TR201909997T4 - 5-HT4 reseptör agonistleri olarak amid bileşikleri. - Google Patents
5-HT4 reseptör agonistleri olarak amid bileşikleri. Download PDFInfo
- Publication number
- TR201909997T4 TR201909997T4 TR2019/09997T TR201909997T TR201909997T4 TR 201909997 T4 TR201909997 T4 TR 201909997T4 TR 2019/09997 T TR2019/09997 T TR 2019/09997T TR 201909997 T TR201909997 T TR 201909997T TR 201909997 T4 TR201909997 T4 TR 201909997T4
- Authority
- TR
- Turkey
- Prior art keywords
- compounds
- receptor agonists
- amide compounds
- relates
- present
- Prior art date
Links
- 108091005482 5-HT4 receptors Proteins 0.000 title 1
- -1 Amide compounds Chemical class 0.000 title 1
- 239000000018 receptor agonist Substances 0.000 title 1
- 229940044601 receptor agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Mevcut buluş, bunların stereoizomerleri ve farmasötik olarak kabul edilebilir tuzları dahil olmak üzere formülün (I) bileşikleri ile ilgilidir. Bu buluş aynı zamanda bu tür bileşiklerin yapılması yöntemleri ve bu tür bileşikleri içeren farmasötik bileşimler ile ilgilidir. Bu buluşun bileşikleri, 5-hidroksitriptamin 4 (5-HT4) reseptörü ile ilgili olan çeşitli bozuklukların tedavisinde faydalıdır.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN709CH2015 | 2015-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201909997T4 true TR201909997T4 (tr) | 2019-07-22 |
Family
ID=55588327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/09997T TR201909997T4 (tr) | 2015-02-13 | 2016-01-07 | 5-HT4 reseptör agonistleri olarak amid bileşikleri. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9957257B2 (tr) |
| EP (1) | EP3265459B1 (tr) |
| JP (1) | JP6487564B2 (tr) |
| KR (1) | KR101966576B1 (tr) |
| CN (1) | CN107406434B (tr) |
| AU (1) | AU2016217461B2 (tr) |
| BR (1) | BR112017017275A2 (tr) |
| CA (1) | CA2975973C (tr) |
| CY (1) | CY1121898T1 (tr) |
| DK (1) | DK3265459T3 (tr) |
| EA (1) | EA034618B1 (tr) |
| ES (1) | ES2734734T3 (tr) |
| HR (1) | HRP20191179T1 (tr) |
| HU (1) | HUE045667T2 (tr) |
| IL (1) | IL253848B (tr) |
| LT (1) | LT3265459T (tr) |
| MA (1) | MA41633B1 (tr) |
| MD (1) | MD3265459T2 (tr) |
| ME (1) | ME03430B (tr) |
| MX (1) | MX368214B (tr) |
| NZ (1) | NZ734400A (tr) |
| PL (1) | PL3265459T3 (tr) |
| PT (1) | PT3265459T (tr) |
| RS (1) | RS59066B1 (tr) |
| SG (1) | SG11201706501VA (tr) |
| SI (1) | SI3265459T1 (tr) |
| TR (1) | TR201909997T4 (tr) |
| WO (1) | WO2016128990A1 (tr) |
| ZA (1) | ZA201705292B (tr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2780015T3 (pl) | 2011-11-18 | 2017-06-30 | Heptares Therapeutics Limited | Agonisty receptora muskarynowego M1 |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| GB201709652D0 (en) * | 2017-06-16 | 2017-08-02 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| CN110818661B (zh) * | 2019-12-02 | 2021-08-06 | 上海再启生物技术有限公司 | 5-ht4受体激动剂的关键中间体4-氨基-5-卤苯并呋喃-7-羧酸的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2545092C (en) | 2003-11-24 | 2010-08-17 | Pfizer Inc. | Quinolonecarboxylic acid compounds having 5-ht4 receptor agonistic activity |
| WO2005092882A1 (en) | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
| DK1856114T3 (en) | 2005-02-25 | 2014-11-17 | Raqualia Pharma Inc | Benzisoxazol-DERIVATIVES |
| US7906532B2 (en) | 2005-07-22 | 2011-03-15 | Pfizer Inc. | Indazole derivatives |
| TW200732327A (en) | 2005-10-28 | 2007-09-01 | Glaxo Group Ltd | Novel compound |
| GB0525661D0 (en) | 2005-12-16 | 2006-01-25 | Glaxo Group Ltd | Novel compounds |
| GB0603550D0 (en) | 2006-02-22 | 2006-04-05 | Glaxo Group Ltd | Novel compounds |
| WO2011099305A1 (en) | 2010-02-12 | 2011-08-18 | Raqualia Pharma Inc. | 5-ht4 receptor agonists for the treatment of dementia |
| MX2012008721A (es) | 2010-02-16 | 2012-08-17 | Pfizer | (r)-4-((4-((4-(tetrahidrofuran-3-iloxi)benzo[d]isoxazol-3-iloxi)m etil) tetrahidro-2h-piran-4-ol, un agonista pacial de receptores 5-ht4. |
| US9079894B2 (en) * | 2011-09-19 | 2015-07-14 | Suven Life Sciences Ltd | Heteroaryl compounds as 5-HT4 receptor ligands |
| CA2907620C (en) * | 2013-03-20 | 2018-03-13 | Suven Life Sciences Limited | 5-amino-quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists |
| KR101824154B1 (ko) * | 2013-12-16 | 2018-03-14 | 수벤 라이프 사이언시스 리미티드 | 5-ｈｔ４ 수용체 작용제로서 인다졸 화합물 |
-
2016
- 2016-01-07 RS RS20190836A patent/RS59066B1/sr unknown
- 2016-01-07 EP EP16711355.4A patent/EP3265459B1/en active Active
- 2016-01-07 MA MA41633A patent/MA41633B1/fr unknown
- 2016-01-07 KR KR1020177025584A patent/KR101966576B1/ko active IP Right Grant
- 2016-01-07 NZ NZ734400A patent/NZ734400A/en not_active IP Right Cessation
- 2016-01-07 US US15/549,663 patent/US9957257B2/en active Active
- 2016-01-07 CN CN201680015614.4A patent/CN107406434B/zh not_active Expired - Fee Related
- 2016-01-07 PL PL16711355T patent/PL3265459T3/pl unknown
- 2016-01-07 SI SI201630311T patent/SI3265459T1/sl unknown
- 2016-01-07 DK DK16711355.4T patent/DK3265459T3/da active
- 2016-01-07 HU HUE16711355A patent/HUE045667T2/hu unknown
- 2016-01-07 LT LTEP16711355.4T patent/LT3265459T/lt unknown
- 2016-01-07 MX MX2017010348A patent/MX368214B/es active IP Right Grant
- 2016-01-07 JP JP2017542107A patent/JP6487564B2/ja not_active Expired - Fee Related
- 2016-01-07 ES ES16711355T patent/ES2734734T3/es active Active
- 2016-01-07 MD MDE20180052T patent/MD3265459T2/ro not_active IP Right Cessation
- 2016-01-07 ME MEP-2019-190A patent/ME03430B/me unknown
- 2016-01-07 EA EA201791829A patent/EA034618B1/ru unknown
- 2016-01-07 BR BR112017017275A patent/BR112017017275A2/pt not_active IP Right Cessation
- 2016-01-07 WO PCT/IN2016/000008 patent/WO2016128990A1/en active Application Filing
- 2016-01-07 SG SG11201706501VA patent/SG11201706501VA/en unknown
- 2016-01-07 PT PT16711355T patent/PT3265459T/pt unknown
- 2016-01-07 AU AU2016217461A patent/AU2016217461B2/en not_active Ceased
- 2016-01-07 CA CA2975973A patent/CA2975973C/en not_active Expired - Fee Related
- 2016-01-07 TR TR2019/09997T patent/TR201909997T4/tr unknown
-
2017
- 2017-08-04 ZA ZA2017/05292A patent/ZA201705292B/en unknown
- 2017-08-06 IL IL253848A patent/IL253848B/en active IP Right Grant
-
2019
- 2019-07-01 HR HRP20191179TT patent/HRP20191179T1/hr unknown
- 2019-07-10 CY CY20191100739T patent/CY1121898T1/el unknown
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