PE20090806A1 - Derivados de triazol que son antagonistas de smo - Google Patents
Derivados de triazol que son antagonistas de smoInfo
- Publication number
- PE20090806A1 PE20090806A1 PE2008000654A PE2008000654A PE20090806A1 PE 20090806 A1 PE20090806 A1 PE 20090806A1 PE 2008000654 A PE2008000654 A PE 2008000654A PE 2008000654 A PE2008000654 A PE 2008000654A PE 20090806 A1 PE20090806 A1 PE 20090806A1
- Authority
- PE
- Peru
- Prior art keywords
- ilo
- methyl
- triazol
- oxadiazole
- bicycle
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical compound [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 abstract 3
- 229910052731 fluorine Inorganic materials 0.000 abstract 3
- -1 CYCLOBUTYL Chemical class 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- VXNQJPMCJMJOMN-UHFFFAOYSA-N 1,1-difluoroethane Chemical class C[C](F)F VXNQJPMCJMJOMN-UHFFFAOYSA-N 0.000 abstract 1
- 241000027355 Ferocactus setispinus Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000002307 prostate Anatomy 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
REFERIDA A UN DERIVADO DE TRIAZOL DE FORMULA (I), DONDE DOS DE X, Y, Z SON N Y EL OTRO ES O; R1 Y R2 JUNTOS FORMAN CICLOBUTILO OPCIONALMENTE SUSTITUIDO CON FLUOR Y R3 ES H O F; O R1 ES METILO, R2 ES METILO O FLUOR Y R3 ES F. SON COMPUESTOS PREFERIDOS: 5-(1,1-DIFLUOROETIL)-3-(4-{4-METIL-5-[2-(TRIFLUOROMETIL)FENIL]-4H-1,2,4-TRIAZOL-3-ILO}BICICLO[2.2.2]OCT-1-ILO)-1,2,4-OXADIAZOL, 5-(3,3-DIFLUOROCICLOBUTIL)-3-(4-{4-METIL-5-[2-(TRIFLUOROMETIL)FENIL]-4H-1,2,4-TRIAZOL-3-ILO}BICICLO[2.2.2]OCT-1-ILO)-1,2,4-OXADIAZOL, 5-(1-FLUORO-1-METILETIL)-3-(4-{4-METIL-5-[2-(TRIFLUOROMETIL)FENIL]-4H-1,2,4-TRIAZOL-3-ILO}BICICLO[2.2.2]OCT-1-ILO)-1,2,4-OXADIAZOL, ENTRE OTROS. DICHOS COMPUESTOS INHIBEN LA VIA DE TRANSDUCCION DE SENALES DE HEDGEHOG SONIC, PARTICULARMENTE SMOTHENED (Smo) Y SON UTILES EN EL TRATAMIENTO DE CANCERES DE PROSTATA, PANCREATICOS, DE HUESOS, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92501807P | 2007-04-18 | 2007-04-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090806A1 true PE20090806A1 (es) | 2009-06-27 |
Family
ID=39433852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000654A PE20090806A1 (es) | 2007-04-18 | 2008-04-15 | Derivados de triazol que son antagonistas de smo |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7691887B2 (es) |
| EP (1) | EP2136803B1 (es) |
| JP (1) | JP5498936B2 (es) |
| CN (1) | CN101663033B (es) |
| AR (1) | AR066063A1 (es) |
| AT (1) | ATE555785T1 (es) |
| AU (1) | AU2008241527B2 (es) |
| CA (1) | CA2683946C (es) |
| CL (1) | CL2008001074A1 (es) |
| PE (1) | PE20090806A1 (es) |
| TW (1) | TW200901987A (es) |
| WO (1) | WO2008130552A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| KR20100137416A (ko) * | 2007-12-27 | 2010-12-30 | 인피니티 파마슈티칼스, 인코포레이티드 | 암 치료법 |
| CN101917853B (zh) | 2007-12-27 | 2014-03-19 | 无限药品股份有限公司 | 立体选择性还原的方法 |
| US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
| GB0813740D0 (en) * | 2008-07-28 | 2008-09-03 | Angeletti P Ist Richerche Biologica | Therapeutic compounds |
| EP2334683B1 (en) * | 2008-08-29 | 2017-03-22 | MSD Italia S.r.l. | Saturated bicyclic heterocyclic derivatives as smo antagonists |
