MA38588B1 - Dérivés bi-aromatiques antibactériens - Google Patents

Dérivés bi-aromatiques antibactériens

Info

Publication number
MA38588B1
MA38588B1 MA38588A MA38588A MA38588B1 MA 38588 B1 MA38588 B1 MA 38588B1 MA 38588 A MA38588 A MA 38588A MA 38588 A MA38588 A MA 38588A MA 38588 B1 MA38588 B1 MA 38588B1
Authority
MA
Morocco
Prior art keywords
hydroxy
alkoxy
cyano
dashed line
oxoethoxy
Prior art date
Application number
MA38588A
Other languages
English (en)
Other versions
MA38588A1 (fr
Inventor
Christian Hubschwerlen
Georg Rueedi
Sylvaine Cren
Astrid Friedli
Cornelia Zumbrunn
Original Assignee
Idorsia Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idorsia Pharmaceuticals Ltd filed Critical Idorsia Pharmaceuticals Ltd
Publication of MA38588A1 publication Critical patent/MA38588A1/fr
Publication of MA38588B1 publication Critical patent/MA38588B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur des composés antibactériens de formule i i dans laquelle r est h, un groupe cyano, alcoxy, cyanométhoxy, cycloalkylméthoxy, hydroxyalcoxy, alcoxyalcoxy, alcoxycarbonyle, 2-éthoxy-2-oxoéthoxy, 2-(méthylamino)-2-oxoéthoxy, (1-cyanocyclobutyl)méthoxy, 3-hydroxy-pyrrolidin-1-yle ou 3,4-dihydroxycyclopentyl)méthoxy; u1 est n ou cr1, u2 est n ou cr2, u3 est n ou cr3 et u4 est n ou cr4, étant entendu qu'au plus trois de u1, u2, u3 et u4 peuvent être n en même temps; v1 est n ou cr5, v2 est n ou cr6, v3 est n ou cr7 et v4 est n ou ch, étant entendu qu'au plus deux de v1, v2, v3 et v4 peuvent être n en même temps; r1 est h, un groupe cyano, hydroxy ou alcoxy; r2 est h, un groupe hydroxy ou alcoxy; r3 est h, un groupe cyano, hydroxy, alcoxy ou carboxamido; r4 est h ou un groupe alcoxy; r5 est h ou un groupe hydroxy ou halogéno; r6 est h ou un groupe hydroxy ou halogéno; r7 est h; la ligne en tirets " " représente une liaison ou est absente; w représente ch ou n quand la ligne en tirets " " est une liaison, ou w représente ch2 quand la ligne en tirets " " est absente; x représente ch ou n; et q représente o ou s; et leurs sels.
MA38588A 2013-04-16 2014-04-15 Dérivés bi-aromatiques antibactériens MA38588B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2013053021 2013-04-16
PCT/IB2014/060724 WO2014170821A1 (fr) 2013-04-16 2014-04-15 Dérivés bi-aromatiques antibactériens

Publications (2)

Publication Number Publication Date
MA38588A1 MA38588A1 (fr) 2017-05-31
MA38588B1 true MA38588B1 (fr) 2018-04-30

Family

ID=50639826

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38588A MA38588B1 (fr) 2013-04-16 2014-04-15 Dérivés bi-aromatiques antibactériens

Country Status (21)

