WO2012061012A3 - 4-amino-2h-pyran-2-one analogs as anticancer agents - Google Patents

4-amino-2h-pyran-2-one analogs as anticancer agents Download PDF

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Publication number
WO2012061012A3
WO2012061012A3 PCT/US2011/056801 US2011056801W WO2012061012A3 WO 2012061012 A3 WO2012061012 A3 WO 2012061012A3 US 2011056801 W US2011056801 W US 2011056801W WO 2012061012 A3 WO2012061012 A3 WO 2012061012A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyran
analogs
amino
anticancer agents
compounds
Prior art date
Application number
PCT/US2011/056801
Other languages
French (fr)
Other versions
WO2012061012A2 (en
Inventor
Kuo-Hsiung Lee
Yizhou Dong
Kenneth F. Bastow
Eva Y.-H. P. Lee
Kyoko Nakagawa-Goto
Original Assignee
The University Of North Carolina At Chapel Hill
University Of California - Irvine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of North Carolina At Chapel Hill, University Of California - Irvine filed Critical The University Of North Carolina At Chapel Hill
Publication of WO2012061012A2 publication Critical patent/WO2012061012A2/en
Publication of WO2012061012A3 publication Critical patent/WO2012061012A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of Formula I are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof.
PCT/US2011/056801 2010-11-02 2011-10-19 4-amino-2h-pyran-2-one analogs as anticancer agents WO2012061012A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40928110P 2010-11-02 2010-11-02
US61/409,281 2010-11-02

Publications (2)

Publication Number Publication Date
WO2012061012A2 WO2012061012A2 (en) 2012-05-10
WO2012061012A3 true WO2012061012A3 (en) 2012-07-26

Family

ID=46025000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/056801 WO2012061012A2 (en) 2010-11-02 2011-10-19 4-amino-2h-pyran-2-one analogs as anticancer agents

Country Status (1)

Country Link
WO (1) WO2012061012A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103145666B (en) * 2013-03-27 2015-04-22 山东省科学院生物研究所 4-substituted alpha-pyrone derivative as well as preparation method and application thereof
CN104211670B (en) * 2013-05-30 2015-11-18 福州大学 A kind of alkyl pyrone compound and its production and use
US10399944B2 (en) 2017-08-10 2019-09-03 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (III) useful as EP3 receptor antagonists
US10590083B2 (en) 2017-08-10 2020-03-17 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (I) useful as EP3 receptor antagonists
US10336701B2 (en) 2017-08-10 2019-07-02 Janssen Pharmaceutica Nv Pyridin-2-one derivatives of formula (II) useful as EP3 receptor antagonists

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010204A1 (en) * 1996-08-05 2002-01-24 Folker Lieb 2- and 2,5-substituted phenylketoenols
US20080161582A1 (en) * 2003-10-24 2008-07-03 Paul Hanselmann Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters
WO2010080415A2 (en) * 2008-12-19 2010-07-15 The University Of North Carolina At Chapel Hill Substituted afpo (6-aryl-4h-furo[3,2-c]pyran-4-one) derivatives as anti-cancer agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020010204A1 (en) * 1996-08-05 2002-01-24 Folker Lieb 2- and 2,5-substituted phenylketoenols
US20080161582A1 (en) * 2003-10-24 2008-07-03 Paul Hanselmann Method for the production of 6,6,6-trihalo-3,5-dioxohexanoic acid esters
WO2010080415A2 (en) * 2008-12-19 2010-07-15 The University Of North Carolina At Chapel Hill Substituted afpo (6-aryl-4h-furo[3,2-c]pyran-4-one) derivatives as anti-cancer agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
IKURO ABE ET AL.: "Enzymatic formation of unnatural novel polyketides from a lternate starter and nonphysiological extension substrate by chalcone synthase.", ORG. LETT., vol. 5, no. 8, 2003, pages 1277 - 1280 *
SIRISILLA RAJU ET AL.: "Tandem versus single C-C bond forming reaction under palladium-copper catalysis: regioselective synthesis of alpha-pyrones fused with thiophene.", TETRAHEDRON, vol. 62, 2006, pages 9554 - 9570 *

Also Published As

Publication number Publication date
WO2012061012A2 (en) 2012-05-10

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