PL2225231T3 - Pochodne aminotriazolu jako agoniści ALX - Google Patents
Pochodne aminotriazolu jako agoniści ALXInfo
- Publication number
- PL2225231T3 PL2225231T3 PL08862134T PL08862134T PL2225231T3 PL 2225231 T3 PL2225231 T3 PL 2225231T3 PL 08862134 T PL08862134 T PL 08862134T PL 08862134 T PL08862134 T PL 08862134T PL 2225231 T3 PL2225231 T3 PL 2225231T3
- Authority
- PL
- Poland
- Prior art keywords
- aminotriazole derivatives
- alx
- agonists
- alx agonists
- aminotriazole
- Prior art date
Links
- JSIAIROWMJGMQZ-UHFFFAOYSA-N 2h-triazol-4-amine Chemical class NC1=CNN=N1 JSIAIROWMJGMQZ-UHFFFAOYSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007055199 | 2007-12-18 | ||
| IB2008054369 | 2008-10-23 | ||
| EP08862134A EP2225231B1 (en) | 2007-12-18 | 2008-12-17 | Aminotriazole derivatives as alx agonists |
| PCT/IB2008/055375 WO2009077990A1 (en) | 2007-12-18 | 2008-12-17 | Aminotriazole derivatives as alx agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2225231T3 true PL2225231T3 (pl) | 2012-01-31 |
Family
ID=40404773
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08862134T PL2225231T3 (pl) | 2007-12-18 | 2008-12-17 | Pochodne aminotriazolu jako agoniści ALX |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8536209B2 (pl) |
| EP (1) | EP2225231B1 (pl) |
| JP (1) | JP4656674B2 (pl) |
| KR (1) | KR101213007B1 (pl) |
| CN (1) | CN101903378B (pl) |
| AR (1) | AR069801A1 (pl) |
| AT (1) | ATE520689T1 (pl) |
| AU (1) | AU2008337097B2 (pl) |
| BR (1) | BRPI0821115A8 (pl) |
| CA (1) | CA2706839C (pl) |
| CY (1) | CY1112465T1 (pl) |
| DK (1) | DK2225231T3 (pl) |
| HR (1) | HRP20110825T1 (pl) |
| IL (1) | IL206399A (pl) |
| MA (1) | MA31949B1 (pl) |
| MX (1) | MX2010006241A (pl) |
| MY (1) | MY153985A (pl) |
| NZ (1) | NZ586735A (pl) |
| PL (1) | PL2225231T3 (pl) |
| PT (1) | PT2225231E (pl) |
| RU (1) | RU2492167C2 (pl) |
| SI (1) | SI2225231T1 (pl) |
| TW (1) | TWI434685B (pl) |
| WO (1) | WO2009077990A1 (pl) |
| ZA (1) | ZA201005080B (pl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| NZ597122A (en) | 2009-05-18 | 2013-06-28 | Actelion Pharmaceuticals Ltd | Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists |
| WO2010143116A1 (en) | 2009-06-09 | 2010-12-16 | Actelion Pharmaceuticals Ltd | Fluorinated aminotriazole derivatives |
| KR20120046159A (ko) | 2009-06-12 | 2012-05-09 | 액테리온 파마슈티칼 리미티드 | Ａｌｘ 수용체 아고니스트로서의 옥사졸 및 티아졸 유도체 |
| WO2012066488A2 (en) | 2010-11-17 | 2012-05-24 | Actelion Pharmaceuticals Ltd | Bridged spiro[2.4]heptane ester derivatives |
| HRP20150049T1 (hr) * | 2010-12-07 | 2015-02-27 | Actelion Pharmaceuticals Ltd. | Derivati oksazolil-metiletera kao agonisti alx-receptora |
| US9346793B2 (en) | 2010-12-07 | 2016-05-24 | Actelion Pharmaceuticals, Ltd. | Hydroxylated aminotriazole derivatives as ALX receptor agonists |
| WO2012152741A1 (de) | 2011-05-10 | 2012-11-15 | Bayer Intellectual Property Gmbh | Bicyclische (thio)carbonylamidine |
| WO2013022766A1 (en) | 2011-08-05 | 2013-02-14 | Flynn Gary A | Preparation and methods of use for ortho-aryl 5- membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors |
| CN102558117B (zh) * | 2011-12-15 | 2014-10-08 | 北京金骄生物质化工有限公司 | 一种利用废弃生物质制备5-硝基-2-糠酸酯的方法 |
| MA37618B1 (fr) | 2012-05-16 | 2017-08-31 | Actelion Pharmaceuticals Ltd | Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx |
| WO2013171687A1 (en) | 2012-05-16 | 2013-11-21 | Actelion Pharmaceuticals Ltd | 1-(p-tolyl)cyclopropyl substituted bridged spiro[2.4]heptane derivatives as alx receptor agonists |
| PT2855453T (pt) | 2012-06-04 | 2017-03-09 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazol-prolina |
| WO2014057435A1 (en) | 2012-10-10 | 2014-04-17 | Actelion Pharmaceuticals Ltd | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives |
| RU2015123982A (ru) * | 2012-12-03 | 2017-01-13 | Ф. Хоффманн-Ля Рош Аг | Соединения замещенных триазола и имидазола |
| EP2970241A1 (en) | 2013-03-12 | 2016-01-20 | Actelion Pharmaceuticals Ltd. | Azetidine amide derivatives as orexin receptor antagonists |
| AR096686A1 (es) | 2013-06-25 | 2016-01-27 | Actelion Pharmaceuticals Ltd | Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx |
| TW201536289A (zh) | 2013-07-18 | 2015-10-01 | Actelion Pharmaceuticals Ltd | 作為ａｌｘ受體激動劑之經哌取代橋聯螺［２，４］庚烷衍生物 |
| AR097279A1 (es) | 2013-08-09 | 2016-03-02 | Actelion Pharmaceuticals Ltd | Derivados de benzimidazolil-metil urea como agonistas del receptor de alx |
| NZ720508A (en) | 2013-11-28 | 2019-03-29 | Kyorin Seiyaku Kk | Urea derivative or pharmacologically acceptable salt thereof |
| UA116053C2 (uk) | 2013-12-04 | 2018-01-25 | Ідорсія Фармасьютікалз Лтд | Застосування похідних бензоімідазолу-проліну |
| EA201792382A1 (ru) | 2015-05-27 | 2018-04-30 | Киорин Фармасютикал Ко., Лтд. | Производное мочевины или его фармакологически приемлемая соль |
| EP3303284B1 (en) | 2015-05-27 | 2020-04-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
| MX2018005756A (es) * | 2015-11-24 | 2018-08-01 | Squibb Bristol Myers Co | Ubicacion como objetivo del receptor 2 de formilo-peptido/receptor de lipoxina a4 (fpr2/alx) para el tratamiento de enfermedades cardiacas. |
| AU2019232704B2 (en) | 2018-03-05 | 2024-03-21 | Bristol-Myers Squibb Company | Phenylpyrrolidinone formyl peptide 2 receptor agonists |
| US11629143B2 (en) | 2020-10-01 | 2023-04-18 | Vibliome Therapeutics, Llc | HipK4 inhibitors and uses thereof |
| JP7743010B2 (ja) * | 2021-03-12 | 2025-09-24 | 国立大学法人 長崎大学 | ハロカルボニル化合物の製造方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62234018A (ja) | 1986-04-02 | 1987-10-14 | Rooto Seiyaku Kk | 糖尿病併発症治療剤 |
| WO2003035006A2 (en) | 2001-10-26 | 2003-05-01 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, The | Amyloid ss is a ligand for fpr class receptors |
| AU2003214249A1 (en) | 2002-04-03 | 2003-10-13 | Bayer Aktiengesellschaft | Diagnostics and therapeutics for diseases associated with n-formyl peptide receptor like 1 (fprl1) |
| KR20060130064A (ko) * | 2003-11-07 | 2006-12-18 | 아카디아 파마슈티칼스 인코포레이티드 | 통증 및 염증 치료에 효과적인 화합물을 동정하기 위한도구로서의 리폭신 수용체, ｆｐｒｌ1의 용도 |
| US7323480B2 (en) * | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| AU2005316034B2 (en) * | 2004-12-13 | 2012-01-19 | Leo Pharma A/S | Triazole substituted aminobenzophenone compounds |
| WO2007055941A2 (en) * | 2005-11-03 | 2007-05-18 | Merck & Co., Inc. | Histone deacetylase inhibitors with aryl-pyrazolyl motifs |
| CA2651072A1 (en) * | 2006-05-01 | 2007-11-08 | Pfizer Products Inc. | Substituted 2-amino-fused heterocyclic compounds |
| RU2522456C2 (ru) | 2007-08-21 | 2014-07-10 | Синомикс, Инк. | Соединения, ингибирующие (блокирующие) горький вкус, способы их применения и получения |
| AR069650A1 (es) | 2007-12-14 | 2010-02-10 | Actelion Pharmaceuticals Ltd | Derivados de aminopirazol como agonistas no peptidicos del receptor alx humano |
| NZ597122A (en) | 2009-05-18 | 2013-06-28 | Actelion Pharmaceuticals Ltd | Bridged spiro [2.4] heptane derivatives as alx receptor and/or fprl2 agonists |
| WO2010143116A1 (en) | 2009-06-09 | 2010-12-16 | Actelion Pharmaceuticals Ltd | Fluorinated aminotriazole derivatives |
| KR20120046159A (ko) | 2009-06-12 | 2012-05-09 | 액테리온 파마슈티칼 리미티드 | Ａｌｘ 수용체 아고니스트로서의 옥사졸 및 티아졸 유도체 |
-
2008
- 2008-12-17 MX MX2010006241A patent/MX2010006241A/es active IP Right Grant
- 2008-12-17 KR KR1020107015871A patent/KR101213007B1/ko not_active Expired - Fee Related
- 2008-12-17 EP EP08862134A patent/EP2225231B1/en not_active Not-in-force
- 2008-12-17 AU AU2008337097A patent/AU2008337097B2/en not_active Ceased
- 2008-12-17 CA CA2706839A patent/CA2706839C/en not_active Expired - Fee Related
- 2008-12-17 SI SI200830412T patent/SI2225231T1/sl unknown
- 2008-12-17 PT PT08862134T patent/PT2225231E/pt unknown
- 2008-12-17 NZ NZ586735A patent/NZ586735A/en not_active IP Right Cessation
- 2008-12-17 JP JP2010539015A patent/JP4656674B2/ja not_active Expired - Fee Related
- 2008-12-17 WO PCT/IB2008/055375 patent/WO2009077990A1/en not_active Ceased
- 2008-12-17 HR HR20110825T patent/HRP20110825T1/hr unknown
- 2008-12-17 US US12/809,545 patent/US8536209B2/en not_active Expired - Fee Related
- 2008-12-17 RU RU2010129272/04A patent/RU2492167C2/ru not_active IP Right Cessation
- 2008-12-17 BR BRPI0821115A patent/BRPI0821115A8/pt not_active IP Right Cessation
- 2008-12-17 PL PL08862134T patent/PL2225231T3/pl unknown
- 2008-12-17 TW TW097149199A patent/TWI434685B/zh not_active IP Right Cessation
- 2008-12-17 MY MYPI2010002834A patent/MY153985A/en unknown
- 2008-12-17 DK DK08862134.7T patent/DK2225231T3/da active
- 2008-12-17 AT AT08862134T patent/ATE520689T1/de active
- 2008-12-17 CN CN200880122188.XA patent/CN101903378B/zh not_active Expired - Fee Related
- 2008-12-18 AR ARP080105522A patent/AR069801A1/es not_active Application Discontinuation
-
2010
- 2010-06-16 IL IL206399A patent/IL206399A/en not_active IP Right Cessation
- 2010-06-29 MA MA32968A patent/MA31949B1/fr unknown
- 2010-07-16 ZA ZA2010/05080A patent/ZA201005080B/en unknown
-
2011
- 2011-11-17 CY CY20111101111T patent/CY1112465T1/el unknown
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