ATE555785T1 - Triazolderivate als smo-antagonisten - Google Patents
Triazolderivate als smo-antagonistenInfo
- Publication number
- ATE555785T1 ATE555785T1 AT08742913T AT08742913T ATE555785T1 AT E555785 T1 ATE555785 T1 AT E555785T1 AT 08742913 T AT08742913 T AT 08742913T AT 08742913 T AT08742913 T AT 08742913T AT E555785 T1 ATE555785 T1 AT E555785T1
- Authority
- AT
- Austria
- Prior art keywords
- triazole derivatives
- smo antagonists
- smo
- antagonists
- triazole
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92501807P | 2007-04-18 | 2007-04-18 | |
PCT/US2008/004862 WO2008130552A1 (en) | 2007-04-18 | 2008-04-15 | Triazole derivatives which are smo antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE555785T1 true ATE555785T1 (de) | 2012-05-15 |
Family
ID=39433852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08742913T ATE555785T1 (de) | 2007-04-18 | 2008-04-15 | Triazolderivate als smo-antagonisten |
Country Status (12)
Country | Link |
---|---|
US (1) | US7691887B2 (de) |
EP (1) | EP2136803B1 (de) |
JP (1) | JP5498936B2 (de) |
CN (1) | CN101663033B (de) |
AR (1) | AR066063A1 (de) |
AT (1) | ATE555785T1 (de) |
AU (1) | AU2008241527B2 (de) |
CA (1) | CA2683946C (de) |
CL (1) | CL2008001074A1 (de) |
PE (1) | PE20090806A1 (de) |
TW (1) | TW200901987A (de) |
WO (1) | WO2008130552A1 (de) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
AU2008345097A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
AU2008345151A1 (en) * | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Therapeutic cancer treatments |
GB0813740D0 (en) * | 2008-07-28 | 2008-09-03 | Angeletti P Ist Richerche Biologica | Therapeutic compounds |
EP2334683B1 (de) * | 2008-08-29 | 2017-03-22 | MSD Italia S.r.l. | Gesättigte bicyclische heterocyclische derivate als smo-antagonisten |
CA2769795C (en) | 2009-08-05 | 2020-01-07 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
JP2013511549A (ja) * | 2009-11-20 | 2013-04-04 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | ヘッジホッグ関連癌の治療のための方法及び組成物 |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
JP2016519684A (ja) | 2013-04-08 | 2016-07-07 | デニス エム ブラウン | 準最適に投与された薬物療法の有効性を改善するための及び/又は副作用を低減するための方法および組成物 |
CN104324039A (zh) * | 2014-10-20 | 2015-02-04 | 付茜 | 一种治疗人身体表面脂肪瘤的药剂及使用方法 |
MX2017015681A (es) | 2015-06-04 | 2018-09-11 | Pellepharm Inc | Formulaciones topicas para suministrar compuestos inhibidores de hedgehog y uso de los mismos. |
CN108623446A (zh) * | 2017-03-24 | 2018-10-09 | 北京艾德旺科技发展有限公司 | 一种合成3,3-二氟环丁烷甲酸的方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
WO2003065983A2 (en) | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
JO2397B1 (en) * | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
EP1638947B1 (de) | 2003-05-29 | 2010-08-04 | Merck Sharp & Dohme Corp. | Triazolderivate als inhibitoren von 11-beta- hydroxysteroid-dehydrogenase-1 |
WO2005033288A2 (en) | 2003-09-29 | 2005-04-14 | The Johns Hopkins University | Hedgehog pathway antagonists |
EP1745041B1 (de) | 2004-04-30 | 2012-06-20 | Genentech, Inc. | Chinoxalin-hemmer des hedgehog-signalweges |
JP2008509146A (ja) | 2004-08-06 | 2008-03-27 | メルク エンド カムパニー インコーポレーテッド | 11−ベータ−ヒドロキシステロイドデヒドロゲナーゼ−1の阻害剤としてのスルホニル化合物 |
CA2579078C (en) | 2004-08-27 | 2016-11-22 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
EA201890903A9 (ru) | 2004-09-02 | 2021-11-10 | Дженентек, Инк. | Соединения пиридиловых ингибиторов передачи сигналов белком hedgehog, способ их получения, композиция и способы лечения рака и ингибирований ангиогенеза и сигнального пути hedgehog в клетках на их основе |
RU2007119637A (ru) | 2004-10-28 | 2008-12-10 | Айрм Ллк (Bm) | Соединения и композиции в качестве модуляторов hedgehog-пути |
WO2006050506A1 (en) | 2004-11-03 | 2006-05-11 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
BRPI0617501A2 (pt) * | 2005-10-20 | 2011-07-26 | Merck & Co Inc | composto ou um sal ou solvato farmaceuticamente aceitÁvel do mesmo, composiÇço farmacÊutica, e, uso de um composto |
-
2008
- 2008-04-15 CN CN2008800127274A patent/CN101663033B/zh active Active
- 2008-04-15 CA CA2683946A patent/CA2683946C/en active Active
- 2008-04-15 AR ARP080101540A patent/AR066063A1/es unknown
- 2008-04-15 PE PE2008000654A patent/PE20090806A1/es not_active Application Discontinuation
- 2008-04-15 WO PCT/US2008/004862 patent/WO2008130552A1/en active Application Filing
- 2008-04-15 AU AU2008241527A patent/AU2008241527B2/en active Active
- 2008-04-15 US US12/082,933 patent/US7691887B2/en active Active
- 2008-04-15 JP JP2010504069A patent/JP5498936B2/ja active Active
- 2008-04-15 AT AT08742913T patent/ATE555785T1/de active
- 2008-04-15 CL CL2008001074A patent/CL2008001074A1/es unknown
- 2008-04-15 EP EP08742913A patent/EP2136803B1/de active Active
- 2008-04-15 TW TW097113665A patent/TW200901987A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2136803A1 (de) | 2009-12-30 |
TW200901987A (en) | 2009-01-16 |
JP2010524937A (ja) | 2010-07-22 |
US20080262051A1 (en) | 2008-10-23 |
CA2683946C (en) | 2013-01-22 |
CA2683946A1 (en) | 2008-10-30 |
PE20090806A1 (es) | 2009-06-27 |
US7691887B2 (en) | 2010-04-06 |
AR066063A1 (es) | 2009-07-22 |
JP5498936B2 (ja) | 2014-05-21 |
AU2008241527A1 (en) | 2008-10-30 |
EP2136803B1 (de) | 2012-05-02 |
AU2008241527B2 (en) | 2014-02-13 |
CL2008001074A1 (es) | 2009-06-05 |
CN101663033A (zh) | 2010-03-03 |
CN101663033B (zh) | 2013-01-16 |
WO2008130552A1 (en) | 2008-10-30 |
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