Center Corporation | Compositions and methods for targeting and delivering therapeutics into cells |
WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
EP3590922A1 (en) | 2013-03-15 | 2020-01-08 | Zymeworks Inc. | Cytotoxic and anti-mitotic compounds, and methods of using the same |
WO2015053381A1 (en) * | 2013-10-10 | 2015-04-16 | 幸成 加藤 | Anti-podoplanin antibody |
CA2935077C (en) | 2013-12-27 | 2022-03-15 | Geoffrey C. Winters | Sulfonamide-containing linkage systems for drug conjugates |
CN113416229A (en) | 2014-09-17 | 2021-09-21 | 酵活有限公司 | Cytotoxic and antimitotic compounds, and methods of use thereof |
JP6412906B2 (en) | 2015-11-03 | 2018-10-24 | 財團法人工業技術研究院Industrial Technology Research Institute | Compound, linker-drug and ligand-drug complex |
KR20180134351A (en) | 2016-03-25 | 2018-12-18 | 시애틀 지네틱스, 인크. | Process for the preparation of pegylated drug-linkers and intermediates thereof |
US10918627B2 (en) | 2016-05-11 | 2021-02-16 | Massachusetts Institute Of Technology | Convergent and enantioselective total synthesis of Communesin analogs |
WO2018175994A1 (en) | 2017-03-24 | 2018-09-27 | Seattle Genetics, Inc. | Process for the preparation of glucuronide drug-linkers and intermediates thereof |
WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
CA3110096A1 (en) * | 2018-08-30 | 2020-03-05 | Innovative Cellular Therapeutics CO., LTD. | Chimeric antigen receptor cells for treating solid tumor |
WO2020229982A1 (en) | 2019-05-10 | 2020-11-19 | Takeda Pharmaceutical Company Limited | Antibody drug conjugates |
TW202138388A (en) | 2019-12-30 | 2021-10-16 | 美商西根公司 | Methods of treating cancer with nonfucosylated anti-cd70 antibodies |
CA3197167A1 (en) | 2020-11-09 | 2022-05-12 | He Xu | Antibody drug conjugates |
AU2022304582A1 (en) | 2021-06-29 | 2024-02-01 | Seagen Inc. | Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4130634A (en) * | 1974-03-15 | 1978-12-19 | University Of Illinois Foundation | Method for detecting and quantifying antigens |
US4331647A (en) * | 1980-03-03 | 1982-05-25 | Goldenberg Milton David | Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers |
US4376110A (en) * | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
-
1983
- 1983-04-11 CA CA000425558A patent/CA1213229A/en not_active Expired
- 1983-04-11 ES ES521370A patent/ES8504461A1/en not_active Expired
- 1983-04-12 CH CH6700/83A patent/CH672796A5/de not_active IP Right Cessation
- 1983-04-12 AT AT0901883A patent/AT394577B/en not_active IP Right Cessation
- 1983-04-12 WO PCT/US1983/000525 patent/WO1983003679A1/en not_active Application Discontinuation
- 1983-04-12 EP EP19830901672 patent/EP0105360A4/en not_active Ceased
- 1983-04-12 AU AU15559/83A patent/AU550486B2/en not_active Expired
- 1983-04-12 GB GB08332646A patent/GB2128631B/en not_active Expired
- 1983-04-12 IT IT20548/83A patent/IT1219778B/en active
- 1983-12-09 FI FI834529A patent/FI834529A/en not_active Application Discontinuation
- 1983-12-12 ES ES527963A patent/ES527963A0/en active Granted
-
1984
- 1984-07-02 ES ES533931A patent/ES8506091A1/en not_active Expired
- 1984-07-02 ES ES533930A patent/ES533930A0/en active Granted
- 1984-10-31 ES ES537257A patent/ES8606655A1/en not_active Expired
- 1984-12-18 ES ES538727A patent/ES8604424A1/en not_active Expired
-
1985
- 1985-07-16 ES ES545247A patent/ES8607386A1/en not_active Expired
- 1985-12-09 GB GB08530309A patent/GB2169921B/en not_active Expired
- 1985-12-09 GB GB08530310A patent/GB2167086B/en not_active Expired
- 1985-12-09 GB GB08530308A patent/GB2168998B/en not_active Expired
-
1987
- 1987-01-05 JP JP62000342A patent/JPH0753119B2/en not_active Expired - Lifetime
-
1994
- 1994-02-10 JP JP6016728A patent/JP2562002B2/en not_active Expired - Lifetime
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |