ATE520689T1 - Aminotriazolderivate als alx-agonisten - Google Patents
Aminotriazolderivate als alx-agonistenInfo
- Publication number
- ATE520689T1 ATE520689T1 AT08862134T AT08862134T ATE520689T1 AT E520689 T1 ATE520689 T1 AT E520689T1 AT 08862134 T AT08862134 T AT 08862134T AT 08862134 T AT08862134 T AT 08862134T AT E520689 T1 ATE520689 T1 AT E520689T1
- Authority
- AT
- Austria
- Prior art keywords
- aminotriazole derivatives
- alx
- agonists
- alx agonists
- aminotriazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007055199 | 2007-12-18 | ||
| IB2008054369 | 2008-10-23 | ||
| PCT/IB2008/055375 WO2009077990A1 (en) | 2007-12-18 | 2008-12-17 | Aminotriazole derivatives as alx agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE520689T1 true ATE520689T1 (de) | 2011-09-15 |
Family
ID=40404773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08862134T ATE520689T1 (de) | 2007-12-18 | 2008-12-17 | Aminotriazolderivate als alx-agonisten |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8536209B2 (de) |
| EP (1) | EP2225231B1 (de) |
| JP (1) | JP4656674B2 (de) |
| KR (1) | KR101213007B1 (de) |
| CN (1) | CN101903378B (de) |
| AR (1) | AR069801A1 (de) |
| AT (1) | ATE520689T1 (de) |
| AU (1) | AU2008337097B2 (de) |
| BR (1) | BRPI0821115A8 (de) |
| CA (1) | CA2706839C (de) |
| CY (1) | CY1112465T1 (de) |
| DK (1) | DK2225231T3 (de) |
| HK (1) | HK1144158A1 (de) |
| HR (1) | HRP20110825T1 (de) |
| IL (1) | IL206399A (de) |
| MA (1) | MA31949B1 (de) |
| MX (1) | MX2010006241A (de) |
| MY (1) | MY153985A (de) |
| NZ (1) | NZ586735A (de) |
| PL (1) | PL2225231T3 (de) |
| PT (1) | PT2225231E (de) |
| RU (1) | RU2492167C2 (de) |
| SI (1) | SI2225231T1 (de) |
| TW (1) | TWI434685B (de) |
| WO (1) | WO2009077990A1 (de) |
| ZA (1) | ZA201005080B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| MX2011012264A (es) * | 2009-05-18 | 2011-12-12 | Actelion Pharmaceuticals Ltd | Derivados spiro[2.4]heptano puenteados como agonistas del receptor de lipoxina a(alx) y/o de formil peptido tipo 2 (fprl2). |
| MX342440B (es) | 2009-06-09 | 2016-09-29 | Actelion Pharmaceuticals Ltd * | Derivados fluorados de aminotriazol. |
| US8674111B2 (en) | 2009-06-12 | 2014-03-18 | Actelion Pharmaceuticals Ltd. | Oxazole and thiazole derivatives as ALX receptor agonists |
| CA2814826C (en) | 2010-11-17 | 2019-02-12 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| DK2649068T3 (en) * | 2010-12-07 | 2014-12-08 | Actelion Pharmaceuticals Ltd | OXAZOLYL METHYLETHER DERIVATIVES AS ALX RECEPTOR AGONISTS |
| TW201305150A (zh) | 2010-12-07 | 2013-02-01 | Actelion Pharmaceuticals Ltd | 作為脂氧素（ａｌｘ）受體激動劑之羥基化胺基三唑衍生物 |
| US20140113824A1 (en) | 2011-05-10 | 2014-04-24 | Bayer Intellectual Property Gmbh | Bicyclic (thio)carbonylamidines |
| WO2013022766A1 (en) * | 2011-08-05 | 2013-02-14 | Flynn Gary A | Preparation and methods of use for ortho-aryl 5- membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors |
| CN102558117B (zh) * | 2011-12-15 | 2014-10-08 | 北京金骄生物质化工有限公司 | 一种利用废弃生物质制备5-硝基-2-糠酸酯的方法 |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| JP6101788B2 (ja) | 2012-05-16 | 2017-03-22 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ＡＬＸ受容体アゴニストとしての１−（ｐ−トリル）シクロプロピル置換架橋スピロ［２．４］ヘプタン誘導体 |
| EP2855453B1 (de) | 2012-06-04 | 2016-12-07 | Actelion Pharmaceuticals Ltd. | Benzimidazolprolinderivate |
| JP6244365B2 (ja) | 2012-10-10 | 2017-12-06 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | ［オルトビ−（ヘテロ−）アリール］−［２−（メタビ−（ヘテロ−）アリール）−ピロリジン−１−イル］−メタノン誘導体であるオレキシン受容体アンタゴニスト |
| CA2893239A1 (en) * | 2012-12-03 | 2014-06-12 | F. Hoffmann-La Roche Ag | Substituted triazole and imidazole compounds |
| JP2016510810A (ja) | 2013-03-12 | 2016-04-11 | アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | オレキシン受容体アンタゴニストとしてのアゼチジンアミド誘導体 |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| JP6330038B2 (ja) | 2013-07-18 | 2018-05-23 | イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ | Ａｌｘ受容体アゴニストとしてのピペラジン置換架橋スピロ［２．４］ヘプタン誘導体 |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| TN2016000210A1 (en) | 2013-11-28 | 2017-10-06 | Kyorin Seiyaku Kk | Urea derivative or pharmacologically acceptable salt thereof. |
| WO2015083094A1 (en) | 2013-12-04 | 2015-06-11 | Actelion Pharmaceuticals Ltd | Use of benzimidazole-proline derivatives |
| EA201792382A1 (ru) | 2015-05-27 | 2018-04-30 | Киорин Фармасютикал Ко., Лтд. | Производное мочевины или его фармакологически приемлемая соль |
