EA202092094A1 - Фенилпирролидиноновые агонисты формилпептидного рецептора 2 - Google Patents

Фенилпирролидиноновые агонисты формилпептидного рецептора 2

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Publication number
EA202092094A1
EA202092094A1 EA202092094A EA202092094A EA202092094A1 EA 202092094 A1 EA202092094 A1 EA 202092094A1 EA 202092094 A EA202092094 A EA 202092094A EA 202092094 A EA202092094 A EA 202092094A EA 202092094 A1 EA202092094 A1 EA 202092094A1
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EA
Eurasian Patent Office
Prior art keywords
agonists
phenylpyrrolidinone
formylpeptide receptor
compounds
peptide receptor
Prior art date
Application number
EA202092094A
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English (en)
Inventor
Правин Судхакар Шируд
Вишвешварайа Балигар
Баладжи Сешадри
Амит Кумар Чаттопадхиай
Николас Р. Вуртц
Эллен К. Кик
Original Assignee
Бристол-Маерс Сквибб Компани
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Application filed by Бристол-Маерс Сквибб Компани filed Critical Бристол-Маерс Сквибб Компани
Publication of EA202092094A1 publication Critical patent/EA202092094A1/ru

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Изобретение относится к соединениям формул (I)-(IX), которые являются агонистами формилпептидного рецептора 2 (FPR2) и/или агонистами формилпептидного рецептора 1 (FPR1). Изобретение также раскрывает композиции и способы применения соединений, например, для лечения атеросклероза, сердечной недостаточности, хронической обструктивной болезни легкого (COPD) и соответствующих заболеваний.
EA202092094A 2018-03-05 2019-03-04 Фенилпирролидиноновые агонисты формилпептидного рецептора 2 EA202092094A1 (ru)

Applications Claiming Priority (2)

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US201862638556P 2018-03-05 2018-03-05
PCT/US2019/020493 WO2019173182A1 (en) 2018-03-05 2019-03-04 Phenylpyrrolidinone formyl peptide 2 receptor agonists

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EA202092094A1 true EA202092094A1 (ru) 2020-12-10

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US (3) US10676431B2 (ru)
EP (2) EP3981767A1 (ru)
JP (1) JP7155276B2 (ru)
KR (1) KR20200128709A (ru)
CN (1) CN111868052B (ru)
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AU (1) AU2019232704B2 (ru)
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CA (1) CA3092927A1 (ru)
CL (1) CL2020002224A1 (ru)
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PE20210046A1 (es) 2018-03-05 2021-01-08 Bristol Myers Squibb Co Agonistas de fenilpirrolidinona del receptor 2 de formil peptido
AR122912A1 (es) * 2020-07-09 2022-10-12 Bristol Myers Squibb Co Agonistas de oxopirrolidina fpr2
JP2023537410A (ja) * 2020-08-12 2023-08-31 ブリストル－マイヤーズ スクイブ カンパニー オキソピロリジン尿素ｆｐｒ２アゴニスト
EP4281452A1 (en) * 2021-01-21 2023-11-29 Beijing Tiantan Hospital Modulators of fpr1 and methods of using the same
JP2024504713A (ja) * 2021-01-21 2024-02-01 バイオフロント セラピューティクス （ベイジン） カンパニー リミテッド Ｆｐｒ１のモジュレーター及びそれを使用する方法
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WO2024079252A1 (en) 2022-10-13 2024-04-18 Bayer Aktiengesellschaft Sos1 inhibitors

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