EA201790046A1 - Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора - Google Patents

Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора

Info

Publication number
EA201790046A1
EA201790046A1 EA201790046A EA201790046A EA201790046A1 EA 201790046 A1 EA201790046 A1 EA 201790046A1 EA 201790046 A EA201790046 A EA 201790046A EA 201790046 A EA201790046 A EA 201790046A EA 201790046 A1 EA201790046 A1 EA 201790046A1
Authority
EA
Eurasian Patent Office
Prior art keywords
mineralocorticoid receptor
benzoxazinous
amides
models
receptor modulators
Prior art date
Application number
EA201790046A
Other languages
English (en)
Other versions
EA029518B1 (ru
Inventor
Гавин О'Махони
Майкл Коссеньянс
Карл Эдман
Йохан Каянус
Карл Андерс Хогнер
Филип Корнуолл
Эндрю Тёрнер
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of EA201790046A1 publication Critical patent/EA201790046A1/ru
Publication of EA029518B1 publication Critical patent/EA029518B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Раскрыты определенные производные бензоксазиноновых амидов формулы (I) или их фармацевтически приемлемых солейкоторые выступают в качестве модуляторов минералокортикоидного рецептора (MR), которые могут снизить окислительный стресс в эндотелии и, таким образом, улучшить функцию сосудов, способы их возможного терапевтического применения, фармацевтические композиции, содержащие их, и способы получения таких соединений.
EA201790046A 2014-06-30 2015-06-26 Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора EA029518B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462018790P 2014-06-30 2014-06-30
PCT/GB2015/051860 WO2016001631A1 (en) 2014-06-30 2015-06-26 Benzoxazinone amides as mineralocorticoid receptor modulators

Publications (2)

Publication Number Publication Date
EA201790046A1 true EA201790046A1 (ru) 2017-08-31
EA029518B1 EA029518B1 (ru) 2018-04-30

Family

ID=53539739

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790046A EA029518B1 (ru) 2014-06-30 2015-06-26 Бензоксазиноновые амиды в качестве модуляторов минералокортикоидного рецептора

Country Status (25)

Country Link
US (2) US10017502B2 (ru)
EP (1) EP3160948B1 (ru)
JP (1) JP6368383B2 (ru)
KR (1) KR102012222B1 (ru)
CN (1) CN106536491B (ru)
AR (1) AR101036A1 (ru)
AU (1) AU2015282450C1 (ru)
CA (1) CA2953655C (ru)
CY (1) CY1121596T1 (ru)
DK (1) DK3160948T3 (ru)
EA (1) EA029518B1 (ru)
ES (1) ES2707726T3 (ru)
HR (1) HRP20190147T1 (ru)
HU (1) HUE042370T2 (ru)
LT (1) LT3160948T (ru)
ME (1) ME03316B (ru)
MX (1) MX367404B (ru)
PL (1) PL3160948T3 (ru)
PT (1) PT3160948T (ru)
RS (1) RS58274B1 (ru)
SI (1) SI3160948T1 (ru)
TR (1) TR201900659T4 (ru)
TW (1) TWI677498B (ru)
UY (1) UY36195A (ru)
WO (1) WO2016001631A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3160948T1 (sl) * 2014-06-30 2020-06-30 Astrazeneca Ab Amidi benzoksazinona, kot modulatorji receptorja mineralokortikoida
EP3823631A1 (en) 2018-07-19 2021-05-26 Astrazeneca AB Methods of treating hfpef employing dapagliflozin and compositions comprising the same
CN112107568B (zh) * 2019-06-19 2022-03-25 北京龙嘉博创医药科技有限公司 二芳基酰胺类化合物及其应用
WO2021037400A1 (en) 2019-08-30 2021-03-04 Astrazeneca Ab Methods of treating heart failure with reduced ejection fraction with dapagliflozin
WO2022022865A1 (en) 2020-07-27 2022-02-03 Astrazeneca Ab Methods of treating chronic kidney disease with dapagliflozin
KR20240021854A (ko) * 2021-06-15 2024-02-19 치아타이 티안큉 파마수티컬 그룹 주식회사 벤조옥사지논 유도체
WO2024015425A1 (en) 2022-07-14 2024-01-18 Fmc Corporation Herbicidal benzoxazines
WO2024047574A1 (en) 2022-09-01 2024-03-07 Astrazeneca Ab Combination of sglt2 inhibitors and mineralcorticoid receptor modulators for use in treatment of cardiorenal diseases

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US6951855B2 (en) * 2001-04-23 2005-10-04 Astrazeneca Ab Benzoxazinone derivatives for use in the treatment of angiogenesis
AU2003303231A1 (en) * 2002-12-20 2004-07-14 Warner-Lambert Company Llc Benzoxazines and derivatives thereof as inhibitors of pi3ks
CN101018552A (zh) * 2004-07-14 2007-08-15 利亘制药公司 细胞内受体调节剂化合物和方法
BRPI0512674A (pt) * 2004-07-28 2007-09-25 Irm Llc compostos e composições como moduladores de receptores nucleares de hormÈnio esteróide
US20090253687A1 (en) 2005-12-28 2009-10-08 Shoji Fukumoto Fused Heterocyclic Compounds and Their Use as Mineralocorticoid Receptor Ligands
TWI385161B (zh) 2006-02-02 2013-02-11 Mitsubishi Tanabe Pharma Corp 含氮雜雙環化合物
CA2667966C (en) 2006-10-31 2011-08-02 Pfizer Products Inc. Pyrazoline compounds as mineralocorticoid receptor antagonists
DE102007009494A1 (de) 2007-02-27 2008-08-28 Bayer Healthcare Ag Substituierte 4-Aryl-1, 4-dihydro-1,6-naphthyridinamide und ihre Verwendung
JP2010522168A (ja) 2007-03-23 2010-07-01 メルク・シャープ・エンド・ドーム・コーポレイション 鉱質コルチコイドレセプターモジュレータ
WO2008126831A1 (ja) 2007-04-09 2008-10-23 Daiichi Sankyo Company, Limited ピロール誘導体のアトロプ異性体
US8258131B2 (en) 2007-08-01 2012-09-04 Mitsubishi Tanabe Pharma Corporation Fused bicyclic compound
JP5173653B2 (ja) * 2007-08-01 2013-04-03 田辺三菱製薬株式会社 医薬組成物
TWI431010B (zh) 2007-12-19 2014-03-21 Lilly Co Eli 礦皮質素受體拮抗劑及使用方法
CA2726746A1 (en) * 2008-06-18 2009-12-23 Astrazeneca Ab Benzoxazinone derivatives acting as beta2-adrenoreceptor agonist for the treatment of respiratory disorders
US20100094000A1 (en) 2008-09-03 2010-04-15 Takeda Pharmaceutical Company Limited Pyrazole compounds
WO2010098286A1 (ja) 2009-02-25 2010-09-02 第一三共株式会社 ミネラルコルチコイド受容体拮抗薬を含有する医薬
AU2010222902B2 (en) 2009-03-12 2013-04-18 Eli Lilly And Company Mineralocorticoid receptor antagonist and methods of use
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EP2569576B1 (en) 2010-05-11 2016-07-06 Koninklijke Philips N.V. Lighting module
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Also Published As

Publication number Publication date
ME03316B (me) 2019-10-20
US20170217945A1 (en) 2017-08-03
AU2015282450A1 (en) 2017-02-02
CA2953655A1 (en) 2016-01-07
HUE042370T2 (hu) 2019-06-28
ES2707726T3 (es) 2019-04-04
JP6368383B2 (ja) 2018-08-01
AU2015282450B2 (en) 2018-05-10
US20150376170A1 (en) 2015-12-31
SI3160948T1 (sl) 2020-06-30
TWI677498B (zh) 2019-11-21
MX367404B (es) 2019-08-20
JP2017522300A (ja) 2017-08-10
CN106536491B (zh) 2018-12-18
EA029518B1 (ru) 2018-04-30
TW201613909A (en) 2016-04-16
MX2017000183A (es) 2017-04-25
PT3160948T (pt) 2019-02-01
UY36195A (es) 2016-01-08
EP3160948A1 (en) 2017-05-03
KR102012222B1 (ko) 2019-10-21
PL3160948T3 (pl) 2019-04-30
CA2953655C (en) 2020-05-12
US9394291B2 (en) 2016-07-19
US10017502B2 (en) 2018-07-10
TR201900659T4 (tr) 2019-02-21
RS58274B1 (sr) 2019-03-29
HRP20190147T1 (hr) 2019-03-22
WO2016001631A1 (en) 2016-01-07
LT3160948T (lt) 2019-02-11
DK3160948T3 (en) 2019-02-18
AR101036A1 (es) 2016-11-16
AU2015282450C1 (en) 2018-09-20
CY1121596T1 (el) 2020-05-29
CN106536491A (zh) 2017-03-22
EP3160948B1 (en) 2018-10-24
KR20170021883A (ko) 2017-02-28

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

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