MX2010008922A - Compuestos antibioticos azatriciclicos. - Google Patents

Compuestos antibioticos azatriciclicos.

Info

Publication number
MX2010008922A
MX2010008922A MX2010008922A MX2010008922A MX2010008922A MX 2010008922 A MX2010008922 A MX 2010008922A MX 2010008922 A MX2010008922 A MX 2010008922A MX 2010008922 A MX2010008922 A MX 2010008922A MX 2010008922 A MX2010008922 A MX 2010008922A
Authority
MX
Mexico
Prior art keywords
antibiotic compounds
azatricyclic
azatricyclic antibiotic
represent
compounds
Prior art date
Application number
MX2010008922A
Other languages
English (en)
Inventor
Christian Hubschwerlen
Jean-Philippe Surivet
Cornelia Zumbrunn Acklin
Georg Rueddi
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of MX2010008922A publication Critical patent/MX2010008922A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención se refiere a compuestos antibacteriales de fórmula I (I) caracterizados porque n es 0 ó 1; R1 representa H o F; U representa CH2 o, cuando n es 1, 0 o NH; "-----" es un enlace o está ausente; V representa CH o N cuando "-----" es un enlace, o CH2 o NH cuando "-----" está ausente; W representa CH o N; A representa -(CH2)p-NH-(CH2)q- caracterizado porque p es 1 y q es 1 ó 2 o, cuando U representa CH2 y n es 1, p también puede ser 0 y q entonces es 2; G representa uno de los grupos caracterizados porque Z representa N o CH y Q representa O o S; y Z0, Z1 y Z2 cada uno representa CH, o Z0 y Z1 cada uno representa CH y Z2 representa N, o Z0 representa CH, Z1 representa N y Z2 representa CH o N, o Z0 representa N y Z1 y Z2 cada uno representa CH; y con sales de tales compuestos.
MX2010008922A 2008-02-20 2009-02-19 Compuestos antibioticos azatriciclicos. MX2010008922A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2008050603 2008-02-20
IB2008054065 2008-10-03
PCT/IB2009/050675 WO2009104147A2 (en) 2008-02-20 2009-02-19 Azatricyclic antibiotic compounds

Publications (1)

Publication Number Publication Date
MX2010008922A true MX2010008922A (es) 2010-09-07

Family

ID=40986002

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008922A MX2010008922A (es) 2008-02-20 2009-02-19 Compuestos antibioticos azatriciclicos.

Country Status (14)

Country Link
US (1) US8349828B2 (es)
EP (1) EP2257551B1 (es)
JP (1) JP5349500B2 (es)
KR (1) KR101590202B1 (es)
CN (1) CN102015710B (es)
AR (1) AR070455A1 (es)
AU (1) AU2009215327A1 (es)
BR (1) BRPI0907892A2 (es)
CA (1) CA2713182C (es)
ES (1) ES2411930T3 (es)
MX (1) MX2010008922A (es)
RU (1) RU2010138648A (es)
TW (1) TW200940551A (es)
WO (1) WO2009104147A2 (es)

Families Citing this family (14)

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EP2346862B1 (en) * 2008-10-10 2012-09-12 Actelion Pharmaceuticals Ltd. 2-benzothiophenyl-and 2-naphthyl-0xaz0lidin0nes and their azaisostere analogues as antibacterial agents
JPWO2012108376A1 (ja) 2011-02-07 2014-07-03 第一三共株式会社 アミノ基含有ピロリジノン誘導体
EP2726489A1 (en) * 2011-06-30 2014-05-07 DSM IP Assets B.V. Silicone-containing monomer
BR112014003200A2 (pt) 2011-08-11 2017-04-04 Actelion Pharmaceuticals Ltd derivados de quinazolina-2,4-diona
TW201326180A (zh) 2011-11-30 2013-07-01 Actelion Pharmaceuticals Ltd ３，７－二取代八氫－２Ｈ－吡啶并［４，３－ｅ］［１，３］□嗪－２－酮抗生素
WO2014024056A1 (en) 2012-08-06 2014-02-13 Daiichi Sankyo Company, Limited Pyrrolidine derivatives with antibacterial properties
EA029361B1 (ru) 2013-04-16 2018-03-30 Идорсиа Фармасьютиклз Лтд Антибактериальные биароматические производные
ITMI20131782A1 (it) * 2013-10-25 2015-04-26 Dipharma Francis Srl Procedimento per la preparazione di un agonista della trombopoietina
JP6112724B2 (ja) * 2013-10-31 2017-04-12 日本化薬株式会社 １，５−ナフチリジン誘導体およびそれを有効成分として含んでなる殺虫剤
AR102256A1 (es) 2014-10-15 2017-02-15 Actelion Pharmaceuticals Ltd Derivados biaromáticos básicos antibacterianos con sustitución de aminoalcoxi
TW201833120A (zh) 2017-02-17 2018-09-16 瑞士商愛杜西亞製藥有限公司 芳基噁唑啶酮抗生素化合物
JP7390728B2 (ja) 2017-11-29 2023-12-04 バグワークス・リサーチ・インコーポレイテッド 抗菌複素環式化合物及びそれらの合成

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US5298518A (en) 1989-09-29 1994-03-29 Eisai Co., Ltd. Biphenylmethane derivative and pharmacological use
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Also Published As

Publication number Publication date
KR101590202B1 (ko) 2016-01-29
CN102015710B (zh) 2013-04-24
WO2009104147A3 (en) 2009-11-05
WO2009104147A2 (en) 2009-08-27
US8349828B2 (en) 2013-01-08
CA2713182A1 (en) 2009-08-27
RU2010138648A (ru) 2012-03-27
EP2257551A2 (en) 2010-12-08
AR070455A1 (es) 2010-04-07
US20100331318A1 (en) 2010-12-30
ES2411930T3 (es) 2013-07-09
TW200940551A (en) 2009-10-01
CA2713182C (en) 2016-09-13
JP5349500B2 (ja) 2013-11-20
EP2257551B1 (en) 2013-04-10
JP2011512398A (ja) 2011-04-21
AU2009215327A1 (en) 2009-08-27
BRPI0907892A2 (pt) 2015-07-28
CN102015710A (zh) 2011-04-13
KR20100124273A (ko) 2010-11-26

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