| CA2769795C (en) | 2009-08-05 | 2020-01-07 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| WO2011063309A1 (en) * | 2009-11-20 | 2011-05-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| CN104324039A (zh) * | 2014-10-20 | 2015-02-04 | 付茜 | 一种治疗人身体表面脂肪瘤的药剂及使用方法 |
| AU2016271468B2 (en) | 2015-06-04 | 2020-01-02 | Sol-Gel Technologies Ltd. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
| CN108623446A (zh) * | 2017-03-24 | 2018-10-09 | 北京艾德旺科技发展有限公司 | 一种合成3，3-二氟环丁烷甲酸的方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP4368683B2 (ja) | 2002-02-01 | 2009-11-18 | メルク エンド カムパニー インコーポレーテッド | 糖尿病、肥満症および脂質代謝異常の治療に有用な１１−ベータ−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤 |
| JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
| JP4499106B2 (ja) | 2003-05-29 | 2010-07-07 | メルク・シャープ・エンド・ドーム・コーポレイション | １１−ベータ−水酸化ステロイド脱水素酵素−１の阻害剤としてのトリアゾール誘導体 |
| US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
| CN101018783B (zh) | 2004-04-30 | 2012-11-21 | 遗传技术研究公司 | Hedgehog信号传导途径的喹喔啉抑制剂 |
| ATE472531T1 (de) | 2004-08-06 | 2010-07-15 | Merck Sharp & Dohme | Sulfonylverbindungen als hemmer von 11-beta- hydroxysteroiddehydrogenase-1 |
| BRPI0514444A (pt) | 2004-08-27 | 2008-06-10 | Infinity Pharmaceuticals Inc | análogos de ciclopamina e métodos de uso destes |
| CN102964294A (zh) | 2004-09-02 | 2013-03-13 | 遗传技术研究公司 | Hedgehog信号转导的吡啶基抑制剂 |
| KR20070083836A (ko) | 2004-10-28 | 2007-08-24 | 아이알엠 엘엘씨 | 헷지혹 경로 조절제로서의 화합물 및 조성물 |
| NZ555419A (en) | 2004-11-03 | 2009-07-31 | Curis Inc | Mediators of the hedgehog gene signaling pathways, compositions and uses related thereto |
| EP1940393B1 (en) * | 2005-10-20 | 2012-07-25 | Merck Sharp & Dohme Corp. | Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1 |
-
2008
- 2008-04-15 CL CL2008001074A patent/CL2008001074A1/es unknown
- 2008-04-15 CN CN2008800127274A patent/CN101663033B/zh active Active
- 2008-04-15 TW TW097113665A patent/TW200901987A/zh unknown
- 2008-04-15 US US12/082,933 patent/US7691887B2/en active Active
- 2008-04-15 JP JP2010504069A patent/JP5498936B2/ja active Active
- 2008-04-15 AR ARP080101540A patent/AR066063A1/es unknown
- 2008-04-15 EP EP08742913A patent/EP2136803B1/en active Active
- 2008-04-15 AT AT08742913T patent/ATE555785T1/de active
- 2008-04-15 WO PCT/US2008/004862 patent/WO2008130552A1/en active Application Filing
- 2008-04-15 PE PE2008000654A patent/PE20090806A1/es not_active Application Discontinuation
- 2008-04-15 CA CA2683946A patent/CA2683946C/en active Active
- 2008-04-15 AU AU2008241527A patent/AU2008241527B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CA2683946C (en) | 2013-01-22 |
| WO2008130552A1 (en) | 2008-10-30 |
| US7691887B2 (en) | 2010-04-06 |
| JP2010524937A (ja) | 2010-07-22 |
| AU2008241527A1 (en) | 2008-10-30 |
| ATE555785T1 (de) | 2012-05-15 |
| CL2008001074A1 (es) | 2009-06-05 |
| EP2136803A1 (en) | 2009-12-30 |
| CA2683946A1 (en) | 2008-10-30 |
| EP2136803B1 (en) | 2012-05-02 |
| US20080262051A1 (en) | 2008-10-23 |
| CN101663033A (zh) | 2010-03-03 |
| JP5498936B2 (ja) | 2014-05-21 |
| AR066063A1 (es) | 2009-07-22 |
| CN101663033B (zh) | 2013-01-16 |
| TW200901987A (en) | 2009-01-16 |
| AU2008241527B2 (en) | 2014-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |