CL2016001524A1 - Derivados antibacterianos de 1h-indazol y 1h-indol. - Google Patents

Derivados antibacterianos de 1h-indazol y 1h-indol.

Info

Publication number
CL2016001524A1
CL2016001524A1 CL2016001524A CL2016001524A CL2016001524A1 CL 2016001524 A1 CL2016001524 A1 CL 2016001524A1 CL 2016001524 A CL2016001524 A CL 2016001524A CL 2016001524 A CL2016001524 A CL 2016001524A CL 2016001524 A1 CL2016001524 A1 CL 2016001524A1
Authority
CL
Chile
Prior art keywords
indazole
indole
antibacterial derivatives
antibacterial
derivatives
Prior art date
Application number
CL2016001524A
Other languages
English (en)
Inventor
Etienne Ochala
Jean-Phillippe Surivet
Christian Hubschwerlwn
Jean-Luc Specklin
Azelu Mirre
Gaëlle Chapoux
Jean-Christophe Gauvin
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of CL2016001524A1 publication Critical patent/CL2016001524A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

<p>COMPUESTOS ANTIBACTERIANOS DERIVADOS DE 1H-INDAZOL Y 1H-INDOL; COMPOSICION FARMACEUTICA; SU USO EN LA PREVENCION O EL TRATAMIENTO DE UNA INFECCION BACTERIANA POR BACTERIAS GRAM-NEGATIVAS.</p>
CL2016001524A 2013-12-19 2016-06-16 Derivados antibacterianos de 1h-indazol y 1h-indol. CL2016001524A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13198338 2013-12-19

Publications (1)

Publication Number Publication Date
CL2016001524A1 true CL2016001524A1 (es) 2017-01-27

Family

ID=49880464

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016001524A CL2016001524A1 (es) 2013-12-19 2016-06-16 Derivados antibacterianos de 1h-indazol y 1h-indol.

Country Status (22)

Country Link
US (1) US9624206B2 (es)
EP (1) EP3083567B1 (es)
JP (1) JP6407288B2 (es)
KR (1) KR20160098503A (es)
CN (1) CN105829288B (es)
AR (1) AR100032A1 (es)
AU (1) AU2014368619B2 (es)
BR (1) BR112016014115A8 (es)
CA (1) CA2933604A1 (es)
CL (1) CL2016001524A1 (es)
EA (1) EA030730B1 (es)
ES (1) ES2666130T3 (es)
IL (1) IL246201A0 (es)
MA (1) MA39189A1 (es)
MX (1) MX360983B (es)
PH (1) PH12016501102A1 (es)
PL (1) PL3083567T3 (es)
SG (1) SG11201605014YA (es)
TR (1) TR201807881T4 (es)
TW (1) TW201609641A (es)
WO (1) WO2015091741A1 (es)
ZA (1) ZA201604968B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
MX2016014989A (es) 2014-05-16 2017-03-31 Actelion Pharmaceuticals Ltd Derivados antibacterianos de quinazolina-4 (3h)-ona.
TW201625569A (zh) 2014-11-19 2016-07-16 艾克泰聯製藥有限公司 抗菌性苯并噻唑衍生物
AR105646A1 (es) 2015-08-11 2017-10-25 Actelion Pharmaceuticals Ltd Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida
MA42679A (fr) * 2015-08-28 2018-07-04 Idorsia Pharmaceuticals Ltd Dérivés de pyrrolidin-2-one annelés antibactériens
AR105848A1 (es) * 2015-08-31 2017-11-15 Actelion Pharmaceuticals Ltd Derivados heterocíclicos antibacterianos
AR105889A1 (es) 2015-09-03 2017-11-22 Actelion Pharmaceuticals Ltd Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos
AU2017267194A1 (en) * 2016-05-17 2019-01-17 Idorsia Pharmaceuticals Ltd 6-(BUTA-1,3-DIYN-1-YL)benzo[D]thiazole derivatives
TW201906819A (zh) 2017-05-25 2019-02-16 日商大正製藥股份有限公司 新穎之咪唑衍生物
WO2019086452A1 (en) * 2017-10-31 2019-05-09 Idorsia Pharmaceuticals Ltd Antibacterial heteroaromatic compounds
CN113666860B (zh) * 2020-05-14 2024-03-15 鲁南制药集团股份有限公司 一种7-乙基色醇的制备方法

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PT3000810T (pt) 2002-03-13 2017-10-25 Array Biopharma Inc Derivados de benzimidazole alquilado n3 como inibidores de mek
DE102004017930A1 (de) 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
KR20070073791A (ko) 2004-10-18 2007-07-10 암젠 인코포레이티드 티아디아졸 화합물 및 이의 사용방법
EP1863818B1 (en) 2005-03-23 2010-03-10 F.Hoffmann-La Roche Ag Acetylenyl-pyrazolo-pvrimidine derivatives as mglur2 antagonists
EP2170814B1 (en) 2007-06-12 2016-08-17 Achaogen, Inc. Antibacterial agents
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ES2525820T3 (es) 2009-12-16 2014-12-30 Pfizer Inc. Derivados del ácido hidroxámico N-enlazados útiles como agentes antibacterianos
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SG193458A1 (en) * 2011-04-08 2013-10-30 Pfizer Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents
WO2013170030A1 (en) 2012-05-09 2013-11-14 Achaogen, Inc. Antibacterial agents
WO2013170165A1 (en) 2012-05-10 2013-11-14 Achaogen, Inc. Antibacterial agents
AR097617A1 (es) 2013-09-13 2016-04-06 Actelion Pharmaceuticals Ltd Derivados antibacterianos del 2h-indazol
AR099612A1 (es) 2014-03-04 2016-08-03 Actelion Pharmaceuticals Ltd Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona
MX2016014989A (es) 2014-05-16 2017-03-31 Actelion Pharmaceuticals Ltd Derivados antibacterianos de quinazolina-4 (3h)-ona.

Also Published As

Publication number Publication date
EA030730B1 (ru) 2018-09-28
AR100032A1 (es) 2016-09-07
AU2014368619A1 (en) 2016-07-28
IL246201A0 (en) 2016-08-02
KR20160098503A (ko) 2016-08-18
SG11201605014YA (en) 2016-07-28
ZA201604968B (en) 2018-11-28
EA201600475A1 (ru) 2016-11-30
JP6407288B2 (ja) 2018-10-17
CN105829288A (zh) 2016-08-03
MA39189A1 (fr) 2017-06-30
PL3083567T3 (pl) 2018-08-31
US9624206B2 (en) 2017-04-18
TR201807881T4 (tr) 2018-06-21
EP3083567A1 (en) 2016-10-26
ES2666130T3 (es) 2018-05-03
WO2015091741A1 (en) 2015-06-25
MX360983B (es) 2018-11-22
PH12016501102A1 (en) 2016-07-11
BR112016014115A2 (es) 2017-08-08
TW201609641A (zh) 2016-03-16
CN105829288B (zh) 2019-01-15
MX2016007991A (es) 2016-10-07
AU2014368619B2 (en) 2018-11-22
CA2933604A1 (en) 2015-06-25
US20170029411A1 (en) 2017-02-02
EP3083567B1 (en) 2018-03-07
BR112016014115A8 (pt) 2017-12-26
JP2017500336A (ja) 2017-01-05

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