EA029818B8 - Цитотоксические и антимитотические соединения и способы их применения - Google Patents

Цитотоксические и антимитотические соединения и способы их применения

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Publication number
EA029818B8
EA029818B8 EA201591632A EA201591632A EA029818B8 EA 029818 B8 EA029818 B8 EA 029818B8 EA 201591632 A EA201591632 A EA 201591632A EA 201591632 A EA201591632 A EA 201591632A EA 029818 B8 EA029818 B8 EA 029818B8
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EA
Eurasian Patent Office
Prior art keywords
cytotoxic
methods
compounds
same
mitotic compounds
Prior art date
Application number
EA201591632A
Other languages
English (en)
Other versions
EA201591632A1 (ru
EA029818B1 (ru
Inventor
Джофри С. Уинтерс
Александер Лоренс Мандел
Джеймс Р. Рич
Бредли Джон Хедберг
Том Хан Хсяо Хсих
Элис Мари Хосе Бурк
Джон Бабкук
Original Assignee
Займворкс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Займворкс Инк. filed Critical Займворкс Инк.
Publication of EA201591632A1 publication Critical patent/EA201591632A1/ru
Publication of EA029818B1 publication Critical patent/EA029818B1/ru
Publication of EA029818B8 publication Critical patent/EA029818B8/ru

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    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

В изобретении представлены соединения, имеющие цитотоксическую и/или антимитотическую активность. Описываются способы, связанные с получением и применением таких соединений, так же как и фармацевтические композиции, содержащие такие соединения. Также описываются композиции, имеющие структуру (T)-(L)-(D), где (T) представляет собой нацеливающий фрагмент, (L) представляет собой необязательный линкер, и (D) представляет собой соединение, имеющее цитотоксическую и/или антимитотическую активность.
EA201591632A 2013-03-15 2014-03-14 Цитотоксические и антимитотические соединения и способы их применения EA029818B8 (ru)

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