| EP3303284B1 (de) | 2015-05-27 | 2020-04-08 | Kyorin Pharmaceutical Co., Ltd. | Harnstoff derivat oder pharmakologisch verträgliches salz davon |
| EP3380091A1 (de) * | 2015-11-24 | 2018-10-03 | Bristol-Myers Squibb Company | Abzielung auf den formylpeptid-rezeptor 2/ lipoxin-a4-rezeptor (fpr2 alx) zur behandlung von herzkrankheiten |
| EP3762380B1 (de) | 2018-03-05 | 2021-12-15 | Bristol-Myers Squibb Company | Phenylpyrrolidinon-formylpeptid-2-rezeptor-agonisten |
| US11629143B2 (en) | 2020-10-01 | 2023-04-18 | Vibliome Therapeutics, Llc | HipK4 inhibitors and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234018A (ja) | 1986-04-02 | 1987-10-14 | Rooto Seiyaku Kk | 糖尿病併発症治療剤 |
| WO2003035006A2 (en) | 2001-10-26 | 2003-05-01 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Amyloid ss is a ligand for fpr class receptors |
| JP2005536187A (ja) | 2002-04-03 | 2005-12-02 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | Ｎ−ホルミルペプチド受容体様１（ｆｐｒｌ１）に関連する疾患の診断および治療 |
| KR20060130064A (ko) * | 2003-11-07 | 2006-12-18 | 아카디아 파마슈티칼스 인코포레이티드 | 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, ｆｐｒｌ1의 용도 |
| MXPA06013581A (es) * | 2004-05-25 | 2007-03-15 | Metabolex Inc | Triazoles sustituidos como moduladores de ppar y metodos para su preparacion. |
| RU2394818C2 (ru) * | 2004-12-13 | 2010-07-20 | Лео Фарма А/С | Триазолзамещенные аминобензофеноновые соединения |
| WO2007055941A2 (en) | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Histone deacetylase inhibitors with aryl-pyrazolyl motifs |
| US7998978B2 (en) * | 2006-05-01 | 2011-08-16 | Pfizer Inc. | Substituted 2-amino-fused heterocyclic compounds |
| MX2010001995A (es) | 2007-08-21 | 2010-06-09 | Senomyx Inc | Identificacion de receptores t2r humanos que responden a compuestos amargos que provocan el sabor amargo en composiciones, y uso de los mismos en ensayos para identificar compuestos que inhiben (bloquean) sabor amargo en composiciones y uso de los mi |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| MX2011012264A (es) | 2009-05-18 | 2011-12-12 | Actelion Pharmaceuticals Ltd | Derivados spiro[2.4]heptano puenteados como agonistas del receptor de lipoxina a(alx) y/o de formil peptido tipo 2 (fprl2). |
| MX342440B (es) | 2009-06-09 | 2016-09-29 | Actelion Pharmaceuticals Ltd * | Derivados fluorados de aminotriazol. |
| US8674111B2 (en) | 2009-06-12 | 2014-03-18 | Actelion Pharmaceuticals Ltd. | Oxazole and thiazole derivatives as ALX receptor agonists |
-
2008
- 2008-12-17 AU AU2008337097A patent/AU2008337097B2/en not_active Ceased
- 2008-12-17 PT PT08862134T patent/PT2225231E/pt unknown
- 2008-12-17 WO PCT/IB2008/055375 patent/WO2009077990A1/en active Application Filing
- 2008-12-17 MX MX2010006241A patent/MX2010006241A/es active IP Right Grant
- 2008-12-17 EP EP08862134A patent/EP2225231B1/de not_active Not-in-force
- 2008-12-17 JP JP2010539015A patent/JP4656674B2/ja not_active Expired - Fee Related
- 2008-12-17 SI SI200830412T patent/SI2225231T1/sl unknown
- 2008-12-17 CN CN200880122188.XA patent/CN101903378B/zh not_active Expired - Fee Related
- 2008-12-17 PL PL08862134T patent/PL2225231T3/pl unknown
- 2008-12-17 DK DK08862134.7T patent/DK2225231T3/da active
- 2008-12-17 TW TW097149199A patent/TWI434685B/zh not_active IP Right Cessation
- 2008-12-17 NZ NZ586735A patent/NZ586735A/en not_active IP Right Cessation
- 2008-12-17 MY MYPI2010002834A patent/MY153985A/en unknown
- 2008-12-17 US US12/809,545 patent/US8536209B2/en not_active Expired - Fee Related
- 2008-12-17 AT AT08862134T patent/ATE520689T1/de active
- 2008-12-17 BR BRPI0821115A patent/BRPI0821115A8/pt not_active IP Right Cessation
- 2008-12-17 RU RU2010129272/04A patent/RU2492167C2/ru not_active IP Right Cessation
- 2008-12-17 KR KR1020107015871A patent/KR101213007B1/ko not_active IP Right Cessation
- 2008-12-17 CA CA2706839A patent/CA2706839C/en not_active Expired - Fee Related
- 2008-12-18 AR ARP080105522A patent/AR069801A1/es not_active Application Discontinuation
-
2010
- 2010-06-16 IL IL206399A patent/IL206399A/en not_active IP Right Cessation
- 2010-06-29 MA MA32968A patent/MA31949B1/fr unknown
- 2010-07-16 ZA ZA2010/05080A patent/ZA201005080B/en unknown
- 2010-11-18 HK HK10110770.3A patent/HK1144158A1/xx not_active IP Right Cessation
-
2011
- 2011-11-10 HR HR20110825T patent/HRP20110825T1/hr unknown
- 2011-11-17 CY CY20111101111T patent/CY1112465T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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