Country Link
US (1) US9527867B2 (fr)
EP (1) EP2986607B1 (fr)
JP (1) JP6375365B2 (fr)
KR (1) KR20150143720A (fr)
CN (1) CN105143216B (fr)
AR (1) AR095884A1 (fr)
AU (1) AU2014255326B2 (fr)
BR (1) BR112015026261A8 (fr)
CA (1) CA2907832A1 (fr)
CL (1) CL2015003019A1 (fr)
EA (1) EA029361B1 (fr)
ES (1) ES2640482T3 (fr)
HK (1) HK1221459A1 (fr)
MA (1) MA38588B1 (fr)
MX (1) MX362338B (fr)
PH (1) PH12015502411A1 (fr)
PL (1) PL2986607T3 (fr)
SA (1) SA515361261B1 (fr)
SG (1) SG11201508479RA (fr)
TW (1) TWI631119B (fr)
WO (1) WO2014170821A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR073774A1 (es) 2008-10-07 2010-12-01 Actelion Pharmaceuticals Ltd Compuestos antibioticos oxazolidinona triciclicos
AR102256A1 (es) * 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物
TW201808906A (zh) 2016-03-16 2018-03-16 拜耳作物科學股份有限公司 作為殺蟲劑之經取代吡啶化合物
AR108108A1 (es) 2016-04-14 2018-07-18 Idorsia Pharmaceuticals Ltd Derivados biaromáticos antibacterianos con sustitución de oxetan-3-iloxi
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
TW201833120A (zh) * 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
EP3284739A1 (fr) 2017-07-19 2018-02-21 Bayer CropScience Aktiengesellschaft Composés (hét)aryl substitués comme produit de lutte contre les parasites
EP3717490B1 (fr) 2017-11-29 2023-05-24 Bugworks Research, Inc. Composés hétérocycliques antibactériens et leurs synthèses
MA53219A (fr) 2018-08-13 2021-11-17 Hoffmann La Roche Nouveaux composés hétérocycliques en tant qu'inhibiteurs de monoacylglycérol lipase
MX2022002311A (es) 2019-09-12 2022-03-25 Hoffmann La Roche Compuestos de 4,4a,5,7,8,8a-hexapirido[4,3-b][1,4]oxazin-3-ona como inhibidores de monoacilglicerol lipasa (magl).
CN115298176A (zh) * 2020-03-24 2022-11-04 豪夫迈·罗氏有限公司 化合物以及它们在治疗细菌感染中的用途
CN115785718B (zh) * 2022-11-25 2023-08-22 四川大学 一种多基底表面的金属配位抗菌涂层及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0297042A1 (fr) 1987-06-23 1988-12-28 Ciba-Geigy Ag Dérivés de pénème substitués
DE19802239A1 (de) 1998-01-22 1999-07-29 Bayer Ag Neue mit Bicyclen substituierte Oxazolidinone
WO2001030782A2 (fr) 1999-10-29 2001-05-03 Syngenta Participations Ag Nouveaux herbicides
AU2002347985A1 (en) 2001-11-15 2003-06-10 Eli Lilly And Company Peroxisome proliferator activated receptor alpha agonists
TW200406413A (en) 2002-06-26 2004-05-01 Glaxo Group Ltd Compounds
WO2006102674A2 (fr) 2005-03-24 2006-09-28 Microbia, Inc. Inhibiteurs d'absorption de cholesterol de diphenylheterocycle
TW200734311A (en) 2005-11-21 2007-09-16 Astrazeneca Ab New compounds
EP2141154A4 (fr) 2007-03-30 2011-06-01 Inst Med Molecular Design Inc Dérivé d'oxazolidinone ayant une activité inhibitrice sur la 11 -hydroxystéroïde déshydrogénase de type i
CL2008001003A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
NZ586013A (en) 2007-12-20 2012-02-24 Pharma Mar Sa Antitumoral compounds
JP5349500B2 (ja) 2008-02-20 2013-11-20 アクテリオン ファーマシューティカルズ リミテッド アザトリシクリック抗菌性化合物
CA2713187C (fr) 2008-02-22 2016-06-07 Actelion Pharmaceuticals Ltd Derives d'oxazolidinone
MX2011000968A (es) * 2008-08-04 2011-03-02 Actelion Pharmaceuticals Ltd Derivados de alquilaminometiloxazolidinona triciclicos.
AR073774A1 (es) 2008-10-07 2010-12-01 Actelion Pharmaceuticals Ltd Compuestos antibioticos oxazolidinona triciclicos
EP2346862B1 (fr) * 2008-10-10 2012-09-12 Actelion Pharmaceuticals Ltd. 2-benzothiophényl- et 2-naphtyl-oxazolidinones et leurs analogues isostères aza utilisés comme agents antibactériens
CA2854264A1 (fr) 2011-11-08 2013-05-16 Actelion Pharmaceuticals Ltd Derives antibiotiques de 2-oxo-oxazolidin-3,5-diyle

Also Published As

Publication number Publication date
SG11201508479RA (en) 2015-11-27
BR112015026261A8 (pt) 2017-12-26
SA515361261B1 (ar) 2016-06-15
AU2014255326A1 (en) 2015-11-26
CA2907832A1 (fr) 2014-10-23
JP6375365B2 (ja) 2018-08-15
JP2016516805A (ja) 2016-06-09
AU2014255326B2 (en) 2018-09-13
HK1221459A1 (zh) 2017-06-02
US9527867B2 (en) 2016-12-27
BR112015026261A2 (pt) 2017-07-25
EP2986607B1 (fr) 2017-06-14
MX2015014576A (es) 2016-03-04
EA029361B1 (ru) 2018-03-30
TWI631119B (zh) 2018-08-01
EA201501025A1 (ru) 2016-08-31
PL2986607T3 (pl) 2017-11-30
CL2015003019A1 (es) 2016-09-30
MX362338B (es) 2019-01-11
ES2640482T3 (es) 2017-11-03
AR095884A1 (es) 2015-11-18
US20160075722A1 (en) 2016-03-17
CN105143216B (zh) 2018-04-13
KR20150143720A (ko) 2015-12-23
TW201516043A (zh) 2015-05-01
EP2986607A1 (fr) 2016-02-24
WO2014170821A1 (fr) 2014-10-23
MA38588A1 (fr) 2017-05-31
PH12015502411A1 (en) 2016-02-22
CN105143216A (zh) 2015-12-09

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